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  <xsd:element abstract="true" id="cmre_DocumentAndEntityInformation" name="DocumentAndEntityInformation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_DryBulkrelatedBusinessMember" name="DryBulkrelatedBusinessMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
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  <xsd:element id="cmre_FairValueOfSharesIssuedToManager" name="FairValueOfSharesIssuedToManager" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_FairbankMaritimeCoMember" name="FairbankMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_FamilyMemberOfKonstantinosKonstantakopoulosMember" name="FamilyMemberOfKonstantinosKonstantakopoulosMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
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  <xsd:element id="cmre_FeePercentageOnContributedCapitalInvested" name="FeePercentageOnContributedCapitalInvested" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_FinancialAndStrategicAdviceMember" name="FinancialAndStrategicAdviceMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_FinancialArrangementSharePurchaseAgreementMember" name="FinancialArrangementSharePurchaseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
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  <xsd:element abstract="true" id="cmre_FivePreAndPostDeliveryFinancialAgreementsMember" name="FivePreAndPostDeliveryFinancialAgreementsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_ForeignExchangeForwardAndFxOptionZeroCostCollarMember" name="ForeignExchangeForwardAndFxOptionZeroCostCollarMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
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  <xsd:element id="cmre_GainLossOnAssetsHeldForSaleDiscontinuedOperation" name="GainLossOnAssetsHeldForSaleDiscontinuedOperation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
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  <xsd:element id="cmre_LesseeAndLessorFinanceLeasesTextBlock" name="LesseeAndLessorFinanceLeasesTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
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  <xsd:element abstract="true" id="cmre_LoansAgreementsOneNMLSubsidiary4Member" name="LoansAgreementsOneNMLSubsidiary4Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoansAgreementsOneNMLSubsidiaryMember" name="LoansAgreementsOneNMLSubsidiaryMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoansAgreementsOneNmlSubsidiary3Member" name="LoansAgreementsOneNmlSubsidiary3Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoansAgreementsOneNmlSubsidiary5Member" name="LoansAgreementsOneNmlSubsidiary5Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoansAgreementsOneNmlSubsidiary6Member" name="LoansAgreementsOneNmlSubsidiary6Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoansAgreementsThreeNMLSubsidiariesMember" name="LoansAgreementsThreeNMLSubsidiariesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoansAgreementsTwoNMLSubsidiaries2Member" name="LoansAgreementsTwoNMLSubsidiaries2Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoansAgreementsTwoNMLSubsidiaries3Member" name="LoansAgreementsTwoNMLSubsidiaries3Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoansAgreementsTwoNMLSubsidiaries4Member" name="LoansAgreementsTwoNMLSubsidiaries4Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoansAgreementsTwoNmlSubsidiariesMember" name="LoansAgreementsTwoNmlSubsidiariesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_LongTermDebtGrossIncludingTermLoansAndOtherFinancingArrangements" name="LongTermDebtGrossIncludingTermLoansAndOtherFinancingArrangements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFiveAndThereafter" name="LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFiveAndThereafter" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_LongtermDebtCurrentDiscontinuedOperation" name="LongtermDebtCurrentDiscontinuedOperation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_LongtermDebtGrossCurrentMaturities" name="LongtermDebtGrossCurrentMaturities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_LongtermDebtNoncurrentDiscontinuedOperation" name="LongtermDebtNoncurrentDiscontinuedOperation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_MajorCustomerAMember" name="MajorCustomerAMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MajorCustomerBMember" name="MajorCustomerBMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MajorCustomerCMember" name="MajorCustomerCMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MajorCustomerDMember" name="MajorCustomerDMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MajorCustomerEMember" name="MajorCustomerEMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MajorCustomersABCDAndEMember" name="MajorCustomersABCDAndEMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ManagementFeePerDayPerVessel" name="ManagementFeePerDayPerVessel" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_ManagementFeePerDayPerVesselUnderBareboatCharter" name="ManagementFeePerDayPerVesselUnderBareboatCharter" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_ManagementFeesRelatedParties" name="ManagementFeesRelatedParties" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ManagementFeesRelatedPartiesDiscontinuedOperation" name="ManagementFeesRelatedPartiesDiscontinuedOperation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_MarginDepositAssetsDiscontinuedOperation" name="MarginDepositAssetsDiscontinuedOperation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_NMLLoan10Member" name="NMLLoan10Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan11Member" name="NMLLoan11Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan12Member" name="NMLLoan12Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan13Member" name="NMLLoan13Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan15Member" name="NMLLoan15Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan16Member" name="NMLLoan16Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan17Member" name="NMLLoan17Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan2Member" name="NMLLoan2Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan3Member" name="NMLLoan3Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan4Member" name="NMLLoan4Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan5Member" name="NMLLoan5Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan6Member" name="NMLLoan6Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan7Member" name="NMLLoan7Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan8Member" name="NMLLoan8Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NMLLoan9Member" name="NMLLoan9Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NavilandsMember" name="NavilandsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NeptuneGlobalFinanceLtdNgfMember" name="NeptuneGlobalFinanceLtdNgfMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NeptuneMaritimeLeasingLimitedNmlMember" name="NeptuneMaritimeLeasingLimitedNmlMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NeptuneMember" name="NeptuneMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NetBookValueMember" name="NetBookValueMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NmlLoan14Member" name="NmlLoan14Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NmlLoanAgreementMember" name="NmlLoanAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_NoncontrollingInterestIncreaseDecreaseFromIssuanceOfSubsidiarySharesToNoncontrollingInterestHolders" name="NoncontrollingInterestIncreaseDecreaseFromIssuanceOfSubsidiarySharesToNoncontrollingInterestHolders" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_NonoperatingIncomeExpenseDiscontinuedOperation" name="NonoperatingIncomeExpenseDiscontinuedOperation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_Note10a2Member" name="Note10a2Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_Note10bMember" name="Note10bMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NoteToFinancialStatementDetailsTextual" name="NoteToFinancialStatementDetailsTextual" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NotesToFinancialStatements" name="NotesToFinancialStatements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NotesToFinancialStatementsAbstract" name="NotesToFinancialStatementsAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_NumberOfContainerVessels" name="NumberOfContainerVessels" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfControlledCompanies" name="NumberOfControlledCompanies" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfControlledCompaniesDryBulkVesselsOwned" name="NumberOfControlledCompaniesDryBulkVesselsOwned" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfControlledCompaniesDryBulkVesselsPreviouslyOwnedOrTobesold" name="NumberOfControlledCompaniesDryBulkVesselsPreviouslyOwnedOrTobesold" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfControlledCompaniesDryBulkVesselsTobeacquired" name="NumberOfControlledCompaniesDryBulkVesselsTobeacquired" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfDryBulkVessels" name="NumberOfDryBulkVessels" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfInterestRateDerivativesTerminated" name="NumberOfInterestRateDerivativesTerminated" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfMajorityOwnedSubsidiaries" name="NumberOfMajorityOwnedSubsidiaries" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfSecondhandDryBulkVessels" name="NumberOfSecondhandDryBulkVessels" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfSubsidiaries" name="NumberOfSubsidiaries" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfUnencumberedVessels" name="NumberOfUnencumberedVessels" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfVessels" name="NumberOfVessels" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfVesselsAcquiredUnderSPA" name="NumberOfVesselsAcquiredUnderSPA" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfVesselsCompletedDdDuringPeriod" name="NumberOfVesselsCompletedDdDuringPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_NumberOfVesselsOrdered" name="NumberOfVesselsOrdered" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_NumberOfVesselsProvidedAsCollateralsToSecureLoans" name="NumberOfVesselsProvidedAsCollateralsToSecureLoans" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfVesselsSurveyInProcess" name="NumberOfVesselsSurveyInProcess" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_O2023Q3October152023ToJanuary142024DividendsMember" name="O2023Q3October152023ToJanuary142024DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_O2023Q4DividendsMember" name="O2023Q4DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_O2024Q1DividendsMember" name="O2024Q1DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_O2024Q1January152024ToApril142024DividendsMember" name="O2024Q1January152024ToApril142024DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_O2024Q3DividendsMember" name="O2024Q3DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_O2024Q4DividendsMember" name="O2024Q4DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_O2024Q4October152024ToJanuary142025DividendsMember" name="O2024Q4October152024ToJanuary142025DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_O2025Q1DividendsMember" name="O2025Q1DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_O2025Q1January152025ToApril142025DividendsMember" name="O2025Q1January152025ToApril142025DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_OaklandMember" name="OaklandMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_OfficersCompensationChargedPeriodEnd" name="OfficersCompensationChargedPeriodEnd" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_OperatingLeaseLiabilityNoncurrentDiscontinuedOperation" name="OperatingLeaseLiabilityNoncurrentDiscontinuedOperation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_OperatingLeaseRightofuseAssetDiscontinuedOperation" name="OperatingLeaseRightofuseAssetDiscontinuedOperation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_OtherComprehensiveIncomeLossDerivativeEffectivePortionOfChangesInFairValueNet" name="OtherComprehensiveIncomeLossDerivativeEffectivePortionOfChangesInFairValueNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_OtherInvestorsMember" name="OtherInvestorsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_OtherNonoperatingIncomeExpenseDiscontinuedOperation" name="OtherNonoperatingIncomeExpenseDiscontinuedOperation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_OtherThirdpartyManagersMember" name="OtherThirdpartyManagersMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_PaymentsForInvestmentsInLeasebackVesselsInvestingActivities" name="PaymentsForInvestmentsInLeasebackVesselsInvestingActivities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_PaymentsToAcquireVessels" name="PaymentsToAcquireVessels" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_PercentageOwnership" name="PercentageOwnership" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_PercentageToBePaidOnOfferedSharesFairValue" name="PercentageToBePaidOnOfferedSharesFairValue" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_PolarBrasilMember" name="PolarBrasilMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_QuarterlyFeeToRelatedParties" name="QuarterlyFeeToRelatedParties" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_QuarterlyFeeToRelatedPartiesShares" name="QuarterlyFeeToRelatedPartiesShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_QuentinShippingCoAndSanderShippingCo2Member" name="QuentinShippingCoAndSanderShippingCo2Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_ReddickShippingCoAndVerandiShippingCo3Member" name="ReddickShippingCoAndVerandiShippingCo3Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_RedeemableNoncontrollingInterestEquityTransferredToAdditionalPaidinCapital" name="RedeemableNoncontrollingInterestEquityTransferredToAdditionalPaidinCapital" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_RefinanceTermLoanForQuentinShippingAndSanderShippingMember" name="RefinanceTermLoanForQuentinShippingAndSanderShippingMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_RefinanceTermLoanForReddickShippingAndVerandiShippingMember" name="RefinanceTermLoanForReddickShippingAndVerandiShippingMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_RefinanceTermLoanForTenCompaniesMember" name="RefinanceTermLoanForTenCompaniesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_RefinanceTermLoanToVulpeculaVolansVirgoAndVelaAndTrancheCOf11CompaniesTermLoanMember" name="RefinanceTermLoanToVulpeculaVolansVirgoAndVelaAndTrancheCOf11CompaniesTermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_RefinanceTermLoansOf17CompaniesMember" name="RefinanceTermLoansOf17CompaniesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_RestrictedCashAndRestrictedCashEquivalentDiscontinuedOperation" name="RestrictedCashAndRestrictedCashEquivalentDiscontinuedOperation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_RestrictedCashAndRestrictedCashEquivalentsNoncurrentDiscontinuedOperation" name="RestrictedCashAndRestrictedCashEquivalentsNoncurrentDiscontinuedOperation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_RevenueDaysPerAnnum" name="RevenueDaysPerAnnum" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SaleLeasebackTransactionsRegardingTheVesselPolarBrasilSlMember" name="SaleLeasebackTransactionsRegardingTheVesselPolarBrasilSlMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_SalestypeLeaseNetInvestmentInLeaseTableTextBlock" name="SalestypeLeaseNetInvestmentInLeaseTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfDeferredChargesTableTextBlock" name="ScheduleOfDeferredChargesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfDerivativeAssetsAndLiabilitiesAtFairValueTableTextBlock" name="ScheduleOfDerivativeAssetsAndLiabilitiesAtFairValueTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfDerivativesInASC815CashFlowHedgingRelationshipsTableTextBlock" name="ScheduleOfDerivativesInASC815CashFlowHedgingRelationshipsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfDerivativesNotDesignatedAsHedgingInstrumentsUnderASC815TableTextBlock" name="ScheduleOfDerivativesNotDesignatedAsHedgingInstrumentsUnderASC815TableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfFinancingCostsTableTextBlock" name="ScheduleOfFinancingCostsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfNonCancelableLongtermTimeCharterContractsTableTextBlock" name="ScheduleOfNonCancelableLongtermTimeCharterContractsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfUnbilledReceivablesNotBillableAtBalanceSheetDateTableTextBlock" name="ScheduleOfUnbilledReceivablesNotBillableAtBalanceSheetDateTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleVesselsAndAdvancesNetTableTextBlock" name="ScheduleVesselsAndAdvancesNetTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SealandIllinoisMember" name="SealandIllinoisMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_SwapInterestExpenseNet" name="SwapInterestExpenseNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SykesMaritimeCoMember" name="SykesMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_TermLoanAndOtherFinancingArrangementsMember" name="TermLoanAndOtherFinancingArrangementsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_TermLoanValueMaintenanceClausesForSpecificOne" name="TermLoanValueMaintenanceClausesForSpecificOne" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_TerminationOfTheServiceContractWithoutCauseMember" name="TerminationOfTheServiceContractWithoutCauseMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_TheBondMember" name="TheBondMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_ThePutNoticeMember" name="ThePutNoticeMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_TheSeventhOrEighthCouponPaymentDateMember" name="TheSeventhOrEighthCouponPaymentDateMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_TimeCharterArrangementsRemainingTermsPeriod" name="TimeCharterArrangementsRemainingTermsPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_TimeCharterAssumedAssetPositionMember" name="TimeCharterAssumedAssetPositionMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_TimeCharterDuration" name="TimeCharterDuration" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_USRelatedGrossTransportationIncomeThatTaxApplies" name="USRelatedGrossTransportationIncomeThatTaxApplies" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_UnamortizedBalanceOfChartersAssumedMember" name="UnamortizedBalanceOfChartersAssumedMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearFive" name="UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearFive" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearFour" name="UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearFour" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearOne" name="UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearOne" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearThree" name="UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearThree" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearTwo" name="UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearTwo" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_UnearnedRevenuesRegardingCharterRevenuesResultingFromVaryingCharterRatesMember" name="UnearnedRevenuesRegardingCharterRevenuesResultingFromVaryingCharterRatesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_UnearnedRevenuesRegardingHiresCollectedInAdvanceMember" name="UnearnedRevenuesRegardingHiresCollectedInAdvanceMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_VShipsGreeceLtdMember" name="VShipsGreeceLtdMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_VelaAndVulpeculaMember" name="VelaAndVulpeculaMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_VenetikoMember" name="VenetikoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_VesselCostMember" name="VesselCostMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VesselHeldForSale" name="VesselHeldForSale" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_VesselImpairmentLossDiscontinuedOperation" name="VesselImpairmentLossDiscontinuedOperation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VesselsAndAdvancesNet" name="VesselsAndAdvancesNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_VesselsAndAdvancesNetTextBlock" name="VesselsAndAdvancesNetTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VesselsAtCost" name="VesselsAtCost" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_VesselsNet" name="VesselsNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_VesselsUnderTimeCharter" name="VesselsUnderTimeCharter" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VoyageExpenses" name="VoyageExpenses" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VoyageExpensesDiscontinuedOperation" name="VoyageExpensesDiscontinuedOperation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VoyageExpensesRelatedParties" name="VoyageExpensesRelatedParties" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VoyageExpensesRelatedPartiesDiscontinuedOperation" name="VoyageExpensesRelatedPartiesDiscontinuedOperation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VoyageRevenues" name="VoyageRevenues" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_WalstonLocktonGlassertonAndStewartonShippingCosMember" name="WalstonLocktonGlassertonAndStewartonShippingCosMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_WorkingCapitalSecurity" name="WorkingCapitalSecurity" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_WorkingCapitalSecurityPerVessel" name="WorkingCapitalSecurityPerVessel" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_YorkMember" name="YorkMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_ZIMNewYorkMember" name="ZIMNewYorkMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_ZIMShanghaiMember" name="ZIMShanghaiMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-1-basis-of-presentation-and-general-information-assets-and-liabilities-of-costamere-bulkers-details" name="statement-statement-note-1-basis-of-presentation-and-general-information-assets-and-liabilities-of-costamere-bulkers-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-1-basis-of-presentation-and-general-information-customer-concentration-risk-details" name="statement-statement-note-1-basis-of-presentation-and-general-information-customer-concentration-risk-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-1-basis-of-presentation-and-general-information-reconciliation-of-cash-cash-equivalents-and-restricted-cash-details" name="statement-statement-note-1-basis-of-presentation-and-general-information-reconciliation-of-cash-cash-equivalents-and-restricted-cash-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-1-basis-of-presentation-and-general-information-tables" name="statement-statement-note-1-basis-of-presentation-and-general-information-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-10-longterm-debt-annual-repayments-under-credit-facilities-and-term-loans-details" name="statement-statement-note-10-longterm-debt-annual-repayments-under-credit-facilities-and-term-loans-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-10-longterm-debt-financing-costs-included-in-loan-balances-details" name="statement-statement-note-10-longterm-debt-financing-costs-included-in-loan-balances-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-10-longterm-debt-schedule-of-longterm-debt-details" name="statement-statement-note-10-longterm-debt-schedule-of-longterm-debt-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-10-longterm-debt-tables" name="statement-statement-note-10-longterm-debt-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-11-rightofuse-assets-finance-lease-liabilities-investment-in-leaseback-vessels-and-net-investment-in-salestype-leases-maturity-of-salestype-lease-receivables-details" name="statement-statement-note-11-rightofuse-assets-finance-lease-liabilities-investment-in-leaseback-vessels-and-net-investment-in-salestype-leases-maturity-of-salestype-lease-receivables-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-11-rightofuse-assets-finance-lease-liabilities-investment-in-leaseback-vessels-and-net-investment-in-salestype-leases-salestype-lease-details" name="statement-statement-note-11-rightofuse-assets-finance-lease-liabilities-investment-in-leaseback-vessels-and-net-investment-in-salestype-leases-salestype-lease-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-11-rightofuse-assets-finance-lease-liabilities-investment-in-leaseback-vessels-and-net-investment-in-salestype-leases-tables" name="statement-statement-note-11-rightofuse-assets-finance-lease-liabilities-investment-in-leaseback-vessels-and-net-investment-in-salestype-leases-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-12-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-schedule-of-accrued-revenue-details" name="statement-statement-note-12-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-schedule-of-accrued-revenue-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-12-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-schedule-of-unearned-revenue-details" name="statement-statement-note-12-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-schedule-of-unearned-revenue-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-12-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-tables" name="statement-statement-note-12-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-13-commitments-and-contingencies-schedule-of-time-charter-arrangements-details" name="statement-statement-note-13-commitments-and-contingencies-schedule-of-time-charter-arrangements-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-13-commitments-and-contingencies-tables" name="statement-statement-note-13-commitments-and-contingencies-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-14-redeemable-noncontrolling-interest-redeemable-noncontrolling-interest-in-subsidiary-details" name="statement-statement-note-14-redeemable-noncontrolling-interest-redeemable-noncontrolling-interest-in-subsidiary-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-14-redeemable-noncontrolling-interest-tables" name="statement-statement-note-14-redeemable-noncontrolling-interest-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-16-earnings-per-share-schedule-of-earnings-per-share-details" name="statement-statement-note-16-earnings-per-share-schedule-of-earnings-per-share-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-16-earnings-per-share-tables" name="statement-statement-note-16-earnings-per-share-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-17-interest-and-finance-costs-schedule-of-income-statement-related-costs-details" name="statement-statement-note-17-interest-and-finance-costs-schedule-of-income-statement-related-costs-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-17-interest-and-finance-costs-tables" name="statement-statement-note-17-interest-and-finance-costs-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-19-derivatives-cross-currency-swaps-details" name="statement-statement-note-19-derivatives-cross-currency-swaps-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-19-derivatives-derivatives-not-designated-as-hedging-instruments-and-ineffectiveness-of-hedging-instruments-details" name="statement-statement-note-19-derivatives-derivatives-not-designated-as-hedging-instruments-and-ineffectiveness-of-hedging-instruments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-19-derivatives-effect-of-derivative-instruments-details" name="statement-statement-note-19-derivatives-effect-of-derivative-instruments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-19-derivatives-tables" name="statement-statement-note-19-derivatives-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-20-financial-instruments-fair-value-of-assets-and-liabilities-details" name="statement-statement-note-20-financial-instruments-fair-value-of-assets-and-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-20-financial-instruments-tables" name="statement-statement-note-20-financial-instruments-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-3-discontinued-operations-components-details" name="statement-statement-note-3-discontinued-operations-components-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-3-discontinued-operations-tables" name="statement-statement-note-3-discontinued-operations-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-5-segmental-financial-information-summary-of-reportable-segments-details" name="statement-statement-note-5-segmental-financial-information-summary-of-reportable-segments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-5-segmental-financial-information-tables" name="statement-statement-note-5-segmental-financial-information-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-8-vessels-net-summary-of-vessels-details" name="statement-statement-note-8-vessels-net-summary-of-vessels-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-8-vessels-net-tables" name="statement-statement-note-8-vessels-net-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-9-deferred-charges-net-schedule-of-deferred-charges-net-details" name="statement-statement-note-9-deferred-charges-net-schedule-of-deferred-charges-net-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-9-deferred-charges-net-tables" name="statement-statement-note-9-deferred-charges-net-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-significant-accounting-policies-policies" name="statement-statement-significant-accounting-policies-policies" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
</xsd:schema>
