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  <link:labelLink xlink:role="http://www.xbrl.org/2003/role/link" xlink:type="extended">
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    <link:label xlink:label="cmre_DocumentAndEntityInformation-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Document And Entity Information</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_DocumentAndEntityInformation" xlink:to="cmre_DocumentAndEntityInformation-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_SecondLoanAgreementToRefinanceCostamareInc3Member" xlink:label="cmre_SecondLoanAgreementToRefinanceCostamareInc3Member" xlink:type="locator"/>
    <link:label xlink:label="cmre_SecondLoanAgreementToRefinanceCostamareInc3Member-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Second Loan Agreement to Refinance Costamare Inc. 3 [Member]</link:label>
    <link:label xlink:label="cmre_SecondLoanAgreementToRefinanceCostamareInc3Member-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to a loan agreement.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_SecondLoanAgreementToRefinanceCostamareInc3Member" xlink:to="cmre_SecondLoanAgreementToRefinanceCostamareInc3Member-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherIncomeAndExpensesAbstract" xlink:label="us-gaap_OtherIncomeAndExpensesAbstract" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_OtherIncomeAndExpensesAbstract-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">OTHER INCOME / (EXPENSES):</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherIncomeAndExpensesAbstract" xlink:to="us-gaap_OtherIncomeAndExpensesAbstract-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeNotionalAmount" xlink:label="us-gaap_DerivativeNotionalAmount" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DerivativeNotionalAmount-label" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Notional amount</link:label>
    <link:label xlink:label="us-gaap_DerivativeNotionalAmount-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DerivativeNotionalAmount</link:label>
    <link:label xlink:label="us-gaap_DerivativeNotionalAmount-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative, Notional Amount</link:label>
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    <link:loc xlink:href="cmre-20220630.xsd#cmre_LoanAgreementToRefinanceCostamareInc3Member" xlink:label="cmre_LoanAgreementToRefinanceCostamareInc3Member" xlink:type="locator"/>
    <link:label xlink:label="cmre_LoanAgreementToRefinanceCostamareInc3Member-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Loan Agreement to Refinance Costamare Inc. 3 [Member]</link:label>
    <link:label xlink:label="cmre_LoanAgreementToRefinanceCostamareInc3Member-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to a loan agreement.</link:label>
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    <link:loc xlink:href="cmre-20220630.xsd#cmre_NoteToFinancialStatementDetailsTextual" xlink:label="cmre_NoteToFinancialStatementDetailsTextual" xlink:type="locator"/>
    <link:label xlink:label="cmre_NoteToFinancialStatementDetailsTextual-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Note To Financial Statement Details Textual</link:label>
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    <link:loc xlink:href="cmre-20220630.xsd#cmre_statement-statement-significant-accounting-policies-policies" xlink:label="cmre_statement-statement-significant-accounting-policies-policies" xlink:type="locator"/>
    <link:label xlink:label="cmre_statement-statement-significant-accounting-policies-policies-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Significant Accounting Policies</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_statement-statement-significant-accounting-policies-policies" xlink:to="cmre_statement-statement-significant-accounting-policies-policies-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_statement-statement-note-1-basis-of-presentation-and-general-information-tables" xlink:label="cmre_statement-statement-note-1-basis-of-presentation-and-general-information-tables" xlink:type="locator"/>
    <link:label xlink:label="cmre_statement-statement-note-1-basis-of-presentation-and-general-information-tables-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Note 1 - Basis of Presentation and General Information</link:label>
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    <link:loc xlink:href="cmre-20220630.xsd#cmre_statement-statement-note-4-segmental-financial-information-tables" xlink:label="cmre_statement-statement-note-4-segmental-financial-information-tables" xlink:type="locator"/>
    <link:label xlink:label="cmre_statement-statement-note-4-segmental-financial-information-tables-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Note 4 - Segmental Financial Information</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_statement-statement-note-4-segmental-financial-information-tables" xlink:to="cmre_statement-statement-note-4-segmental-financial-information-tables-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_statement-statement-note-7-vessels-and-advances-net-tables" xlink:label="cmre_statement-statement-note-7-vessels-and-advances-net-tables" xlink:type="locator"/>
    <link:label xlink:label="cmre_statement-statement-note-7-vessels-and-advances-net-tables-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Note 7 - Vessels and Advances, Net</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_statement-statement-note-7-vessels-and-advances-net-tables" xlink:to="cmre_statement-statement-note-7-vessels-and-advances-net-tables-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_statement-statement-note-8-deferred-charges-net-tables" xlink:label="cmre_statement-statement-note-8-deferred-charges-net-tables" xlink:type="locator"/>
    <link:label xlink:label="cmre_statement-statement-note-8-deferred-charges-net-tables-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Note 8 - Deferred Charges, Net</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_statement-statement-note-8-deferred-charges-net-tables" xlink:to="cmre_statement-statement-note-8-deferred-charges-net-tables-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_statement-statement-note-10-equity-method-investments-tables" xlink:label="cmre_statement-statement-note-10-equity-method-investments-tables" xlink:type="locator"/>
    <link:label xlink:label="cmre_statement-statement-note-10-equity-method-investments-tables-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Note 10 - Equity Method Investments</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_statement-statement-note-10-equity-method-investments-tables" xlink:to="cmre_statement-statement-note-10-equity-method-investments-tables-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_statement-statement-note-11-longterm-debt-tables" xlink:label="cmre_statement-statement-note-11-longterm-debt-tables" xlink:type="locator"/>
    <link:label xlink:label="cmre_statement-statement-note-11-longterm-debt-tables-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Note 11 - Long-term Debt</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_statement-statement-note-11-longterm-debt-tables" xlink:to="cmre_statement-statement-note-11-longterm-debt-tables-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearOne" xlink:label="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearOne" xlink:type="locator"/>
    <link:label xlink:label="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearOne-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearOne</link:label>
    <link:label xlink:label="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearOne-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">2023</link:label>
    <link:label xlink:label="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearOne-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount of receivables under long-term contracts that have not been billed and were not billable that are expected to be collected in the first fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date.</link:label>
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    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesNoncurrentAbstract" xlink:label="us-gaap_LiabilitiesNoncurrentAbstract" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_LiabilitiesNoncurrentAbstract-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">NON-CURRENT LIABILITIES:</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LiabilitiesNoncurrentAbstract" xlink:to="us-gaap_LiabilitiesNoncurrentAbstract-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_statement-statement-note-12-rightofuse-assets-and-finance-lease-liabilities-tables" xlink:label="cmre_statement-statement-note-12-rightofuse-assets-and-finance-lease-liabilities-tables" xlink:type="locator"/>
    <link:label xlink:label="cmre_statement-statement-note-12-rightofuse-assets-and-finance-lease-liabilities-tables-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Note 12 - Right-of-Use Assets and Finance Lease Liabilities</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_statement-statement-note-12-rightofuse-assets-and-finance-lease-liabilities-tables" xlink:to="cmre_statement-statement-note-12-rightofuse-assets-and-finance-lease-liabilities-tables-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermPurchaseCommitmentByCategoryOfItemPurchasedAxis" xlink:label="us-gaap_LongTermPurchaseCommitmentByCategoryOfItemPurchasedAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_LongTermPurchaseCommitmentByCategoryOfItemPurchasedAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Category of Item Purchased [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LongTermPurchaseCommitmentByCategoryOfItemPurchasedAxis" xlink:to="us-gaap_LongTermPurchaseCommitmentByCategoryOfItemPurchasedAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_statement-statement-note-13-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-tables" xlink:label="cmre_statement-statement-note-13-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-tables" xlink:type="locator"/>
    <link:label xlink:label="cmre_statement-statement-note-13-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-tables-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Note 13 - Accrued Charter Revenue, Current and Non-current, Unearned Revenue, Current and Non-current and Time Charter Assumed, Current and Non-current</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_statement-statement-note-13-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-tables" xlink:to="cmre_statement-statement-note-13-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-tables-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermPurchaseCommitmentCategoryOfItemPurchasedDomain" xlink:label="us-gaap_LongTermPurchaseCommitmentCategoryOfItemPurchasedDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_LongTermPurchaseCommitmentCategoryOfItemPurchasedDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Long-Term Purchase Commitment, Category of Item Purchased [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LongTermPurchaseCommitmentCategoryOfItemPurchasedDomain" xlink:to="us-gaap_LongTermPurchaseCommitmentCategoryOfItemPurchasedDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_StockRepurchasedAndRetiredDuringPeriodAveragePricePerShare" xlink:label="cmre_StockRepurchasedAndRetiredDuringPeriodAveragePricePerShare" xlink:type="locator"/>
    <link:label xlink:label="cmre_StockRepurchasedAndRetiredDuringPeriodAveragePricePerShare-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_StockRepurchasedAndRetiredDuringPeriodAveragePricePerShare</link:label>
    <link:label xlink:label="cmre_StockRepurchasedAndRetiredDuringPeriodAveragePricePerShare-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Stock Repurchased and Retired During Period, Average Price Per Share (in dollars per share)</link:label>
    <link:label xlink:label="cmre_StockRepurchasedAndRetiredDuringPeriodAveragePricePerShare-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The average price per share of stock repurchased and retired during the period.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_StockRepurchasedAndRetiredDuringPeriodAveragePricePerShare" xlink:to="cmre_StockRepurchasedAndRetiredDuringPeriodAveragePricePerShare-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxDisclosureTextBlock" xlink:label="us-gaap_IncomeTaxDisclosureTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_IncomeTaxDisclosureTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Income Tax Disclosure [Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_IncomeTaxDisclosureTextBlock" xlink:to="us-gaap_IncomeTaxDisclosureTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_statement-statement-note-14-commitments-and-contingencies-tables" xlink:label="cmre_statement-statement-note-14-commitments-and-contingencies-tables" xlink:type="locator"/>
    <link:label xlink:label="cmre_statement-statement-note-14-commitments-and-contingencies-tables-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Note 14 - Commitments and Contingencies</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_statement-statement-note-14-commitments-and-contingencies-tables" xlink:to="cmre_statement-statement-note-14-commitments-and-contingencies-tables-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_statement-statement-note-16-earnings-per-share-tables" xlink:label="cmre_statement-statement-note-16-earnings-per-share-tables" xlink:type="locator"/>
    <link:label xlink:label="cmre_statement-statement-note-16-earnings-per-share-tables-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Note 16 - Earnings Per Share</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_statement-statement-note-16-earnings-per-share-tables" xlink:to="cmre_statement-statement-note-16-earnings-per-share-tables-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostAfterAllowanceForCreditLoss" xlink:label="us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostAfterAllowanceForCreditLoss" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostAfterAllowanceForCreditLoss-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostAfterAllowanceForCreditLoss</link:label>
    <link:label xlink:label="us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostAfterAllowanceForCreditLoss-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Debt Securities, Held-to-Maturity, Amortized Cost, after Allowance for Credit Loss, Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostAfterAllowanceForCreditLoss" xlink:to="us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostAfterAllowanceForCreditLoss-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationAxis" xlink:label="us-gaap_HedgingDesignationAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_HedgingDesignationAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Hedging Designation [Axis]</link:label>
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    <link:label xlink:label="cmre_statement-statement-note-20-financial-instruments-tables-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Note 20 - Financial Instruments</link:label>
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    <link:label xlink:label="us-gaap_DueToRelatedPartiesCurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Due to related parties (Note 3)</link:label>
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    <link:label xlink:label="us-gaap_ScheduleOfMaturitiesOfLongTermDebtTableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Maturities of Long-Term Debt [Table Text Block]</link:label>
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    <link:label xlink:label="us-gaap_ScheduleOfDebtTableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Debt [Table Text Block]</link:label>
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    <link:loc xlink:href="cmre-20220630.xsd#cmre_statement-statement-note-4-segmented-financial-information-summary-of-reportable-segments-details" xlink:label="cmre_statement-statement-note-4-segmented-financial-information-summary-of-reportable-segments-details" xlink:type="locator"/>
    <link:label xlink:label="cmre_statement-statement-note-4-segmented-financial-information-summary-of-reportable-segments-details-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Note 4 - Segmented Financial Information - Summary of Reportable Segments (Details)</link:label>
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    <link:label xlink:label="us-gaap_OtherLiabilitiesCurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Other current liabilities</link:label>
    <link:label xlink:label="us-gaap_OtherLiabilitiesCurrent-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Other Liabilities, Current, Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherLiabilitiesCurrent" xlink:to="us-gaap_OtherLiabilitiesCurrent-label" xlink:type="arc"/>
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    <link:label xlink:label="cmre_statement-statement-note-7-vessels-and-advances-net-summary-of-vessels-details-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Note 7 - Vessels and Advances, Net - Summary of Vessels (Details)</link:label>
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    <link:label xlink:label="cmre_statement-statement-note-10-equity-method-investments-companies-accounted-for-as-equity-method-investments-details-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Note 10 - Equity Method Investments - Companies Accounted for as Equity Method Investments (Details)</link:label>
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    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_statement-statement-note-10-equity-method-investments-summarized-financial-information-on-equity-method-investments-details" xlink:to="cmre_statement-statement-note-10-equity-method-investments-summarized-financial-information-on-equity-method-investments-details-label" xlink:type="arc"/>
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    <link:label xlink:label="cmre_statement-statement-note-11-longterm-debt-schedule-of-longterm-debt-details-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Note 11 - Long-term Debt - Schedule of Long-term Debt (Details)</link:label>
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    <link:label xlink:label="cmre_InterestAndFinanceCostsMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Interest and Finance Costs [Member]</link:label>
    <link:label xlink:label="cmre_InterestAndFinanceCostsMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to interest and finance costs.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_InterestAndFinanceCostsMember" xlink:to="cmre_InterestAndFinanceCostsMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_statement-statement-note-13-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-schedule-of-unearned-revenue-details" xlink:label="cmre_statement-statement-note-13-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-schedule-of-unearned-revenue-details" xlink:type="locator"/>
    <link:label xlink:label="cmre_statement-statement-note-13-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-schedule-of-unearned-revenue-details-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Note 13 - Accrued Charter Revenue, Current and Non-current, Unearned Revenue, Current and Non-current and Time Charter Assumed, Current and Non-current - Schedule of Unearned Revenue (Details)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_statement-statement-note-13-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-schedule-of-unearned-revenue-details" xlink:to="cmre_statement-statement-note-13-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-schedule-of-unearned-revenue-details-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeVariableInterestRate" xlink:label="us-gaap_DerivativeVariableInterestRate" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DerivativeVariableInterestRate-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DerivativeVariableInterestRate</link:label>
    <link:label xlink:label="us-gaap_DerivativeVariableInterestRate-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative, Variable Interest Rate</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DerivativeVariableInterestRate" xlink:to="us-gaap_DerivativeVariableInterestRate-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_statement-statement-note-14-commitments-and-contingencies-schedule-of-time-charter-arrangements-details" xlink:label="cmre_statement-statement-note-14-commitments-and-contingencies-schedule-of-time-charter-arrangements-details" xlink:type="locator"/>
    <link:label xlink:label="cmre_statement-statement-note-14-commitments-and-contingencies-schedule-of-time-charter-arrangements-details-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Note 14 - Commitments and Contingencies - Schedule of Time Charter Arrangements (Details)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_statement-statement-note-14-commitments-and-contingencies-schedule-of-time-charter-arrangements-details" xlink:to="cmre_statement-statement-note-14-commitments-and-contingencies-schedule-of-time-charter-arrangements-details-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_TotalMember" xlink:label="cmre_TotalMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_TotalMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Total [Member]</link:label>
    <link:label xlink:label="cmre_TotalMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents information related to total.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_TotalMember" xlink:to="cmre_TotalMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_InterestCostsCapitalizedToVesselsAndAdvancesNet" xlink:label="cmre_InterestCostsCapitalizedToVesselsAndAdvancesNet" xlink:type="locator"/>
    <link:label xlink:label="cmre_InterestCostsCapitalizedToVesselsAndAdvancesNet-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_InterestCostsCapitalizedToVesselsAndAdvancesNet</link:label>
    <link:label xlink:label="cmre_InterestCostsCapitalizedToVesselsAndAdvancesNet-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Interest Costs Capitalized to Vessels and Advances, Net</link:label>
    <link:label xlink:label="cmre_InterestCostsCapitalizedToVesselsAndAdvancesNet-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount of interest capitalized during the period to Vessels and Advances, net.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_InterestCostsCapitalizedToVesselsAndAdvancesNet" xlink:to="cmre_InterestCostsCapitalizedToVesselsAndAdvancesNet-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_UnbilledReceivablesNotBillableValueAmountExpectedToBeCollectedInRemainderOfFiscalYear" xlink:label="cmre_UnbilledReceivablesNotBillableValueAmountExpectedToBeCollectedInRemainderOfFiscalYear" xlink:type="locator"/>
    <link:label xlink:label="cmre_UnbilledReceivablesNotBillableValueAmountExpectedToBeCollectedInRemainderOfFiscalYear-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_UnbilledReceivablesNotBillableValueAmountExpectedToBeCollectedInRemainderOfFiscalYear</link:label>
    <link:label xlink:label="cmre_UnbilledReceivablesNotBillableValueAmountExpectedToBeCollectedInRemainderOfFiscalYear-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">2022</link:label>
    <link:label xlink:label="cmre_UnbilledReceivablesNotBillableValueAmountExpectedToBeCollectedInRemainderOfFiscalYear-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount of receivables under long-term contracts that have not been billed and were not billable that are expected to be collected in the remainder of the fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_UnbilledReceivablesNotBillableValueAmountExpectedToBeCollectedInRemainderOfFiscalYear" xlink:to="cmre_UnbilledReceivablesNotBillableValueAmountExpectedToBeCollectedInRemainderOfFiscalYear-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_OtherMember" xlink:label="cmre_OtherMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_OtherMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Other [Member]</link:label>
    <link:label xlink:label="cmre_OtherMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents information related to other.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_OtherMember" xlink:to="cmre_OtherMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_statement-statement-note-16-earnings-per-share-schedule-of-earnings-per-share-details" xlink:label="cmre_statement-statement-note-16-earnings-per-share-schedule-of-earnings-per-share-details" xlink:type="locator"/>
    <link:label xlink:label="cmre_statement-statement-note-16-earnings-per-share-schedule-of-earnings-per-share-details-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Note 16 - Earnings Per Share - Schedule of Earnings Per Share (Details)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_statement-statement-note-16-earnings-per-share-schedule-of-earnings-per-share-details" xlink:to="cmre_statement-statement-note-16-earnings-per-share-schedule-of-earnings-per-share-details-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_LongTermDebtGrossIncludingTermLoansAndOtherFinancingArrangements" xlink:label="cmre_LongTermDebtGrossIncludingTermLoansAndOtherFinancingArrangements" xlink:type="locator"/>
    <link:label xlink:label="cmre_LongTermDebtGrossIncludingTermLoansAndOtherFinancingArrangements-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_LongTermDebtGrossIncludingTermLoansAndOtherFinancingArrangements</link:label>
    <link:label xlink:label="cmre_LongTermDebtGrossIncludingTermLoansAndOtherFinancingArrangements-label" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total</link:label>
    <link:label xlink:label="cmre_LongTermDebtGrossIncludingTermLoansAndOtherFinancingArrangements-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the gross amount of long-term debt at the balance sheet date, including term loans and other financing arrangements.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_LongTermDebtGrossIncludingTermLoansAndOtherFinancingArrangements" xlink:to="cmre_LongTermDebtGrossIncludingTermLoansAndOtherFinancingArrangements-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_statement-statement-note-17-interest-and-finance-costs-schedule-of-income-statement-related-costs-details" xlink:label="cmre_statement-statement-note-17-interest-and-finance-costs-schedule-of-income-statement-related-costs-details" xlink:type="locator"/>
    <link:label xlink:label="cmre_statement-statement-note-17-interest-and-finance-costs-schedule-of-income-statement-related-costs-details-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Note 17 - Interest and Finance Costs - Schedule of Income Statement Related Costs (Details)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_statement-statement-note-17-interest-and-finance-costs-schedule-of-income-statement-related-costs-details" xlink:to="cmre_statement-statement-note-17-interest-and-finance-costs-schedule-of-income-statement-related-costs-details-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_statement-statement-note-19-derivatives-cross-currency-swaps-details" xlink:label="cmre_statement-statement-note-19-derivatives-cross-currency-swaps-details" xlink:type="locator"/>
    <link:label xlink:label="cmre_statement-statement-note-19-derivatives-cross-currency-swaps-details-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Note 19 - Derivatives - Cross Currency Swaps (Details)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_statement-statement-note-19-derivatives-cross-currency-swaps-details" xlink:to="cmre_statement-statement-note-19-derivatives-cross-currency-swaps-details-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired" xlink:label="us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired</link:label>
    <link:label xlink:label="us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Business Acquisition, Percentage of Voting Interests Acquired</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired" xlink:to="us-gaap_BusinessAcquisitionPercentageOfVotingInterestsAcquired-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeLiabilitiesCurrent" xlink:label="us-gaap_DerivativeLiabilitiesCurrent" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DerivativeLiabilitiesCurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DerivativeLiabilitiesCurrent</link:label>
    <link:label xlink:label="us-gaap_DerivativeLiabilitiesCurrent-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Fair value of derivatives (Notes 19 and 20)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DerivativeLiabilitiesCurrent" xlink:to="us-gaap_DerivativeLiabilitiesCurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_statement-statement-note-19-derivatives-effect-of-derivative-instruments-details" xlink:label="cmre_statement-statement-note-19-derivatives-effect-of-derivative-instruments-details" xlink:type="locator"/>
    <link:label xlink:label="cmre_statement-statement-note-19-derivatives-effect-of-derivative-instruments-details-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Note 19 - Derivatives - Effect of Derivative Instruments (Details)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_statement-statement-note-19-derivatives-effect-of-derivative-instruments-details" xlink:to="cmre_statement-statement-note-19-derivatives-effect-of-derivative-instruments-details-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NumberOfAssetAcquired" xlink:label="cmre_NumberOfAssetAcquired" xlink:type="locator"/>
    <link:label xlink:label="cmre_NumberOfAssetAcquired-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_NumberOfAssetAcquired</link:label>
    <link:label xlink:label="cmre_NumberOfAssetAcquired-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Number of Asset Acquired</link:label>
    <link:label xlink:label="cmre_NumberOfAssetAcquired-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Number of asset acquired.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NumberOfAssetAcquired" xlink:to="cmre_NumberOfAssetAcquired-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_statement-statement-note-19-derivatives-derivatives-not-designated-as-hedging-instruments-and-ineffectiveness-of-hedging-instruments-details" xlink:label="cmre_statement-statement-note-19-derivatives-derivatives-not-designated-as-hedging-instruments-and-ineffectiveness-of-hedging-instruments-details" xlink:type="locator"/>
    <link:label xlink:label="cmre_statement-statement-note-19-derivatives-derivatives-not-designated-as-hedging-instruments-and-ineffectiveness-of-hedging-instruments-details-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Note 19 - Derivatives - Derivatives Not Designated as Hedging Instruments and Ineffectiveness of Hedging Instruments (Details)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_statement-statement-note-19-derivatives-derivatives-not-designated-as-hedging-instruments-and-ineffectiveness-of-hedging-instruments-details" xlink:to="cmre_statement-statement-note-19-derivatives-derivatives-not-designated-as-hedging-instruments-and-ineffectiveness-of-hedging-instruments-details-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_AssetAcquistionRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNetTotal" xlink:label="cmre_AssetAcquistionRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNetTotal" xlink:type="locator"/>
    <link:label xlink:label="cmre_AssetAcquistionRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNetTotal-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_AssetAcquistionRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNetTotal</link:label>
    <link:label xlink:label="cmre_AssetAcquistionRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNetTotal-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Asset Acquistion, Recognized Identifiable Assets Acquired and Liabilities Assumed, Net, Total</link:label>
    <link:label xlink:label="cmre_AssetAcquistionRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNetTotal-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount recognized as of the acquisition date for the identifiable assets acquired in excess of (less than) the aggregate liabilities assumed.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_AssetAcquistionRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNetTotal" xlink:to="cmre_AssetAcquistionRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNetTotal-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_statement-statement-note-20-financial-instruments-fair-value-of-assets-and-liabilities-details" xlink:label="cmre_statement-statement-note-20-financial-instruments-fair-value-of-assets-and-liabilities-details" xlink:type="locator"/>
    <link:label xlink:label="cmre_statement-statement-note-20-financial-instruments-fair-value-of-assets-and-liabilities-details-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Note 20 - Financial Instruments - Fair Value of Assets and Liabilities (Details)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_statement-statement-note-20-financial-instruments-fair-value-of-assets-and-liabilities-details" xlink:to="cmre_statement-statement-note-20-financial-instruments-fair-value-of-assets-and-liabilities-details-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_FirstFourNewbuildVesselsPurchasedMember" xlink:label="cmre_FirstFourNewbuildVesselsPurchasedMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_FirstFourNewbuildVesselsPurchasedMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">First Four Newbuild Vessels Purchased [Member]</link:label>
    <link:label xlink:label="cmre_FirstFourNewbuildVesselsPurchasedMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents first four newbuild vessels purchased.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_FirstFourNewbuildVesselsPurchasedMember" xlink:to="cmre_FirstFourNewbuildVesselsPurchasedMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NotesToFinancialStatements" xlink:label="cmre_NotesToFinancialStatements" xlink:type="locator"/>
    <link:label xlink:label="cmre_NotesToFinancialStatements-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Notes To Financial Statements</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NotesToFinancialStatements" xlink:to="cmre_NotesToFinancialStatements-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_SecondFourNewbuildVesselsPurchasedMember" xlink:label="cmre_SecondFourNewbuildVesselsPurchasedMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_SecondFourNewbuildVesselsPurchasedMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Second Four Newbuild Vessels Purchased [Member]</link:label>
    <link:label xlink:label="cmre_SecondFourNewbuildVesselsPurchasedMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents second four newbuild vessels purchased.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_SecondFourNewbuildVesselsPurchasedMember" xlink:to="cmre_SecondFourNewbuildVesselsPurchasedMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NotesToFinancialStatementsAbstract" xlink:label="cmre_NotesToFinancialStatementsAbstract" xlink:type="locator"/>
    <link:label xlink:label="cmre_NotesToFinancialStatementsAbstract-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Notes To Financial Statements [Abstract]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NotesToFinancialStatementsAbstract" xlink:to="cmre_NotesToFinancialStatementsAbstract-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfHeldToMaturitySecurities" xlink:label="us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfHeldToMaturitySecurities" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfHeldToMaturitySecurities-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt securities capital redemption</link:label>
    <link:label xlink:label="us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfHeldToMaturitySecurities-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Proceeds from Maturities, Prepayments and Calls of Held-to-maturity Securities</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfHeldToMaturitySecurities" xlink:to="us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfHeldToMaturitySecurities-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_AmountTransferredFromDeferredCharges" xlink:label="cmre_AmountTransferredFromDeferredCharges" xlink:type="locator"/>
    <link:label xlink:label="cmre_AmountTransferredFromDeferredCharges-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_AmountTransferredFromDeferredCharges</link:label>
    <link:label xlink:label="cmre_AmountTransferredFromDeferredCharges-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Amount Transferred from Deferred Charges</link:label>
    <link:label xlink:label="cmre_AmountTransferredFromDeferredCharges-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents amount transferred from deferred charges.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_AmountTransferredFromDeferredCharges" xlink:to="cmre_AmountTransferredFromDeferredCharges-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfDerivativeInstrumentsTextBlock" xlink:label="us-gaap_ScheduleOfDerivativeInstrumentsTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ScheduleOfDerivativeInstrumentsTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Derivative Instruments [Table Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ScheduleOfDerivativeInstrumentsTextBlock" xlink:to="us-gaap_ScheduleOfDerivativeInstrumentsTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_AccruedCharterRevenueNet" xlink:label="cmre_AccruedCharterRevenueNet" xlink:type="locator"/>
    <link:label xlink:label="cmre_AccruedCharterRevenueNet-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_AccruedCharterRevenueNet</link:label>
    <link:label xlink:label="cmre_AccruedCharterRevenueNet-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Accrued Charter Revenue, Net</link:label>
    <link:label xlink:label="cmre_AccruedCharterRevenueNet-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents net accrued charter revenue.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_AccruedCharterRevenueNet" xlink:to="cmre_AccruedCharterRevenueNet-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_AssetAcquisitionPercentageOfVotingInterestsAcquired" xlink:label="cmre_AssetAcquisitionPercentageOfVotingInterestsAcquired" xlink:type="locator"/>
    <link:label xlink:label="cmre_AssetAcquisitionPercentageOfVotingInterestsAcquired-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_AssetAcquisitionPercentageOfVotingInterestsAcquired</link:label>
    <link:label xlink:label="cmre_AssetAcquisitionPercentageOfVotingInterestsAcquired-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Asset Acquisition, Percentage of Voting Interests Acquired</link:label>
    <link:label xlink:label="cmre_AssetAcquisitionPercentageOfVotingInterestsAcquired-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Percentage of voting equity interests acquired at the acquisition date in asset acquisition.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_AssetAcquisitionPercentageOfVotingInterestsAcquired" xlink:to="cmre_AssetAcquisitionPercentageOfVotingInterestsAcquired-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtCurrent" xlink:label="us-gaap_LongTermDebtCurrent" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_LongTermDebtCurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Current portion of long-term debt, net of deferred financing costs (Note 11)</link:label>
    <link:label xlink:label="us-gaap_LongTermDebtCurrent-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Long-Term Debt, Current Maturities, Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LongTermDebtCurrent" xlink:to="us-gaap_LongTermDebtCurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:label="us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_OtherComprehensiveIncomeLossNetOfTax-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">- Other comprehensive income (loss)</link:label>
    <link:label xlink:label="us-gaap_OtherComprehensiveIncomeLossNetOfTax-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Other Comprehensive Income (Loss), Net of Tax, Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:to="us-gaap_OtherComprehensiveIncomeLossNetOfTax-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquitySecuritiesMember" xlink:label="us-gaap_EquitySecuritiesMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_EquitySecuritiesMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Equity Securities [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_EquitySecuritiesMember" xlink:to="us-gaap_EquitySecuritiesMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireInvestments" xlink:label="us-gaap_PaymentsToAcquireInvestments" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_PaymentsToAcquireInvestments-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_PaymentsToAcquireInvestments</link:label>
    <link:label xlink:label="us-gaap_PaymentsToAcquireInvestments-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Purchase of short-term investments, net</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PaymentsToAcquireInvestments" xlink:to="us-gaap_PaymentsToAcquireInvestments-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_MajorCustomersABCDAndEMember" xlink:label="cmre_MajorCustomersABCDAndEMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_MajorCustomersABCDAndEMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Major Customers A, B, C, D and E [Member]</link:label>
    <link:label xlink:label="cmre_MajorCustomersABCDAndEMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents major customer A, B, C, D and E.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_MajorCustomersABCDAndEMember" xlink:to="cmre_MajorCustomersABCDAndEMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax" xlink:label="us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax</link:label>
    <link:label xlink:label="us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Reclassification from Accumulated Other Comprehensive Income, Current Period, Net of Tax</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax" xlink:to="us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodNetOfTax-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_YorkMember" xlink:label="cmre_YorkMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_YorkMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">York [Member]</link:label>
    <link:label xlink:label="cmre_YorkMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents information pertaining to York.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_YorkMember" xlink:to="cmre_YorkMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireMarketableSecurities" xlink:label="us-gaap_PaymentsToAcquireMarketableSecurities" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_PaymentsToAcquireMarketableSecurities-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_PaymentsToAcquireMarketableSecurities</link:label>
    <link:label xlink:label="us-gaap_PaymentsToAcquireMarketableSecurities-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Payments to Acquire Marketable Securities</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PaymentsToAcquireMarketableSecurities" xlink:to="us-gaap_PaymentsToAcquireMarketableSecurities-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Financial Instruments [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:to="us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_CompaniesOwningTritonTitanTalosTaurusAndTheseusMember" xlink:label="cmre_CompaniesOwningTritonTitanTalosTaurusAndTheseusMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_CompaniesOwningTritonTitanTalosTaurusAndTheseusMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Companies Owning Triton, Titan, Talos, Taurus and Theseus [Member]</link:label>
    <link:label xlink:label="cmre_CompaniesOwningTritonTitanTalosTaurusAndTheseusMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents information pertaining to companies owning Triton, Titan, Talos, Taurus and Theseus.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_CompaniesOwningTritonTitanTalosTaurusAndTheseusMember" xlink:to="cmre_CompaniesOwningTritonTitanTalosTaurusAndTheseusMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisTrancheBMember" xlink:label="cmre_LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisTrancheBMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisTrancheBMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Loan Agreement to Partially Finance the Acquisition of Megalopolis and Marathopolis, Tranche B [Member]</link:label>
    <link:label xlink:label="cmre_LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisTrancheBMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Refers to information regarding tranche B of the loan agreement partially finance the Megalopolis and Marathopolis acquisition.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisTrancheBMember" xlink:to="cmre_LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisTrancheBMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="us-gaap_FinancialInstrumentAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_FinancialInstrumentAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Financial Instrument [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FinancialInstrumentAxis" xlink:to="us-gaap_FinancialInstrumentAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisTrancheAMember" xlink:label="cmre_LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisTrancheAMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisTrancheAMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Loan Agreement to Partially Finance the Acquisition of Megalopolis and Marathopolis, Tranche A [Member]</link:label>
    <link:label xlink:label="cmre_LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisTrancheAMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Refers to information regarding tranche A of the loan agreement partially finance the Megalopolis and Marathopolis acquisition.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisTrancheAMember" xlink:to="cmre_LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisTrancheAMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_LoraStylianouMember" xlink:label="cmre_LoraStylianouMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_LoraStylianouMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Lora Stylianou [Member]</link:label>
    <link:label xlink:label="cmre_LoraStylianouMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents Lora Stylianou .</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_LoraStylianouMember" xlink:to="cmre_LoraStylianouMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesCurrent" xlink:label="us-gaap_AccruedLiabilitiesCurrent" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_AccruedLiabilitiesCurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accrued liabilities</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AccruedLiabilitiesCurrent" xlink:to="us-gaap_AccruedLiabilitiesCurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_LCLawStylianouAssociatesLlcMember" xlink:label="cmre_LCLawStylianouAssociatesLlcMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_LCLawStylianouAssociatesLlcMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">LC LAW Stylianou &amp; Associates LLC [Member]</link:label>
    <link:label xlink:label="cmre_LCLawStylianouAssociatesLlcMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents LC LAW Stylianou &amp; Associates LLC.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_LCLawStylianouAssociatesLlcMember" xlink:to="cmre_LCLawStylianouAssociatesLlcMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeFinanceLeasesTextBlock" xlink:label="us-gaap_LesseeFinanceLeasesTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_LesseeFinanceLeasesTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Lessee, Finance Leases [Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LesseeFinanceLeasesTextBlock" xlink:to="us-gaap_LesseeFinanceLeasesTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_LegalServiceMember" xlink:label="cmre_LegalServiceMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_LegalServiceMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Legal Service [Member]</link:label>
    <link:label xlink:label="cmre_LegalServiceMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents legal service.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_LegalServiceMember" xlink:to="cmre_LegalServiceMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableCurrent" xlink:label="us-gaap_AccountsPayableCurrent" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_AccountsPayableCurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accounts payable</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AccountsPayableCurrent" xlink:to="us-gaap_AccountsPayableCurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevolvingCreditFacilityMember" xlink:label="us-gaap_RevolvingCreditFacilityMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_RevolvingCreditFacilityMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Revolving Credit Facility [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RevolvingCreditFacilityMember" xlink:to="us-gaap_RevolvingCreditFacilityMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber</link:label>
    <link:label xlink:label="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number, Ending Balance (in shares)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xlink:to="us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CreditFacilityAxis" xlink:label="us-gaap_CreditFacilityAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_CreditFacilityAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Credit Facility [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CreditFacilityAxis" xlink:to="us-gaap_CreditFacilityAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CreditFacilityDomain" xlink:label="us-gaap_CreditFacilityDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_CreditFacilityDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Credit Facility [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CreditFacilityDomain" xlink:to="us-gaap_CreditFacilityDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PolicyTextBlockAbstract" xlink:label="us-gaap_PolicyTextBlockAbstract" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_PolicyTextBlockAbstract-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_PolicyTextBlockAbstract</link:label>
    <link:label xlink:label="us-gaap_PolicyTextBlockAbstract-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Accounting Policies</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PolicyTextBlockAbstract" xlink:to="us-gaap_PolicyTextBlockAbstract-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NoncashInvestingAndFinancingItemsAbstract" xlink:label="us-gaap_NoncashInvestingAndFinancingItemsAbstract" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_NoncashInvestingAndFinancingItemsAbstract-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Non-Cash Investing and Financing Activities:</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_NoncashInvestingAndFinancingItemsAbstract" xlink:to="us-gaap_NoncashInvestingAndFinancingItemsAbstract-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_DebtInstrumentRedemptionPremiumPercentage" xlink:label="cmre_DebtInstrumentRedemptionPremiumPercentage" xlink:type="locator"/>
    <link:label xlink:label="cmre_DebtInstrumentRedemptionPremiumPercentage-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_DebtInstrumentRedemptionPremiumPercentage</link:label>
    <link:label xlink:label="cmre_DebtInstrumentRedemptionPremiumPercentage-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Debt Instrument, Redemption, Premium Percentage</link:label>
    <link:label xlink:label="cmre_DebtInstrumentRedemptionPremiumPercentage-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The percentage of premium upon redemption of the debt instrument.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_DebtInstrumentRedemptionPremiumPercentage" xlink:to="cmre_DebtInstrumentRedemptionPremiumPercentage-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_TheFifthOrSixthCouponPaymentDateMember" xlink:label="cmre_TheFifthOrSixthCouponPaymentDateMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_TheFifthOrSixthCouponPaymentDateMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">The Fifth or Sixth Coupon Payment Date [Member]</link:label>
    <link:label xlink:label="cmre_TheFifthOrSixthCouponPaymentDateMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the fifth or sixth coupon payment date.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_TheFifthOrSixthCouponPaymentDateMember" xlink:to="cmre_TheFifthOrSixthCouponPaymentDateMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_TheSeventhOrEighthCouponPaymentDateMember" xlink:label="cmre_TheSeventhOrEighthCouponPaymentDateMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_TheSeventhOrEighthCouponPaymentDateMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">The Seventh or Eighth Coupon Payment Date [Member]</link:label>
    <link:label xlink:label="cmre_TheSeventhOrEighthCouponPaymentDateMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the seventh or eighth coupon payment date.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_TheSeventhOrEighthCouponPaymentDateMember" xlink:to="cmre_TheSeventhOrEighthCouponPaymentDateMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_LoanAgreementWith11CompaniesRefinancingTrancheMember" xlink:label="cmre_LoanAgreementWith11CompaniesRefinancingTrancheMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_LoanAgreementWith11CompaniesRefinancingTrancheMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Loan Agreement with 11 Companies, Refinancing Tranche [Member]</link:label>
    <link:label xlink:label="cmre_LoanAgreementWith11CompaniesRefinancingTrancheMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents refinancing tranche of the loan agreement with Achilleas Maritime Corporation, Angistri Corporation, Fanakos Maritime Corporation, Fastsailing Maritime Co., Lindner Shipping Co., Miko Shipping Co., Saval Shipping Co., Spedding Shipping Co., Tanera Shipping Co., Timpson Shipping Co. and Wester Shipping Co.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_LoanAgreementWith11CompaniesRefinancingTrancheMember" xlink:to="cmre_LoanAgreementWith11CompaniesRefinancingTrancheMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheAAndBMember" xlink:label="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheAAndBmember" xlink:type="locator"/>
    <link:label xlink:label="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheAAndBmember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Novara Shipping Co., Finney Shipping Co., Alford Shipping Co. and Nisbet Shipping Co. Loan Agreement, Tranche A and B[Member]</link:label>
    <link:label xlink:label="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheAAndBmember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents tranche A and B of the loan agreement with Novara Shipping Co., Finney Shipping Co., Alford Shipping Co. and Nisbet Shipping Co.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheAAndBmember" xlink:to="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheAAndBmember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss" xlink:label="us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair value measurement of equity securities (Note 5)</link:label>
    <link:label xlink:label="us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Fair value measurement of equity securities</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss" xlink:to="us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheCMember" xlink:label="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheCMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheCMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Novara Shipping Co., Finney Shipping Co., Alford Shipping Co. and Nisbet Shipping Co. Loan Agreement, Tranche C [Member]</link:label>
    <link:label xlink:label="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheCMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents tranche C of the loan agreement with Novara Shipping Co., Finney Shipping Co., Alford Shipping Co. and Nisbet Shipping Co.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheCMember" xlink:to="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheCMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheDMember" xlink:label="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheDMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheDMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Novara Shipping Co., Finney Shipping Co., Alford Shipping Co. and Nisbet Shipping Co. Loan Agreement, Tranche D [Member]</link:label>
    <link:label xlink:label="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheDMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents tranche D of the loan agreement with Novara Shipping Co., Finney Shipping Co., Alford Shipping Co. and Nisbet Shipping Co.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheDMember" xlink:to="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheDMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NumberOfDrybulkVesselsNotSecuredEmployment" xlink:label="cmre_NumberOfDrybulkVesselsNotSecuredEmployment" xlink:type="locator"/>
    <link:label xlink:label="cmre_NumberOfDrybulkVesselsNotSecuredEmployment-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_NumberOfDrybulkVesselsNotSecuredEmployment</link:label>
    <link:label xlink:label="cmre_NumberOfDrybulkVesselsNotSecuredEmployment-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Number of Dry-bulk Vessels Not Secured Employment</link:label>
    <link:label xlink:label="cmre_NumberOfDrybulkVesselsNotSecuredEmployment-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The number of dry-bulk vessels that have not secured employment.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NumberOfDrybulkVesselsNotSecuredEmployment" xlink:to="cmre_NumberOfDrybulkVesselsNotSecuredEmployment-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentsDisclosureTextBlock" xlink:label="us-gaap_FinancialInstrumentsDisclosureTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_FinancialInstrumentsDisclosureTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Financial Instruments Disclosure [Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FinancialInstrumentsDisclosureTextBlock" xlink:to="us-gaap_FinancialInstrumentsDisclosureTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrentAbstract" xlink:label="us-gaap_LiabilitiesCurrentAbstract" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_LiabilitiesCurrentAbstract-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">CURRENT LIABILITIES:</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LiabilitiesCurrentAbstract" xlink:to="us-gaap_LiabilitiesCurrentAbstract-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_TheNinthCouponPaymentDateMember" xlink:label="cmre_TheNinthCouponPaymentDateMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_TheNinthCouponPaymentDateMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">The Ninth Coupon Payment Date [Member]</link:label>
    <link:label xlink:label="cmre_TheNinthCouponPaymentDateMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represent the ninth coupon payment date.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_TheNinthCouponPaymentDateMember" xlink:to="cmre_TheNinthCouponPaymentDateMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_DebtInstrumentEarlyRedemptionRequirementMinimumPrepaymentByIssuer" xlink:label="cmre_DebtInstrumentEarlyRedemptionRequirementMinimumPrepaymentByIssuer" xlink:type="locator"/>
    <link:label xlink:label="cmre_DebtInstrumentEarlyRedemptionRequirementMinimumPrepaymentByIssuer-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_DebtInstrumentEarlyRedemptionRequirementMinimumPrepaymentByIssuer</link:label>
    <link:label xlink:label="cmre_DebtInstrumentEarlyRedemptionRequirementMinimumPrepaymentByIssuer-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Debt Instrument, Early Redemption Requirement, Minimum Prepayment by Issuer</link:label>
    <link:label xlink:label="cmre_DebtInstrumentEarlyRedemptionRequirementMinimumPrepaymentByIssuer-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The minimum amount of prepayment by issuer allowed to be redeemed early under the debt instrument.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_DebtInstrumentEarlyRedemptionRequirementMinimumPrepaymentByIssuer" xlink:to="cmre_DebtInstrumentEarlyRedemptionRequirementMinimumPrepaymentByIssuer-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_DebtInstrumentEarlyRedemptionRequirementMinimumNominalValueOfAfterPrepayment" xlink:label="cmre_DebtInstrumentEarlyRedemptionRequirementMinimumNominalValueOfAfterPrepayment" xlink:type="locator"/>
    <link:label xlink:label="cmre_DebtInstrumentEarlyRedemptionRequirementMinimumNominalValueOfAfterPrepayment-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_DebtInstrumentEarlyRedemptionRequirementMinimumNominalValueOfAfterPrepayment</link:label>
    <link:label xlink:label="cmre_DebtInstrumentEarlyRedemptionRequirementMinimumNominalValueOfAfterPrepayment-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Debt Instrument, Early Redemption Requirement, Minimum Nominal Value of After Prepayment</link:label>
    <link:label xlink:label="cmre_DebtInstrumentEarlyRedemptionRequirementMinimumNominalValueOfAfterPrepayment-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The minimum nominal value after prepayment that is required for early redemption by the issuer of the debt instrument.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_DebtInstrumentEarlyRedemptionRequirementMinimumNominalValueOfAfterPrepayment" xlink:to="cmre_DebtInstrumentEarlyRedemptionRequirementMinimumNominalValueOfAfterPrepayment-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Assets" xlink:label="us-gaap_Assets" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_Assets-label" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Total Assets</link:label>
    <link:label xlink:label="us-gaap_Assets-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_Assets</link:label>
    <link:label xlink:label="us-gaap_Assets-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Assets, Total</link:label>
    <link:label xlink:label="us-gaap_Assets-label" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total assets</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_Assets" xlink:to="us-gaap_Assets-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NumberOfDrybulkVesselsWithIndexlinkedTimeCharterRate" xlink:label="cmre_NumberOfDrybulkVesselsWithIndexlinkedTimeCharterRate" xlink:type="locator"/>
    <link:label xlink:label="cmre_NumberOfDrybulkVesselsWithIndexlinkedTimeCharterRate-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_NumberOfDrybulkVesselsWithIndexlinkedTimeCharterRate</link:label>
    <link:label xlink:label="cmre_NumberOfDrybulkVesselsWithIndexlinkedTimeCharterRate-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Number of Dry-bulk Vessels with Index-linked Time Charter Rate</link:label>
    <link:label xlink:label="cmre_NumberOfDrybulkVesselsWithIndexlinkedTimeCharterRate-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The number of dry-bulk vessels with index-linked time charter rate.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NumberOfDrybulkVesselsWithIndexlinkedTimeCharterRate" xlink:to="cmre_NumberOfDrybulkVesselsWithIndexlinkedTimeCharterRate-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SupplementalCashFlowInformationAbstract" xlink:label="us-gaap_SupplementalCashFlowInformationAbstract" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_SupplementalCashFlowInformationAbstract-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Supplemental Cash Information:</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_SupplementalCashFlowInformationAbstract" xlink:to="us-gaap_SupplementalCashFlowInformationAbstract-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtFairValue" xlink:label="us-gaap_LongTermDebtFairValue" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_LongTermDebtFairValue-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_LongTermDebtFairValue</link:label>
    <link:label xlink:label="us-gaap_LongTermDebtFairValue-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Long-Term Debt, Fair Value</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LongTermDebtFairValue" xlink:to="us-gaap_LongTermDebtFairValue-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NumberOfContainerVessels" xlink:label="cmre_NumberOfContainerVessels" xlink:type="locator"/>
    <link:label xlink:label="cmre_NumberOfContainerVessels-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_NumberOfContainerVessels</link:label>
    <link:label xlink:label="cmre_NumberOfContainerVessels-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Number of Container Vessels</link:label>
    <link:label xlink:label="cmre_NumberOfContainerVessels-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The number of container vessels.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NumberOfContainerVessels" xlink:to="cmre_NumberOfContainerVessels-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsDisclosureTextBlock" xlink:label="us-gaap_OtherAssetsDisclosureTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_OtherAssetsDisclosureTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Other Assets Disclosure [Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherAssetsDisclosureTextBlock" xlink:to="us-gaap_OtherAssetsDisclosureTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_VShipsGreeceLtdMember" xlink:label="cmre_VShipsGreeceLtdMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_VShipsGreeceLtdMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">V.Ships Greece Ltd. [Member]</link:label>
    <link:label xlink:label="cmre_VShipsGreeceLtdMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to V.Ships Greece Ltd.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_VShipsGreeceLtdMember" xlink:to="cmre_VShipsGreeceLtdMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic" xlink:label="us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic</link:label>
    <link:label xlink:label="us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic-label" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Net income available to Common Stockholders</link:label>
    <link:label xlink:label="us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Net income available to common stockholders</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic" xlink:to="us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_BlueNetCharteringGmbhCoKgContainershipsOnlyMember" xlink:label="cmre_BlueNetCharteringGmbhCoKgContainershipsOnlyMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_BlueNetCharteringGmbhCoKgContainershipsOnlyMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Blue Net Chartering GmbH &amp; Co. KG (Containerships Only) [Member]</link:label>
    <link:label xlink:label="cmre_BlueNetCharteringGmbhCoKgContainershipsOnlyMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents Blue Net Chartering GmbH &amp; Co. KG (containerships only).</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_BlueNetCharteringGmbhCoKgContainershipsOnlyMember" xlink:to="cmre_BlueNetCharteringGmbhCoKgContainershipsOnlyMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_BlueNetAsiaPteLtdBnaContainershipsOnlyMember" xlink:label="cmre_BlueNetAsiaPteLtdBnaContainershipsOnlyMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_BlueNetAsiaPteLtdBnaContainershipsOnlyMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Blue Net Asia Pte., Ltd. (&#8220;BNA&#8221;) (Containerships Only) [Member]</link:label>
    <link:label xlink:label="cmre_BlueNetAsiaPteLtdBnaContainershipsOnlyMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents Blue Net Asia Pte., Ltd. (&#8220;BNA&#8221;) (containerships only).</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_BlueNetAsiaPteLtdBnaContainershipsOnlyMember" xlink:to="cmre_BlueNetAsiaPteLtdBnaContainershipsOnlyMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_Zim3PercentSeries1NotesAnd5PercentSeries2NotesDue2023Member" xlink:label="cmre_Zim3PercentSeries1NotesAnd5PercentSeries2NotesDue2023Member" xlink:type="locator"/>
    <link:label xlink:label="cmre_Zim3PercentSeries1NotesAnd5PercentSeries2NotesDue2023Member-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Zim 3 Percent Series 1 Notes and 5 Percent Series 2 Notes Due 2023 [Member]</link:label>
    <link:label xlink:label="cmre_Zim3PercentSeries1NotesAnd5PercentSeries2NotesDue2023Member-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Information pertaining to 3.0% Series 1 Notes due 2023 and 5.0% Series 2 Notes due 2023- debt securities received from Zim Integrated Services.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_Zim3PercentSeries1NotesAnd5PercentSeries2NotesDue2023Member" xlink:to="cmre_Zim3PercentSeries1NotesAnd5PercentSeries2NotesDue2023Member-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_CostamareShippingMember" xlink:label="cmre_CostamareShippingMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_CostamareShippingMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Costamare Shipping [Member]</link:label>
    <link:label xlink:label="cmre_CostamareShippingMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents Costamare Shipping Company S.A. (&#8220;Costamare Shipping&#8221;).</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_CostamareShippingMember" xlink:to="cmre_CostamareShippingMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_CostamareServicesMember" xlink:label="cmre_CostamareServicesMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_CostamareServicesMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Costamare Services [Member]</link:label>
    <link:label xlink:label="cmre_CostamareServicesMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Costamare Shipping Services Ltd. (&#8220;Costamare Services&#8221;).</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_CostamareServicesMember" xlink:to="cmre_CostamareServicesMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_VshipsShanghaiLimitedMember" xlink:label="cmre_VshipsShanghaiLimitedMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_VshipsShanghaiLimitedMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">V.Ships (Shanghai) Limited [Member]</link:label>
    <link:label xlink:label="cmre_VshipsShanghaiLimitedMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents V.Ships (Shanghai) Limited.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_VshipsShanghaiLimitedMember" xlink:to="cmre_VshipsShanghaiLimitedMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NumberOfShipsSubcontracted" xlink:label="cmre_NumberOfShipsSubcontracted" xlink:type="locator"/>
    <link:label xlink:label="cmre_NumberOfShipsSubcontracted-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_NumberOfShipsSubcontracted</link:label>
    <link:label xlink:label="cmre_NumberOfShipsSubcontracted-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Number of Ships Subcontracted</link:label>
    <link:label xlink:label="cmre_NumberOfShipsSubcontracted-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The number of ships subcontracted.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NumberOfShipsSubcontracted" xlink:to="cmre_NumberOfShipsSubcontracted-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_AmortizationOfTimeCharterAssumedLiability" xlink:label="cmre_AmortizationOfTimeCharterAssumedLiability" xlink:type="locator"/>
    <link:label xlink:label="cmre_AmortizationOfTimeCharterAssumedLiability-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_AmortizationOfTimeCharterAssumedLiability</link:label>
    <link:label xlink:label="cmre_AmortizationOfTimeCharterAssumedLiability-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Amortization of Time Charter Assumed, Liability</link:label>
    <link:label xlink:label="cmre_AmortizationOfTimeCharterAssumedLiability-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The amortization of the time charter assumed, liability.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_AmortizationOfTimeCharterAssumedLiability" xlink:to="cmre_AmortizationOfTimeCharterAssumedLiability-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_AmortizationOfAssumedTimeCharterAsset" xlink:label="cmre_AmortizationOfAssumedTimeCharterAsset" xlink:type="locator"/>
    <link:label xlink:label="cmre_AmortizationOfAssumedTimeCharterAsset-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_AmortizationOfAssumedTimeCharterAsset</link:label>
    <link:label xlink:label="cmre_AmortizationOfAssumedTimeCharterAsset-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Amortization of Assumed Time Charter, Asset</link:label>
    <link:label xlink:label="cmre_AmortizationOfAssumedTimeCharterAsset-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The amount of amortization of the time charter assumed, asset.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_AmortizationOfAssumedTimeCharterAsset" xlink:to="cmre_AmortizationOfAssumedTimeCharterAsset-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockDividendsAndOtherAdjustments" xlink:label="us-gaap_PreferredStockDividendsAndOtherAdjustments" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_PreferredStockDividendsAndOtherAdjustments-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_PreferredStockDividendsAndOtherAdjustments</link:label>
    <link:label xlink:label="us-gaap_PreferredStockDividendsAndOtherAdjustments-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Earnings allocated to Preferred Stock (Note 16)</link:label>
    <link:label xlink:label="us-gaap_PreferredStockDividendsAndOtherAdjustments-label" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Less: paid and accrued earnings allocated to Preferred Stock</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PreferredStockDividendsAndOtherAdjustments" xlink:to="us-gaap_PreferredStockDividendsAndOtherAdjustments-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_FinanceLeaseLiabilityCurrentExcludingLiabilitiesToBeSettledThroughTermLoanProceeds" xlink:label="cmre_FinanceLeaseLiabilityCurrentExcludingLiabilitiesToBeSettledThroughTermLoanProceeds" xlink:type="locator"/>
    <link:label xlink:label="cmre_FinanceLeaseLiabilityCurrentExcludingLiabilitiesToBeSettledThroughTermLoanProceeds-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Finance lease liabilities, net (Note 12)</link:label>
    <link:label xlink:label="cmre_FinanceLeaseLiabilityCurrentExcludingLiabilitiesToBeSettledThroughTermLoanProceeds-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Present value of lessee's discounted obligation for lease payments from finance lease, classified as current, excluding finance lease liabilities to be settled through term-loan proceeds included in current restricted cash, net.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_FinanceLeaseLiabilityCurrentExcludingLiabilitiesToBeSettledThroughTermLoanProceeds" xlink:to="cmre_FinanceLeaseLiabilityCurrentExcludingLiabilitiesToBeSettledThroughTermLoanProceeds-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss" xlink:label="us-gaap_NetIncomeLoss" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_NetIncomeLoss-label" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Net income</link:label>
    <link:label xlink:label="us-gaap_NetIncomeLoss-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Net income for the period</link:label>
    <link:label xlink:label="us-gaap_NetIncomeLoss-label" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Net Income</link:label>
    <link:label xlink:label="us-gaap_NetIncomeLoss-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Net income</link:label>
    <link:label xlink:label="us-gaap_NetIncomeLoss-label" xlink:role="http://www.xbrl.org/2009/role/netLabel" xlink:type="resource" xml:lang="en-US">Net income:</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_NetIncomeLoss" xlink:to="us-gaap_NetIncomeLoss-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsNet" xlink:label="us-gaap_FiniteLivedIntangibleAssetsNet" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_FiniteLivedIntangibleAssetsNet-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_FiniteLivedIntangibleAssetsNet</link:label>
    <link:label xlink:label="us-gaap_FiniteLivedIntangibleAssetsNet-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Finite-Lived Intangible Assets, Net, Ending Balance</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FiniteLivedIntangibleAssetsNet" xlink:to="us-gaap_FiniteLivedIntangibleAssetsNet-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:label="us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_IntangibleAssetsNetExcludingGoodwill-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Time charter assumed, non-current (Note 13)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:to="us-gaap_IntangibleAssetsNetExcludingGoodwill-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromInsuranceSettlementInvestingActivities" xlink:label="us-gaap_ProceedsFromInsuranceSettlementInvestingActivities" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ProceedsFromInsuranceSettlementInvestingActivities-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Proceeds from the settlement of insurance claims</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ProceedsFromInsuranceSettlementInvestingActivities" xlink:to="us-gaap_ProceedsFromInsuranceSettlementInvestingActivities-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NumberOfVesselsCompletedDdDuringPeriod" xlink:label="cmre_NumberOfVesselsCompletedDdDuringPeriod" xlink:type="locator"/>
    <link:label xlink:label="cmre_NumberOfVesselsCompletedDdDuringPeriod-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_NumberOfVesselsCompletedDdDuringPeriod</link:label>
    <link:label xlink:label="cmre_NumberOfVesselsCompletedDdDuringPeriod-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Number of Vessels Completed DD During Period</link:label>
    <link:label xlink:label="cmre_NumberOfVesselsCompletedDdDuringPeriod-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The number of vessels completed dry-docking (DD) during the reporting period.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NumberOfVesselsCompletedDdDuringPeriod" xlink:to="cmre_NumberOfVesselsCompletedDdDuringPeriod-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_SaleLeasebackTransactionsRegardingVesselsMSCAthensAndMSCAthosMember" xlink:label="cmre_SaleLeasebackTransactionsRegardingVesselsMSCAthensAndMSCAthosMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_SaleLeasebackTransactionsRegardingVesselsMSCAthensAndMSCAthosMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Sale Leaseback Transactions Regarding Vessels MSC Athens and MSC Athos [Member]</link:label>
    <link:label xlink:label="cmre_SaleLeasebackTransactionsRegardingVesselsMSCAthensAndMSCAthosMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents information pertaining to sale leaseback transactions regarding vessels MSC Athens and MSC Athos.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_SaleLeasebackTransactionsRegardingVesselsMSCAthensAndMSCAthosMember" xlink:to="cmre_SaleLeasebackTransactionsRegardingVesselsMSCAthensAndMSCAthosMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_CostamareInc5Member" xlink:label="cmre_CostamareInc5Member" xlink:type="locator"/>
    <link:label xlink:label="cmre_CostamareInc5Member-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Costamare Inc. 5 [Member]</link:label>
    <link:label xlink:label="cmre_CostamareInc5Member-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents information pertaining to a fifth Costamare loan agreement.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_CostamareInc5Member" xlink:to="cmre_CostamareInc5Member-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_CostamareInc4Member" xlink:label="cmre_CostamareInc4Member" xlink:type="locator"/>
    <link:label xlink:label="cmre_CostamareInc4Member-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Costamare Inc. 4 [Member]</link:label>
    <link:label xlink:label="cmre_CostamareInc4Member-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents information pertaining to a fourth Costamare loan agreement.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_CostamareInc4Member" xlink:to="cmre_CostamareInc4Member-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ForeignExchangeGainsLossesInOperatingIncomeLoss" xlink:label="cmre_ForeignExchangeGainsLossesInOperatingIncomeLoss" xlink:type="locator"/>
    <link:label xlink:label="cmre_ForeignExchangeGainsLossesInOperatingIncomeLoss-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Foreign exchange gains</link:label>
    <link:label xlink:label="cmre_ForeignExchangeGainsLossesInOperatingIncomeLoss-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the amount of foreign exchange gains (losses) included in operating income (loss) during the period.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ForeignExchangeGainsLossesInOperatingIncomeLoss" xlink:to="cmre_ForeignExchangeGainsLossesInOperatingIncomeLoss-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_TermLoanAndOtherFinancingArrangementsMember" xlink:label="cmre_TermLoanAndOtherFinancingArrangementsMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_TermLoanAndOtherFinancingArrangementsMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Term Loan and Other Financing Arrangements [Member]</link:label>
    <link:label xlink:label="cmre_TermLoanAndOtherFinancingArrangementsMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Term loans and other financing arrangements classified as long term debt.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_TermLoanAndOtherFinancingArrangementsMember" xlink:to="cmre_TermLoanAndOtherFinancingArrangementsMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NeridaShippingCompanyTermLoanMember" xlink:label="cmre_NeridaShippingCompanyTermLoanMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_NeridaShippingCompanyTermLoanMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Nerida Shipping Company Term Loan [Member]</link:label>
    <link:label xlink:label="cmre_NeridaShippingCompanyTermLoanMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents information about term loan issued by Nerida Shipping Co.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NeridaShippingCompanyTermLoanMember" xlink:to="cmre_NeridaShippingCompanyTermLoanMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingenciesDisclosureTextBlock" xlink:label="us-gaap_CommitmentsAndContingenciesDisclosureTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_CommitmentsAndContingenciesDisclosureTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Commitments and Contingencies Disclosure [Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CommitmentsAndContingenciesDisclosureTextBlock" xlink:to="us-gaap_CommitmentsAndContingenciesDisclosureTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:label="us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment-label" xlink:role="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:type="resource" xml:lang="en-US">Balance, Accumulated Depreciation at beginning of the period</link:label>
    <link:label xlink:label="us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment-label" xlink:role="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:type="resource" xml:lang="en-US">Balance, Accumulated Depreciation at end of the period</link:label>
    <link:label xlink:label="us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:to="us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnsecuredDebtMember" xlink:label="us-gaap_UnsecuredDebtMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_UnsecuredDebtMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Unsecured Debt [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_UnsecuredDebtMember" xlink:to="us-gaap_UnsecuredDebtMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="us-gaap_LongtermDebtTypeAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_LongtermDebtTypeAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Long-Term Debt, Type [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LongtermDebtTypeAxis" xlink:to="us-gaap_LongtermDebtTypeAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="us-gaap_LongtermDebtTypeDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_LongtermDebtTypeDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Long-Term Debt, Type [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LongtermDebtTypeDomain" xlink:to="us-gaap_LongtermDebtTypeDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DueFromRelatedParties" xlink:label="us-gaap_DueFromRelatedParties" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DueFromRelatedParties-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DueFromRelatedParties</link:label>
    <link:label xlink:label="us-gaap_DueFromRelatedParties-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Due from Related Parties, Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DueFromRelatedParties" xlink:to="us-gaap_DueFromRelatedParties-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNetAbstract" xlink:label="us-gaap_PropertyPlantAndEquipmentNetAbstract" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_PropertyPlantAndEquipmentNetAbstract-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">FIXED ASSETS, NET:</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PropertyPlantAndEquipmentNetAbstract" xlink:to="us-gaap_PropertyPlantAndEquipmentNetAbstract-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:label="us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_EquityMethodInvestmentOwnershipPercentage-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Participation percentage</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:to="us-gaap_EquityMethodInvestmentOwnershipPercentage-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments" xlink:label="us-gaap_GainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_GainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Forward contracts</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_GainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments" xlink:to="us-gaap_GainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_VesselsUnderTimeCharter" xlink:label="cmre_VesselsUnderTimeCharter" xlink:type="locator"/>
    <link:label xlink:label="cmre_VesselsUnderTimeCharter-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_VesselsUnderTimeCharter</link:label>
    <link:label xlink:label="cmre_VesselsUnderTimeCharter-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Vessels Under Time Charter</link:label>
    <link:label xlink:label="cmre_VesselsUnderTimeCharter-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The number of vessels under time charter.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_VesselsUnderTimeCharter" xlink:to="cmre_VesselsUnderTimeCharter-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CrossCurrencyInterestRateContractMember" xlink:label="us-gaap_CrossCurrencyInterestRateContractMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_CrossCurrencyInterestRateContractMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Cross Currency Interest Rate Contract [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CrossCurrencyInterestRateContractMember" xlink:to="us-gaap_CrossCurrencyInterestRateContractMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue" xlink:label="us-gaap_ForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_ForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue</link:label>
    <link:label xlink:label="us-gaap_ForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Foreign Currency Derivative Instruments Not Designated as Hedging Instruments, Liability at Fair Value</link:label>
    <link:label xlink:label="us-gaap_ForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Forward contracts-liability position</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue" xlink:to="us-gaap_ForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstrumentsLiabilityAtFairValue-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="us-gaap_DerivativeInstrumentRiskAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DerivativeInstrumentRiskAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative Instrument [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DerivativeInstrumentRiskAxis" xlink:to="us-gaap_DerivativeInstrumentRiskAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="us-gaap_DerivativeContractTypeDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DerivativeContractTypeDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative Contract [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DerivativeContractTypeDomain" xlink:to="us-gaap_DerivativeContractTypeDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Cash Flows From Investing Activities:</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:to="us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionSellingGeneralAndAdministrativeExpensesFromTransactionsWithRelatedParty" xlink:label="us-gaap_RelatedPartyTransactionSellingGeneralAndAdministrativeExpensesFromTransactionsWithRelatedParty" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_RelatedPartyTransactionSellingGeneralAndAdministrativeExpensesFromTransactionsWithRelatedParty-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_RelatedPartyTransactionSellingGeneralAndAdministrativeExpensesFromTransactionsWithRelatedParty</link:label>
    <link:label xlink:label="us-gaap_RelatedPartyTransactionSellingGeneralAndAdministrativeExpensesFromTransactionsWithRelatedParty-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Related Party Transaction, Selling, General and Administrative Expenses from Transactions with Related Party</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RelatedPartyTransactionSellingGeneralAndAdministrativeExpensesFromTransactionsWithRelatedParty" xlink:to="us-gaap_RelatedPartyTransactionSellingGeneralAndAdministrativeExpensesFromTransactionsWithRelatedParty-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount" xlink:label="us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount</link:label>
    <link:label xlink:label="us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Equity Securities without Readily Determinable Fair Value, Amount</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount" xlink:to="us-gaap_EquitySecuritiesWithoutReadilyDeterminableFairValueAmount-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecurities" xlink:label="us-gaap_HeldToMaturitySecurities" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_HeldToMaturitySecurities-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_HeldToMaturitySecurities</link:label>
    <link:label xlink:label="us-gaap_HeldToMaturitySecurities-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Debt Securities, Held-to-maturity, Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_HeldToMaturitySecurities" xlink:to="us-gaap_HeldToMaturitySecurities-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_FinancingArrangementsMember" xlink:label="cmre_FinancingArrangementsMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_FinancingArrangementsMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Financing Arrangements [Member]</link:label>
    <link:label xlink:label="cmre_FinancingArrangementsMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to financing arrangements.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_FinancingArrangementsMember" xlink:to="cmre_FinancingArrangementsMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_TrancheAMember" xlink:label="cmre_TrancheAMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_TrancheAMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Tranche A [Member]</link:label>
    <link:label xlink:label="cmre_TrancheAMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to Tranche A.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_TrancheAMember" xlink:to="cmre_TrancheAMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_TrancheBMember" xlink:label="cmre_TrancheBMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_TrancheBMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Tranche B [Member]</link:label>
    <link:label xlink:label="cmre_TrancheBMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to Tranche B.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_TrancheBMember" xlink:to="cmre_TrancheBMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ThreeTranchesPerTrancheInfoMember" xlink:label="cmre_ThreeTranchesPerTrancheInfoMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_ThreeTranchesPerTrancheInfoMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Three Tranches Per Tranche Info [Member]</link:label>
    <link:label xlink:label="cmre_ThreeTranchesPerTrancheInfoMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to three tranches per tranche info.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ThreeTranchesPerTrancheInfoMember" xlink:to="cmre_ThreeTranchesPerTrancheInfoMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareTextBlock" xlink:label="us-gaap_EarningsPerShareTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_EarningsPerShareTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Earnings Per Share [Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_EarningsPerShareTextBlock" xlink:to="us-gaap_EarningsPerShareTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquitySecuritiesFvNi" xlink:label="us-gaap_EquitySecuritiesFvNi" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_EquitySecuritiesFvNi-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_EquitySecuritiesFvNi</link:label>
    <link:label xlink:label="us-gaap_EquitySecuritiesFvNi-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Equity Securities, FV-NI</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_EquitySecuritiesFvNi" xlink:to="us-gaap_EquitySecuritiesFvNi-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOtherOperatingLiabilities" xlink:label="us-gaap_IncreaseDecreaseInOtherOperatingLiabilities" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_IncreaseDecreaseInOtherOperatingLiabilities-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_IncreaseDecreaseInOtherOperatingLiabilities</link:label>
    <link:label xlink:label="us-gaap_IncreaseDecreaseInOtherOperatingLiabilities-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Other current liabilities</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_IncreaseDecreaseInOtherOperatingLiabilities" xlink:to="us-gaap_IncreaseDecreaseInOtherOperatingLiabilities-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ForeignCurrencyFairValueHedgeDerivativeAtFairValueNet" xlink:label="us-gaap_ForeignCurrencyFairValueHedgeDerivativeAtFairValueNet" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ForeignCurrencyFairValueHedgeDerivativeAtFairValueNet-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_ForeignCurrencyFairValueHedgeDerivativeAtFairValueNet</link:label>
    <link:label xlink:label="us-gaap_ForeignCurrencyFairValueHedgeDerivativeAtFairValueNet-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Foreign Currency Fair Value Hedge Derivative at Fair Value, Net, Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ForeignCurrencyFairValueHedgeDerivativeAtFairValueNet" xlink:to="us-gaap_ForeignCurrencyFairValueHedgeDerivativeAtFairValueNet-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainLossOnForeignCurrencyFairValueHedgeDerivatives" xlink:label="us-gaap_GainLossOnForeignCurrencyFairValueHedgeDerivatives" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_GainLossOnForeignCurrencyFairValueHedgeDerivatives-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_GainLossOnForeignCurrencyFairValueHedgeDerivatives</link:label>
    <link:label xlink:label="us-gaap_GainLossOnForeignCurrencyFairValueHedgeDerivatives-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Gain (Loss) on Foreign Currency Fair Value Hedge Derivatives</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_GainLossOnForeignCurrencyFairValueHedgeDerivatives" xlink:to="us-gaap_GainLossOnForeignCurrencyFairValueHedgeDerivatives-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromEquityMethodInvestments" xlink:label="us-gaap_IncomeLossFromEquityMethodInvestments" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_IncomeLossFromEquityMethodInvestments-label" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Income from equity method investments</link:label>
    <link:label xlink:label="us-gaap_IncomeLossFromEquityMethodInvestments-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Income from equity method investments (Note 10)</link:label>
    <link:label xlink:label="us-gaap_IncomeLossFromEquityMethodInvestments-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Income (Loss) from Equity Method Investments</link:label>
    <link:label xlink:label="us-gaap_IncomeLossFromEquityMethodInvestments-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Income from equity method investments</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_IncomeLossFromEquityMethodInvestments" xlink:to="us-gaap_IncomeLossFromEquityMethodInvestments-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_CapetanissaMaritimeCorporationEtAlMember" xlink:label="cmre_CapetanissaMaritimeCorporationEtAlMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_CapetanissaMaritimeCorporationEtAlMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Capetanissa Maritime Corporation et al. [Member]</link:label>
    <link:label xlink:label="cmre_CapetanissaMaritimeCorporationEtAlMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to debt.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_CapetanissaMaritimeCorporationEtAlMember" xlink:to="cmre_CapetanissaMaritimeCorporationEtAlMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionAmountsOfTransaction" xlink:label="us-gaap_RelatedPartyTransactionAmountsOfTransaction" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_RelatedPartyTransactionAmountsOfTransaction-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_RelatedPartyTransactionAmountsOfTransaction</link:label>
    <link:label xlink:label="us-gaap_RelatedPartyTransactionAmountsOfTransaction-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Related Party Transaction, Amounts of Transaction</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RelatedPartyTransactionAmountsOfTransaction" xlink:to="us-gaap_RelatedPartyTransactionAmountsOfTransaction-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredFinanceCostsGross" xlink:label="us-gaap_DeferredFinanceCostsGross" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DeferredFinanceCostsGross-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DeferredFinanceCostsGross</link:label>
    <link:label xlink:label="us-gaap_DeferredFinanceCostsGross-label" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Less: Deferred financing costs</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DeferredFinanceCostsGross" xlink:to="us-gaap_DeferredFinanceCostsGross-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ForeignCurrencyFairValueHedgeLiabilityAtFairValue" xlink:label="us-gaap_ForeignCurrencyFairValueHedgeLiabilityAtFairValue" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ForeignCurrencyFairValueHedgeLiabilityAtFairValue-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_ForeignCurrencyFairValueHedgeLiabilityAtFairValue</link:label>
    <link:label xlink:label="us-gaap_ForeignCurrencyFairValueHedgeLiabilityAtFairValue-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Foreign Currency Fair Value Hedge Liability at Fair Value</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ForeignCurrencyFairValueHedgeLiabilityAtFairValue" xlink:to="us-gaap_ForeignCurrencyFairValueHedgeLiabilityAtFairValue-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityMethodInvestments" xlink:label="us-gaap_EquityMethodInvestments" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_EquityMethodInvestments-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Equity method investments (Notes 2 and 10)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_EquityMethodInvestments" xlink:to="us-gaap_EquityMethodInvestments-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_TwoTranchesPerTrancheInfoMember" xlink:label="cmre_TwoTranchesPerTrancheInfoMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_TwoTranchesPerTrancheInfoMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Two Tranches Per Tranche Info [Member]</link:label>
    <link:label xlink:label="cmre_TwoTranchesPerTrancheInfoMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to the two tranches per tranche info.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_TwoTranchesPerTrancheInfoMember" xlink:to="cmre_TwoTranchesPerTrancheInfoMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionsDisclosureTextBlock" xlink:label="us-gaap_RelatedPartyTransactionsDisclosureTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_RelatedPartyTransactionsDisclosureTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Related Party Transactions Disclosure [Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RelatedPartyTransactionsDisclosureTextBlock" xlink:to="us-gaap_RelatedPartyTransactionsDisclosureTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoansPayableMember" xlink:label="us-gaap_LoansPayableMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_LoansPayableMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Loans Payable [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LoansPayableMember" xlink:to="us-gaap_LoansPayableMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities" xlink:label="us-gaap_IncreaseDecreaseInAccruedLiabilities" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_IncreaseDecreaseInAccruedLiabilities-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_IncreaseDecreaseInAccruedLiabilities</link:label>
    <link:label xlink:label="us-gaap_IncreaseDecreaseInAccruedLiabilities-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Accrued liabilities</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_IncreaseDecreaseInAccruedLiabilities" xlink:to="us-gaap_IncreaseDecreaseInAccruedLiabilities-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsPayable" xlink:label="us-gaap_IncreaseDecreaseInAccountsPayable" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_IncreaseDecreaseInAccountsPayable-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_IncreaseDecreaseInAccountsPayable</link:label>
    <link:label xlink:label="us-gaap_IncreaseDecreaseInAccountsPayable-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Accounts payable</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_IncreaseDecreaseInAccountsPayable" xlink:to="us-gaap_IncreaseDecreaseInAccountsPayable-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainLossOnDerivativeInstrumentsNetPretax" xlink:label="us-gaap_GainLossOnDerivativeInstrumentsNetPretax" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_GainLossOnDerivativeInstrumentsNetPretax-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_GainLossOnDerivativeInstrumentsNetPretax</link:label>
    <link:label xlink:label="us-gaap_GainLossOnDerivativeInstrumentsNetPretax-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Loss on derivative instruments, net</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_GainLossOnDerivativeInstrumentsNetPretax" xlink:to="us-gaap_GainLossOnDerivativeInstrumentsNetPretax-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_MajorCustomerEMember" xlink:label="cmre_MajorCustomerEMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_MajorCustomerEMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Major Customer E [Member]</link:label>
    <link:label xlink:label="cmre_MajorCustomerEMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents customer D, a major customer of the company.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_MajorCustomerEMember" xlink:to="cmre_MajorCustomerEMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.sec.gov/country/2022/country-2022.xsd#country_CY" xlink:label="country_CY" xlink:type="locator"/>
    <link:label xlink:label="country_CY-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">CYPRUS</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="country_CY" xlink:to="country_CY-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentRedemptionPeriodAxis" xlink:label="us-gaap_DebtInstrumentRedemptionPeriodAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DebtInstrumentRedemptionPeriodAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt Instrument, Redemption, Period [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DebtInstrumentRedemptionPeriodAxis" xlink:to="us-gaap_DebtInstrumentRedemptionPeriodAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain" xlink:label="us-gaap_DebtInstrumentRedemptionPeriodDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DebtInstrumentRedemptionPeriodDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt Instrument, Redemption, Period [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DebtInstrumentRedemptionPeriodDomain" xlink:to="us-gaap_DebtInstrumentRedemptionPeriodDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashAndCashEquivalentsNoncurrent" xlink:label="us-gaap_RestrictedCashAndCashEquivalentsNoncurrent" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_RestrictedCashAndCashEquivalentsNoncurrent-label" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Restricted cash &#8211; non-current portion</link:label>
    <link:label xlink:label="us-gaap_RestrictedCashAndCashEquivalentsNoncurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Restricted cash, non-current (Note 1)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RestrictedCashAndCashEquivalentsNoncurrent" xlink:to="us-gaap_RestrictedCashAndCashEquivalentsNoncurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GeneralAndAdministrativeExpense" xlink:label="us-gaap_GeneralAndAdministrativeExpense" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_GeneralAndAdministrativeExpense-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_GeneralAndAdministrativeExpense</link:label>
    <link:label xlink:label="us-gaap_GeneralAndAdministrativeExpense-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">General and administrative expenses</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_GeneralAndAdministrativeExpense" xlink:to="us-gaap_GeneralAndAdministrativeExpense-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue" xlink:label="us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue-label" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Restricted cash &#8211; current portion</link:label>
    <link:label xlink:label="us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue</link:label>
    <link:label xlink:label="us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Restricted cash (Note 1)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue" xlink:to="us-gaap_RestrictedCashAndCashEquivalentsAtCarryingValue-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInDueToRelatedParties" xlink:label="us-gaap_IncreaseDecreaseInDueToRelatedParties" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_IncreaseDecreaseInDueToRelatedParties-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_IncreaseDecreaseInDueToRelatedParties</link:label>
    <link:label xlink:label="us-gaap_IncreaseDecreaseInDueToRelatedParties-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Due to related parties</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_IncreaseDecreaseInDueToRelatedParties" xlink:to="us-gaap_IncreaseDecreaseInDueToRelatedParties-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NumberOfForeignCurrencyDerivativesHeld" xlink:label="us-gaap_NumberOfForeignCurrencyDerivativesHeld" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_NumberOfForeignCurrencyDerivativesHeld-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_NumberOfForeignCurrencyDerivativesHeld</link:label>
    <link:label xlink:label="us-gaap_NumberOfForeignCurrencyDerivativesHeld-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Number of Foreign Currency Derivatives Held</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_NumberOfForeignCurrencyDerivativesHeld" xlink:to="us-gaap_NumberOfForeignCurrencyDerivativesHeld-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_CashAndCashEquivalentsAtCarryingValue-label" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Cash and cash equivalents</link:label>
    <link:label xlink:label="us-gaap_CashAndCashEquivalentsAtCarryingValue-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Cash and cash equivalents (Note 1)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:to="us-gaap_CashAndCashEquivalentsAtCarryingValue-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_VesselsNet" xlink:label="cmre_VesselsNet" xlink:type="locator"/>
    <link:label xlink:label="cmre_VesselsNet-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_VesselsNet</link:label>
    <link:label xlink:label="cmre_VesselsNet-label" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US">Balance, Net Book Value at beginning of the period</link:label>
    <link:label xlink:label="cmre_VesselsNet-label" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US">Balance, Net Book Value at end of the period</link:label>
    <link:label xlink:label="cmre_VesselsNet-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Cost of vessels, including contract price and any material expenses incurred upon acquisition (initial repairs, improvements and delivery expenses, interest and on-site supervision costs incurred during the construction periods), less accumulated depreciation.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_VesselsNet" xlink:to="cmre_VesselsNet-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_VesselHeldForSale" xlink:label="cmre_VesselHeldForSale" xlink:type="locator"/>
    <link:label xlink:label="cmre_VesselHeldForSale-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Vessels held for sale (Note 7)</link:label>
    <link:label xlink:label="cmre_VesselHeldForSale-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Vessel Held For Sale</link:label>
    <link:label xlink:label="cmre_VesselHeldForSale-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to vessels held for sale.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_VesselHeldForSale" xlink:to="cmre_VesselHeldForSale-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestRateDerivativeLiabilitiesAtFairValue" xlink:label="us-gaap_InterestRateDerivativeLiabilitiesAtFairValue" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_InterestRateDerivativeLiabilitiesAtFairValue-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_InterestRateDerivativeLiabilitiesAtFairValue</link:label>
    <link:label xlink:label="us-gaap_InterestRateDerivativeLiabilitiesAtFairValue-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Interest rate -liability position</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InterestRateDerivativeLiabilitiesAtFairValue" xlink:to="us-gaap_InterestRateDerivativeLiabilitiesAtFairValue-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_VoyageExpenses" xlink:label="cmre_VoyageExpenses" xlink:type="locator"/>
    <link:label xlink:label="cmre_VoyageExpenses-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_VoyageExpenses</link:label>
    <link:label xlink:label="cmre_VoyageExpenses-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Voyage expenses</link:label>
    <link:label xlink:label="cmre_VoyageExpenses-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Expenses paid to third parties primarily consisting of port, canal and bunker expenses, commissions that are unique to a particular charter and are paid for by the charterer under time charter arrangements or by the company under voyage charter arrangements, and commissions that are paid directly to brokers by the company.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_VoyageExpenses" xlink:to="cmre_VoyageExpenses-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestRateDerivativesAtFairValueNet" xlink:label="us-gaap_InterestRateDerivativesAtFairValueNet" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_InterestRateDerivativesAtFairValueNet-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair value of derivatives, non-current (Notes 19 and 20)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InterestRateDerivativesAtFairValueNet" xlink:to="us-gaap_InterestRateDerivativesAtFairValueNet-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ManagementFeesRelatedParties" xlink:label="cmre_ManagementFeesRelatedParties" xlink:type="locator"/>
    <link:label xlink:label="cmre_ManagementFeesRelatedParties-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_ManagementFeesRelatedParties</link:label>
    <link:label xlink:label="cmre_ManagementFeesRelatedParties-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Management Fees Related Parties</link:label>
    <link:label xlink:label="cmre_ManagementFeesRelatedParties-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Management fees-related parties (Note 3)</link:label>
    <link:label xlink:label="cmre_ManagementFeesRelatedParties-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Fees paid to related parties for providing the company with technical, crewing, bunkering, accounting, provisions, sale, purchase services, as well as general administrative, certain commercial services, director and officer related insurance services.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ManagementFeesRelatedParties" xlink:to="cmre_ManagementFeesRelatedParties-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_TwentyfootEquivalentUnitsMeasuredOnEachVesselAgreedToAcquire" xlink:label="cmre_TwentyfootEquivalentUnitsMeasuredOnEachVesselAgreedToAcquire" xlink:type="locator"/>
    <link:label xlink:label="cmre_TwentyfootEquivalentUnitsMeasuredOnEachVesselAgreedToAcquire-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_TwentyfootEquivalentUnitsMeasuredOnEachVesselAgreedToAcquire</link:label>
    <link:label xlink:label="cmre_TwentyfootEquivalentUnitsMeasuredOnEachVesselAgreedToAcquire-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Twenty-foot Equivalent Units Measured on Each Vessel Agreed to Acquire</link:label>
    <link:label xlink:label="cmre_TwentyfootEquivalentUnitsMeasuredOnEachVesselAgreedToAcquire-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">This element represents the carrying capacity of vessels in TEUs (twenty-foot equivalet units) measured on each vessel agreed to acquire.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_TwentyfootEquivalentUnitsMeasuredOnEachVesselAgreedToAcquire" xlink:to="cmre_TwentyfootEquivalentUnitsMeasuredOnEachVesselAgreedToAcquire-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_AmortizationDeferredDrydockingSpecialSurvey" xlink:label="cmre_AmortizationDeferredDrydockingSpecialSurvey" xlink:type="locator"/>
    <link:label xlink:label="cmre_AmortizationDeferredDrydockingSpecialSurvey-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_AmortizationDeferredDrydockingSpecialSurvey</link:label>
    <link:label xlink:label="cmre_AmortizationDeferredDrydockingSpecialSurvey-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Amortization of dry-docking and special survey costs (Note 8)</link:label>
    <link:label xlink:label="cmre_AmortizationDeferredDrydockingSpecialSurvey-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Amortization of deferred dry-docking and special survey costs</link:label>
    <link:label xlink:label="cmre_AmortizationDeferredDrydockingSpecialSurvey-label" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Amortization of dry-docking and special survey costs</link:label>
    <link:label xlink:label="cmre_AmortizationDeferredDrydockingSpecialSurvey-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amortization of deferred drydocking and special survey costs.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_AmortizationDeferredDrydockingSpecialSurvey" xlink:to="cmre_AmortizationDeferredDrydockingSpecialSurvey-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_VoyageExpensesRelatedParties" xlink:label="cmre_VoyageExpensesRelatedParties" xlink:type="locator"/>
    <link:label xlink:label="cmre_VoyageExpensesRelatedParties-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_VoyageExpensesRelatedParties</link:label>
    <link:label xlink:label="cmre_VoyageExpensesRelatedParties-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Voyage Expenses Related Parties</link:label>
    <link:label xlink:label="cmre_VoyageExpensesRelatedParties-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Voyage expenses-related parties (Note 3)</link:label>
    <link:label xlink:label="cmre_VoyageExpensesRelatedParties-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Expenses paid to related parties primarily consisting of commissions and fees, which are paid for by the company, regardless of the charter type.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_VoyageExpensesRelatedParties" xlink:to="cmre_VoyageExpensesRelatedParties-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_GeneralAdministrativeExpensesRelatedParties" xlink:label="cmre_GeneralAdministrativeExpensesRelatedParties" xlink:type="locator"/>
    <link:label xlink:label="cmre_GeneralAdministrativeExpensesRelatedParties-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_GeneralAdministrativeExpensesRelatedParties</link:label>
    <link:label xlink:label="cmre_GeneralAdministrativeExpensesRelatedParties-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">General and administrative expenses &#8211; related parties (Note 3)</link:label>
    <link:label xlink:label="cmre_GeneralAdministrativeExpensesRelatedParties-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The total of expenses of managing and administering the affairs of an entity paid to related parties, including affiliates of the reporting entity, which are not directly or indirectly associated with vessel operations.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_GeneralAdministrativeExpensesRelatedParties" xlink:to="cmre_GeneralAdministrativeExpensesRelatedParties-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestRateDerivativeAssetsAtFairValue" xlink:label="us-gaap_InterestRateDerivativeAssetsAtFairValue" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_InterestRateDerivativeAssetsAtFairValue-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Interest rate -asset position</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InterestRateDerivativeAssetsAtFairValue" xlink:to="us-gaap_InterestRateDerivativeAssetsAtFairValue-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_GainLossOnAssetsHeldForSale" xlink:label="cmre_GainLossOnAssetsHeldForSale" xlink:type="locator"/>
    <link:label xlink:label="cmre_GainLossOnAssetsHeldForSale-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_GainLossOnAssetsHeldForSale</link:label>
    <link:label xlink:label="cmre_GainLossOnAssetsHeldForSale-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Gain (Loss) on Assets Held for Sale</link:label>
    <link:label xlink:label="cmre_GainLossOnAssetsHeldForSale-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to the gain (loss) on assets held for sale.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_GainLossOnAssetsHeldForSale" xlink:to="cmre_GainLossOnAssetsHeldForSale-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_AmountsReclassifiedFromNetSettlementsOnInterestRateSwapsQualifyingForHedgeAccountingToDepreciation" xlink:label="cmre_AmountsReclassifiedFromNetSettlementsOnInterestRateSwapsQualifyingForHedgeAccountingToDepreciation" xlink:type="locator"/>
    <link:label xlink:label="cmre_AmountsReclassifiedFromNetSettlementsOnInterestRateSwapsQualifyingForHedgeAccountingToDepreciation-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_AmountsReclassifiedFromNetSettlementsOnInterestRateSwapsQualifyingForHedgeAccountingToDepreciation</link:label>
    <link:label xlink:label="cmre_AmountsReclassifiedFromNetSettlementsOnInterestRateSwapsQualifyingForHedgeAccountingToDepreciation-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Amounts Reclassified From Net Settlements on Interest Rate Swaps Qualifying for Hedge Accounting to Depreciation</link:label>
    <link:label xlink:label="cmre_AmountsReclassifiedFromNetSettlementsOnInterestRateSwapsQualifyingForHedgeAccountingToDepreciation-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Amounts reclassified from Net settlements on interest rate swaps qualifying for hedge accounting to Depreciation (Note 21)</link:label>
    <link:label xlink:label="cmre_AmountsReclassifiedFromNetSettlementsOnInterestRateSwapsQualifyingForHedgeAccountingToDepreciation-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">This element represents the amounts reclassified from Net settlements on interest rate swaps qualifying for hedge accounting to Depreciation</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_AmountsReclassifiedFromNetSettlementsOnInterestRateSwapsQualifyingForHedgeAccountingToDepreciation" xlink:to="cmre_AmountsReclassifiedFromNetSettlementsOnInterestRateSwapsQualifyingForHedgeAccountingToDepreciation-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainLossOnInterestRateDerivativeInstrumentsNotDesignatedAsHedgingInstruments" xlink:label="us-gaap_GainLossOnInterestRateDerivativeInstrumentsNotDesignatedAsHedgingInstruments" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_GainLossOnInterestRateDerivativeInstrumentsNotDesignatedAsHedgingInstruments-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Loss on derivative instruments, net (Note 19)</link:label>
    <link:label xlink:label="us-gaap_GainLossOnInterestRateDerivativeInstrumentsNotDesignatedAsHedgingInstruments-label" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_GainLossOnInterestRateDerivativeInstrumentsNotDesignatedAsHedgingInstruments" xlink:to="us-gaap_GainLossOnInterestRateDerivativeInstrumentsNotDesignatedAsHedgingInstruments-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_GainLossOnSaleVessels" xlink:label="cmre_GainLossOnSaleVessels" xlink:type="locator"/>
    <link:label xlink:label="cmre_GainLossOnSaleVessels-label" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Gain on sale of vessels, net</link:label>
    <link:label xlink:label="cmre_GainLossOnSaleVessels-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Gain on sale of vessels, net (Note 7)</link:label>
    <link:label xlink:label="cmre_GainLossOnSaleVessels-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Gain (Loss) on Sale Vessels</link:label>
    <link:label xlink:label="cmre_GainLossOnSaleVessels-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Gain on sale of vessels, net</link:label>
    <link:label xlink:label="cmre_GainLossOnSaleVessels-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The difference between the sale price or salvage price and the book value of a vessel that was sold during the reporting period. This element refers to the gain (loss).</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_GainLossOnSaleVessels" xlink:to="cmre_GainLossOnSaleVessels-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_IncreaseDecreaseInAccruedCharterRevenue" xlink:label="cmre_IncreaseDecreaseInAccruedCharterRevenue" xlink:type="locator"/>
    <link:label xlink:label="cmre_IncreaseDecreaseInAccruedCharterRevenue-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_IncreaseDecreaseInAccruedCharterRevenue</link:label>
    <link:label xlink:label="cmre_IncreaseDecreaseInAccruedCharterRevenue-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Accrued charter revenue</link:label>
    <link:label xlink:label="cmre_IncreaseDecreaseInAccruedCharterRevenue-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The increase (decrease) during the reporting period, in revenue earned but not yet received, which were recognized in under the straight-line method in conformity with revenue recognition criteria based on specific contractual terms.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_IncreaseDecreaseInAccruedCharterRevenue" xlink:to="cmre_IncreaseDecreaseInAccruedCharterRevenue-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_DrydockingCosts" xlink:label="cmre_DrydockingCosts" xlink:type="locator"/>
    <link:label xlink:label="cmre_DrydockingCosts-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_DrydockingCosts</link:label>
    <link:label xlink:label="cmre_DrydockingCosts-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Dry-dockings</link:label>
    <link:label xlink:label="cmre_DrydockingCosts-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Cash paid during the reporting period for vessel drydocking costs.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_DrydockingCosts" xlink:to="cmre_DrydockingCosts-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_AmendmentFlag" xlink:label="dei_AmendmentFlag" xlink:type="locator"/>
    <link:label xlink:label="dei_AmendmentFlag-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Amendment Flag</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_AmendmentFlag" xlink:to="dei_AmendmentFlag-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_PaymentsToAcquireVessels" xlink:label="cmre_PaymentsToAcquireVessels" xlink:type="locator"/>
    <link:label xlink:label="cmre_PaymentsToAcquireVessels-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_PaymentsToAcquireVessels</link:label>
    <link:label xlink:label="cmre_PaymentsToAcquireVessels-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Vessel acquisition (and time charters) and advances/Additions to vessel cost</link:label>
    <link:label xlink:label="cmre_PaymentsToAcquireVessels-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The cash outflow associated with the acquisition of vessel that are used in the normal conduct of business to produce goods and services and not intended for resale and or upgrades of existing vessels to increase their earnings capacity.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_PaymentsToAcquireVessels" xlink:to="cmre_PaymentsToAcquireVessels-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComprehensiveIncomeNetOfTax" xlink:label="us-gaap_ComprehensiveIncomeNetOfTax" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ComprehensiveIncomeNetOfTax-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_ComprehensiveIncomeNetOfTax</link:label>
    <link:label xlink:label="us-gaap_ComprehensiveIncomeNetOfTax-label" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total comprehensive income for the period</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ComprehensiveIncomeNetOfTax" xlink:to="us-gaap_ComprehensiveIncomeNetOfTax-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ProceedsFromSaleVessels" xlink:label="cmre_ProceedsFromSaleVessels" xlink:type="locator"/>
    <link:label xlink:label="cmre_ProceedsFromSaleVessels-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Proceeds from the sale of vessels, net</link:label>
    <link:label xlink:label="cmre_ProceedsFromSaleVessels-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The cash inflow from the sale of vessels.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ProceedsFromSaleVessels" xlink:to="cmre_ProceedsFromSaleVessels-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentPeriodicPayment" xlink:label="us-gaap_DebtInstrumentPeriodicPayment" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DebtInstrumentPeriodicPayment-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DebtInstrumentPeriodicPayment</link:label>
    <link:label xlink:label="us-gaap_DebtInstrumentPeriodicPayment-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Debt Instrument, Periodic Payment, Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DebtInstrumentPeriodicPayment" xlink:to="us-gaap_DebtInstrumentPeriodicPayment-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_MajorCustomerCMember" xlink:label="cmre_MajorCustomerCMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_MajorCustomerCMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Major Customer C [Member]</link:label>
    <link:label xlink:label="cmre_MajorCustomerCMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Information pertaining to major customer C.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_MajorCustomerCMember" xlink:to="cmre_MajorCustomerCMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xlink:label="us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">New Accounting Pronouncements, Policy [Policy Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xlink:to="us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_MajorCustomerDMember" xlink:label="cmre_MajorCustomerDMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_MajorCustomerDMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Major Customer D [Member]</link:label>
    <link:label xlink:label="cmre_MajorCustomerDMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Information pertaining to major customer D.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_MajorCustomerDMember" xlink:to="cmre_MajorCustomerDMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_HalifaxExpressMember" xlink:label="cmre_HalifaxExpressMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_HalifaxExpressMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Halifax Express [Member]</link:label>
    <link:label xlink:label="cmre_HalifaxExpressMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents Halifax Express.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_HalifaxExpressMember" xlink:to="cmre_HalifaxExpressMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_MajorCustomerAMember" xlink:label="cmre_MajorCustomerAMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_MajorCustomerAMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Major Customer A [Member]</link:label>
    <link:label xlink:label="cmre_MajorCustomerAMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Information pertaining to major customer A.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_MajorCustomerAMember" xlink:to="cmre_MajorCustomerAMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentPeriodicPaymentTermsBalloonPaymentToBePaid" xlink:label="us-gaap_DebtInstrumentPeriodicPaymentTermsBalloonPaymentToBePaid" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DebtInstrumentPeriodicPaymentTermsBalloonPaymentToBePaid-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DebtInstrumentPeriodicPaymentTermsBalloonPaymentToBePaid</link:label>
    <link:label xlink:label="us-gaap_DebtInstrumentPeriodicPaymentTermsBalloonPaymentToBePaid-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Debt Instrument, Periodic Payment Terms, Balloon Payment to be Paid</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DebtInstrumentPeriodicPaymentTermsBalloonPaymentToBePaid" xlink:to="us-gaap_DebtInstrumentPeriodicPaymentTermsBalloonPaymentToBePaid-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_MajorCustomerBMember" xlink:label="cmre_MajorCustomerBMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_MajorCustomerBMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Major Customer B [Member]</link:label>
    <link:label xlink:label="cmre_MajorCustomerBMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Information pertaining to major customer B.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_MajorCustomerBMember" xlink:to="cmre_MajorCustomerBMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_OfficersCompensationChargedPeriodEnd" xlink:label="cmre_OfficersCompensationChargedPeriodEnd" xlink:type="locator"/>
    <link:label xlink:label="cmre_OfficersCompensationChargedPeriodEnd-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_OfficersCompensationChargedPeriodEnd</link:label>
    <link:label xlink:label="cmre_OfficersCompensationChargedPeriodEnd-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Officers Compensation Charged, Period End</link:label>
    <link:label xlink:label="cmre_OfficersCompensationChargedPeriodEnd-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Portion of expenditures for salaries of officers charged at period end. Does not include allocated share-based compensation, pension and post-retirement benefit expense or other labor-related non-salary expense. For commercial and industrial companies, excludes any direct and overhead labor that is included in cost of goods sold.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_OfficersCompensationChargedPeriodEnd" xlink:to="cmre_OfficersCompensationChargedPeriodEnd-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestRateFairValueHedgeAssetAtFairValue" xlink:label="us-gaap_InterestRateFairValueHedgeAssetAtFairValue" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_InterestRateFairValueHedgeAssetAtFairValue-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_InterestRateFairValueHedgeAssetAtFairValue</link:label>
    <link:label xlink:label="us-gaap_InterestRateFairValueHedgeAssetAtFairValue-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Interest Rate Fair Value Hedge Asset at Fair Value</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InterestRateFairValueHedgeAssetAtFairValue" xlink:to="us-gaap_InterestRateFairValueHedgeAssetAtFairValue-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestRateFairValueHedgeLiabilityAtFairValue" xlink:label="us-gaap_InterestRateFairValueHedgeLiabilityAtFairValue" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_InterestRateFairValueHedgeLiabilityAtFairValue-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_InterestRateFairValueHedgeLiabilityAtFairValue</link:label>
    <link:label xlink:label="us-gaap_InterestRateFairValueHedgeLiabilityAtFairValue-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Interest Rate Fair Value Hedge Liability at Fair Value</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InterestRateFairValueHedgeLiabilityAtFairValue" xlink:to="us-gaap_InterestRateFairValueHedgeLiabilityAtFairValue-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TreasuryStockSharesAcquired" xlink:label="us-gaap_TreasuryStockSharesAcquired" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_TreasuryStockSharesAcquired-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_TreasuryStockSharesAcquired</link:label>
    <link:label xlink:label="us-gaap_TreasuryStockSharesAcquired-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Treasury Stock, Shares, Acquired (in shares)</link:label>
    <link:label xlink:label="us-gaap_TreasuryStockSharesAcquired-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">- Repurchase of common stock (Note 15) (in shares)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_TreasuryStockSharesAcquired" xlink:to="us-gaap_TreasuryStockSharesAcquired-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtWeightedAverageInterestRate" xlink:label="us-gaap_LongtermDebtWeightedAverageInterestRate" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_LongtermDebtWeightedAverageInterestRate-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_LongtermDebtWeightedAverageInterestRate</link:label>
    <link:label xlink:label="us-gaap_LongtermDebtWeightedAverageInterestRate-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Long-Term Debt, Weighted Average Interest Rate, at Point in Time</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LongtermDebtWeightedAverageInterestRate" xlink:to="us-gaap_LongtermDebtWeightedAverageInterestRate-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharesOutstanding" xlink:label="us-gaap_SharesOutstanding" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_SharesOutstanding-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_SharesOutstanding</link:label>
    <link:label xlink:label="us-gaap_SharesOutstanding-label" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US">Balance (in shares)</link:label>
    <link:label xlink:label="us-gaap_SharesOutstanding-label" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US">Balance (in shares)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_SharesOutstanding" xlink:to="us-gaap_SharesOutstanding-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding" xlink:label="us-gaap_CommonStockSharesOutstanding" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_CommonStockSharesOutstanding-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_CommonStockSharesOutstanding</link:label>
    <link:label xlink:label="us-gaap_CommonStockSharesOutstanding-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Common Stock, Shares, Outstanding, Ending Balance (in shares)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CommonStockSharesOutstanding" xlink:to="us-gaap_CommonStockSharesOutstanding-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_CostamareShippingCompanySAAndCostamareShippingServicesLTDMember" xlink:label="cmre_CostamareShippingCompanySAAndCostamareShippingServicesLTDMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_CostamareShippingCompanySAAndCostamareShippingServicesLTDMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Costamare Shipping Company SA and Costamare Shipping Services Ltd. [Member]</link:label>
    <link:label xlink:label="cmre_CostamareShippingCompanySAAndCostamareShippingServicesLTDMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Information pertaining to Costamare Shipping Comany SA and Costamare Shipping Services Ltd.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_CostamareShippingCompanySAAndCostamareShippingServicesLTDMember" xlink:to="cmre_CostamareShippingCompanySAAndCostamareShippingServicesLTDMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ManagementFeePerDayPerVesselUnderBareboatCharter" xlink:label="cmre_ManagementFeePerDayPerVesselUnderBareboatCharter" xlink:type="locator"/>
    <link:label xlink:label="cmre_ManagementFeePerDayPerVesselUnderBareboatCharter-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_ManagementFeePerDayPerVesselUnderBareboatCharter</link:label>
    <link:label xlink:label="cmre_ManagementFeePerDayPerVesselUnderBareboatCharter-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Management Fee Per Day, Per Vessel Under Bareboat Charter</link:label>
    <link:label xlink:label="cmre_ManagementFeePerDayPerVesselUnderBareboatCharter-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The amount of management fee per day, per vessel under bareboat charter.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ManagementFeePerDayPerVesselUnderBareboatCharter" xlink:to="cmre_ManagementFeePerDayPerVesselUnderBareboatCharter-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ConstructionSupervisoryFee" xlink:label="cmre_ConstructionSupervisoryFee" xlink:type="locator"/>
    <link:label xlink:label="cmre_ConstructionSupervisoryFee-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_ConstructionSupervisoryFee</link:label>
    <link:label xlink:label="cmre_ConstructionSupervisoryFee-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Construction Supervisory Fee</link:label>
    <link:label xlink:label="cmre_ConstructionSupervisoryFee-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">This item represents the commission payable to Managers upfront in lieu of the fixed management fee.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ConstructionSupervisoryFee" xlink:to="cmre_ConstructionSupervisoryFee-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentInterestRateDuringPeriod" xlink:label="us-gaap_DebtInstrumentInterestRateDuringPeriod" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DebtInstrumentInterestRateDuringPeriod-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DebtInstrumentInterestRateDuringPeriod</link:label>
    <link:label xlink:label="us-gaap_DebtInstrumentInterestRateDuringPeriod-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Debt Instrument, Interest Rate During Period</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DebtInstrumentInterestRateDuringPeriod" xlink:to="us-gaap_DebtInstrumentInterestRateDuringPeriod-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ManagementFeePerDayPerVessel" xlink:label="cmre_ManagementFeePerDayPerVessel" xlink:type="locator"/>
    <link:label xlink:label="cmre_ManagementFeePerDayPerVessel-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_ManagementFeePerDayPerVessel</link:label>
    <link:label xlink:label="cmre_ManagementFeePerDayPerVessel-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Management Fee Per Day, Per Vessel</link:label>
    <link:label xlink:label="cmre_ManagementFeePerDayPerVessel-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The amount of management fee per day per vessel.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ManagementFeePerDayPerVessel" xlink:to="cmre_ManagementFeePerDayPerVessel-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CurrentFiscalYearEndDate" xlink:label="dei_CurrentFiscalYearEndDate" xlink:type="locator"/>
    <link:label xlink:label="dei_CurrentFiscalYearEndDate-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Current Fiscal Year End Date</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_CurrentFiscalYearEndDate" xlink:to="dei_CurrentFiscalYearEndDate-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DebtInstrumentInterestRateStatedPercentage-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DebtInstrumentInterestRateStatedPercentage</link:label>
    <link:label xlink:label="us-gaap_DebtInstrumentInterestRateStatedPercentage-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Debt Instrument, Interest Rate, Stated Percentage</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:to="us-gaap_DebtInstrumentInterestRateStatedPercentage-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestRateCashFlowHedgeAssetAtFairValue" xlink:label="us-gaap_InterestRateCashFlowHedgeAssetAtFairValue" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_InterestRateCashFlowHedgeAssetAtFairValue-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_InterestRateCashFlowHedgeAssetAtFairValue</link:label>
    <link:label xlink:label="us-gaap_InterestRateCashFlowHedgeAssetAtFairValue-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Interest Rate Cash Flow Hedge Asset at Fair Value</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InterestRateCashFlowHedgeAssetAtFairValue" xlink:to="us-gaap_InterestRateCashFlowHedgeAssetAtFairValue-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_AnnualFeeToRelatedParties" xlink:label="cmre_AnnualFeeToRelatedParties" xlink:type="locator"/>
    <link:label xlink:label="cmre_AnnualFeeToRelatedParties-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_AnnualFeeToRelatedParties</link:label>
    <link:label xlink:label="cmre_AnnualFeeToRelatedParties-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Annual Fee to Related Parties</link:label>
    <link:label xlink:label="cmre_AnnualFeeToRelatedParties-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Annual fee for services provided by Costamare Shipping and/ or Costamare Services as at period end</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_AnnualFeeToRelatedParties" xlink:to="cmre_AnnualFeeToRelatedParties-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_CommissionChargedOnCharterHireAgreements" xlink:label="cmre_CommissionChargedOnCharterHireAgreements" xlink:type="locator"/>
    <link:label xlink:label="cmre_CommissionChargedOnCharterHireAgreements-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_CommissionChargedOnCharterHireAgreements</link:label>
    <link:label xlink:label="cmre_CommissionChargedOnCharterHireAgreements-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Commission Charged on Charter Hire Agreements</link:label>
    <link:label xlink:label="cmre_CommissionChargedOnCharterHireAgreements-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">This item represents the commission as a percentage paid to Managers on charter hire agreements.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_CommissionChargedOnCharterHireAgreements" xlink:to="cmre_CommissionChargedOnCharterHireAgreements-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_WorkingCapitalSecurityPerVessel" xlink:label="cmre_WorkingCapitalSecurityPerVessel" xlink:type="locator"/>
    <link:label xlink:label="cmre_WorkingCapitalSecurityPerVessel-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_WorkingCapitalSecurityPerVessel</link:label>
    <link:label xlink:label="cmre_WorkingCapitalSecurityPerVessel-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Working Capital Security Per Vessel</link:label>
    <link:label xlink:label="cmre_WorkingCapitalSecurityPerVessel-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The per vessel amount hold by a third party manager as working capital security in accordance with the management agreement between the reporting entity and the third party manager.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_WorkingCapitalSecurityPerVessel" xlink:to="cmre_WorkingCapitalSecurityPerVessel-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentFiscalPeriodFocus" xlink:label="dei_DocumentFiscalPeriodFocus" xlink:type="locator"/>
    <link:label xlink:label="dei_DocumentFiscalPeriodFocus-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Document Fiscal Period Focus</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_DocumentFiscalPeriodFocus" xlink:to="dei_DocumentFiscalPeriodFocus-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_FairValueOfSharesIssuedToManager" xlink:label="cmre_FairValueOfSharesIssuedToManager" xlink:type="locator"/>
    <link:label xlink:label="cmre_FairValueOfSharesIssuedToManager-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_FairValueOfSharesIssuedToManager</link:label>
    <link:label xlink:label="cmre_FairValueOfSharesIssuedToManager-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Fair Value of Shares Issued to Manager</link:label>
    <link:label xlink:label="cmre_FairValueOfSharesIssuedToManager-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the fair value of shares issued to managers.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_FairValueOfSharesIssuedToManager" xlink:to="cmre_FairValueOfSharesIssuedToManager-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_KelsenShippingCoLoanAgreementMember" xlink:label="cmre_KelsenShippingCoLoanAgreementMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_KelsenShippingCoLoanAgreementMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Kelsen Shipping Co. Loan Agreement [Member]</link:label>
    <link:label xlink:label="cmre_KelsenShippingCoLoanAgreementMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the Kelsen Shipping Co. loan agreement</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_KelsenShippingCoLoanAgreementMember" xlink:to="cmre_KelsenShippingCoLoanAgreementMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentFiscalYearFocus" xlink:label="dei_DocumentFiscalYearFocus" xlink:type="locator"/>
    <link:label xlink:label="dei_DocumentFiscalYearFocus-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Document Fiscal Year Focus</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_DocumentFiscalYearFocus" xlink:to="dei_DocumentFiscalYearFocus-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_WorkingCapitalSecurity" xlink:label="cmre_WorkingCapitalSecurity" xlink:type="locator"/>
    <link:label xlink:label="cmre_WorkingCapitalSecurity-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_WorkingCapitalSecurity</link:label>
    <link:label xlink:label="cmre_WorkingCapitalSecurity-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Working Capital Security</link:label>
    <link:label xlink:label="cmre_WorkingCapitalSecurity-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The total amount hold by a third party manager as working capital security in accordance with the management agreement between the reporting entity and the third party manager.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_WorkingCapitalSecurity" xlink:to="cmre_WorkingCapitalSecurity-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquitySecuritiesFvNiRealizedGainLoss" xlink:label="us-gaap_EquitySecuritiesFvNiRealizedGainLoss" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_EquitySecuritiesFvNiRealizedGainLoss-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_EquitySecuritiesFvNiRealizedGainLoss</link:label>
    <link:label xlink:label="us-gaap_EquitySecuritiesFvNiRealizedGainLoss-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Equity Securities, FV-NI, Realized Gain (Loss), Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_EquitySecuritiesFvNiRealizedGainLoss" xlink:to="us-gaap_EquitySecuritiesFvNiRealizedGainLoss-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ShanghaiCostamareShipManagementCoLtdMember" xlink:label="cmre_ShanghaiCostamareShipManagementCoLtdMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_ShanghaiCostamareShipManagementCoLtdMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Shanghai Costamare Ship Management Co Ltd [Member]</link:label>
    <link:label xlink:label="cmre_ShanghaiCostamareShipManagementCoLtdMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Information pertaining to Shanghai Costamare Ship Management Co Ltd.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ShanghaiCostamareShipManagementCoLtdMember" xlink:to="cmre_ShanghaiCostamareShipManagementCoLtdMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_TotalChargesByManagerToCompanysAffiliates" xlink:label="cmre_TotalChargesByManagerToCompanysAffiliates" xlink:type="locator"/>
    <link:label xlink:label="cmre_TotalChargesByManagerToCompanysAffiliates-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_TotalChargesByManagerToCompanysAffiliates</link:label>
    <link:label xlink:label="cmre_TotalChargesByManagerToCompanysAffiliates-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Total Charges by Manager to Companys Affiliates</link:label>
    <link:label xlink:label="cmre_TotalChargesByManagerToCompanysAffiliates-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Aggregate amount charged to the companies established pursuant to the Framework Agreement for services provided in accordance with the respective management agreements.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_TotalChargesByManagerToCompanysAffiliates" xlink:to="cmre_TotalChargesByManagerToCompanysAffiliates-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInPrepaidExpense" xlink:label="us-gaap_IncreaseDecreaseInPrepaidExpense" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_IncreaseDecreaseInPrepaidExpense-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_IncreaseDecreaseInPrepaidExpense</link:label>
    <link:label xlink:label="us-gaap_IncreaseDecreaseInPrepaidExpense-label" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Prepayments and other</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_IncreaseDecreaseInPrepaidExpense" xlink:to="us-gaap_IncreaseDecreaseInPrepaidExpense-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NumberVesselsManaged" xlink:label="cmre_NumberVesselsManaged" xlink:type="locator"/>
    <link:label xlink:label="cmre_NumberVesselsManaged-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_NumberVesselsManaged</link:label>
    <link:label xlink:label="cmre_NumberVesselsManaged-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Number Vessels Managed</link:label>
    <link:label xlink:label="cmre_NumberVesselsManaged-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the number of vessels managed.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NumberVesselsManaged" xlink:to="cmre_NumberVesselsManaged-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="us-gaap_DebtInstrumentFaceAmount" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DebtInstrumentFaceAmount-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DebtInstrumentFaceAmount</link:label>
    <link:label xlink:label="us-gaap_DebtInstrumentFaceAmount-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Debt Instrument, Face Amount</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DebtInstrumentFaceAmount" xlink:to="us-gaap_DebtInstrumentFaceAmount-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_PercentageOwnership" xlink:label="cmre_PercentageOwnership" xlink:type="locator"/>
    <link:label xlink:label="cmre_PercentageOwnership-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_PercentageOwnership</link:label>
    <link:label xlink:label="cmre_PercentageOwnership-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Percentage Ownership</link:label>
    <link:label xlink:label="cmre_PercentageOwnership-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">This item represents the percentage of ownership of a related party.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_PercentageOwnership" xlink:to="cmre_PercentageOwnership-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_DeferredFinanceCostsTransferAndOtherMovements" xlink:label="cmre_DeferredFinanceCostsTransferAndOtherMovements" xlink:type="locator"/>
    <link:label xlink:label="cmre_DeferredFinanceCostsTransferAndOtherMovements-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Transfers and other movements</link:label>
    <link:label xlink:label="cmre_DeferredFinanceCostsTransferAndOtherMovements-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The amount of adjustments to deferred finance costs attribute to transfer and other movements.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_DeferredFinanceCostsTransferAndOtherMovements" xlink:to="cmre_DeferredFinanceCostsTransferAndOtherMovements-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DividendsCommonStockCash" xlink:label="us-gaap_DividendsCommonStockCash" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DividendsCommonStockCash-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DividendsCommonStockCash</link:label>
    <link:label xlink:label="us-gaap_DividendsCommonStockCash-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Dividends, Common Stock, Cash</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DividendsCommonStockCash" xlink:to="us-gaap_DividendsCommonStockCash-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DividendsPreferredStockCash" xlink:label="us-gaap_DividendsPreferredStockCash" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DividendsPreferredStockCash-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DividendsPreferredStockCash</link:label>
    <link:label xlink:label="us-gaap_DividendsPreferredStockCash-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Dividends, Preferred Stock, Cash</link:label>
    <link:label xlink:label="us-gaap_DividendsPreferredStockCash-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">- Dividends &#8211; Preferred stock (Note 15)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DividendsPreferredStockCash" xlink:to="us-gaap_DividendsPreferredStockCash-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentInformationLineItems" xlink:label="dei_DocumentInformationLineItems" xlink:type="locator"/>
    <link:label xlink:label="dei_DocumentInformationLineItems-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Document Information [Line Items]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_DocumentInformationLineItems-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.sec.gov/country/2022/country-2022.xsd#country_LR" xlink:label="country_LR" xlink:type="locator"/>
    <link:label xlink:label="country_LR-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">LIBERIA</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="country_LR" xlink:to="country_LR-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DividendsPreferredStock" xlink:label="us-gaap_DividendsPreferredStock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DividendsPreferredStock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DividendsPreferredStock</link:label>
    <link:label xlink:label="us-gaap_DividendsPreferredStock-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Dividends, Preferred Stock, Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DividendsPreferredStock" xlink:to="us-gaap_DividendsPreferredStock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentInformationTable" xlink:label="dei_DocumentInformationTable" xlink:type="locator"/>
    <link:label xlink:label="dei_DocumentInformationTable-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Document Information [Table]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_DocumentInformationTable" xlink:to="dei_DocumentInformationTable-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_WriteoffDerivingFromFairValueMeasurement" xlink:label="cmre_WriteoffDerivingFromFairValueMeasurement" xlink:type="locator"/>
    <link:label xlink:label="cmre_WriteoffDerivingFromFairValueMeasurement-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_WriteoffDerivingFromFairValueMeasurement</link:label>
    <link:label xlink:label="cmre_WriteoffDerivingFromFairValueMeasurement-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Write-off Deriving from Fair Value Measurement</link:label>
    <link:label xlink:label="cmre_WriteoffDerivingFromFairValueMeasurement-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The write-off of the difference between the aggregate fair value of the debt and equity securities received from ZIM and the then net carrying value of the amounts due from ZIM and is included in General and administrative expenses in the accompanying consolidated statement of income.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_WriteoffDerivingFromFairValueMeasurement" xlink:to="cmre_WriteoffDerivingFromFairValueMeasurement-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NumberOfInterestRateDerivativesHeld" xlink:label="us-gaap_NumberOfInterestRateDerivativesHeld" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_NumberOfInterestRateDerivativesHeld-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_NumberOfInterestRateDerivativesHeld</link:label>
    <link:label xlink:label="us-gaap_NumberOfInterestRateDerivativesHeld-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Number of Interest Rate Derivatives Held</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_NumberOfInterestRateDerivativesHeld" xlink:to="us-gaap_NumberOfInterestRateDerivativesHeld-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ScheduleOfDerivativeAssetsAndLiabilitiesAtFairValueTableTextBlock" xlink:label="cmre_ScheduleOfDerivativeAssetsAndLiabilitiesAtFairValueTableTextBlock" xlink:type="locator"/>
    <link:label xlink:label="cmre_ScheduleOfDerivativeAssetsAndLiabilitiesAtFairValueTableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Derivative Assets and Liabilities at Fair Value [Table Text Block]</link:label>
    <link:label xlink:label="cmre_ScheduleOfDerivativeAssetsAndLiabilitiesAtFairValueTableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Tabular disclosure of derivative assets and liabilities at fair value.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ScheduleOfDerivativeAssetsAndLiabilitiesAtFairValueTableTextBlock" xlink:to="cmre_ScheduleOfDerivativeAssetsAndLiabilitiesAtFairValueTableTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentAxis" xlink:label="us-gaap_DebtInstrumentAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DebtInstrumentAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt Instrument [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DebtInstrumentAxis" xlink:to="us-gaap_DebtInstrumentAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_Zim5PercentSeries2NotesDue2023Member" xlink:label="cmre_Zim5PercentSeries2NotesDue2023Member" xlink:type="locator"/>
    <link:label xlink:label="cmre_Zim5PercentSeries2NotesDue2023Member-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Zim 5.0% Series 2 Notes Due 2023 [Member]</link:label>
    <link:label xlink:label="cmre_Zim5PercentSeries2NotesDue2023Member-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Information pertaining to 5.0% Series 1 Notes due 2023 debt securities received from Zim Integrated Services.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_Zim5PercentSeries2NotesDue2023Member" xlink:to="cmre_Zim5PercentSeries2NotesDue2023Member-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentOwnedBalanceShares" xlink:label="us-gaap_InvestmentOwnedBalanceShares" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_InvestmentOwnedBalanceShares-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_InvestmentOwnedBalanceShares</link:label>
    <link:label xlink:label="us-gaap_InvestmentOwnedBalanceShares-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Investment Owned, Balance, Shares (in shares)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InvestmentOwnedBalanceShares" xlink:to="us-gaap_InvestmentOwnedBalanceShares-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_Zim3PercentSeries1NotesDue2023Member" xlink:label="cmre_Zim3PercentSeries1NotesDue2023Member" xlink:type="locator"/>
    <link:label xlink:label="cmre_Zim3PercentSeries1NotesDue2023Member-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Zim 3.0% Series 1 Notes Due 2023 [Member]</link:label>
    <link:label xlink:label="cmre_Zim3PercentSeries1NotesDue2023Member-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Information pertaining to 3.0% Series 1 Notes due 2023 - debt securities received from Zim Integrated Services.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_Zim3PercentSeries1NotesDue2023Member" xlink:to="cmre_Zim3PercentSeries1NotesDue2023Member-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="us-gaap_DebtInstrumentNameDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DebtInstrumentNameDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt Instrument, Name [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DebtInstrumentNameDomain" xlink:to="us-gaap_DebtInstrumentNameDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentOwnedBalancePrincipalAmount" xlink:label="us-gaap_InvestmentOwnedBalancePrincipalAmount" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_InvestmentOwnedBalancePrincipalAmount-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_InvestmentOwnedBalancePrincipalAmount</link:label>
    <link:label xlink:label="us-gaap_InvestmentOwnedBalancePrincipalAmount-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Investment Owned, Balance, Principal Amount</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InvestmentOwnedBalancePrincipalAmount" xlink:to="us-gaap_InvestmentOwnedBalancePrincipalAmount-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DividendsCommonStock" xlink:label="us-gaap_DividendsCommonStock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DividendsCommonStock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DividendsCommonStock</link:label>
    <link:label xlink:label="us-gaap_DividendsCommonStock-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">- Dividends &#8211; Common stock (Note 15)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DividendsCommonStock" xlink:to="us-gaap_DividendsCommonStock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LondonInterbankOfferedRateLIBORMember" xlink:label="us-gaap_LondonInterbankOfferedRateLIBORMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_LondonInterbankOfferedRateLIBORMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">London Interbank Offered Rate (LIBOR) [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LondonInterbankOfferedRateLIBORMember" xlink:to="us-gaap_LondonInterbankOfferedRateLIBORMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_The5PercentSeries2NotesDue2023Member" xlink:label="cmre_The5PercentSeries2NotesDue2023Member" xlink:type="locator"/>
    <link:label xlink:label="cmre_The5PercentSeries2NotesDue2023Member-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">The 5.0% Series 2 Notes Due 2023 [Member]</link:label>
    <link:label xlink:label="cmre_The5PercentSeries2NotesDue2023Member-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Information pertaining to the 5% Series 2 Notes Due 2023.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_The5PercentSeries2NotesDue2023Member" xlink:to="cmre_The5PercentSeries2NotesDue2023Member-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ZimIntegratedServicesMember" xlink:label="cmre_ZimIntegratedServicesMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_ZimIntegratedServicesMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Zim Integrated Services [Member]</link:label>
    <link:label xlink:label="cmre_ZimIntegratedServicesMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The legal entity of Zim Integrated Services.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ZimIntegratedServicesMember" xlink:to="cmre_ZimIntegratedServicesMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_The3PercentSeries1NotesDue2023Member" xlink:label="cmre_The3PercentSeries1NotesDue2023Member" xlink:type="locator"/>
    <link:label xlink:label="cmre_The3PercentSeries1NotesDue2023Member-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">The 3.0% Series 1 Notes Due 2023 [Member]</link:label>
    <link:label xlink:label="cmre_The3PercentSeries1NotesDue2023Member-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Information pertaining to the 3.0% Series 1 Notes Due 2023.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_The3PercentSeries1NotesDue2023Member" xlink:to="cmre_The3PercentSeries1NotesDue2023Member-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableRateDomain" xlink:label="us-gaap_VariableRateDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_VariableRateDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Variable Rate [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_VariableRateDomain" xlink:to="us-gaap_VariableRateDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_WriteoffAndOtherMovements" xlink:label="cmre_WriteoffAndOtherMovements" xlink:type="locator"/>
    <link:label xlink:label="cmre_WriteoffAndOtherMovements-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_WriteoffAndOtherMovements</link:label>
    <link:label xlink:label="cmre_WriteoffAndOtherMovements-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Write-off and other movements (Note 7)</link:label>
    <link:label xlink:label="cmre_WriteoffAndOtherMovements-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Write-off of deferred charges and other movements.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_WriteoffAndOtherMovements" xlink:to="cmre_WriteoffAndOtherMovements-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.sec.gov/country/2022/country-2022.xsd#country_MH" xlink:label="country_MH" xlink:type="locator"/>
    <link:label xlink:label="country_MH-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">MARSHALL ISLANDS</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="country_MH" xlink:to="country_MH-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_HeldtomaturitySecuritiesEquityInterestAcquired" xlink:label="cmre_HeldtomaturitySecuritiesEquityInterestAcquired" xlink:type="locator"/>
    <link:label xlink:label="cmre_HeldtomaturitySecuritiesEquityInterestAcquired-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_HeldtomaturitySecuritiesEquityInterestAcquired</link:label>
    <link:label xlink:label="cmre_HeldtomaturitySecuritiesEquityInterestAcquired-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Held-to-Maturity Securities, Equity Interest Acquired</link:label>
    <link:label xlink:label="cmre_HeldtomaturitySecuritiesEquityInterestAcquired-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the amount of equity interest in the investment acquired.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_HeldtomaturitySecuritiesEquityInterestAcquired" xlink:to="cmre_HeldtomaturitySecuritiesEquityInterestAcquired-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableRateAxis" xlink:label="us-gaap_VariableRateAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_VariableRateAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Variable Rate [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_VariableRateAxis" xlink:to="us-gaap_VariableRateAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskPercentage1" xlink:label="us-gaap_ConcentrationRiskPercentage1" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ConcentrationRiskPercentage1-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Concentration risk percentage</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ConcentrationRiskPercentage1" xlink:to="us-gaap_ConcentrationRiskPercentage1-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:label="us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_IncreaseDecreaseInAccountsReceivable-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_IncreaseDecreaseInAccountsReceivable</link:label>
    <link:label xlink:label="us-gaap_IncreaseDecreaseInAccountsReceivable-label" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Accounts receivable</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:to="us-gaap_IncreaseDecreaseInAccountsReceivable-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract" xlink:label="us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Statement of Comprehensive Income [Abstract]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract" xlink:to="us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCentralIndexKey" xlink:label="dei_EntityCentralIndexKey" xlink:type="locator"/>
    <link:label xlink:label="dei_EntityCentralIndexKey-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Entity Central Index Key</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityCentralIndexKey" xlink:to="dei_EntityCentralIndexKey-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityRegistrantName" xlink:label="dei_EntityRegistrantName" xlink:type="locator"/>
    <link:label xlink:label="dei_EntityRegistrantName-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Entity Registrant Name</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityRegistrantName" xlink:to="dei_EntityRegistrantName-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByLiabilityClassAxis" xlink:label="us-gaap_FairValueByLiabilityClassAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_FairValueByLiabilityClassAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Liability Class [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FairValueByLiabilityClassAxis" xlink:to="us-gaap_FairValueByLiabilityClassAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:label="us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair Value by Liability Class [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:to="us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityDomain" xlink:label="dei_EntityDomain" xlink:type="locator"/>
    <link:label xlink:label="dei_EntityDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Entity [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityDomain" xlink:to="dei_EntityDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInInsuranceSettlementsReceivable" xlink:label="us-gaap_IncreaseDecreaseInInsuranceSettlementsReceivable" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_IncreaseDecreaseInInsuranceSettlementsReceivable-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_IncreaseDecreaseInInsuranceSettlementsReceivable</link:label>
    <link:label xlink:label="us-gaap_IncreaseDecreaseInInsuranceSettlementsReceivable-label" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Insurance claims receivable</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_IncreaseDecreaseInInsuranceSettlementsReceivable" xlink:to="us-gaap_IncreaseDecreaseInInsuranceSettlementsReceivable-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LegalEntityAxis" xlink:label="dei_LegalEntityAxis" xlink:type="locator"/>
    <link:label xlink:label="dei_LegalEntityAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Legal Entity [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_LegalEntityAxis" xlink:to="dei_LegalEntityAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CustomerConcentrationRiskMember" xlink:label="us-gaap_CustomerConcentrationRiskMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_CustomerConcentrationRiskMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Customer Concentration Risk [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CustomerConcentrationRiskMember" xlink:to="us-gaap_CustomerConcentrationRiskMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NumberOfVesselsProvidedAsCollateralsToSecureLoans" xlink:label="cmre_NumberOfVesselsProvidedAsCollateralsToSecureLoans" xlink:type="locator"/>
    <link:label xlink:label="cmre_NumberOfVesselsProvidedAsCollateralsToSecureLoans-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_NumberOfVesselsProvidedAsCollateralsToSecureLoans</link:label>
    <link:label xlink:label="cmre_NumberOfVesselsProvidedAsCollateralsToSecureLoans-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Number of Vessels Provided as Collaterals to Secure Loans</link:label>
    <link:label xlink:label="cmre_NumberOfVesselsProvidedAsCollateralsToSecureLoans-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The number of vessels provided as collaterals to secure loans as of the reporting period.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NumberOfVesselsProvidedAsCollateralsToSecureLoans" xlink:to="cmre_NumberOfVesselsProvidedAsCollateralsToSecureLoans-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfDeferredCharges" xlink:label="us-gaap_AmortizationOfDeferredCharges" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_AmortizationOfDeferredCharges-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_AmortizationOfDeferredCharges</link:label>
    <link:label xlink:label="us-gaap_AmortizationOfDeferredCharges-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Amortization</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AmortizationOfDeferredCharges" xlink:to="us-gaap_AmortizationOfDeferredCharges-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_CarryingValueOfVesselsProvidedAsCollateralsToSecureLoans" xlink:label="cmre_CarryingValueOfVesselsProvidedAsCollateralsToSecureLoans" xlink:type="locator"/>
    <link:label xlink:label="cmre_CarryingValueOfVesselsProvidedAsCollateralsToSecureLoans-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_CarryingValueOfVesselsProvidedAsCollateralsToSecureLoans</link:label>
    <link:label xlink:label="cmre_CarryingValueOfVesselsProvidedAsCollateralsToSecureLoans-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Carrying Value of Vessels Provided as Collaterals to Secure Loans</link:label>
    <link:label xlink:label="cmre_CarryingValueOfVesselsProvidedAsCollateralsToSecureLoans-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The carrying value of vessels provided as collaterals to secure loans as of the reporting period.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_CarryingValueOfVesselsProvidedAsCollateralsToSecureLoans" xlink:to="cmre_CarryingValueOfVesselsProvidedAsCollateralsToSecureLoans-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod" xlink:label="us-gaap_TreasuryStockValueAcquiredCostMethod" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_TreasuryStockValueAcquiredCostMethod-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_TreasuryStockValueAcquiredCostMethod</link:label>
    <link:label xlink:label="us-gaap_TreasuryStockValueAcquiredCostMethod-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Treasury Stock, Value, Acquired, Cost Method</link:label>
    <link:label xlink:label="us-gaap_TreasuryStockValueAcquiredCostMethod-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">- Repurchase of common stock (Note 15)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_TreasuryStockValueAcquiredCostMethod" xlink:to="us-gaap_TreasuryStockValueAcquiredCostMethod-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInDueFromRelatedParties" xlink:label="us-gaap_IncreaseDecreaseInDueFromRelatedParties" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_IncreaseDecreaseInDueFromRelatedParties-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_IncreaseDecreaseInDueFromRelatedParties</link:label>
    <link:label xlink:label="us-gaap_IncreaseDecreaseInDueFromRelatedParties-label" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Due from related parties</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_IncreaseDecreaseInDueFromRelatedParties" xlink:to="us-gaap_IncreaseDecreaseInDueFromRelatedParties-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_VesselsAtCost" xlink:label="cmre_VesselsAtCost" xlink:type="locator"/>
    <link:label xlink:label="cmre_VesselsAtCost-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_VesselsAtCost</link:label>
    <link:label xlink:label="cmre_VesselsAtCost-label" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US">Balance, Vessel Cost at beginning of the period</link:label>
    <link:label xlink:label="cmre_VesselsAtCost-label" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US">Balance, Vessel Cost at end of the period</link:label>
    <link:label xlink:label="cmre_VesselsAtCost-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Cost of vessels, including contract price and any material expenses incurred upon acquisition (initial repairs, improvements and delivery expenses, interest and on-site supervision costs incurred during the construction periods).</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_VesselsAtCost" xlink:to="cmre_VesselsAtCost-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_PropertyPlantAndEquipmentNetPeriodIncreaseDecrease" xlink:label="cmre_PropertyPlantAndEquipmentNetPeriodIncreaseDecrease" xlink:type="locator"/>
    <link:label xlink:label="cmre_PropertyPlantAndEquipmentNetPeriodIncreaseDecrease-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_PropertyPlantAndEquipmentNetPeriodIncreaseDecrease</link:label>
    <link:label xlink:label="cmre_PropertyPlantAndEquipmentNetPeriodIncreaseDecrease-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Vessel sales, transfers and other movements</link:label>
    <link:label xlink:label="cmre_PropertyPlantAndEquipmentNetPeriodIncreaseDecrease-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount of increase (decrease) of long-lived, physical assets used in the normal conduct of business and not intended for resale net of accumulated depreciation.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_PropertyPlantAndEquipmentNetPeriodIncreaseDecrease" xlink:to="cmre_PropertyPlantAndEquipmentNetPeriodIncreaseDecrease-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByTypeAxis" xlink:label="us-gaap_ConcentrationRiskByTypeAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ConcentrationRiskByTypeAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Concentration Risk Type [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ConcentrationRiskByTypeAxis" xlink:to="us-gaap_ConcentrationRiskByTypeAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_The2009BuiltVesselMember" xlink:label="cmre_The2009BuiltVesselMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_The2009BuiltVesselMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">The 2009-built, Vessel [Member]</link:label>
    <link:label xlink:label="cmre_The2009BuiltVesselMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the 2009-built, vessel.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_The2009BuiltVesselMember" xlink:to="cmre_The2009BuiltVesselMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTypeDomain" xlink:label="us-gaap_ConcentrationRiskTypeDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ConcentrationRiskTypeDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Concentration Risk Type [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ConcentrationRiskTypeDomain" xlink:to="us-gaap_ConcentrationRiskTypeDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfDeferredHedgeGains" xlink:label="us-gaap_AmortizationOfDeferredHedgeGains" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_AmortizationOfDeferredHedgeGains-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Amortization of hedge reserve cost</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AmortizationOfDeferredHedgeGains" xlink:to="us-gaap_AmortizationOfDeferredHedgeGains-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TreasuryStockValue" xlink:label="us-gaap_TreasuryStockValue" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_TreasuryStockValue-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_TreasuryStockValue</link:label>
    <link:label xlink:label="us-gaap_TreasuryStockValue-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Treasury stock (Note 15)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_TreasuryStockValue" xlink:to="us-gaap_TreasuryStockValue-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ScheduleOfDeferredChargesTableTextBlock" xlink:label="cmre_ScheduleOfDeferredChargesTableTextBlock" xlink:type="locator"/>
    <link:label xlink:label="cmre_ScheduleOfDeferredChargesTableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Deferred Charges [Table Text Block]</link:label>
    <link:label xlink:label="cmre_ScheduleOfDeferredChargesTableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Tabular disclosure relating to deferred charges including additions, amortization and write-offs of financing cost and vessels drydocking costs. And if applicable transfers to assets held for sale.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ScheduleOfDeferredChargesTableTextBlock" xlink:to="cmre_ScheduleOfDeferredChargesTableTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_DeferredChargesTextBlock" xlink:label="cmre_DeferredChargesTextBlock" xlink:type="locator"/>
    <link:label xlink:label="cmre_DeferredChargesTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Deferred Charges [Text Block]</link:label>
    <link:label xlink:label="cmre_DeferredChargesTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The entire disclosure for deferred charges.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_DeferredChargesTextBlock" xlink:to="cmre_DeferredChargesTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchasedAndRetiredDuringPeriodShares" xlink:label="us-gaap_StockRepurchasedAndRetiredDuringPeriodShares" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_StockRepurchasedAndRetiredDuringPeriodShares-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_StockRepurchasedAndRetiredDuringPeriodShares</link:label>
    <link:label xlink:label="us-gaap_StockRepurchasedAndRetiredDuringPeriodShares-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Stock Repurchased and Retired During Period, Shares (in shares)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StockRepurchasedAndRetiredDuringPeriodShares" xlink:to="us-gaap_StockRepurchasedAndRetiredDuringPeriodShares-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_DeferredChargesAdditions" xlink:label="cmre_DeferredChargesAdditions" xlink:type="locator"/>
    <link:label xlink:label="cmre_DeferredChargesAdditions-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_DeferredChargesAdditions</link:label>
    <link:label xlink:label="cmre_DeferredChargesAdditions-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Additions</link:label>
    <link:label xlink:label="cmre_DeferredChargesAdditions-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the amount of additions to deferred charges.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_DeferredChargesAdditions" xlink:to="cmre_DeferredChargesAdditions-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_USRelatedGrossTransportationIncomeThatTaxApplies" xlink:label="cmre_USRelatedGrossTransportationIncomeThatTaxApplies" xlink:type="locator"/>
    <link:label xlink:label="cmre_USRelatedGrossTransportationIncomeThatTaxApplies-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_USRelatedGrossTransportationIncomeThatTaxApplies</link:label>
    <link:label xlink:label="cmre_USRelatedGrossTransportationIncomeThatTaxApplies-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">US Related Gross Transportation Income That Tax Applies</link:label>
    <link:label xlink:label="cmre_USRelatedGrossTransportationIncomeThatTaxApplies-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The percentage of United States related gross transportation income on which tax applied, unless an exemption applies.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_USRelatedGrossTransportationIncomeThatTaxApplies" xlink:to="cmre_USRelatedGrossTransportationIncomeThatTaxApplies-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_InterestFinanceCostsTextBlock" xlink:label="cmre_InterestFinanceCostsTextBlock" xlink:type="locator"/>
    <link:label xlink:label="cmre_InterestFinanceCostsTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Interest Finance Costs [Text Block]</link:label>
    <link:label xlink:label="cmre_InterestFinanceCostsTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Tabular disclosure of interest and finance costs and amortization of financing costs.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_InterestFinanceCostsTextBlock" xlink:to="cmre_InterestFinanceCostsTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USTreasuryBillSecuritiesMember" xlink:label="us-gaap_USTreasuryBillSecuritiesMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_USTreasuryBillSecuritiesMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">US Treasury Bill Securities [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_USTreasuryBillSecuritiesMember" xlink:to="us-gaap_USTreasuryBillSecuritiesMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_UrizaShippingCoTermLoan2Member" xlink:label="cmre_UrizaShippingCoTermLoan2Member" xlink:type="locator"/>
    <link:label xlink:label="cmre_UrizaShippingCoTermLoan2Member-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Uriza Shipping Co. Term Loan 2 [Member]</link:label>
    <link:label xlink:label="cmre_UrizaShippingCoTermLoan2Member-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the second term loan issued by Uriza Shipping Co.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_UrizaShippingCoTermLoan2Member" xlink:to="cmre_UrizaShippingCoTermLoan2Member-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueDividendReinvestmentPlan" xlink:label="us-gaap_StockIssuedDuringPeriodValueDividendReinvestmentPlan" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_StockIssuedDuringPeriodValueDividendReinvestmentPlan-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Dividend reinvested in common stock of the Company</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StockIssuedDuringPeriodValueDividendReinvestmentPlan" xlink:to="us-gaap_StockIssuedDuringPeriodValueDividendReinvestmentPlan-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesDividendReinvestmentPlan" xlink:label="us-gaap_StockIssuedDuringPeriodSharesDividendReinvestmentPlan" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_StockIssuedDuringPeriodSharesDividendReinvestmentPlan-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_StockIssuedDuringPeriodSharesDividendReinvestmentPlan</link:label>
    <link:label xlink:label="us-gaap_StockIssuedDuringPeriodSharesDividendReinvestmentPlan-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Stock Issued During Period, Shares, Dividend Reinvestment Plan (in shares)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StockIssuedDuringPeriodSharesDividendReinvestmentPlan" xlink:to="us-gaap_StockIssuedDuringPeriodSharesDividendReinvestmentPlan-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_CostamareVenturesIncTextBlock" xlink:label="cmre_CostamareVenturesIncTextBlock" xlink:type="locator"/>
    <link:label xlink:label="cmre_CostamareVenturesIncTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Costamare Ventures Inc. [Text Block]</link:label>
    <link:label xlink:label="cmre_CostamareVenturesIncTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The entire disclosure relating to the Framework Deed that Costamare Ventures Inc. (wholly owned subsidiary of the reporting Company) entered into, with York Capital Management Advisors LLC and its affiliate Sparrow Holdings LP.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_CostamareVenturesIncTextBlock" xlink:to="cmre_CostamareVenturesIncTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtTextBlock" xlink:label="us-gaap_LongTermDebtTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_LongTermDebtTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Long-Term Debt [Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LongTermDebtTextBlock" xlink:to="us-gaap_LongTermDebtTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentTypeCategorizationMember" xlink:label="us-gaap_InvestmentTypeCategorizationMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_InvestmentTypeCategorizationMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Investments [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InvestmentTypeCategorizationMember" xlink:to="us-gaap_InvestmentTypeCategorizationMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NumberOfVesselsAgreedToAcquire" xlink:label="cmre_NumberOfVesselsAgreedToAcquire" xlink:type="locator"/>
    <link:label xlink:label="cmre_NumberOfVesselsAgreedToAcquire-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_NumberOfVesselsAgreedToAcquire</link:label>
    <link:label xlink:label="cmre_NumberOfVesselsAgreedToAcquire-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Number of Vessels Agreed to Acquire</link:label>
    <link:label xlink:label="cmre_NumberOfVesselsAgreedToAcquire-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The number of vessels that agreed to acquire by the company.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NumberOfVesselsAgreedToAcquire" xlink:to="cmre_NumberOfVesselsAgreedToAcquire-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerMember" xlink:label="us-gaap_RevenueFromContractWithCustomerMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_RevenueFromContractWithCustomerMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Revenue from Contract with Customer Benchmark [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RevenueFromContractWithCustomerMember" xlink:to="us-gaap_RevenueFromContractWithCustomerMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInInventories" xlink:label="us-gaap_IncreaseDecreaseInInventories" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_IncreaseDecreaseInInventories-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_IncreaseDecreaseInInventories</link:label>
    <link:label xlink:label="us-gaap_IncreaseDecreaseInInventories-label" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Inventories</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_IncreaseDecreaseInInventories" xlink:to="us-gaap_IncreaseDecreaseInInventories-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_InterestFinanceCostsTableTextBlock" xlink:label="cmre_InterestFinanceCostsTableTextBlock" xlink:type="locator"/>
    <link:label xlink:label="cmre_InterestFinanceCostsTableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Interest Finance Costs [Table Text Block]</link:label>
    <link:label xlink:label="cmre_InterestFinanceCostsTableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Tabular disclosure of interest and debt related expenses.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_InterestFinanceCostsTableTextBlock" xlink:to="cmre_InterestFinanceCostsTableTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockDividendsShares" xlink:label="us-gaap_CommonStockDividendsShares" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_CommonStockDividendsShares-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_CommonStockDividendsShares</link:label>
    <link:label xlink:label="us-gaap_CommonStockDividendsShares-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Common Stock Dividends, Shares (in shares)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CommonStockDividendsShares" xlink:to="us-gaap_CommonStockDividendsShares-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NumberOfJointlyOwnedCompanies" xlink:label="cmre_NumberOfJointlyOwnedCompanies" xlink:type="locator"/>
    <link:label xlink:label="cmre_NumberOfJointlyOwnedCompanies-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_NumberOfJointlyOwnedCompanies</link:label>
    <link:label xlink:label="cmre_NumberOfJointlyOwnedCompanies-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Number of Jointly Owned Companies</link:label>
    <link:label xlink:label="cmre_NumberOfJointlyOwnedCompanies-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The number of jointly owned companies formed pursuant to the Framework Agreement with York, that the Company holds a percentage of their capital stock as at the end of the reporting period.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NumberOfJointlyOwnedCompanies" xlink:to="cmre_NumberOfJointlyOwnedCompanies-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:label="us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ConcentrationRiskByBenchmarkAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Concentration Risk Benchmark [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:to="us-gaap_ConcentrationRiskByBenchmarkAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskBenchmarkDomain" xlink:label="us-gaap_ConcentrationRiskBenchmarkDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ConcentrationRiskBenchmarkDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Concentration Risk Benchmark [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ConcentrationRiskBenchmarkDomain" xlink:to="us-gaap_ConcentrationRiskBenchmarkDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentTypeAxis" xlink:label="us-gaap_InvestmentTypeAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_InvestmentTypeAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Investment Type [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InvestmentTypeAxis" xlink:to="us-gaap_InvestmentTypeAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ParticipationOfCompanysWhollyOwnedSubsidiary" xlink:label="cmre_ParticipationOfCompanysWhollyOwnedSubsidiary" xlink:type="locator"/>
    <link:label xlink:label="cmre_ParticipationOfCompanysWhollyOwnedSubsidiary-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_ParticipationOfCompanysWhollyOwnedSubsidiary</link:label>
    <link:label xlink:label="cmre_ParticipationOfCompanysWhollyOwnedSubsidiary-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Participation of Company's Wholly Owned Subsidiary</link:label>
    <link:label xlink:label="cmre_ParticipationOfCompanysWhollyOwnedSubsidiary-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">This element represents the percentage of the shareholding of the Company through Costamare Ventures, to each entity.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ParticipationOfCompanysWhollyOwnedSubsidiary" xlink:to="cmre_ParticipationOfCompanysWhollyOwnedSubsidiary-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock" xlink:label="us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock" xlink:to="us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_TwentyfootEquivalentUnitsMeasuredOnVessel" xlink:label="cmre_TwentyfootEquivalentUnitsMeasuredOnVessel" xlink:type="locator"/>
    <link:label xlink:label="cmre_TwentyfootEquivalentUnitsMeasuredOnVessel-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_TwentyfootEquivalentUnitsMeasuredOnVessel</link:label>
    <link:label xlink:label="cmre_TwentyfootEquivalentUnitsMeasuredOnVessel-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Twenty-foot Equivalent Units Measured on Vessel</link:label>
    <link:label xlink:label="cmre_TwentyfootEquivalentUnitsMeasuredOnVessel-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The number of twenty-foot equivalent units measured on vessel.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_TwentyfootEquivalentUnitsMeasuredOnVessel" xlink:to="cmre_TwentyfootEquivalentUnitsMeasuredOnVessel-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_AnnualFeeToRelatedPartiesCharteredInCurrentPeriod" xlink:label="cmre_AnnualFeeToRelatedPartiesCharteredInCurrentPeriod" xlink:type="locator"/>
    <link:label xlink:label="cmre_AnnualFeeToRelatedPartiesCharteredInCurrentPeriod-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_AnnualFeeToRelatedPartiesCharteredInCurrentPeriod</link:label>
    <link:label xlink:label="cmre_AnnualFeeToRelatedPartiesCharteredInCurrentPeriod-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Annual Fee to Related Parties, Chartered in Current Period</link:label>
    <link:label xlink:label="cmre_AnnualFeeToRelatedPartiesCharteredInCurrentPeriod-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Annual fee for services provided by Costamare Shipping and/ or Costamare Services chartered in the current period.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_AnnualFeeToRelatedPartiesCharteredInCurrentPeriod" xlink:to="cmre_AnnualFeeToRelatedPartiesCharteredInCurrentPeriod-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_CommonStockIssuedForTheServicesAgreementMember" xlink:label="cmre_CommonStockIssuedForTheServicesAgreementMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_CommonStockIssuedForTheServicesAgreementMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Common Stock Issued for the Services Agreement [Member]</link:label>
    <link:label xlink:label="cmre_CommonStockIssuedForTheServicesAgreementMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Refers to information regarding common stock issued for the services agreement.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_CommonStockIssuedForTheServicesAgreementMember" xlink:to="cmre_CommonStockIssuedForTheServicesAgreementMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NumberOfVesselsHeldForSale" xlink:label="cmre_NumberOfVesselsHeldForSale" xlink:type="locator"/>
    <link:label xlink:label="cmre_NumberOfVesselsHeldForSale-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_NumberOfVesselsHeldForSale</link:label>
    <link:label xlink:label="cmre_NumberOfVesselsHeldForSale-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Number of Vessels Held for Sale</link:label>
    <link:label xlink:label="cmre_NumberOfVesselsHeldForSale-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The number of vessels held for sale.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NumberOfVesselsHeldForSale" xlink:to="cmre_NumberOfVesselsHeldForSale-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TableTextBlock" xlink:label="us-gaap_TableTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_TableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_TableTextBlock</link:label>
    <link:label xlink:label="us-gaap_TableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Notes Tables</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_TableTextBlock" xlink:to="us-gaap_TableTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_CommonStockIssuedForDividendReinvestmentPlanMember" xlink:label="cmre_CommonStockIssuedForDividendReinvestmentPlanMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_CommonStockIssuedForDividendReinvestmentPlanMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Common Stock Issued for Dividend Reinvestment Plan [Member]</link:label>
    <link:label xlink:label="cmre_CommonStockIssuedForDividendReinvestmentPlanMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Refers to information regarding common stock issued for the dividend reinvestment plan.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_CommonStockIssuedForDividendReinvestmentPlanMember" xlink:to="cmre_CommonStockIssuedForDividendReinvestmentPlanMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_SteadmanMaritimeCoMember" xlink:label="cmre_SteadmanMaritimeCoMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_SteadmanMaritimeCoMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Steadman Maritime Co. [Member]</link:label>
    <link:label xlink:label="cmre_SteadmanMaritimeCoMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Investment in Steadman Maritime Co.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_SteadmanMaritimeCoMember" xlink:to="cmre_SteadmanMaritimeCoMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity" xlink:label="us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity</link:label>
    <link:label xlink:label="us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Line of Credit Facility, Maximum Borrowing Capacity</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity" xlink:to="us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_SmalesMaritimeCoMember" xlink:label="cmre_SmalesMaritimeCoMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_SmalesMaritimeCoMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Smales Maritime Co. [Member]</link:label>
    <link:label xlink:label="cmre_SmalesMaritimeCoMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Investment in Smales Maritime Co.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_SmalesMaritimeCoMember" xlink:to="cmre_SmalesMaritimeCoMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Related Party [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:to="us-gaap_RelatedPartyTransactionsByRelatedPartyAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_GoodwayMaritimeCoMember" xlink:label="cmre_GoodwayMaritimeCoMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_GoodwayMaritimeCoMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Goodway Maritime Co. [Member]</link:label>
    <link:label xlink:label="cmre_GoodwayMaritimeCoMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Investment in Goodway Maritime Co.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_GoodwayMaritimeCoMember" xlink:to="cmre_GoodwayMaritimeCoMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyDomain" xlink:label="us-gaap_RelatedPartyDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_RelatedPartyDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Related Party [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RelatedPartyDomain" xlink:to="us-gaap_RelatedPartyDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_PlattMaritimeCoMember" xlink:label="cmre_PlattMaritimeCoMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_PlattMaritimeCoMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Platt Maritime Co. [Member]</link:label>
    <link:label xlink:label="cmre_PlattMaritimeCoMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Investment in Platt Maritime Co.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_PlattMaritimeCoMember" xlink:to="cmre_PlattMaritimeCoMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_GeyerMaritimeCoMember" xlink:label="cmre_GeyerMaritimeCoMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_GeyerMaritimeCoMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Geyer Maritime Co. [Member]</link:label>
    <link:label xlink:label="cmre_GeyerMaritimeCoMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Investments in Geyer Maritime Co.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_GeyerMaritimeCoMember" xlink:to="cmre_GeyerMaritimeCoMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_StockIssuedDuringPeriodSharesNewIssues-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">- Issuance of common stock (Notes 3 and 15) (in shares)</link:label>
    <link:label xlink:label="us-gaap_StockIssuedDuringPeriodSharesNewIssues-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Stock Issued During Period, Shares, New Issues (in shares)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:to="us-gaap_StockIssuedDuringPeriodSharesNewIssues-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_YearOfEstablishmentOrAcquisition" xlink:label="cmre_YearOfEstablishmentOrAcquisition" xlink:type="locator"/>
    <link:label xlink:label="cmre_YearOfEstablishmentOrAcquisition-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Date of establishment</link:label>
    <link:label xlink:label="cmre_YearOfEstablishmentOrAcquisition-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The dates of establishment or acquisition of the jointly owned companies formed pursuant to the Framework Agreement.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_YearOfEstablishmentOrAcquisition" xlink:to="cmre_YearOfEstablishmentOrAcquisition-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingCostsAndExpenses" xlink:label="us-gaap_OperatingCostsAndExpenses" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_OperatingCostsAndExpenses-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_OperatingCostsAndExpenses</link:label>
    <link:label xlink:label="us-gaap_OperatingCostsAndExpenses-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Vessels&#8217; operating expenses</link:label>
    <link:label xlink:label="us-gaap_OperatingCostsAndExpenses-label" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Vessels&#8217; operating expenses</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OperatingCostsAndExpenses" xlink:to="us-gaap_OperatingCostsAndExpenses-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_EquityMethodInvestmentsSummarizedFinancialInformationTableTextBlock" xlink:label="cmre_EquityMethodInvestmentsSummarizedFinancialInformationTableTextBlock" xlink:type="locator"/>
    <link:label xlink:label="cmre_EquityMethodInvestmentsSummarizedFinancialInformationTableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Equity Method Investments Summarized Financial Information [Table Text Block]</link:label>
    <link:label xlink:label="cmre_EquityMethodInvestmentsSummarizedFinancialInformationTableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Tabular disclosure of the summarized financial information regarding equity method investments.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_EquityMethodInvestmentsSummarizedFinancialInformationTableTextBlock" xlink:to="cmre_EquityMethodInvestmentsSummarizedFinancialInformationTableTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesIssuedForServices" xlink:label="us-gaap_StockIssuedDuringPeriodSharesIssuedForServices" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_StockIssuedDuringPeriodSharesIssuedForServices-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_StockIssuedDuringPeriodSharesIssuedForServices</link:label>
    <link:label xlink:label="us-gaap_StockIssuedDuringPeriodSharesIssuedForServices-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Stock Issued During Period, Shares, Issued for Services (in shares)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StockIssuedDuringPeriodSharesIssuedForServices" xlink:to="us-gaap_StockIssuedDuringPeriodSharesIssuedForServices-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_SykesMaritimeCoMember" xlink:label="cmre_SykesMaritimeCoMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_SykesMaritimeCoMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Sykes Maritime Co. [Member]</link:label>
    <link:label xlink:label="cmre_SykesMaritimeCoMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Investment in Sykes Maritime Co.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_SykesMaritimeCoMember" xlink:to="cmre_SykesMaritimeCoMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesFairValue" xlink:label="us-gaap_HeldToMaturitySecuritiesFairValue" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_HeldToMaturitySecuritiesFairValue-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_HeldToMaturitySecuritiesFairValue</link:label>
    <link:label xlink:label="us-gaap_HeldToMaturitySecuritiesFairValue-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Debt Securities, Held-to-maturity, Fair Value, Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_HeldToMaturitySecuritiesFairValue" xlink:to="us-gaap_HeldToMaturitySecuritiesFairValue-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_VesselNameOrHullName" xlink:label="cmre_VesselNameOrHullName" xlink:type="locator"/>
    <link:label xlink:label="cmre_VesselNameOrHullName-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Vessel name or hull name</link:label>
    <link:label xlink:label="cmre_VesselNameOrHullName-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The name of vessel or under construction hull name owned by the jointly owned companies formed pursuant to the Framework Agreement.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_VesselNameOrHullName" xlink:to="cmre_VesselNameOrHullName-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="us-gaap_LiabilitiesAndStockholdersEquity" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_LiabilitiesAndStockholdersEquity-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_LiabilitiesAndStockholdersEquity</link:label>
    <link:label xlink:label="us-gaap_LiabilitiesAndStockholdersEquity-label" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total liabilities and stockholders&#8217; equity</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LiabilitiesAndStockholdersEquity" xlink:to="us-gaap_LiabilitiesAndStockholdersEquity-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:label="us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_StockIssuedDuringPeriodValueNewIssues-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">- Issuance of common stock (Notes 3 and 15)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:to="us-gaap_StockIssuedDuringPeriodValueNewIssues-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionAxis" xlink:label="us-gaap_RelatedPartyTransactionAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_RelatedPartyTransactionAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Related Party Transaction [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RelatedPartyTransactionAxis" xlink:to="us-gaap_RelatedPartyTransactionAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionDomain" xlink:label="us-gaap_RelatedPartyTransactionDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_RelatedPartyTransactionDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Related Party Transaction [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RelatedPartyTransactionDomain" xlink:to="us-gaap_RelatedPartyTransactionDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentsGainLossReclassifiedFromAccumulatedOCIIntoIncomeEffectivePortionNet" xlink:label="us-gaap_DerivativeInstrumentsGainLossReclassifiedFromAccumulatedOCIIntoIncomeEffectivePortionNet" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DerivativeInstrumentsGainLossReclassifiedFromAccumulatedOCIIntoIncomeEffectivePortionNet-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DerivativeInstrumentsGainLossReclassifiedFromAccumulatedOCIIntoIncomeEffectivePortionNet</link:label>
    <link:label xlink:label="us-gaap_DerivativeInstrumentsGainLossReclassifiedFromAccumulatedOCIIntoIncomeEffectivePortionNet-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative Instruments, Gain (Loss) Reclassified from Accumulated OCI into Income, Effective Portion, Net, Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DerivativeInstrumentsGainLossReclassifiedFromAccumulatedOCIIntoIncomeEffectivePortionNet" xlink:to="us-gaap_DerivativeInstrumentsGainLossReclassifiedFromAccumulatedOCIIntoIncomeEffectivePortionNet-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="us-gaap_RetainedEarningsAccumulatedDeficit" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_RetainedEarningsAccumulatedDeficit-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Retained earnings</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RetainedEarningsAccumulatedDeficit" xlink:to="us-gaap_RetainedEarningsAccumulatedDeficit-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsNoncurrent" xlink:label="us-gaap_AssetsNoncurrent" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_AssetsNoncurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Non-current assets</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AssetsNoncurrent" xlink:to="us-gaap_AssetsNoncurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accumulated other comprehensive income / (loss) (Notes 19 and 21)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:to="us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpense" xlink:label="us-gaap_InterestExpense" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_InterestExpense-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Interest expense</link:label>
    <link:label xlink:label="us-gaap_InterestExpense-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Interest Expense, Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InterestExpense" xlink:to="us-gaap_InterestExpense-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpenseDebt" xlink:label="us-gaap_InterestExpenseDebt" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_InterestExpenseDebt-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_InterestExpenseDebt</link:label>
    <link:label xlink:label="us-gaap_InterestExpenseDebt-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Interest Expense, Debt, Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InterestExpenseDebt" xlink:to="us-gaap_InterestExpenseDebt-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:label="us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_IncreaseDecreaseInOperatingCapitalAbstract-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Changes in operating assets and liabilities:</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:to="us-gaap_IncreaseDecreaseInOperatingCapitalAbstract-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfFinancingCosts" xlink:label="us-gaap_AmortizationOfFinancingCosts" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_AmortizationOfFinancingCosts-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Amortization and write-off of financing costs</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AmortizationOfFinancingCosts" xlink:to="us-gaap_AmortizationOfFinancingCosts-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_RevenueDaysPerAnnum" xlink:label="cmre_RevenueDaysPerAnnum" xlink:type="locator"/>
    <link:label xlink:label="cmre_RevenueDaysPerAnnum-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_RevenueDaysPerAnnum</link:label>
    <link:label xlink:label="cmre_RevenueDaysPerAnnum-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Revenue Days Per Annum (Day)</link:label>
    <link:label xlink:label="cmre_RevenueDaysPerAnnum-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The number of assumed revenue days used in the calculation of the contracted revenue.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_RevenueDaysPerAnnum" xlink:to="cmre_RevenueDaysPerAnnum-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureTextBlockAbstract" xlink:label="us-gaap_DisclosureTextBlockAbstract" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DisclosureTextBlockAbstract-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DisclosureTextBlockAbstract</link:label>
    <link:label xlink:label="us-gaap_DisclosureTextBlockAbstract-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Notes to Financial Statements</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DisclosureTextBlockAbstract" xlink:to="us-gaap_DisclosureTextBlockAbstract-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_TimeCharterArrangementsRemainingTermsPeriod" xlink:label="cmre_TimeCharterArrangementsRemainingTermsPeriod" xlink:type="locator"/>
    <link:label xlink:label="cmre_TimeCharterArrangementsRemainingTermsPeriod-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_TimeCharterArrangementsRemainingTermsPeriod</link:label>
    <link:label xlink:label="cmre_TimeCharterArrangementsRemainingTermsPeriod-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Time Charter Arrangements Remaining Terms Period (Month)</link:label>
    <link:label xlink:label="cmre_TimeCharterArrangementsRemainingTermsPeriod-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The remaining terms period (in total months) of the contracted time charter agreements, including the contracted time charter agreements of vessels under construction, from the end of the reporting period.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_TimeCharterArrangementsRemainingTermsPeriod" xlink:to="cmre_TimeCharterArrangementsRemainingTermsPeriod-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock" xlink:label="us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative Instruments and Hedging Activities Disclosure [Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock" xlink:to="us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryDisclosureTextBlock" xlink:label="us-gaap_InventoryDisclosureTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_InventoryDisclosureTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Inventory Disclosure [Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InventoryDisclosureTextBlock" xlink:to="us-gaap_InventoryDisclosureTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventMember" xlink:label="us-gaap_SubsequentEventMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_SubsequentEventMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Subsequent Event [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_SubsequentEventMember" xlink:to="us-gaap_SubsequentEventMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ScheduleOfNonCancelableLongtermTimeCharterContractsTableTextBlock" xlink:label="cmre_ScheduleOfNonCancelableLongtermTimeCharterContractsTableTextBlock" xlink:type="locator"/>
    <link:label xlink:label="cmre_ScheduleOfNonCancelableLongtermTimeCharterContractsTableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Non Cancelable Long-Term Time Charter Contracts [Table Text Block]</link:label>
    <link:label xlink:label="cmre_ScheduleOfNonCancelableLongtermTimeCharterContractsTableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Tabular disclosure of the long term time charter contracted revenue.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ScheduleOfNonCancelableLongtermTimeCharterContractsTableTextBlock" xlink:to="cmre_ScheduleOfNonCancelableLongtermTimeCharterContractsTableTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearTwo" xlink:label="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearTwo" xlink:type="locator"/>
    <link:label xlink:label="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearTwo-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearTwo</link:label>
    <link:label xlink:label="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearTwo-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">2024</link:label>
    <link:label xlink:label="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearTwo-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount of receivables under long-term contracts that have not been billed and were not billable that are expected to be collected in the second fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearTwo" xlink:to="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearTwo-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_FutureMinimumContractualCharterRevenuesAssumptionsMember" xlink:label="cmre_FutureMinimumContractualCharterRevenuesAssumptionsMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_FutureMinimumContractualCharterRevenuesAssumptionsMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Future Minimum Contractual Charter Revenues Assumptions [Member]</link:label>
    <link:label xlink:label="cmre_FutureMinimumContractualCharterRevenuesAssumptionsMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Refers to information regarding future minimum contractual charter revenues assumptions.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_FutureMinimumContractualCharterRevenuesAssumptionsMember" xlink:to="cmre_FutureMinimumContractualCharterRevenuesAssumptionsMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_UnearnedRevenuesRegardingHiresCollectedInAdvanceMember" xlink:label="cmre_UnearnedRevenuesRegardingHiresCollectedInAdvanceMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_UnearnedRevenuesRegardingHiresCollectedInAdvanceMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Unearned Revenues Regarding Hires Collected in Advance [Member]</link:label>
    <link:label xlink:label="cmre_UnearnedRevenuesRegardingHiresCollectedInAdvanceMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Refers to information regarding unearned revenues regarding hires collected in advance.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_UnearnedRevenuesRegardingHiresCollectedInAdvanceMember" xlink:to="cmre_UnearnedRevenuesRegardingHiresCollectedInAdvanceMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="us-gaap_SubsequentEventTypeAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_SubsequentEventTypeAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Subsequent Event Type [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_SubsequentEventTypeAxis" xlink:to="us-gaap_SubsequentEventTypeAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearThree" xlink:label="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearThree" xlink:type="locator"/>
    <link:label xlink:label="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearThree-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearThree</link:label>
    <link:label xlink:label="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearThree-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">2025</link:label>
    <link:label xlink:label="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearThree-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount of receivables under long-term contracts that have not been billed and were not billable that are expected to be collected in the third fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearThree" xlink:to="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearThree-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IntangibleAssetsCurrent" xlink:label="us-gaap_IntangibleAssetsCurrent" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_IntangibleAssetsCurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Time charter assumed (Note 13)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_IntangibleAssetsCurrent" xlink:to="us-gaap_IntangibleAssetsCurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="us-gaap_SubsequentEventTypeDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_SubsequentEventTypeDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Subsequent Event Type [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_SubsequentEventTypeDomain" xlink:to="us-gaap_SubsequentEventTypeDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_AccruedCharterRevenueCurrentAndNoncurrentAndUnearnedRevenueCurrentAndNoncurrentTextBlock" xlink:label="cmre_AccruedCharterRevenueCurrentAndNoncurrentAndUnearnedRevenueCurrentAndNoncurrentTextBlock" xlink:type="locator"/>
    <link:label xlink:label="cmre_AccruedCharterRevenueCurrentAndNoncurrentAndUnearnedRevenueCurrentAndNoncurrentTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accrued Charter Revenue, Current and Non-Current and Unearned Revenue, Current and Non-Current [Text Block]</link:label>
    <link:label xlink:label="cmre_AccruedCharterRevenueCurrentAndNoncurrentAndUnearnedRevenueCurrentAndNoncurrentTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Includes entire disclosure for accrued and deferred revenue.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_AccruedCharterRevenueCurrentAndNoncurrentAndUnearnedRevenueCurrentAndNoncurrentTextBlock" xlink:to="cmre_AccruedCharterRevenueCurrentAndNoncurrentAndUnearnedRevenueCurrentAndNoncurrentTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredCosts" xlink:label="us-gaap_DeferredCosts" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DeferredCosts-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Deferred charges, net (Note 8)</link:label>
    <link:label xlink:label="us-gaap_DeferredCosts-label" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US">Balance, at beginning of the period</link:label>
    <link:label xlink:label="us-gaap_DeferredCosts-label" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US">Balance, at end of the period</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DeferredCosts" xlink:to="us-gaap_DeferredCosts-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_UnearnedRevenuesRegardingCharterRevenuesResultingFromVaryingCharterRatesMember" xlink:label="cmre_UnearnedRevenuesRegardingCharterRevenuesResultingFromVaryingCharterRatesMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_UnearnedRevenuesRegardingCharterRevenuesResultingFromVaryingCharterRatesMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Unearned Revenues Regarding Charter Revenues Resulting from Varying Charter Rates [Member]</link:label>
    <link:label xlink:label="cmre_UnearnedRevenuesRegardingCharterRevenuesResultingFromVaryingCharterRatesMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Refers to information regarding unearned revenues from charter revenues resulting from varying charter rates.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_UnearnedRevenuesRegardingCharterRevenuesResultingFromVaryingCharterRatesMember" xlink:to="cmre_UnearnedRevenuesRegardingCharterRevenuesResultingFromVaryingCharterRatesMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseLiabilityNoncurrent" xlink:label="us-gaap_FinanceLeaseLiabilityNoncurrent" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_FinanceLeaseLiabilityNoncurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Finance lease liabilities, net of current portion (Note 12)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FinanceLeaseLiabilityNoncurrent" xlink:to="us-gaap_FinanceLeaseLiabilityNoncurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventsTextBlock" xlink:label="us-gaap_SubsequentEventsTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_SubsequentEventsTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Subsequent Events [Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_SubsequentEventsTextBlock" xlink:to="us-gaap_SubsequentEventsTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ScheduleOfUnbilledReceivablesNotBillableAtBalanceSheetDateTableTextBlock" xlink:label="cmre_ScheduleOfUnbilledReceivablesNotBillableAtBalanceSheetDateTableTextBlock" xlink:type="locator"/>
    <link:label xlink:label="cmre_ScheduleOfUnbilledReceivablesNotBillableAtBalanceSheetDateTableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Unbilled Receivables, Not Billable at Balance Sheet Date [Table Text Block]</link:label>
    <link:label xlink:label="cmre_ScheduleOfUnbilledReceivablesNotBillableAtBalanceSheetDateTableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">A schedule of unbilled receivables under long-term contracts that have not been billed and were not billable.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ScheduleOfUnbilledReceivablesNotBillableAtBalanceSheetDateTableTextBlock" xlink:to="cmre_ScheduleOfUnbilledReceivablesNotBillableAtBalanceSheetDateTableTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_VesselsSaleAndLeasebackPrice" xlink:label="cmre_VesselsSaleAndLeasebackPrice" xlink:type="locator"/>
    <link:label xlink:label="cmre_VesselsSaleAndLeasebackPrice-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_VesselsSaleAndLeasebackPrice</link:label>
    <link:label xlink:label="cmre_VesselsSaleAndLeasebackPrice-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Vessel's sale and leaseback price</link:label>
    <link:label xlink:label="cmre_VesselsSaleAndLeasebackPrice-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The per vessel price for the 3 vessels (MSC Azov, MSC Ajaccio and MSC Amalfi), due to the sale and leaseback transaction.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_VesselsSaleAndLeasebackPrice" xlink:to="cmre_VesselsSaleAndLeasebackPrice-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityMethodInvestmentDividendsOrDistributions" xlink:label="us-gaap_EquityMethodInvestmentDividendsOrDistributions" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_EquityMethodInvestmentDividendsOrDistributions-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Dividend from equity method investees</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_EquityMethodInvestmentDividendsOrDistributions" xlink:to="us-gaap_EquityMethodInvestmentDividendsOrDistributions-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_SaleLeasebackTransactionTerm" xlink:label="cmre_SaleLeasebackTransactionTerm" xlink:type="locator"/>
    <link:label xlink:label="cmre_SaleLeasebackTransactionTerm-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_SaleLeasebackTransactionTerm</link:label>
    <link:label xlink:label="cmre_SaleLeasebackTransactionTerm-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Sale Leaseback Transaction, Term (Year)</link:label>
    <link:label xlink:label="cmre_SaleLeasebackTransactionTerm-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The term of the sale of the property to another party and the lease of the property back to the seller.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_SaleLeasebackTransactionTerm" xlink:to="cmre_SaleLeasebackTransactionTerm-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseLiability" xlink:label="us-gaap_FinanceLeaseLiability" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_FinanceLeaseLiability-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_FinanceLeaseLiability</link:label>
    <link:label xlink:label="us-gaap_FinanceLeaseLiability-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Total Finance lease liability</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FinanceLeaseLiability" xlink:to="us-gaap_FinanceLeaseLiability-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_SaleLeasebackTransactionsRegardingTheVesselsMscAzovMscAjaccioAndMscAmalfiMember" xlink:label="cmre_SaleLeasebackTransactionsRegardingTheVesselsMscAzovMscAjaccioAndMscAmalfiMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_SaleLeasebackTransactionsRegardingTheVesselsMscAzovMscAjaccioAndMscAmalfiMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Sale Leaseback Transactions Regarding the Vessels MSC Azov, MSC Ajaccio and MSC Amalfi [Member]</link:label>
    <link:label xlink:label="cmre_SaleLeasebackTransactionsRegardingTheVesselsMscAzovMscAjaccioAndMscAmalfiMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Refers to information regarding the sale leaseback transaction related to the vessels MSC Azov, MSC Ajaccio and MSC Amalfi.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_SaleLeasebackTransactionsRegardingTheVesselsMscAzovMscAjaccioAndMscAmalfiMember" xlink:to="cmre_SaleLeasebackTransactionsRegardingTheVesselsMscAzovMscAjaccioAndMscAmalfiMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseRightOfUseAsset" xlink:label="us-gaap_FinanceLeaseRightOfUseAsset" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_FinanceLeaseRightOfUseAsset-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Right-of-use assets (Note 12)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FinanceLeaseRightOfUseAsset" xlink:to="us-gaap_FinanceLeaseRightOfUseAsset-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_LoanAgreementToPartiallyRefinanceTermLoanMember" xlink:label="cmre_LoanAgreementToPartiallyRefinanceTermLoanMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_LoanAgreementToPartiallyRefinanceTermLoanMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Loan Agreement to Partially Refinance Term Loan [Member]</link:label>
    <link:label xlink:label="cmre_LoanAgreementToPartiallyRefinanceTermLoanMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the partial refinance of term loan agreement.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_LoanAgreementToPartiallyRefinanceTermLoanMember" xlink:to="cmre_LoanAgreementToPartiallyRefinanceTermLoanMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_AdeleShippingCoLoanAgreementMember" xlink:label="cmre_AdeleShippingCoLoanAgreementMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_AdeleShippingCoLoanAgreementMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Adele Shipping Co Loan Agreement [Member]</link:label>
    <link:label xlink:label="cmre_AdeleShippingCoLoanAgreementMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the Adele Shipping Co loan agreement.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_AdeleShippingCoLoanAgreementMember" xlink:to="cmre_AdeleShippingCoLoanAgreementMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_BastianShippingCoAndCadenceShippingCoLoanAgreementMember" xlink:label="cmre_BastianShippingCoAndCadenceShippingCoLoanAgreementMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_BastianShippingCoAndCadenceShippingCoLoanAgreementMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Bastian Shipping Co and Cadence Shipping Co Loan Agreement [Member]</link:label>
    <link:label xlink:label="cmre_BastianShippingCoAndCadenceShippingCoLoanAgreementMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the Bastian Shipping Co and Cadence Shipping Co loan agreement.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_BastianShippingCoAndCadenceShippingCoLoanAgreementMember" xlink:to="cmre_BastianShippingCoAndCadenceShippingCoLoanAgreementMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensation" xlink:label="us-gaap_ShareBasedCompensation" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ShareBasedCompensation-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Equity based payments</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ShareBasedCompensation" xlink:to="us-gaap_ShareBasedCompensation-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsNoncurrent" xlink:label="us-gaap_OtherAssetsNoncurrent" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_OtherAssetsNoncurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Other non-current assets (Note 5)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherAssetsNoncurrent" xlink:to="us-gaap_OtherAssetsNoncurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_SaleAndLeasebackTransactionAdditionalAmount" xlink:label="cmre_SaleAndLeasebackTransactionAdditionalAmount" xlink:type="locator"/>
    <link:label xlink:label="cmre_SaleAndLeasebackTransactionAdditionalAmount-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_SaleAndLeasebackTransactionAdditionalAmount</link:label>
    <link:label xlink:label="cmre_SaleAndLeasebackTransactionAdditionalAmount-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Sale and Leaseback Transaction, Additional Amount</link:label>
    <link:label xlink:label="cmre_SaleAndLeasebackTransactionAdditionalAmount-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The amount of additional borrowings under sale and leaseback transaction.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_SaleAndLeasebackTransactionAdditionalAmount" xlink:to="cmre_SaleAndLeasebackTransactionAdditionalAmount-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestCostsCapitalizedAdjustment" xlink:label="us-gaap_InterestCostsCapitalizedAdjustment" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_InterestCostsCapitalizedAdjustment-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_InterestCostsCapitalizedAdjustment</link:label>
    <link:label xlink:label="us-gaap_InterestCostsCapitalizedAdjustment-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Interest capitalized</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InterestCostsCapitalizedAdjustment" xlink:to="us-gaap_InterestCostsCapitalizedAdjustment-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_DebtInstrumentPrepaidPaymentOnPrincipal" xlink:label="cmre_DebtInstrumentPrepaidPaymentOnPrincipal" xlink:type="locator"/>
    <link:label xlink:label="cmre_DebtInstrumentPrepaidPaymentOnPrincipal-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_DebtInstrumentPrepaidPaymentOnPrincipal</link:label>
    <link:label xlink:label="cmre_DebtInstrumentPrepaidPaymentOnPrincipal-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Debt Instrument, Prepaid Payment on Principal</link:label>
    <link:label xlink:label="cmre_DebtInstrumentPrepaidPaymentOnPrincipal-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The amount of cash paid towards principal on outstanding debts.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_DebtInstrumentPrepaidPaymentOnPrincipal" xlink:to="cmre_DebtInstrumentPrepaidPaymentOnPrincipal-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfFinancingCostsAndDiscounts" xlink:label="us-gaap_AmortizationOfFinancingCostsAndDiscounts" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_AmortizationOfFinancingCostsAndDiscounts-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_AmortizationOfFinancingCostsAndDiscounts</link:label>
    <link:label xlink:label="us-gaap_AmortizationOfFinancingCostsAndDiscounts-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Amortization and write-off of financing costs</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AmortizationOfFinancingCostsAndDiscounts" xlink:to="us-gaap_AmortizationOfFinancingCostsAndDiscounts-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_FinanceLeaseObligationsCurrentAndNoncurrentTableTextBlock" xlink:label="cmre_FinanceLeaseObligationsCurrentAndNoncurrentTableTextBlock" xlink:type="locator"/>
    <link:label xlink:label="cmre_FinanceLeaseObligationsCurrentAndNoncurrentTableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Finance Lease Obligations Current and Non-Current [Table Text Block]</link:label>
    <link:label xlink:label="cmre_FinanceLeaseObligationsCurrentAndNoncurrentTableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Tabular disclosure of the finance lease obligations presenting current and non-current balance as at the period end.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_FinanceLeaseObligationsCurrentAndNoncurrentTableTextBlock" xlink:to="cmre_FinanceLeaseObligationsCurrentAndNoncurrentTableTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Revenues" xlink:label="us-gaap_Revenues" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_Revenues-label" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Voyage revenue</link:label>
    <link:label xlink:label="us-gaap_Revenues-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Voyage revenue</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_Revenues" xlink:to="us-gaap_Revenues-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_FinanceLeaseLiabilityExcludingFinanceCostsCurrent" xlink:label="cmre_FinanceLeaseLiabilityExcludingFinanceCostsCurrent" xlink:type="locator"/>
    <link:label xlink:label="cmre_FinanceLeaseLiabilityExcludingFinanceCostsCurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_FinanceLeaseLiabilityExcludingFinanceCostsCurrent</link:label>
    <link:label xlink:label="cmre_FinanceLeaseLiabilityExcludingFinanceCostsCurrent-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Finance lease liabilities &#8211; current</link:label>
    <link:label xlink:label="cmre_FinanceLeaseLiabilityExcludingFinanceCostsCurrent-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount of finance lease liability before finance costs, current portion.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_FinanceLeaseLiabilityExcludingFinanceCostsCurrent" xlink:to="cmre_FinanceLeaseLiabilityExcludingFinanceCostsCurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_FinanceLeaseLiabilityExcludingFinanceCostsNoncurrent" xlink:label="cmre_FinanceLeaseLiabilityExcludingFinanceCostsNoncurrent" xlink:type="locator"/>
    <link:label xlink:label="cmre_FinanceLeaseLiabilityExcludingFinanceCostsNoncurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_FinanceLeaseLiabilityExcludingFinanceCostsNoncurrent</link:label>
    <link:label xlink:label="cmre_FinanceLeaseLiabilityExcludingFinanceCostsNoncurrent-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Finance lease liabilities &#8211; non-current</link:label>
    <link:label xlink:label="cmre_FinanceLeaseLiabilityExcludingFinanceCostsNoncurrent-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount of finance lease liability before finance costs, non-current portion.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_FinanceLeaseLiabilityExcludingFinanceCostsNoncurrent" xlink:to="cmre_FinanceLeaseLiabilityExcludingFinanceCostsNoncurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfDebtDiscountPremium" xlink:label="us-gaap_AmortizationOfDebtDiscountPremium" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_AmortizationOfDebtDiscountPremium-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Amortization of debt discount</link:label>
    <link:label xlink:label="us-gaap_AmortizationOfDebtDiscountPremium-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Amortization of Debt Discount (Premium)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AmortizationOfDebtDiscountPremium" xlink:to="us-gaap_AmortizationOfDebtDiscountPremium-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsReceivableNetNoncurrent" xlink:label="us-gaap_AccountsReceivableNetNoncurrent" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_AccountsReceivableNetNoncurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accounts receivable, net, non-current (Note 3)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AccountsReceivableNetNoncurrent" xlink:to="us-gaap_AccountsReceivableNetNoncurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_FinanceLeaseLiabilityDeferredFinanceCostsCurrent" xlink:label="cmre_FinanceLeaseLiabilityDeferredFinanceCostsCurrent" xlink:type="locator"/>
    <link:label xlink:label="cmre_FinanceLeaseLiabilityDeferredFinanceCostsCurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_FinanceLeaseLiabilityDeferredFinanceCostsCurrent</link:label>
    <link:label xlink:label="cmre_FinanceLeaseLiabilityDeferredFinanceCostsCurrent-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Less: current portion of financing costs</link:label>
    <link:label xlink:label="cmre_FinanceLeaseLiabilityDeferredFinanceCostsCurrent-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount of current deferred finance costs related to finance lease liability.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_FinanceLeaseLiabilityDeferredFinanceCostsCurrent" xlink:to="cmre_FinanceLeaseLiabilityDeferredFinanceCostsCurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_FinanceLeaseLiabilityDeferredFinanceCostsNoncurrent" xlink:label="cmre_FinanceLeaseLiabilityDeferredFinanceCostsNoncurrent" xlink:type="locator"/>
    <link:label xlink:label="cmre_FinanceLeaseLiabilityDeferredFinanceCostsNoncurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_FinanceLeaseLiabilityDeferredFinanceCostsNoncurrent</link:label>
    <link:label xlink:label="cmre_FinanceLeaseLiabilityDeferredFinanceCostsNoncurrent-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Less: non-current portion of financing costs</link:label>
    <link:label xlink:label="cmre_FinanceLeaseLiabilityDeferredFinanceCostsNoncurrent-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount of non-current deferred finance costs related to finance lease liability.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_FinanceLeaseLiabilityDeferredFinanceCostsNoncurrent" xlink:to="cmre_FinanceLeaseLiabilityDeferredFinanceCostsNoncurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueNetAssetLiability" xlink:label="us-gaap_FairValueNetAssetLiability" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_FairValueNetAssetLiability-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_FairValueNetAssetLiability</link:label>
    <link:label xlink:label="us-gaap_FairValueNetAssetLiability-label" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FairValueNetAssetLiability" xlink:to="us-gaap_FairValueNetAssetLiability-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Depreciation" xlink:label="us-gaap_Depreciation" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_Depreciation-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_Depreciation</link:label>
    <link:label xlink:label="us-gaap_Depreciation-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Depreciation</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_Depreciation" xlink:to="us-gaap_Depreciation-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_CurrentPeriodReclassificationAdjustment" xlink:label="cmre_CurrentPeriodReclassificationAdjustment" xlink:type="locator"/>
    <link:label xlink:label="cmre_CurrentPeriodReclassificationAdjustment-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_CurrentPeriodReclassificationAdjustment</link:label>
    <link:label xlink:label="cmre_CurrentPeriodReclassificationAdjustment-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Current Period Reclassification Adjustment</link:label>
    <link:label xlink:label="cmre_CurrentPeriodReclassificationAdjustment-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The amount of a reclassification adjustment made to current period financial statement amounts.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_CurrentPeriodReclassificationAdjustment" xlink:to="cmre_CurrentPeriodReclassificationAdjustment-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="us-gaap_DepreciationDepletionAndAmortization" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DepreciationDepletionAndAmortization-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DepreciationDepletionAndAmortization</link:label>
    <link:label xlink:label="us-gaap_DepreciationDepletionAndAmortization-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Depreciation (Notes 7, 12 and 21)</link:label>
    <link:label xlink:label="us-gaap_DepreciationDepletionAndAmortization-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Depreciation</link:label>
    <link:label xlink:label="us-gaap_DepreciationDepletionAndAmortization-label" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Depreciation</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DepreciationDepletionAndAmortization" xlink:to="us-gaap_DepreciationDepletionAndAmortization-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_CarryingCapacityOfVesselsAtPeriodEndTEU" xlink:label="cmre_CarryingCapacityOfVesselsAtPeriodEndTEU" xlink:type="locator"/>
    <link:label xlink:label="cmre_CarryingCapacityOfVesselsAtPeriodEndTEU-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_CarryingCapacityOfVesselsAtPeriodEndTEU</link:label>
    <link:label xlink:label="cmre_CarryingCapacityOfVesselsAtPeriodEndTEU-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Carrying Capacity of Vessels at Period End (TEU)</link:label>
    <link:label xlink:label="cmre_CarryingCapacityOfVesselsAtPeriodEndTEU-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">This element represents the carrying capacity of vessels in TEUs (twenty-foot equivalet units) as at the end of each reporting period.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_CarryingCapacityOfVesselsAtPeriodEndTEU" xlink:to="cmre_CarryingCapacityOfVesselsAtPeriodEndTEU-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NumberOfSubsidiaries" xlink:label="cmre_NumberOfSubsidiaries" xlink:type="locator"/>
    <link:label xlink:label="cmre_NumberOfSubsidiaries-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_NumberOfSubsidiaries</link:label>
    <link:label xlink:label="cmre_NumberOfSubsidiaries-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Number of Subsidiaries</link:label>
    <link:label xlink:label="cmre_NumberOfSubsidiaries-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The number of subsidiaries owned by the entity.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NumberOfSubsidiaries" xlink:to="cmre_NumberOfSubsidiaries-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsTableTextBlock" xlink:label="cmre_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsTableTextBlock" xlink:type="locator"/>
    <link:label xlink:label="cmre_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsTableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents [Table Text Block]</link:label>
    <link:label xlink:label="cmre_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsTableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Tabular disclosure of cash and cash equivalents unrestricted and restricted as to withdrawal or usage.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsTableTextBlock" xlink:to="cmre_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsTableTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_TwentyfootEquivalentUnitsMeasuredOnEachVesselAcquired" xlink:label="cmre_TwentyfootEquivalentUnitsMeasuredOnEachVesselAcquired" xlink:type="locator"/>
    <link:label xlink:label="cmre_TwentyfootEquivalentUnitsMeasuredOnEachVesselAcquired-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_TwentyfootEquivalentUnitsMeasuredOnEachVesselAcquired</link:label>
    <link:label xlink:label="cmre_TwentyfootEquivalentUnitsMeasuredOnEachVesselAcquired-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Twenty-foot Equivalent Units Measured on Each Vessel Acquired</link:label>
    <link:label xlink:label="cmre_TwentyfootEquivalentUnitsMeasuredOnEachVesselAcquired-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">This element represents the carrying capacity of vessels in TEUs (twenty-foot equivalet units) measured on each vessel acquired.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_TwentyfootEquivalentUnitsMeasuredOnEachVesselAcquired" xlink:to="cmre_TwentyfootEquivalentUnitsMeasuredOnEachVesselAcquired-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharesIssuedPricePerShare" xlink:label="us-gaap_SharesIssuedPricePerShare" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_SharesIssuedPricePerShare-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_SharesIssuedPricePerShare</link:label>
    <link:label xlink:label="us-gaap_SharesIssuedPricePerShare-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Shares Issued, Price Per Share (in dollars per share)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_SharesIssuedPricePerShare" xlink:to="us-gaap_SharesIssuedPricePerShare-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_CommonStockIssuedToCostamareShippingServicesLTDMember" xlink:label="cmre_CommonStockIssuedToCostamareShippingServicesLTDMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_CommonStockIssuedToCostamareShippingServicesLTDMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Common Stock Issued to Costamare Shipping Services Ltd. [Member]</link:label>
    <link:label xlink:label="cmre_CommonStockIssuedToCostamareShippingServicesLTDMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Refers to information regarding common stock issued for Costamare Shipping Services Ltd.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_CommonStockIssuedToCostamareShippingServicesLTDMember" xlink:to="cmre_CommonStockIssuedToCostamareShippingServicesLTDMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent" xlink:label="us-gaap_AssetsCurrent" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_AssetsCurrent-label" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Current assets</link:label>
    <link:label xlink:label="us-gaap_AssetsCurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_AssetsCurrent</link:label>
    <link:label xlink:label="us-gaap_AssetsCurrent-label" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total current assets</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AssetsCurrent" xlink:to="us-gaap_AssetsCurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsNoncurrentAbstract" xlink:label="us-gaap_AssetsNoncurrentAbstract" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_AssetsNoncurrentAbstract-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">OTHER NON-CURRENT ASSETS:</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AssetsNoncurrentAbstract" xlink:to="us-gaap_AssetsNoncurrentAbstract-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_TermLoanValueMaintenanceClauses" xlink:label="cmre_TermLoanValueMaintenanceClauses" xlink:type="locator"/>
    <link:label xlink:label="cmre_TermLoanValueMaintenanceClauses-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_TermLoanValueMaintenanceClauses</link:label>
    <link:label xlink:label="cmre_TermLoanValueMaintenanceClauses-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Term Loan, Value Maintenance Clauses</link:label>
    <link:label xlink:label="cmre_TermLoanValueMaintenanceClauses-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The required fair market value of vessels in relation to the outstanding principal amount on loans.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_TermLoanValueMaintenanceClauses" xlink:to="cmre_TermLoanValueMaintenanceClauses-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityNoteDisclosureTextBlock" xlink:label="us-gaap_StockholdersEquityNoteDisclosureTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_StockholdersEquityNoteDisclosureTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Stockholders' Equity Note Disclosure [Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StockholdersEquityNoteDisclosureTextBlock" xlink:to="us-gaap_StockholdersEquityNoteDisclosureTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ScheduleOfFinancingCostsTableTextBlock" xlink:label="cmre_ScheduleOfFinancingCostsTableTextBlock" xlink:type="locator"/>
    <link:label xlink:label="cmre_ScheduleOfFinancingCostsTableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Financing Costs [Table Text Block]</link:label>
    <link:label xlink:label="cmre_ScheduleOfFinancingCostsTableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The tabular disclosure of financing costs associated with outstanding debts.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ScheduleOfFinancingCostsTableTextBlock" xlink:to="cmre_ScheduleOfFinancingCostsTableTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_DeferredFinanceCostsAdditions" xlink:label="cmre_DeferredFinanceCostsAdditions" xlink:type="locator"/>
    <link:label xlink:label="cmre_DeferredFinanceCostsAdditions-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Additions</link:label>
    <link:label xlink:label="cmre_DeferredFinanceCostsAdditions-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Finance costs that have been incurred and deferred during the period.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_DeferredFinanceCostsAdditions" xlink:to="cmre_DeferredFinanceCostsAdditions-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_TwentyfootEquivaletUnitsMeasuredOnEachVesselsAgreedToPurchase" xlink:label="cmre_TwentyfootEquivaletUnitsMeasuredOnEachVesselsAgreedToPurchase" xlink:type="locator"/>
    <link:label xlink:label="cmre_TwentyfootEquivaletUnitsMeasuredOnEachVesselsAgreedToPurchase-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_TwentyfootEquivaletUnitsMeasuredOnEachVesselsAgreedToPurchase</link:label>
    <link:label xlink:label="cmre_TwentyfootEquivaletUnitsMeasuredOnEachVesselsAgreedToPurchase-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Twenty-foot Equivalet Units Measured on Each Vessel Agreed to Purchase</link:label>
    <link:label xlink:label="cmre_TwentyfootEquivaletUnitsMeasuredOnEachVesselsAgreedToPurchase-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">This element represents the carrying capacity of vessels in TEUs (twenty-foot equivalet units) measured on each vessel agreed to be purchased.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_TwentyfootEquivaletUnitsMeasuredOnEachVesselsAgreedToPurchase" xlink:to="cmre_TwentyfootEquivaletUnitsMeasuredOnEachVesselsAgreedToPurchase-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_KonstantakopoulosFamilyMember" xlink:label="cmre_KonstantakopoulosFamilyMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_KonstantakopoulosFamilyMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Konstantakopoulos Family [Member]</link:label>
    <link:label xlink:label="cmre_KonstantakopoulosFamilyMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Refers to information regarding the Konstantakopoulos family.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_KonstantakopoulosFamilyMember" xlink:to="cmre_KonstantakopoulosFamilyMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_GainLossOnInterestRateSwapsNotDesignatedAsHedgingInstruments" xlink:label="cmre_GainLossOnInterestRateSwapsNotDesignatedAsHedgingInstruments" xlink:type="locator"/>
    <link:label xlink:label="cmre_GainLossOnInterestRateSwapsNotDesignatedAsHedgingInstruments-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Non-hedging interest rate swaps</link:label>
    <link:label xlink:label="cmre_GainLossOnInterestRateSwapsNotDesignatedAsHedgingInstruments-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount of gain (loss) included in earnings for the period from the increase (decrease) in fair value of interest rate swaps not designated as hedging instruments.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_GainLossOnInterestRateSwapsNotDesignatedAsHedgingInstruments" xlink:to="cmre_GainLossOnInterestRateSwapsNotDesignatedAsHedgingInstruments-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NumberOfUnencumberedVessels" xlink:label="cmre_NumberOfUnencumberedVessels" xlink:type="locator"/>
    <link:label xlink:label="cmre_NumberOfUnencumberedVessels-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_NumberOfUnencumberedVessels</link:label>
    <link:label xlink:label="cmre_NumberOfUnencumberedVessels-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Number of Unencumbered Vessels</link:label>
    <link:label xlink:label="cmre_NumberOfUnencumberedVessels-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The number of unencumbered vessels.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NumberOfUnencumberedVessels" xlink:to="cmre_NumberOfUnencumberedVessels-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_RealizedGainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments" xlink:label="cmre_RealizedGainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments" xlink:type="locator"/>
    <link:label xlink:label="cmre_RealizedGainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_RealizedGainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments</link:label>
    <link:label xlink:label="cmre_RealizedGainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Realized Gain (Loss) on Foreign Currency Derivative Instruments Not Designated as Hedging Instruments</link:label>
    <link:label xlink:label="cmre_RealizedGainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount of realized gain (loss) recognized in earnings in the period from the increase (decrease) in fair value of foreign currency derivatives not designated as hedging instruments.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_RealizedGainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments" xlink:to="cmre_RealizedGainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_DeferredFinanceCostsAmortizationAndWriteoff" xlink:label="cmre_DeferredFinanceCostsAmortizationAndWriteoff" xlink:type="locator"/>
    <link:label xlink:label="cmre_DeferredFinanceCostsAmortizationAndWriteoff-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_DeferredFinanceCostsAmortizationAndWriteoff</link:label>
    <link:label xlink:label="cmre_DeferredFinanceCostsAmortizationAndWriteoff-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Amortization and write-off</link:label>
    <link:label xlink:label="cmre_DeferredFinanceCostsAmortizationAndWriteoff-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The amount of amortization and write-offs related to deferred finance costs.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_DeferredFinanceCostsAmortizationAndWriteoff" xlink:to="cmre_DeferredFinanceCostsAmortizationAndWriteoff-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_DeferredFinanceCostsIncludingCaptialLeaseNetNoncurrent" xlink:label="cmre_DeferredFinanceCostsIncludingCaptialLeaseNetNoncurrent" xlink:type="locator"/>
    <link:label xlink:label="cmre_DeferredFinanceCostsIncludingCaptialLeaseNetNoncurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Financing costs, non-current portion</link:label>
    <link:label xlink:label="cmre_DeferredFinanceCostsIncludingCaptialLeaseNetNoncurrent-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount, after accumulated amortization, of debt and capital lease issuance costs classified as noncurrent.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_DeferredFinanceCostsIncludingCaptialLeaseNetNoncurrent" xlink:to="cmre_DeferredFinanceCostsIncludingCaptialLeaseNetNoncurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_LongtermDebtGrossCurrentMaturities" xlink:label="cmre_LongtermDebtGrossCurrentMaturities" xlink:type="locator"/>
    <link:label xlink:label="cmre_LongtermDebtGrossCurrentMaturities-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_LongtermDebtGrossCurrentMaturities</link:label>
    <link:label xlink:label="cmre_LongtermDebtGrossCurrentMaturities-label" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Less: Long-term debt current portion</link:label>
    <link:label xlink:label="cmre_LongtermDebtGrossCurrentMaturities-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount, before unamortized (discount) premium and debt issuance costs, of long-term debt, classified as current. Includes, but not limited to, notes payable, bonds payable, debentures, mortgage loans and commercial paper. Excludes capital lease obligations.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_LongtermDebtGrossCurrentMaturities" xlink:to="cmre_LongtermDebtGrossCurrentMaturities-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_DeferredFinancingCostsIncludingCapitalLeaseNet" xlink:label="cmre_DeferredFinancingCostsIncludingCapitalLeaseNet" xlink:type="locator"/>
    <link:label xlink:label="cmre_DeferredFinancingCostsIncludingCapitalLeaseNet-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_DeferredFinancingCostsIncludingCapitalLeaseNet</link:label>
    <link:label xlink:label="cmre_DeferredFinancingCostsIncludingCapitalLeaseNet-label" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US">Balance, at beginning of the period</link:label>
    <link:label xlink:label="cmre_DeferredFinancingCostsIncludingCapitalLeaseNet-label" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US">Balance, at end of period</link:label>
    <link:label xlink:label="cmre_DeferredFinancingCostsIncludingCapitalLeaseNet-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount, after accumulated amortization, of debt and capital lease issuance costs.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_DeferredFinancingCostsIncludingCapitalLeaseNet" xlink:to="cmre_DeferredFinancingCostsIncludingCapitalLeaseNet-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockValue" xlink:label="us-gaap_CommonStockValue" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_CommonStockValue-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Common stock (Note 15)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CommonStockValue" xlink:to="us-gaap_CommonStockValue-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentOwnedAtFairValue" xlink:label="us-gaap_InvestmentOwnedAtFairValue" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_InvestmentOwnedAtFairValue-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_InvestmentOwnedAtFairValue</link:label>
    <link:label xlink:label="us-gaap_InvestmentOwnedAtFairValue-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Investment Owned, at Fair Value</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InvestmentOwnedAtFairValue" xlink:to="us-gaap_InvestmentOwnedAtFairValue-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_DeferredFinanceCostsIncludingCapitalLeasesNetCurrent" xlink:label="cmre_DeferredFinanceCostsIncludingCapitalLeasesNetCurrent" xlink:type="locator"/>
    <link:label xlink:label="cmre_DeferredFinanceCostsIncludingCapitalLeasesNetCurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_DeferredFinanceCostsIncludingCapitalLeasesNetCurrent</link:label>
    <link:label xlink:label="cmre_DeferredFinanceCostsIncludingCapitalLeasesNetCurrent-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Less: Current portion of financing costs</link:label>
    <link:label xlink:label="cmre_DeferredFinanceCostsIncludingCapitalLeasesNetCurrent-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount, after accumulated amortization, of debt and capital lease issuance costs classified as current.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_DeferredFinanceCostsIncludingCapitalLeasesNetCurrent" xlink:to="cmre_DeferredFinanceCostsIncludingCapitalLeasesNetCurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Adjustments to reconcile net income to net cash provided by operating activities:</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:to="us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="us-gaap_FairValueByMeasurementFrequencyAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_FairValueByMeasurementFrequencyAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Measurement Frequency [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FairValueByMeasurementFrequencyAxis" xlink:to="us-gaap_FairValueByMeasurementFrequencyAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="us-gaap_FairValueMeasurementFrequencyDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_FairValueMeasurementFrequencyDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Measurement Frequency [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FairValueMeasurementFrequencyDomain" xlink:to="us-gaap_FairValueMeasurementFrequencyDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsRecurringMember" xlink:label="us-gaap_FairValueMeasurementsRecurringMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_FairValueMeasurementsRecurringMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair Value, Recurring [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FairValueMeasurementsRecurringMember" xlink:to="us-gaap_FairValueMeasurementsRecurringMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesIssued" xlink:label="us-gaap_CommonStockSharesIssued" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_CommonStockSharesIssued-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_CommonStockSharesIssued</link:label>
    <link:label xlink:label="us-gaap_CommonStockSharesIssued-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Common Stock, Shares, Issued (in shares)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CommonStockSharesIssued" xlink:to="us-gaap_CommonStockSharesIssued-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityPolicyTextBlock" xlink:label="us-gaap_StockholdersEquityPolicyTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_StockholdersEquityPolicyTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Stockholders' Equity, Policy [Policy Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StockholdersEquityPolicyTextBlock" xlink:to="us-gaap_StockholdersEquityPolicyTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockParOrStatedValuePerShare" xlink:label="us-gaap_CommonStockParOrStatedValuePerShare" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_CommonStockParOrStatedValuePerShare-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_CommonStockParOrStatedValuePerShare</link:label>
    <link:label xlink:label="us-gaap_CommonStockParOrStatedValuePerShare-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Common Stock, Par or Stated Value Per Share (in dollars per share)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CommonStockParOrStatedValuePerShare" xlink:to="us-gaap_CommonStockParOrStatedValuePerShare-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeAssetsCurrent" xlink:label="us-gaap_DerivativeAssetsCurrent" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DerivativeAssetsCurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair value of derivatives (Notes 19 and 20)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DerivativeAssetsCurrent" xlink:to="us-gaap_DerivativeAssetsCurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember" xlink:label="srt_RangeMember" xlink:type="locator"/>
    <link:label xlink:label="srt_RangeMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Statistical Measurement [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="srt_RangeMember" xlink:to="srt_RangeMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NumberOfDryBulkVessels" xlink:label="cmre_NumberOfDryBulkVessels" xlink:type="locator"/>
    <link:label xlink:label="cmre_NumberOfDryBulkVessels-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_NumberOfDryBulkVessels</link:label>
    <link:label xlink:label="cmre_NumberOfDryBulkVessels-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Number of Dry-bulk Vessels</link:label>
    <link:label xlink:label="cmre_NumberOfDryBulkVessels-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The number of dry-bulk vessels owned by the company.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NumberOfDryBulkVessels" xlink:to="cmre_NumberOfDryBulkVessels-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember" xlink:label="srt_MaximumMember" xlink:type="locator"/>
    <link:label xlink:label="srt_MaximumMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Maximum [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="srt_MaximumMember" xlink:to="srt_MaximumMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember" xlink:label="srt_MinimumMember" xlink:type="locator"/>
    <link:label xlink:label="srt_MinimumMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Minimum [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="srt_MinimumMember" xlink:to="srt_MinimumMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_OwnershipDomain" xlink:label="srt_OwnershipDomain" xlink:type="locator"/>
    <link:label xlink:label="srt_OwnershipDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Ownership [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="srt_OwnershipDomain" xlink:to="srt_OwnershipDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_StockholdersEquityGainLossFromCommonControlTransaction" xlink:label="cmre_StockholdersEquityGainLossFromCommonControlTransaction" xlink:type="locator"/>
    <link:label xlink:label="cmre_StockholdersEquityGainLossFromCommonControlTransaction-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">- Gain from common control transaction (Note 3)</link:label>
    <link:label xlink:label="cmre_StockholdersEquityGainLossFromCommonControlTransaction-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Stockholders' Equity, Gain (loss) from Common Control Transaction</link:label>
    <link:label xlink:label="cmre_StockholdersEquityGainLossFromCommonControlTransaction-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount of adjustments to stockholders' equity attributable to the gain (loss) from common control transaction.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_StockholdersEquityGainLossFromCommonControlTransaction" xlink:to="cmre_StockholdersEquityGainLossFromCommonControlTransaction-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis" xlink:label="srt_RangeAxis" xlink:type="locator"/>
    <link:label xlink:label="srt_RangeAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Statistical Measurement [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="srt_RangeAxis" xlink:to="srt_RangeAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_EquityMethodInvesteeNameDomain" xlink:label="srt_EquityMethodInvesteeNameDomain" xlink:type="locator"/>
    <link:label xlink:label="srt_EquityMethodInvesteeNameDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Investment, Name [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="srt_EquityMethodInvesteeNameDomain" xlink:to="srt_EquityMethodInvesteeNameDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_DailyBrokerageCommissionOnTimeCharter" xlink:label="cmre_DailyBrokerageCommissionOnTimeCharter" xlink:type="locator"/>
    <link:label xlink:label="cmre_DailyBrokerageCommissionOnTimeCharter-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_DailyBrokerageCommissionOnTimeCharter</link:label>
    <link:label xlink:label="cmre_DailyBrokerageCommissionOnTimeCharter-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Daily Brokerage Commission on Time Charter</link:label>
    <link:label xlink:label="cmre_DailyBrokerageCommissionOnTimeCharter-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The daily brokerage commission per day on time charters.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_DailyBrokerageCommissionOnTimeCharter" xlink:to="cmre_DailyBrokerageCommissionOnTimeCharter-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_LongshawMaritimeInvestmentsSAMember" xlink:label="cmre_LongshawMaritimeInvestmentsSAMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_LongshawMaritimeInvestmentsSAMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Longshaw Maritime Investments S.A. [Member]</link:label>
    <link:label xlink:label="cmre_LongshawMaritimeInvestmentsSAMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents Longshaw Maritime Investments S.A. (&#8220;Longshaw&#8221;).</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_LongshawMaritimeInvestmentsSAMember" xlink:to="cmre_LongshawMaritimeInvestmentsSAMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_OwnershipAxis" xlink:label="srt_OwnershipAxis" xlink:type="locator"/>
    <link:label xlink:label="srt_OwnershipAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Ownership [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="srt_OwnershipAxis" xlink:to="srt_OwnershipAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NumberOfCompaniesAcquired" xlink:label="cmre_NumberOfCompaniesAcquired" xlink:type="locator"/>
    <link:label xlink:label="cmre_NumberOfCompaniesAcquired-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_NumberOfCompaniesAcquired</link:label>
    <link:label xlink:label="cmre_NumberOfCompaniesAcquired-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Number of Companies Acquired</link:label>
    <link:label xlink:label="cmre_NumberOfCompaniesAcquired-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The number of companies acquired.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NumberOfCompaniesAcquired" xlink:to="cmre_NumberOfCompaniesAcquired-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockValue" xlink:label="us-gaap_PreferredStockValue" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_PreferredStockValue-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Preferred stock (Note 15)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PreferredStockValue" xlink:to="us-gaap_PreferredStockValue-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_DryBulkVesselsMember" xlink:label="cmre_DryBulkVesselsMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_DryBulkVesselsMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Dry-bulk Vessels [Member]</link:label>
    <link:label xlink:label="cmre_DryBulkVesselsMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the dry-bulk vessels.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_DryBulkVesselsMember" xlink:to="cmre_DryBulkVesselsMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestPaidNet" xlink:label="us-gaap_InterestPaidNet" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_InterestPaidNet-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Cash paid during the period for interest, net of capitalized interest</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InterestPaidNet" xlink:to="us-gaap_InterestPaidNet-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:label="srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:type="locator"/>
    <link:label xlink:label="srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Investment, Name [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:to="srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrepaidExpenseCurrent" xlink:label="us-gaap_PrepaidExpenseCurrent" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_PrepaidExpenseCurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Prepayments and other assets</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PrepaidExpenseCurrent" xlink:to="us-gaap_PrepaidExpenseCurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_DryBulkVesselsSegmentMember" xlink:label="cmre_DryBulkVesselsSegmentMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_DryBulkVesselsSegmentMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Dry Bulk Vessels Segment [Member]</link:label>
    <link:label xlink:label="cmre_DryBulkVesselsSegmentMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents dry bulk vessels segment.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_DryBulkVesselsSegmentMember" xlink:to="cmre_DryBulkVesselsSegmentMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis" xlink:label="srt_StatementGeographicalAxis" xlink:type="locator"/>
    <link:label xlink:label="srt_StatementGeographicalAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Geographical [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="srt_StatementGeographicalAxis" xlink:to="srt_StatementGeographicalAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_AriesArgusGlenCanyonAndrousaNorfolkPortoCheliPortoKagioAndPortoGermenoMember" xlink:label="cmre_AriesArgusGlenCanyonAndrousaNorfolkPortoCheliPortoKagioAndPortoGermenoMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_AriesArgusGlenCanyonAndrousaNorfolkPortoCheliPortoKagioAndPortoGermenoMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Aries, Argus, Glen Canyon, Androusa, Norfolk, Porto Cheli, Porto Kagio and Porto Germeno [Member]</link:label>
    <link:label xlink:label="cmre_AriesArgusGlenCanyonAndrousaNorfolkPortoCheliPortoKagioAndPortoGermenoMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents Aries, Argus, Glen Canyon, Androusa, Norfolk, Porto Cheli, Porto Kagio and Porto Germeno.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_AriesArgusGlenCanyonAndrousaNorfolkPortoCheliPortoKagioAndPortoGermenoMember" xlink:to="cmre_AriesArgusGlenCanyonAndrousaNorfolkPortoCheliPortoKagioAndPortoGermenoMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfRevenueByMajorCustomersByReportingSegmentsTableTextBlock" xlink:label="us-gaap_ScheduleOfRevenueByMajorCustomersByReportingSegmentsTableTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ScheduleOfRevenueByMajorCustomersByReportingSegmentsTableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Revenue by Major Customers by Reporting Segments [Table Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ScheduleOfRevenueByMajorCustomersByReportingSegmentsTableTextBlock" xlink:to="us-gaap_ScheduleOfRevenueByMajorCustomersByReportingSegmentsTableTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain" xlink:label="srt_SegmentGeographicalDomain" xlink:type="locator"/>
    <link:label xlink:label="srt_SegmentGeographicalDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Geographical [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="srt_SegmentGeographicalDomain" xlink:to="srt_SegmentGeographicalDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_YmTargetAndYmTiptopMember" xlink:label="cmre_YmTargetAndYmTiptopMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_YmTargetAndYmTiptopMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">YM Target and YM Tiptop [Member]</link:label>
    <link:label xlink:label="cmre_YmTargetAndYmTiptopMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents YM Target and YM Tiptop.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_YmTargetAndYmTiptopMember" xlink:to="cmre_YmTargetAndYmTiptopMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_VesselOwningCompaniesOfFiveVesselsPurchasedFromYorkMember" xlink:label="cmre_VesselOwningCompaniesOfFiveVesselsPurchasedFromYorkMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_VesselOwningCompaniesOfFiveVesselsPurchasedFromYorkMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Vessel Owning Companies of Five Vessels Purchased from York [Member]</link:label>
    <link:label xlink:label="cmre_VesselOwningCompaniesOfFiveVesselsPurchasedFromYorkMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the vessel owning companies of five vessels purchased from York.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_VesselOwningCompaniesOfFiveVesselsPurchasedFromYorkMember" xlink:to="cmre_VesselOwningCompaniesOfFiveVesselsPurchasedFromYorkMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_The16CompaniesWhichOwnedOrCommittedToAcquireBulkVesselsMember" xlink:label="cmre_The16CompaniesWhichOwnedOrCommittedToAcquireBulkVesselsMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_The16CompaniesWhichOwnedOrCommittedToAcquireBulkVesselsMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">The16 Companies Which Owned or Committed to Acquire Bulk Vessels [Member]</link:label>
    <link:label xlink:label="cmre_The16CompaniesWhichOwnedOrCommittedToAcquireBulkVesselsMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the 16 companies which owned or are committed to acquire bulk vessels.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_The16CompaniesWhichOwnedOrCommittedToAcquireBulkVesselsMember" xlink:to="cmre_The16CompaniesWhichOwnedOrCommittedToAcquireBulkVesselsMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_DeadWeightTonnageOfVessels" xlink:label="cmre_DeadWeightTonnageOfVessels" xlink:type="locator"/>
    <link:label xlink:label="cmre_DeadWeightTonnageOfVessels-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_DeadWeightTonnageOfVessels</link:label>
    <link:label xlink:label="cmre_DeadWeightTonnageOfVessels-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Dead Weight Tonnage of Vessels</link:label>
    <link:label xlink:label="cmre_DeadWeightTonnageOfVessels-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The DWT of vessels.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_DeadWeightTonnageOfVessels" xlink:to="cmre_DeadWeightTonnageOfVessels-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryNet" xlink:label="us-gaap_InventoryNet" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_InventoryNet-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Inventories (Note 6)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InventoryNet" xlink:to="us-gaap_InventoryNet-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_BuilderPegasusAndAdventureMember" xlink:label="cmre_BuilderPegasusAndAdventureMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_BuilderPegasusAndAdventureMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Builder, Pegasus and Adventure [Member]</link:label>
    <link:label xlink:label="cmre_BuilderPegasusAndAdventureMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the Builder, Pegasus and Adventure.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_BuilderPegasusAndAdventureMember" xlink:to="cmre_BuilderPegasusAndAdventureMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ContainerVesselsSegmentMember" xlink:label="cmre_ContainerVesselsSegmentMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_ContainerVesselsSegmentMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Container Vessels Segment [Member]</link:label>
    <link:label xlink:label="cmre_ContainerVesselsSegmentMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents container vessels segment.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ContainerVesselsSegmentMember" xlink:to="cmre_ContainerVesselsSegmentMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_AccruedCharterRevenue" xlink:label="cmre_AccruedCharterRevenue" xlink:type="locator"/>
    <link:label xlink:label="cmre_AccruedCharterRevenue-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accrued charter revenue (Note 13)</link:label>
    <link:label xlink:label="cmre_AccruedCharterRevenue-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Current portion of revenue earned, but not collected, resulting from charter agreements providing for varying annual charter rates over their terms, which were accounted for on a straight-line basis at their average rates.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_AccruedCharterRevenue" xlink:to="cmre_AccruedCharterRevenue-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NumberOfVesselsSurveyInProcess" xlink:label="cmre_NumberOfVesselsSurveyInProcess" xlink:type="locator"/>
    <link:label xlink:label="cmre_NumberOfVesselsSurveyInProcess-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_NumberOfVesselsSurveyInProcess</link:label>
    <link:label xlink:label="cmre_NumberOfVesselsSurveyInProcess-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Number of Vessels Survey in Process</link:label>
    <link:label xlink:label="cmre_NumberOfVesselsSurveyInProcess-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The number of vessels that special survey for dry docking is still in process.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NumberOfVesselsSurveyInProcess" xlink:to="cmre_NumberOfVesselsSurveyInProcess-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax" xlink:label="us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax</link:label>
    <link:label xlink:label="us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Voyage revenue</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax" xlink:to="us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_BergShippingCoLoanAgreementMember" xlink:label="cmre_BergShippingCoLoanAgreementMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_BergShippingCoLoanAgreementMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Berg Shipping Co. Loan Agreement [Member]</link:label>
    <link:label xlink:label="cmre_BergShippingCoLoanAgreementMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the Berg Shipping Co. loan agreement.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_BergShippingCoLoanAgreementMember" xlink:to="cmre_BergShippingCoLoanAgreementMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_CapeAkritasCapeTainaroCapeArtemisioCapeKortiaAndCapeSounioMember" xlink:label="cmre_CapeAkritasCapeTainaroCapeArtemisioCapeKortiaAndCapeSounioMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_CapeAkritasCapeTainaroCapeArtemisioCapeKortiaAndCapeSounioMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Cape Akritas, Cape Tainaro, Cape Artemisio, Cape Kortia and Cape Sounio [Member]</link:label>
    <link:label xlink:label="cmre_CapeAkritasCapeTainaroCapeArtemisioCapeKortiaAndCapeSounioMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents Cape Akritas, Cape Tainaro, Cape Artemisio, Cape Kortia and Cape Sounio.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_CapeAkritasCapeTainaroCapeArtemisioCapeKortiaAndCapeSounioMember" xlink:to="cmre_CapeAkritasCapeTainaroCapeArtemisioCapeKortiaAndCapeSounioMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="us-gaap_FairValueInputsLevel3Member" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_FairValueInputsLevel3Member-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair Value, Inputs, Level 3 [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FairValueInputsLevel3Member" xlink:to="us-gaap_FairValueInputsLevel3Member-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedTimeCharterLiabilities" xlink:label="cmre_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedTimeCharterLiabilities" xlink:type="locator"/>
    <link:label xlink:label="cmre_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedTimeCharterLiabilities-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedTimeCharterLiabilities</link:label>
    <link:label xlink:label="cmre_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedTimeCharterLiabilities-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Time Charter Liabilities</link:label>
    <link:label xlink:label="cmre_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedTimeCharterLiabilities-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount of time charter liabilities assumed at the acquisition date.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedTimeCharterLiabilities" xlink:to="cmre_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedTimeCharterLiabilities-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_DebtSecuritiesHeldToMaturityCreditLossExpense" xlink:label="cmre_DebtSecuritiesHeldToMaturityCreditLossExpense" xlink:type="locator"/>
    <link:label xlink:label="cmre_DebtSecuritiesHeldToMaturityCreditLossExpense-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Credit loss provision</link:label>
    <link:label xlink:label="cmre_DebtSecuritiesHeldToMaturityCreditLossExpense-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount of credit loss expense for debt securities, held to maturity.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_DebtSecuritiesHeldToMaturityCreditLossExpense" xlink:to="cmre_DebtSecuritiesHeldToMaturityCreditLossExpense-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_OtherThirdpartyManagersMember" xlink:label="cmre_OtherThirdpartyManagersMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_OtherThirdpartyManagersMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Other Third-party Managers [Member]</link:label>
    <link:label xlink:label="cmre_OtherThirdpartyManagersMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents other third-party managers.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_OtherThirdpartyManagersMember" xlink:to="cmre_OtherThirdpartyManagersMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_The2008BuiltVesselMember" xlink:label="cmre_The2008BuiltVesselMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_The2008BuiltVesselMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">The 2008-built Vessel [Member]</link:label>
    <link:label xlink:label="cmre_The2008BuiltVesselMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the 2008-built vessel.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_The2008BuiltVesselMember" xlink:to="cmre_The2008BuiltVesselMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_DeadWeightTonnageOfVesselsAgreedToAcquire" xlink:label="cmre_DeadWeightTonnageOfVesselsAgreedToAcquire" xlink:type="locator"/>
    <link:label xlink:label="cmre_DeadWeightTonnageOfVesselsAgreedToAcquire-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_DeadWeightTonnageOfVesselsAgreedToAcquire</link:label>
    <link:label xlink:label="cmre_DeadWeightTonnageOfVesselsAgreedToAcquire-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Dead Weight Tonnage of Vessels Agreed to Acquire</link:label>
    <link:label xlink:label="cmre_DeadWeightTonnageOfVesselsAgreedToAcquire-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The DTW of vessels agreed to acquire.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_DeadWeightTonnageOfVesselsAgreedToAcquire" xlink:to="cmre_DeadWeightTonnageOfVesselsAgreedToAcquire-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_LeonidioAndKyparissiaMember" xlink:label="cmre_LeonidioAndKyparissiaMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_LeonidioAndKyparissiaMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Leonidio and Kyparissia [Member]</link:label>
    <link:label xlink:label="cmre_LeonidioAndKyparissiaMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Leonidio and Kyparissia.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_LeonidioAndKyparissiaMember" xlink:to="cmre_LeonidioAndKyparissiaMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_AinsleyMaritimeCoAndAmbroseMaritimeCoLoanAgreementMember" xlink:label="cmre_AinsleyMaritimeCoAndAmbroseMaritimeCoLoanAgreementMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_AinsleyMaritimeCoAndAmbroseMaritimeCoLoanAgreementMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Ainsley Maritime Co. and Ambrose Maritime Co. Loan Agreement [Member]</link:label>
    <link:label xlink:label="cmre_AinsleyMaritimeCoAndAmbroseMaritimeCoLoanAgreementMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the Ainsley Maritime Co. and Ambrose Maritime Co. loan agreement.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_AinsleyMaritimeCoAndAmbroseMaritimeCoLoanAgreementMember" xlink:to="cmre_AinsleyMaritimeCoAndAmbroseMaritimeCoLoanAgreementMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_FairValueMeasurementsFairValueHierarchyDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair Value Hierarchy and NAV [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:to="us-gaap_FairValueMeasurementsFairValueHierarchyDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_TritonMember" xlink:label="cmre_TritonMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_TritonMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Triton [Member]</link:label>
    <link:label xlink:label="cmre_TritonMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Triton.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_TritonMember" xlink:to="cmre_TritonMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MajorCustomersAxis" xlink:label="srt_MajorCustomersAxis" xlink:type="locator"/>
    <link:label xlink:label="srt_MajorCustomersAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Customer [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="srt_MajorCustomersAxis" xlink:to="srt_MajorCustomersAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_SealandWashingtonAndMaerskKalamataMember" xlink:label="cmre_SealandWashingtonAndMaerskKalamataMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_SealandWashingtonAndMaerskKalamataMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Sealand Washington and Maersk Kalamata [Member]</link:label>
    <link:label xlink:label="cmre_SealandWashingtonAndMaerskKalamataMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Sealand Washington and Maersk Kalamata.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_SealandWashingtonAndMaerskKalamataMember" xlink:to="cmre_SealandWashingtonAndMaerskKalamataMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_NameOfMajorCustomerDomain" xlink:label="srt_NameOfMajorCustomerDomain" xlink:type="locator"/>
    <link:label xlink:label="srt_NameOfMajorCustomerDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Customer [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="srt_NameOfMajorCustomerDomain" xlink:to="srt_NameOfMajorCustomerDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="us-gaap_FairValueInputsLevel1Member" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_FairValueInputsLevel1Member-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair Value, Inputs, Level 1 [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FairValueInputsLevel1Member" xlink:to="us-gaap_FairValueInputsLevel1Member-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ThunderAndMessiniMember" xlink:label="cmre_ThunderAndMessiniMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_ThunderAndMessiniMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Thunder and Messini [Member]</link:label>
    <link:label xlink:label="cmre_ThunderAndMessiniMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Thunder and Messini.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ThunderAndMessiniMember" xlink:to="cmre_ThunderAndMessiniMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_HydeMaritimeCoAndSkerrettMaritimeCoLoanAgreementMember" xlink:label="cmre_HydeMaritimeCoAndSkerrettMaritimeCoLoanAgreementMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_HydeMaritimeCoAndSkerrettMaritimeCoLoanAgreementMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Hyde Maritime Co. and Skerrett Maritime Co. Loan Agreement [Member]</link:label>
    <link:label xlink:label="cmre_HydeMaritimeCoAndSkerrettMaritimeCoLoanAgreementMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the Hyde Maritime Co. and Skerrett Maritime Co. loan agreement.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_HydeMaritimeCoAndSkerrettMaritimeCoLoanAgreementMember" xlink:to="cmre_HydeMaritimeCoAndSkerrettMaritimeCoLoanAgreementMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="us-gaap_FairValueInputsLevel2Member" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_FairValueInputsLevel2Member-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair Value, Inputs, Level 2 [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FairValueInputsLevel2Member" xlink:to="us-gaap_FairValueInputsLevel2Member-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ReddickShippingCoAndVerandiShippingCoSecondTermLoanMember" xlink:label="cmre_ReddickShippingCoAndVerandiShippingCoSecondTermLoanMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_ReddickShippingCoAndVerandiShippingCoSecondTermLoanMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Reddick Shipping Co. and Verandi Shipping Co Second Term Loan [Member]</link:label>
    <link:label xlink:label="cmre_ReddickShippingCoAndVerandiShippingCoSecondTermLoanMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the second term loan for Reddick Shipping Co. and Verandi Shipping Co.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ReddickShippingCoAndVerandiShippingCoSecondTermLoanMember" xlink:to="cmre_ReddickShippingCoAndVerandiShippingCoSecondTermLoanMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipmentPeriodIncreaseDecrease" xlink:label="us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipmentPeriodIncreaseDecrease" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipmentPeriodIncreaseDecrease-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Vessel sales, transfers and other movements</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipmentPeriodIncreaseDecrease" xlink:to="us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipmentPeriodIncreaseDecrease-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NetSettlementsOnInterestRateSwapsQualifyingForCashFlowHedge" xlink:label="cmre_NetSettlementsOnInterestRateSwapsQualifyingForCashFlowHedge" xlink:type="locator"/>
    <link:label xlink:label="cmre_NetSettlementsOnInterestRateSwapsQualifyingForCashFlowHedge-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Effective portion of changes in fair value of cash flow hedges (Notes 19 and 21)</link:label>
    <link:label xlink:label="cmre_NetSettlementsOnInterestRateSwapsQualifyingForCashFlowHedge-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The amount of net settlements on interest rate swaps qualifying for cash flow hedge.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NetSettlementsOnInterestRateSwapsQualifyingForCashFlowHedge" xlink:to="cmre_NetSettlementsOnInterestRateSwapsQualifyingForCashFlowHedge-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_OracleLibraAndNormaMember" xlink:label="cmre_OracleLibraAndNormaMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_OracleLibraAndNormaMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Oracle, Libra and Norma [Member]</link:label>
    <link:label xlink:label="cmre_OracleLibraAndNormaMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Oracle, Libra and Norma.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_OracleLibraAndNormaMember" xlink:to="cmre_OracleLibraAndNormaMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_MscAthensAndMscAthosMember" xlink:label="cmre_MscAthensAndMscAthosMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_MscAthensAndMscAthosMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">MSC Athens and MSC Athos [Member]</link:label>
    <link:label xlink:label="cmre_MscAthensAndMscAthosMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">MSC Athens and MSC Athos.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_MscAthensAndMscAthosMember" xlink:to="cmre_MscAthensAndMscAthosMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_EvantoneShippingCoAndFortroseShippingCoLoanAgreementMember" xlink:label="cmre_EvantoneShippingCoAndFortroseShippingCoLoanAgreementMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_EvantoneShippingCoAndFortroseShippingCoLoanAgreementMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Evantone Shipping Co. and Fortrose Shipping Co. Loan Agreement [Member]</link:label>
    <link:label xlink:label="cmre_EvantoneShippingCoAndFortroseShippingCoLoanAgreementMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the Evantone Shipping Co. and Fortrose Shipping Co. loan agreement.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_EvantoneShippingCoAndFortroseShippingCoLoanAgreementMember" xlink:to="cmre_EvantoneShippingCoAndFortroseShippingCoLoanAgreementMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_BankChargesAndOtherFinancingCosts" xlink:label="cmre_BankChargesAndOtherFinancingCosts" xlink:type="locator"/>
    <link:label xlink:label="cmre_BankChargesAndOtherFinancingCosts-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Bank charges and other financing costs</link:label>
    <link:label xlink:label="cmre_BankChargesAndOtherFinancingCosts-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The amount of bank charges and other financing costs.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_BankChargesAndOtherFinancingCosts" xlink:to="cmre_BankChargesAndOtherFinancingCosts-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_FairValueByFairValueHierarchyLevelAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair Value Hierarchy and NAV [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:to="us-gaap_FairValueByFairValueHierarchyLevelAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromDividendsReceived" xlink:label="us-gaap_ProceedsFromDividendsReceived" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ProceedsFromDividendsReceived-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_ProceedsFromDividendsReceived</link:label>
    <link:label xlink:label="us-gaap_ProceedsFromDividendsReceived-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Proceeds from Dividends Received</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ProceedsFromDividendsReceived" xlink:to="us-gaap_ProceedsFromDividendsReceived-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_LoanAgreementWith11CompaniesMember" xlink:label="cmre_LoanAgreementWith11CompaniesMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_LoanAgreementWith11CompaniesMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Loan Agreement with 11 Companies [Member]</link:label>
    <link:label xlink:label="cmre_LoanAgreementWith11CompaniesMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the loan agreement with Achilleas Maritime Corporation, Angistri Corporation, Fanakos Maritime Corporation, Fastsailing Maritime Co., Lindner Shipping Co., Miko Shipping Co., Saval Shipping Co., Spedding Shipping Co., Tanera Shipping Co., Timpson Shipping Co. and Wester Shipping Co.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_LoanAgreementWith11CompaniesMember" xlink:to="cmre_LoanAgreementWith11CompaniesMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_LoanAgreementWith11CompaniesTrancheAMember" xlink:label="cmre_LoanAgreementWith11CompaniesTrancheAMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_LoanAgreementWith11CompaniesTrancheAMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Loan Agreement with 11 Companies, Tranche A [Member]</link:label>
    <link:label xlink:label="cmre_LoanAgreementWith11CompaniesTrancheAMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents tranche A of the loan agreement with Achilleas Maritime Corporation, Angistri Corporation, Fanakos Maritime Corporation, Fastsailing Maritime Co., Lindner Shipping Co., Miko Shipping Co., Saval Shipping Co., Spedding Shipping Co., Tanera Shipping Co., Timpson Shipping Co. and Wester Shipping Co.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_LoanAgreementWith11CompaniesTrancheAMember" xlink:to="cmre_LoanAgreementWith11CompaniesTrancheAMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentGrossPeriodIncreaseDecrease" xlink:label="us-gaap_PropertyPlantAndEquipmentGrossPeriodIncreaseDecrease" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_PropertyPlantAndEquipmentGrossPeriodIncreaseDecrease-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_PropertyPlantAndEquipmentGrossPeriodIncreaseDecrease</link:label>
    <link:label xlink:label="us-gaap_PropertyPlantAndEquipmentGrossPeriodIncreaseDecrease-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Vessel sales, transfers and other movements</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PropertyPlantAndEquipmentGrossPeriodIncreaseDecrease" xlink:to="us-gaap_PropertyPlantAndEquipmentGrossPeriodIncreaseDecrease-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisMember" xlink:label="cmre_LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Loan Agreement to Partially Finance the Acquisition of Megalopolis and Marathopolis [Member]</link:label>
    <link:label xlink:label="cmre_LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Refers to information regarding the loan agreement partially finance the Megalopolis and Marathopolis acquisition.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisMember" xlink:to="cmre_LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_LoanAgreementWith11CompaniesTrancheCMember" xlink:label="cmre_LoanAgreementWith11CompaniesTrancheCMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_LoanAgreementWith11CompaniesTrancheCMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Loan Agreement with 11 Companies, Tranche C [Member]</link:label>
    <link:label xlink:label="cmre_LoanAgreementWith11CompaniesTrancheCMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents tranche C of the loan agreement with Achilleas Maritime Corporation, Angistri Corporation, Fanakos Maritime Corporation, Fastsailing Maritime Co., Lindner Shipping Co., Miko Shipping Co., Saval Shipping Co., Spedding Shipping Co., Tanera Shipping Co., Timpson Shipping Co. and Wester Shipping Co.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_LoanAgreementWith11CompaniesTrancheCMember" xlink:to="cmre_LoanAgreementWith11CompaniesTrancheCMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ReconciliationOfRevenueFromSegmentsToConsolidatedTextBlock" xlink:label="us-gaap_ReconciliationOfRevenueFromSegmentsToConsolidatedTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ReconciliationOfRevenueFromSegmentsToConsolidatedTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Reconciliation of Revenue from Segments to Consolidated [Table Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ReconciliationOfRevenueFromSegmentsToConsolidatedTextBlock" xlink:to="us-gaap_ReconciliationOfRevenueFromSegmentsToConsolidatedTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_LoanAgreementWith11CompaniesTrancheBMember" xlink:label="cmre_LoanAgreementWith11CompaniesTrancheBMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_LoanAgreementWith11CompaniesTrancheBMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Loan Agreement with 11 Companies, Tranche B [Member]</link:label>
    <link:label xlink:label="cmre_LoanAgreementWith11CompaniesTrancheBMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents tranche B of the loan agreement with Achilleas Maritime Corporation, Angistri Corporation, Fanakos Maritime Corporation, Fastsailing Maritime Co., Lindner Shipping Co., Miko Shipping Co., Saval Shipping Co., Spedding Shipping Co., Tanera Shipping Co., Timpson Shipping Co. and Wester Shipping Co.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_LoanAgreementWith11CompaniesTrancheBMember" xlink:to="cmre_LoanAgreementWith11CompaniesTrancheBMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_HydeMaritimeCoAndSkerrettMaritimeCoLoanAgreementTrancheAMember" xlink:label="cmre_HydeMaritimeCoAndSkerrettMaritimeCoLoanAgreementTrancheAMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_HydeMaritimeCoAndSkerrettMaritimeCoLoanAgreementTrancheAMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Hyde Maritime Co. and Skerrett Maritime Co. Loan Agreement, Tranche A [Member]</link:label>
    <link:label xlink:label="cmre_HydeMaritimeCoAndSkerrettMaritimeCoLoanAgreementTrancheAMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents tranche A of the Hyde Maritime Co. and Skerrett Maritime Co. loan agreement.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_HydeMaritimeCoAndSkerrettMaritimeCoLoanAgreementTrancheAMember" xlink:to="cmre_HydeMaritimeCoAndSkerrettMaritimeCoLoanAgreementTrancheAMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_HydeMaritimeCoAndSkerrettMaritimeCoLoanAgreementTrancheBMember" xlink:label="cmre_HydeMaritimeCoAndSkerrettMaritimeCoLoanAgreementTrancheBMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_HydeMaritimeCoAndSkerrettMaritimeCoLoanAgreementTrancheBMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Hyde Maritime Co. and Skerrett Maritime Co. Loan Agreement, Tranche B [Member]</link:label>
    <link:label xlink:label="cmre_HydeMaritimeCoAndSkerrettMaritimeCoLoanAgreementTrancheBMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents tranche B of the Hyde Maritime Co. and Skerrett Maritime Co. loan agreement.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_HydeMaritimeCoAndSkerrettMaritimeCoLoanAgreementTrancheBMember" xlink:to="cmre_HydeMaritimeCoAndSkerrettMaritimeCoLoanAgreementTrancheBMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_KempMaritimeCoLoanAgreementMember" xlink:label="cmre_KempMaritimeCoLoanAgreementMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_KempMaritimeCoLoanAgreementMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Kemp Maritime Co. Loan Agreement [Member]</link:label>
    <link:label xlink:label="cmre_KempMaritimeCoLoanAgreementMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the Kemp Maritime Co. loan agreement.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_KempMaritimeCoLoanAgreementMember" xlink:to="cmre_KempMaritimeCoLoanAgreementMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentAdditions" xlink:label="us-gaap_PropertyPlantAndEquipmentAdditions" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_PropertyPlantAndEquipmentAdditions-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Vessel acquisitions, advances and other vessels&#8217; costs</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PropertyPlantAndEquipmentAdditions" xlink:to="us-gaap_PropertyPlantAndEquipmentAdditions-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_VernesShippingCoLoanAgreementMember" xlink:label="cmre_VernesShippingCoLoanAgreementMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_VernesShippingCoLoanAgreementMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Vernes Shipping Co. Loan Agreement [Member]</link:label>
    <link:label xlink:label="cmre_VernesShippingCoLoanAgreementMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the Vernes Shipping Co. loan agreement.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_VernesShippingCoLoanAgreementMember" xlink:to="cmre_VernesShippingCoLoanAgreementMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_TheBondMember" xlink:label="cmre_TheBondMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_TheBondMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">The Bond [Member]</link:label>
    <link:label xlink:label="cmre_TheBondMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the Bond.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_TheBondMember" xlink:to="cmre_TheBondMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFiveAndThereafter" xlink:label="cmre_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFiveAndThereafter" xlink:type="locator"/>
    <link:label xlink:label="cmre_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFiveAndThereafter-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFiveAndThereafter</link:label>
    <link:label xlink:label="cmre_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFiveAndThereafter-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">2027 and thereafter</link:label>
    <link:label xlink:label="cmre_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFiveAndThereafter-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount of long-term debt payable, sinking fund requirement, and other securities issued that are redeemable by holder at fixed or determinable price and date, maturing in fifth fiscal year following current fiscal year and thereafter. Excludes interim and annual periods when interim periods are reported from current statement of financial position date (rolling approach).</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFiveAndThereafter" xlink:to="cmre_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFiveAndThereafter-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_CompanyOwningCapeArtemisioMember" xlink:label="cmre_CompanyOwningCapeArtemisioMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_CompanyOwningCapeArtemisioMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Company Owning Cape Artemisio [Member]</link:label>
    <link:label xlink:label="cmre_CompanyOwningCapeArtemisioMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the company owning Cape Artemisio.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_CompanyOwningCapeArtemisioMember" xlink:to="cmre_CompanyOwningCapeArtemisioMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInDeferredRevenue" xlink:label="us-gaap_IncreaseDecreaseInDeferredRevenue" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_IncreaseDecreaseInDeferredRevenue-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_IncreaseDecreaseInDeferredRevenue</link:label>
    <link:label xlink:label="us-gaap_IncreaseDecreaseInDeferredRevenue-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Unearned revenue</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_IncreaseDecreaseInDeferredRevenue" xlink:to="us-gaap_IncreaseDecreaseInDeferredRevenue-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementMember" xlink:label="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Novara Shipping Co., Finney Shipping Co., Alford Shipping Co. and Nisbet Shipping Co. Loan Agreement [Member]</link:label>
    <link:label xlink:label="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the Novara Shipping Co., Finney Shipping Co., Alford Shipping Co. and Nisbet Shipping Co. loan agreement.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementMember" xlink:to="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DueFromRelatedPartiesCurrent" xlink:label="us-gaap_DueFromRelatedPartiesCurrent" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DueFromRelatedPartiesCurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Due from related parties (Note 3)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DueFromRelatedPartiesCurrent" xlink:to="us-gaap_DueFromRelatedPartiesCurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheAMember" xlink:label="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheAMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheAMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Novara Shipping Co., Finney Shipping Co., Alford Shipping Co. and Nisbet Shipping Co. Loan Agreement, Tranche A [Member]</link:label>
    <link:label xlink:label="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheAMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents tranche A of the Novara Shipping Co., Finney Shipping Co., Alford Shipping Co. and Nisbet Shipping Co. loan agreement.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheAMember" xlink:to="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheAMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Cash Flows From Operating Activities:</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:to="us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_RefinanceTermLoansOf17CompaniesMember" xlink:label="cmre_RefinanceTermLoansOf17CompaniesMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_RefinanceTermLoansOf17CompaniesMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Refinance Term Loans of 17 Companies [Member]</link:label>
    <link:label xlink:label="cmre_RefinanceTermLoansOf17CompaniesMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the refinance term loan of 17 companies.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_RefinanceTermLoansOf17CompaniesMember" xlink:to="cmre_RefinanceTermLoansOf17CompaniesMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_FirstQuarterOf2021Member" xlink:label="cmre_FirstQuarterOf2021Member" xlink:type="locator"/>
    <link:label xlink:label="cmre_FirstQuarterOf2021Member-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">First Quarter of 2021 [Member]</link:label>
    <link:label xlink:label="cmre_FirstQuarterOf2021Member-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the first quarter of 2021.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_FirstQuarterOf2021Member" xlink:to="cmre_FirstQuarterOf2021Member-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ReclassifiedToVesselsAndAdvancesNet" xlink:label="cmre_ReclassifiedToVesselsAndAdvancesNet" xlink:type="locator"/>
    <link:label xlink:label="cmre_ReclassifiedToVesselsAndAdvancesNet-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_ReclassifiedToVesselsAndAdvancesNet</link:label>
    <link:label xlink:label="cmre_ReclassifiedToVesselsAndAdvancesNet-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Reclassified to Vessels and Advances, Net</link:label>
    <link:label xlink:label="cmre_ReclassifiedToVesselsAndAdvancesNet-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount reclassified to vessels and advances, net.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ReclassifiedToVesselsAndAdvancesNet" xlink:to="cmre_ReclassifiedToVesselsAndAdvancesNet-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_January152021ToApril142021DividendsMember" xlink:label="cmre_January152021ToApril142021DividendsMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_January152021ToApril142021DividendsMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">January 15, 2021 to April 14, 2021 Dividends [Member]</link:label>
    <link:label xlink:label="cmre_January152021ToApril142021DividendsMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to dividends.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_January152021ToApril142021DividendsMember" xlink:to="cmre_January152021ToApril142021DividendsMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_FourthQuarterOf2021Member" xlink:label="cmre_FourthQuarterOf2021Member" xlink:type="locator"/>
    <link:label xlink:label="cmre_FourthQuarterOf2021Member-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fourth Quarter of 2021 [Member]</link:label>
    <link:label xlink:label="cmre_FourthQuarterOf2021Member-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the fourth quarter of 2021.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_FourthQuarterOf2021Member" xlink:to="cmre_FourthQuarterOf2021Member-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_October152020ToJanuary142021DividendsMember" xlink:label="cmre_October152020ToJanuary142021DividendsMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_October152020ToJanuary142021DividendsMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">October 15, 2020 to January 14, 2021 Dividends [Member]</link:label>
    <link:label xlink:label="cmre_October152020ToJanuary142021DividendsMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to dividends.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_October152020ToJanuary142021DividendsMember" xlink:to="cmre_October152020ToJanuary142021DividendsMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_FirstQuarterOf2022Member" xlink:label="cmre_FirstQuarterOf2022Member" xlink:type="locator"/>
    <link:label xlink:label="cmre_FirstQuarterOf2022Member-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">First Quarter of 2022 [Member]</link:label>
    <link:label xlink:label="cmre_FirstQuarterOf2022Member-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the first quarter of 2022.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_FirstQuarterOf2022Member" xlink:to="cmre_FirstQuarterOf2022Member-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="us-gaap_StatementLineItems" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_StatementLineItems-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Statement [Line Items]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StatementLineItems" xlink:to="us-gaap_StatementLineItems-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_SealandIllinoisMember" xlink:label="cmre_SealandIllinoisMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_SealandIllinoisMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Sealand Illinois [Member]</link:label>
    <link:label xlink:label="cmre_SealandIllinoisMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents Sealand Illinois.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_SealandIllinoisMember" xlink:to="cmre_SealandIllinoisMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_RefinanceTermLoanToVulpeculaVolansVirgoAndVelaAndTrancheCOf11CompaniesTermLoanMember" xlink:label="cmre_RefinanceTermLoanToVulpeculaVolansVirgoAndVelaAndTrancheCOf11CompaniesTermLoanMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_RefinanceTermLoanToVulpeculaVolansVirgoAndVelaAndTrancheCOf11CompaniesTermLoanMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Refinance Term Loan to Vulpecula, Volans, Virgo and Vela and Tranche C of 11 Companies Term Loan [Member]</link:label>
    <link:label xlink:label="cmre_RefinanceTermLoanToVulpeculaVolansVirgoAndVelaAndTrancheCOf11CompaniesTermLoanMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the refinance term loan for Vulpecula, Volans, Virgo and Vela and term loan of 11 companies tranche C.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_RefinanceTermLoanToVulpeculaVolansVirgoAndVelaAndTrancheCOf11CompaniesTermLoanMember" xlink:to="cmre_RefinanceTermLoanToVulpeculaVolansVirgoAndVelaAndTrancheCOf11CompaniesTermLoanMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ConstructionContractorReceivableExcludingContractRetainageYearFiveAndAfter" xlink:label="cmre_ConstructionContractorReceivableExcludingContractRetainageYearFiveAndAfter" xlink:type="locator"/>
    <link:label xlink:label="cmre_ConstructionContractorReceivableExcludingContractRetainageYearFiveAndAfter-label" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">2027 and thereafter</link:label>
    <link:label xlink:label="cmre_ConstructionContractorReceivableExcludingContractRetainageYearFiveAndAfter-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_ConstructionContractorReceivableExcludingContractRetainageYearFiveAndAfter</link:label>
    <link:label xlink:label="cmre_ConstructionContractorReceivableExcludingContractRetainageYearFiveAndAfter-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount of right to consideration in exchange for good or service transferred to customer under long-term contract or program when right to consideration is unconditional, excluding amount withheld under retainage provision in contract, to be collected in fifth fiscal year following current fiscal year and thereafter. Excludes interim and annual periods when interim periods are reported from current statement of financial position date (rolling approach).</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ConstructionContractorReceivableExcludingContractRetainageYearFiveAndAfter" xlink:to="cmre_ConstructionContractorReceivableExcludingContractRetainageYearFiveAndAfter-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_HuntingLicenseLoanAgreementWith15CompaniesMember" xlink:label="cmre_HuntingLicenseLoanAgreementWith15CompaniesMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_HuntingLicenseLoanAgreementWith15CompaniesMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Hunting License Loan Agreement with 15 Companies [Member]</link:label>
    <link:label xlink:label="cmre_HuntingLicenseLoanAgreementWith15CompaniesMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the hunting license loan agreement with 15 companies.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_HuntingLicenseLoanAgreementWith15CompaniesMember" xlink:to="cmre_HuntingLicenseLoanAgreementWith15CompaniesMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="us-gaap_AccountsReceivableNetCurrent" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_AccountsReceivableNetCurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accounts receivable, net (Note 3)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AccountsReceivableNetCurrent" xlink:to="us-gaap_AccountsReceivableNetCurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NumberOfReportableSegments" xlink:label="us-gaap_NumberOfReportableSegments" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_NumberOfReportableSegments-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_NumberOfReportableSegments</link:label>
    <link:label xlink:label="us-gaap_NumberOfReportableSegments-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Number of Reportable Segments</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_NumberOfReportableSegments" xlink:to="us-gaap_NumberOfReportableSegments-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_RefinanceTermLoanForMeridaBermondiTitanIAndUruguayMember" xlink:label="cmre_RefinanceTermLoanForMeridaBermondiTitanIAndUruguayMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_RefinanceTermLoanForMeridaBermondiTitanIAndUruguayMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Refinance Term Loan for Merida, Bermondi, Titan I and Uruguay [Member]</link:label>
    <link:label xlink:label="cmre_RefinanceTermLoanForMeridaBermondiTitanIAndUruguayMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the refinance term loan for Merida, Bermondi, Titan I and Uruguay.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_RefinanceTermLoanForMeridaBermondiTitanIAndUruguayMember" xlink:to="cmre_RefinanceTermLoanForMeridaBermondiTitanIAndUruguayMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_FourthQuarterOf2020Member" xlink:label="cmre_FourthQuarterOf2020Member" xlink:type="locator"/>
    <link:label xlink:label="cmre_FourthQuarterOf2020Member-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fourth Quarter of 2020 [Member]</link:label>
    <link:label xlink:label="cmre_FourthQuarterOf2020Member-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the fourth quarter of 2020.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_FourthQuarterOf2020Member" xlink:to="cmre_FourthQuarterOf2020Member-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_InterestRateCapThreeMonthLIBORExceeds150PercentMember" xlink:label="cmre_InterestRateCapThreeMonthLIBORExceeds150PercentMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_InterestRateCapThreeMonthLIBORExceeds150PercentMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Interest Rate Cap, Three Month LIBOR Exceeds 1.50 Percent [Member]</link:label>
    <link:label xlink:label="cmre_InterestRateCapThreeMonthLIBORExceeds150PercentMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Contract in which the cap writer, in return for a premium, agrees to limit, or cap, the cap holder's risk associated with an increase in interest rates. If rates go above three month LIBOR of 1.50% (the strike price or the cap rate), the cap holder is entitled to receive cash payments equal to the excess of the market rate over the strike price multiplied by the notional principal amount.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_InterestRateCapThreeMonthLIBORExceeds150PercentMember" xlink:to="cmre_InterestRateCapThreeMonthLIBORExceeds150PercentMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="us-gaap_AdditionalPaidInCapital" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_AdditionalPaidInCapital-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Additional paid-in capital (Note 15)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AdditionalPaidInCapital" xlink:to="us-gaap_AdditionalPaidInCapital-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_CrossCurrencyInterestRateContractEffective2552021Member" xlink:label="cmre_CrossCurrencyInterestRateContractEffective2552021Member" xlink:type="locator"/>
    <link:label xlink:label="cmre_CrossCurrencyInterestRateContractEffective2552021Member-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Cross Currency Interest Rate Contract, Effective 25/5/2021 [Member]</link:label>
    <link:label xlink:label="cmre_CrossCurrencyInterestRateContractEffective2552021Member-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Derivative instrument whose primary underlying risk is tied to interest rates and foreign exchange rates.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_CrossCurrencyInterestRateContractEffective2552021Member" xlink:to="cmre_CrossCurrencyInterestRateContractEffective2552021Member-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_October152021ToJanuary142022DividendsMember" xlink:label="cmre_October152021ToJanuary142022DividendsMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_October152021ToJanuary142022DividendsMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">October 15, 2021 to January 14, 2022 Dividends [Member]</link:label>
    <link:label xlink:label="cmre_October152021ToJanuary142022DividendsMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to dividends.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_October152021ToJanuary142022DividendsMember" xlink:to="cmre_October152021ToJanuary142022DividendsMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenuesAbstract" xlink:label="us-gaap_RevenuesAbstract" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_RevenuesAbstract-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">REVENUES:</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RevenuesAbstract" xlink:to="us-gaap_RevenuesAbstract-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_January152022ToApril142022DividendsMember" xlink:label="cmre_January152022ToApril142022DividendsMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_January152022ToApril142022DividendsMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">January 15, 2022 to April 14, 2022 Dividends [Member]</link:label>
    <link:label xlink:label="cmre_January152022ToApril142022DividendsMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to dividends.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_January152022ToApril142022DividendsMember" xlink:to="cmre_January152022ToApril142022DividendsMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_DerivativeCrossCurrencyInterestRateContractEuroMember" xlink:label="cmre_DerivativeCrossCurrencyInterestRateContractEuroMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_DerivativeCrossCurrencyInterestRateContractEuroMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivative Cross Currency Interest Rate Contract, Euro, Effective 25/5/2021 [Member]</link:label>
    <link:label xlink:label="cmre_DerivativeCrossCurrencyInterestRateContractEuroMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Derivative instrument whose primary underlying risk is tied to interest rates and foreign exchange rates.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_DerivativeCrossCurrencyInterestRateContractEuroMember" xlink:to="cmre_DerivativeCrossCurrencyInterestRateContractEuroMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_CrossCurrencyInterestRateContractEuroEffective2152021Member" xlink:label="cmre_CrossCurrencyInterestRateContractEuroEffective2152021Member" xlink:type="locator"/>
    <link:label xlink:label="cmre_CrossCurrencyInterestRateContractEuroEffective2152021Member-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Cross Currency Interest Rate Contract, Euro, Effective 21/5/2021 [Member]</link:label>
    <link:label xlink:label="cmre_CrossCurrencyInterestRateContractEuroEffective2152021Member-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Derivative instrument whose primary underlying risk is tied to interest rates and foreign exchange rates.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_CrossCurrencyInterestRateContractEuroEffective2152021Member" xlink:to="cmre_CrossCurrencyInterestRateContractEuroEffective2152021Member-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_InterestRateCapThreeMonthLIBORExceeds3percentMember" xlink:label="cmre_InterestRateCapThreeMonthLIBORExceeds3percentMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_InterestRateCapThreeMonthLIBORExceeds3percentMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Interest Rate Cap, Three Month LIBOR Exceeds 3%Percent [Member]</link:label>
    <link:label xlink:label="cmre_InterestRateCapThreeMonthLIBORExceeds3percentMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Contract in which the cap writer, in return for a premium, agrees to limit, or cap, the cap holder's risk associated with an increase in interest rates. If rates go above a a three-month LIBOR of 3.00% (the strike price or the cap rate), the cap holder is entitled to receive cash payments equal to the excess of the market rate over the strike price multiplied by the notional principal amount.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_InterestRateCapThreeMonthLIBORExceeds3percentMember" xlink:to="cmre_InterestRateCapThreeMonthLIBORExceeds3percentMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShortTermInvestments" xlink:label="us-gaap_ShortTermInvestments" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ShortTermInvestments-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Short-term investments (Note 5)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ShortTermInvestments" xlink:to="us-gaap_ShortTermInvestments-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:label="us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_AccumulatedOtherComprehensiveIncomeMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">AOCI Attributable to Parent [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:to="us-gaap_AccumulatedOtherComprehensiveIncomeMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_CrossCurrencyInterestRateContractEffective2152021Member" xlink:label="cmre_CrossCurrencyInterestRateContractEffective2152021Member" xlink:type="locator"/>
    <link:label xlink:label="cmre_CrossCurrencyInterestRateContractEffective2152021Member-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Cross Currency Interest Rate Contract, Effective 21/5/2021 [Member]</link:label>
    <link:label xlink:label="cmre_CrossCurrencyInterestRateContractEffective2152021Member-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Derivative instrument whose primary underlying risk is tied to interest rates and foreign exchange rates.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_CrossCurrencyInterestRateContractEffective2152021Member" xlink:to="cmre_CrossCurrencyInterestRateContractEffective2152021Member-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityAbstract" xlink:label="us-gaap_StockholdersEquityAbstract" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_StockholdersEquityAbstract-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">STOCKHOLDERS&#8217; EQUITY:</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StockholdersEquityAbstract" xlink:to="us-gaap_StockholdersEquityAbstract-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestAndDebtExpense" xlink:label="us-gaap_InterestAndDebtExpense" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_InterestAndDebtExpense-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_InterestAndDebtExpense</link:label>
    <link:label xlink:label="us-gaap_InterestAndDebtExpense-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Interest and finance costs (Note 17)</link:label>
    <link:label xlink:label="us-gaap_InterestAndDebtExpense-label" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total</link:label>
    <link:label xlink:label="us-gaap_InterestAndDebtExpense-label" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Interest and finance costs</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InterestAndDebtExpense" xlink:to="us-gaap_InterestAndDebtExpense-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_PropertyPlantAndEquipmentByTypeAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Long-Lived Tangible Asset [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:to="us-gaap_PropertyPlantAndEquipmentByTypeAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="us-gaap_NonoperatingIncomeExpense" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_NonoperatingIncomeExpense-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_NonoperatingIncomeExpense</link:label>
    <link:label xlink:label="us-gaap_NonoperatingIncomeExpense-label" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total other income / (expenses), net</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_NonoperatingIncomeExpense" xlink:to="us-gaap_NonoperatingIncomeExpense-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentReportingDisclosureTextBlock" xlink:label="us-gaap_SegmentReportingDisclosureTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_SegmentReportingDisclosureTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Segment Reporting Disclosure [Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_SegmentReportingDisclosureTextBlock" xlink:to="us-gaap_SegmentReportingDisclosureTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_PropertyPlantAndEquipmentTypeDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Long-Lived Tangible Asset [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:to="us-gaap_PropertyPlantAndEquipmentTypeDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNonoperatingIncome" xlink:label="us-gaap_OtherNonoperatingIncome" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_OtherNonoperatingIncome-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Other, net</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherNonoperatingIncome" xlink:to="us-gaap_OtherNonoperatingIncome-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents</link:label>
    <link:label xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents-label" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total cash, cash equivalents and restricted cash</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:to="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations" xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations</link:label>
    <link:label xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations-label" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US">Cash, cash equivalents and restricted cash at beginning of the period</link:label>
    <link:label xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations-label" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US">Cash, cash equivalents and restricted cash at end of the period</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations" xlink:to="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleLeasebackTransactionHistoricalCost" xlink:label="us-gaap_SaleLeasebackTransactionHistoricalCost" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_SaleLeasebackTransactionHistoricalCost-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_SaleLeasebackTransactionHistoricalCost</link:label>
    <link:label xlink:label="us-gaap_SaleLeasebackTransactionHistoricalCost-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Sale Leaseback Transaction, Historical Cost</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_SaleLeasebackTransactionHistoricalCost" xlink:to="us-gaap_SaleLeasebackTransactionHistoricalCost-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleLeasebackTransactionAccumulatedDepreciation" xlink:label="us-gaap_SaleLeasebackTransactionAccumulatedDepreciation" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_SaleLeasebackTransactionAccumulatedDepreciation-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_SaleLeasebackTransactionAccumulatedDepreciation</link:label>
    <link:label xlink:label="us-gaap_SaleLeasebackTransactionAccumulatedDepreciation-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Sale Leaseback Transaction, Accumulated Depreciation</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_SaleLeasebackTransactionAccumulatedDepreciation" xlink:to="us-gaap_SaleLeasebackTransactionAccumulatedDepreciation-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentIncomeInterest" xlink:label="us-gaap_InvestmentIncomeInterest" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_InvestmentIncomeInterest-label" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Interest income</link:label>
    <link:label xlink:label="us-gaap_InvestmentIncomeInterest-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Interest income</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InvestmentIncomeInterest" xlink:to="us-gaap_InvestmentIncomeInterest-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleLeasebackTransactionNetBookValue" xlink:label="us-gaap_SaleLeasebackTransactionNetBookValue" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_SaleLeasebackTransactionNetBookValue-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_SaleLeasebackTransactionNetBookValue</link:label>
    <link:label xlink:label="us-gaap_SaleLeasebackTransactionNetBookValue-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Sale Leaseback Transaction, Net Book Value, Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_SaleLeasebackTransactionNetBookValue" xlink:to="us-gaap_SaleLeasebackTransactionNetBookValue-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect</link:label>
    <link:label xlink:label="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect-label" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Net increase in cash, cash equivalents and restricted cash</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:to="us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities" xlink:label="us-gaap_Liabilities" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_Liabilities-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_Liabilities</link:label>
    <link:label xlink:label="us-gaap_Liabilities-label" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total liabilities</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_Liabilities" xlink:to="us-gaap_Liabilities-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_NetCashProvidedByUsedInFinancingActivities-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_NetCashProvidedByUsedInFinancingActivities</link:label>
    <link:label xlink:label="us-gaap_NetCashProvidedByUsedInFinancingActivities-label" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Net Cash provided by Financing Activities</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:to="us-gaap_NetCashProvidedByUsedInFinancingActivities-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingencies" xlink:label="us-gaap_CommitmentsAndContingencies" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_CommitmentsAndContingencies-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">COMMITMENTS AND CONTINGENCIES (Note 14)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CommitmentsAndContingencies" xlink:to="us-gaap_CommitmentsAndContingencies-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss" xlink:label="us-gaap_OperatingIncomeLoss" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_OperatingIncomeLoss-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_OperatingIncomeLoss</link:label>
    <link:label xlink:label="us-gaap_OperatingIncomeLoss-label" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Operating income</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OperatingIncomeLoss" xlink:to="us-gaap_OperatingIncomeLoss-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_NetCashProvidedByUsedInOperatingActivities-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_NetCashProvidedByUsedInOperatingActivities</link:label>
    <link:label xlink:label="us-gaap_NetCashProvidedByUsedInOperatingActivities-label" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Net Cash provided by Operating Activities</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:to="us-gaap_NetCashProvidedByUsedInOperatingActivities-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_NetCashProvidedByUsedInInvestingActivities-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_NetCashProvidedByUsedInInvestingActivities</link:label>
    <link:label xlink:label="us-gaap_NetCashProvidedByUsedInInvestingActivities-label" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Net Cash used in Investing Activities</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:to="us-gaap_NetCashProvidedByUsedInInvestingActivities-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis" xlink:label="srt_CounterpartyNameAxis" xlink:type="locator"/>
    <link:label xlink:label="srt_CounterpartyNameAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Counterparty Name [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="srt_CounterpartyNameAxis" xlink:to="srt_CounterpartyNameAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain" xlink:label="srt_RepurchaseAgreementCounterpartyNameDomain" xlink:type="locator"/>
    <link:label xlink:label="srt_RepurchaseAgreementCounterpartyNameDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Counterparty Name [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="srt_RepurchaseAgreementCounterpartyNameDomain" xlink:to="srt_RepurchaseAgreementCounterpartyNameDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativesPolicyTextBlock" xlink:label="us-gaap_DerivativesPolicyTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DerivativesPolicyTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Derivatives, Policy [Policy Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DerivativesPolicyTextBlock" xlink:to="us-gaap_DerivativesPolicyTextBlock-label" xlink:type="arc"/>
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    <link:label xlink:label="srt_ConsolidationItemsDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Consolidation Items [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="srt_ConsolidationItemsDomain" xlink:to="srt_ConsolidationItemsDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ScheduleOfDerivativesInASC815CashFlowHedgingRelationshipsTableTextBlock" xlink:label="cmre_ScheduleOfDerivativesInASC815CashFlowHedgingRelationshipsTableTextBlock" xlink:type="locator"/>
    <link:label xlink:label="cmre_ScheduleOfDerivativesInASC815CashFlowHedgingRelationshipsTableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Derivatives In ASC 815 Cash Flow Hedging Relationships [Table Text Block]</link:label>
    <link:label xlink:label="cmre_ScheduleOfDerivativesInASC815CashFlowHedgingRelationshipsTableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Tabular disclosure of the effective portion of the gains and losses on derivative instruments designated (and non-derivative instruments) designated and qualifying in cash flow hedges and net investment hedges that was recognized in other comprehensive income (loss) as well as the ineffective portion recognized in the income statement during the current period.</link:label>
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    <link:loc xlink:href="cmre-20220630.xsd#cmre_QuarterlyFeeToRelatedParties" xlink:label="cmre_QuarterlyFeeToRelatedParties" xlink:type="locator"/>
    <link:label xlink:label="cmre_QuarterlyFeeToRelatedParties-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_QuarterlyFeeToRelatedParties</link:label>
    <link:label xlink:label="cmre_QuarterlyFeeToRelatedParties-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Quarterly Fee to Related Parties</link:label>
    <link:label xlink:label="cmre_QuarterlyFeeToRelatedParties-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Quarterly fee for services provided by Costamare Shipping and/ or Costamare Services as at period end.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_QuarterlyFeeToRelatedParties" xlink:to="cmre_QuarterlyFeeToRelatedParties-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DueToRelatedPartiesCurrentAndNoncurrent" xlink:label="us-gaap_DueToRelatedPartiesCurrentAndNoncurrent" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DueToRelatedPartiesCurrentAndNoncurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DueToRelatedPartiesCurrentAndNoncurrent</link:label>
    <link:label xlink:label="us-gaap_DueToRelatedPartiesCurrentAndNoncurrent-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Due to Related Parties, Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DueToRelatedPartiesCurrentAndNoncurrent" xlink:to="us-gaap_DueToRelatedPartiesCurrentAndNoncurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_InvestmentStatedInterestRatePayableQuarterly" xlink:label="cmre_InvestmentStatedInterestRatePayableQuarterly" xlink:type="locator"/>
    <link:label xlink:label="cmre_InvestmentStatedInterestRatePayableQuarterly-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_InvestmentStatedInterestRatePayableQuarterly</link:label>
    <link:label xlink:label="cmre_InvestmentStatedInterestRatePayableQuarterly-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Investment Stated Interest Rate, Payable Quarterly</link:label>
    <link:label xlink:label="cmre_InvestmentStatedInterestRatePayableQuarterly-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Portion of the stated investment interest rate that is payable quarterly.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_InvestmentStatedInterestRatePayableQuarterly" xlink:to="cmre_InvestmentStatedInterestRatePayableQuarterly-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleLeasebackTransactionNameDomain" xlink:label="us-gaap_SaleLeasebackTransactionNameDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_SaleLeasebackTransactionNameDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Sale Leaseback Transaction, Name [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_SaleLeasebackTransactionNameDomain" xlink:to="us-gaap_SaleLeasebackTransactionNameDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_InvestmentStatedInterestRate" xlink:label="cmre_InvestmentStatedInterestRate" xlink:type="locator"/>
    <link:label xlink:label="cmre_InvestmentStatedInterestRate-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_InvestmentStatedInterestRate</link:label>
    <link:label xlink:label="cmre_InvestmentStatedInterestRate-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Investment Stated Interest Rate</link:label>
    <link:label xlink:label="cmre_InvestmentStatedInterestRate-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The stated interest rate of an investment.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_InvestmentStatedInterestRate" xlink:to="cmre_InvestmentStatedInterestRate-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ScheduleOfDerivativesNotDesignatedAsHedgingInstrumentsUnderASC815TableTextBlock" xlink:label="cmre_ScheduleOfDerivativesNotDesignatedAsHedgingInstrumentsUnderASC815TableTextBlock" xlink:type="locator"/>
    <link:label xlink:label="cmre_ScheduleOfDerivativesNotDesignatedAsHedgingInstrumentsUnderASC815TableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Derivatives Not Designated as Hedging Instruments under ASC 815 [Table Text Block]</link:label>
    <link:label xlink:label="cmre_ScheduleOfDerivativesNotDesignatedAsHedgingInstrumentsUnderASC815TableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Tabular disclosure of the gain and losses on derivative instruments not designated as hedging instruments that was recognized in the income statement during the current period.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ScheduleOfDerivativesNotDesignatedAsHedgingInstrumentsUnderASC815TableTextBlock" xlink:to="cmre_ScheduleOfDerivativesNotDesignatedAsHedgingInstrumentsUnderASC815TableTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidationItemsAxis" xlink:label="srt_ConsolidationItemsAxis" xlink:type="locator"/>
    <link:label xlink:label="srt_ConsolidationItemsAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Consolidation Items [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="srt_ConsolidationItemsAxis" xlink:to="srt_ConsolidationItemsAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_InvestmentInterestRateStatedPercentageDeferredAccrual" xlink:label="cmre_InvestmentInterestRateStatedPercentageDeferredAccrual" xlink:type="locator"/>
    <link:label xlink:label="cmre_InvestmentInterestRateStatedPercentageDeferredAccrual-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_InvestmentInterestRateStatedPercentageDeferredAccrual</link:label>
    <link:label xlink:label="cmre_InvestmentInterestRateStatedPercentageDeferredAccrual-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Investment Interest Rate, Stated Percentage, Deferred Accrual</link:label>
    <link:label xlink:label="cmre_InvestmentInterestRateStatedPercentageDeferredAccrual-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The portion of investment interest rate that accrues quarterly, but payment is deferred until maturity.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_InvestmentInterestRateStatedPercentageDeferredAccrual" xlink:to="cmre_InvestmentInterestRateStatedPercentageDeferredAccrual-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleLeasebackTransactionDescriptionAxis" xlink:label="us-gaap_SaleLeasebackTransactionDescriptionAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_SaleLeasebackTransactionDescriptionAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Sale Leaseback Transaction, Description [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_SaleLeasebackTransactionDescriptionAxis" xlink:to="us-gaap_SaleLeasebackTransactionDescriptionAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentPolicyTextBlock" xlink:label="us-gaap_InvestmentPolicyTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_InvestmentPolicyTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Investment, Policy [Policy Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InvestmentPolicyTextBlock" xlink:to="us-gaap_InvestmentPolicyTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_QuarterlyFeeToRelatedPartiesShares" xlink:label="cmre_QuarterlyFeeToRelatedPartiesShares" xlink:type="locator"/>
    <link:label xlink:label="cmre_QuarterlyFeeToRelatedPartiesShares-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_QuarterlyFeeToRelatedPartiesShares</link:label>
    <link:label xlink:label="cmre_QuarterlyFeeToRelatedPartiesShares-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Quarterly Fee to Related Parties, Shares (in shares)</link:label>
    <link:label xlink:label="cmre_QuarterlyFeeToRelatedPartiesShares-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Quarterly fee, in shares, for services provided by Costamare Shipping and/ or Costamare Services as at period end.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_QuarterlyFeeToRelatedPartiesShares" xlink:to="cmre_QuarterlyFeeToRelatedPartiesShares-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfAdoptionMember" xlink:label="us-gaap_TypeOfAdoptionMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_TypeOfAdoptionMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accounting Standards Update [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_TypeOfAdoptionMember" xlink:to="us-gaap_TypeOfAdoptionMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsForNewAccountingPronouncementsAxis" xlink:label="us-gaap_AdjustmentsForNewAccountingPronouncementsAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_AdjustmentsForNewAccountingPronouncementsAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accounting Standards Update [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AdjustmentsForNewAccountingPronouncementsAxis" xlink:to="us-gaap_AdjustmentsForNewAccountingPronouncementsAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsOfDividends" xlink:label="us-gaap_PaymentsOfDividends" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_PaymentsOfDividends-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_PaymentsOfDividends</link:label>
    <link:label xlink:label="us-gaap_PaymentsOfDividends-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Dividends paid</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PaymentsOfDividends" xlink:to="us-gaap_PaymentsOfDividends-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityMethodInvestmentsDisclosureTextBlock" xlink:label="us-gaap_EquityMethodInvestmentsDisclosureTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_EquityMethodInvestmentsDisclosureTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Equity Method Investments and Joint Ventures Disclosure [Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_EquityMethodInvestmentsDisclosureTextBlock" xlink:to="us-gaap_EquityMethodInvestmentsDisclosureTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityMethodInvestmentsTextBlock" xlink:label="us-gaap_EquityMethodInvestmentsTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_EquityMethodInvestmentsTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Equity Method Investments [Table Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_EquityMethodInvestmentsTextBlock" xlink:to="us-gaap_EquityMethodInvestmentsTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostsAndExpensesAbstract" xlink:label="us-gaap_CostsAndExpensesAbstract" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_CostsAndExpensesAbstract-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">EXPENSES:</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CostsAndExpensesAbstract" xlink:to="us-gaap_CostsAndExpensesAbstract-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:label="us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_PaymentsForRepurchaseOfCommonStock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_PaymentsForRepurchaseOfCommonStock</link:label>
    <link:label xlink:label="us-gaap_PaymentsForRepurchaseOfCommonStock-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Repurchase of common stock</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:to="us-gaap_PaymentsForRepurchaseOfCommonStock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ScenarioUnspecifiedDomain" xlink:label="srt_ScenarioUnspecifiedDomain" xlink:type="locator"/>
    <link:label xlink:label="srt_ScenarioUnspecifiedDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Scenario [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="srt_ScenarioUnspecifiedDomain" xlink:to="srt_ScenarioUnspecifiedDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsMember" xlink:label="us-gaap_RetainedEarningsMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_RetainedEarningsMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Retained Earnings [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RetainedEarningsMember" xlink:to="us-gaap_RetainedEarningsMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnbilledReceivablesNotBillableAtBalanceSheetDate" xlink:label="us-gaap_UnbilledReceivablesNotBillableAtBalanceSheetDate" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_UnbilledReceivablesNotBillableAtBalanceSheetDate-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_UnbilledReceivablesNotBillableAtBalanceSheetDate</link:label>
    <link:label xlink:label="us-gaap_UnbilledReceivablesNotBillableAtBalanceSheetDate-label" xlink:role="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:type="resource" xml:lang="en-US">Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_UnbilledReceivablesNotBillableAtBalanceSheetDate" xlink:to="us-gaap_UnbilledReceivablesNotBillableAtBalanceSheetDate-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TreasuryStockMember" xlink:label="us-gaap_TreasuryStockMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_TreasuryStockMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Treasury Stock [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_TreasuryStockMember" xlink:to="us-gaap_TreasuryStockMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementScenarioAxis" xlink:label="srt_StatementScenarioAxis" xlink:type="locator"/>
    <link:label xlink:label="srt_StatementScenarioAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Scenario [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="srt_StatementScenarioAxis" xlink:to="srt_StatementScenarioAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapitalMember" xlink:label="us-gaap_AdditionalPaidInCapitalMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_AdditionalPaidInCapitalMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Additional Paid-in Capital [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AdditionalPaidInCapitalMember" xlink:to="us-gaap_AdditionalPaidInCapitalMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember" xlink:label="us-gaap_CommonStockMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_CommonStockMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Common Stock [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CommonStockMember" xlink:to="us-gaap_CommonStockMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchaseProgramAuthorizedAmount1" xlink:label="us-gaap_StockRepurchaseProgramAuthorizedAmount1" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_StockRepurchaseProgramAuthorizedAmount1-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_StockRepurchaseProgramAuthorizedAmount1</link:label>
    <link:label xlink:label="us-gaap_StockRepurchaseProgramAuthorizedAmount1-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Stock Repurchase Program, Authorized Amount</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StockRepurchaseProgramAuthorizedAmount1" xlink:to="us-gaap_StockRepurchaseProgramAuthorizedAmount1-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockMember" xlink:label="us-gaap_PreferredStockMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_PreferredStockMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Preferred Stock [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PreferredStockMember" xlink:to="us-gaap_PreferredStockMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="us-gaap_StatementEquityComponentsAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_StatementEquityComponentsAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Equity Components [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StatementEquityComponentsAxis" xlink:to="us-gaap_StatementEquityComponentsAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain" xlink:label="us-gaap_EquityComponentDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_EquityComponentDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Equity Component [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_EquityComponentDomain" xlink:to="us-gaap_EquityComponentDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_DebtAgreementMaximumBorrowingCapacity" xlink:label="cmre_DebtAgreementMaximumBorrowingCapacity" xlink:type="locator"/>
    <link:label xlink:label="cmre_DebtAgreementMaximumBorrowingCapacity-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_DebtAgreementMaximumBorrowingCapacity</link:label>
    <link:label xlink:label="cmre_DebtAgreementMaximumBorrowingCapacity-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Debt Agreement, Maximum Borrowing Capacity</link:label>
    <link:label xlink:label="cmre_DebtAgreementMaximumBorrowingCapacity-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Maximum borrowing capacity under a debt agreement on the amount that could be borrowed with a combination of, but not limited to, a line of credit and term loan.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_DebtAgreementMaximumBorrowingCapacity" xlink:to="cmre_DebtAgreementMaximumBorrowingCapacity-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherLongTermDebt" xlink:label="us-gaap_OtherLongTermDebt" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_OtherLongTermDebt-label" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Other financing arrangements</link:label>
    <link:label xlink:label="us-gaap_OtherLongTermDebt-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_OtherLongTermDebt</link:label>
    <link:label xlink:label="us-gaap_OtherLongTermDebt-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Other Long-Term Debt, Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherLongTermDebt" xlink:to="us-gaap_OtherLongTermDebt-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebt" xlink:label="us-gaap_LongTermDebt" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_LongTermDebt-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_LongTermDebt</link:label>
    <link:label xlink:label="us-gaap_LongTermDebt-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Total long-term debt, net</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LongTermDebt" xlink:to="us-gaap_LongTermDebt-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_DyrosMember" xlink:label="cmre_DyrosMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_DyrosMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Dyros [Member]</link:label>
    <link:label xlink:label="cmre_DyrosMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the Dyros.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_DyrosMember" xlink:to="cmre_DyrosMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_SealandIllinoisSealandMichiganYorkAndMessiniMember" xlink:label="cmre_SealandIllinoisSealandMichiganYorkAndMessiniMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_SealandIllinoisSealandMichiganYorkAndMessiniMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Sealand Illinois, Sealand Michigan, York and Messini [Member]</link:label>
    <link:label xlink:label="cmre_SealandIllinoisSealandMichiganYorkAndMessiniMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to Sealand Illinois, Sealand Michigan, York and Messini.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_SealandIllinoisSealandMichiganYorkAndMessiniMember" xlink:to="cmre_SealandIllinoisSealandMichiganYorkAndMessiniMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredRevenueCurrent" xlink:label="us-gaap_DeferredRevenueCurrent" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DeferredRevenueCurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Unearned revenue (Note 13)</link:label>
    <link:label xlink:label="us-gaap_DeferredRevenueCurrent-label" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xml:lang="en-US">Less current portion</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DeferredRevenueCurrent" xlink:to="us-gaap_DeferredRevenueCurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredRevenueNoncurrent" xlink:label="us-gaap_DeferredRevenueNoncurrent" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DeferredRevenueNoncurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Unearned revenue, net of current portion (Note 13)</link:label>
    <link:label xlink:label="us-gaap_DeferredRevenueNoncurrent-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Non-current portion</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DeferredRevenueNoncurrent" xlink:to="us-gaap_DeferredRevenueNoncurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsOfFinancingCosts" xlink:label="us-gaap_PaymentsOfFinancingCosts" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_PaymentsOfFinancingCosts-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_PaymentsOfFinancingCosts</link:label>
    <link:label xlink:label="us-gaap_PaymentsOfFinancingCosts-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Payment of financing costs</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PaymentsOfFinancingCosts" xlink:to="us-gaap_PaymentsOfFinancingCosts-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_DeferredRevenueMember" xlink:label="cmre_DeferredRevenueMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_DeferredRevenueMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Deferred Revenue [Member]</link:label>
    <link:label xlink:label="cmre_DeferredRevenueMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents deferred revenue.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_DeferredRevenueMember" xlink:to="cmre_DeferredRevenueMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_VesselsAndAdvancesNetTextBlock" xlink:label="cmre_VesselsAndAdvancesNetTextBlock" xlink:type="locator"/>
    <link:label xlink:label="cmre_VesselsAndAdvancesNetTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Vessels and advances, net [Text block]</link:label>
    <link:label xlink:label="cmre_VesselsAndAdvancesNetTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Disclosure of vessels net of accumulated depreciation, additions to vessels' cost and advances for vessel acquisitions and or vessels under construction.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_VesselsAndAdvancesNetTextBlock" xlink:to="cmre_VesselsAndAdvancesNetTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComprehensiveIncomeNoteTextBlock" xlink:label="us-gaap_ComprehensiveIncomeNoteTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ComprehensiveIncomeNoteTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Comprehensive Income (Loss) Note [Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ComprehensiveIncomeNoteTextBlock" xlink:to="us-gaap_ComprehensiveIncomeNoteTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredRevenueByArrangementDisclosureTextBlock" xlink:label="us-gaap_DeferredRevenueByArrangementDisclosureTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DeferredRevenueByArrangementDisclosureTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Deferred Revenue, by Arrangement, Disclosure [Table Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DeferredRevenueByArrangementDisclosureTextBlock" xlink:to="us-gaap_DeferredRevenueByArrangementDisclosureTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract" xlink:label="us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Other comprehensive income:</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract" xlink:to="us-gaap_OtherComprehensiveIncomeLossNetOfTaxPeriodIncreaseDecreaseAbstract-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_VesselsAndAdvancesNet" xlink:label="cmre_VesselsAndAdvancesNet" xlink:type="locator"/>
    <link:label xlink:label="cmre_VesselsAndAdvancesNet-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Vessels and advances, net (Note 7)</link:label>
    <link:label xlink:label="cmre_VesselsAndAdvancesNet-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">This element includes vessels' book value net of accumulated depreciation and advances for vessel acquisitions and or under construction.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_VesselsAndAdvancesNet" xlink:to="cmre_VesselsAndAdvancesNet-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_SaleLeasebackTransactionsRegardingTheVesselsLeonidioAndKyparissiaMember" xlink:label="cmre_SaleLeasebackTransactionsRegardingTheVesselsLeonidioAndKyparissiaMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_SaleLeasebackTransactionsRegardingTheVesselsLeonidioAndKyparissiaMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Sale Leaseback Transactions Regarding the Vessels Leonidio and Kyparissia [Member]</link:label>
    <link:label xlink:label="cmre_SaleLeasebackTransactionsRegardingTheVesselsLeonidioAndKyparissiaMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Refers to the sales leaseback regarding the vessels Leonidio and Kyparissia.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_SaleLeasebackTransactionsRegardingTheVesselsLeonidioAndKyparissiaMember" xlink:to="cmre_SaleLeasebackTransactionsRegardingTheVesselsLeonidioAndKyparissiaMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ScheduleVesselsAndAdvancesNetTableTextBlock" xlink:label="cmre_ScheduleVesselsAndAdvancesNetTableTextBlock" xlink:type="locator"/>
    <link:label xlink:label="cmre_ScheduleVesselsAndAdvancesNetTableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule Vessels and Advances, Net [Table Text Block]</link:label>
    <link:label xlink:label="cmre_ScheduleVesselsAndAdvancesNetTableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Tabular disclosure of the cost and accumulated depreciation of vessels that are used in the normal conduct of business to produce goods and services and not intended for resale and advances for vessel acquisitions and or vessels under construction.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ScheduleVesselsAndAdvancesNetTableTextBlock" xlink:to="cmre_ScheduleVesselsAndAdvancesNetTableTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_AccruedCharterRevenueLiability" xlink:label="cmre_AccruedCharterRevenueLiability" xlink:type="locator"/>
    <link:label xlink:label="cmre_AccruedCharterRevenueLiability-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_AccruedCharterRevenueLiability</link:label>
    <link:label xlink:label="cmre_AccruedCharterRevenueLiability-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Accrued Charter Revenue Liability</link:label>
    <link:label xlink:label="cmre_AccruedCharterRevenueLiability-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The amount of accrued charter revenue liability.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_AccruedCharterRevenueLiability" xlink:to="cmre_AccruedCharterRevenueLiability-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_AccruedCharterRevenueCurrent" xlink:label="cmre_AccruedCharterRevenueCurrent" xlink:type="locator"/>
    <link:label xlink:label="cmre_AccruedCharterRevenueCurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_AccruedCharterRevenueCurrent</link:label>
    <link:label xlink:label="cmre_AccruedCharterRevenueCurrent-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Accrued Charter Revenue, Current</link:label>
    <link:label xlink:label="cmre_AccruedCharterRevenueCurrent-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">The amount of accrued charter revenue, classified as current.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_AccruedCharterRevenueCurrent" xlink:to="cmre_AccruedCharterRevenueCurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_AccruedCharterRevenueNoncurrent" xlink:label="cmre_AccruedCharterRevenueNoncurrent" xlink:type="locator"/>
    <link:label xlink:label="cmre_AccruedCharterRevenueNoncurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accrued charter revenue, non-current (Note 13)</link:label>
    <link:label xlink:label="cmre_AccruedCharterRevenueNoncurrent-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Accrued Charter Revenue, Noncurrent</link:label>
    <link:label xlink:label="cmre_AccruedCharterRevenueNoncurrent-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Non-Current portion of revenue earned, but not collected, resulting from charter agreements providing for varying annual charter rates over their terms, which were accounted for on a straight-line basis at their average rates.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_AccruedCharterRevenueNoncurrent" xlink:to="cmre_AccruedCharterRevenueNoncurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_SwapInterestExpenseNet" xlink:label="cmre_SwapInterestExpenseNet" xlink:type="locator"/>
    <link:label xlink:label="cmre_SwapInterestExpenseNet-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Swap effect</link:label>
    <link:label xlink:label="cmre_SwapInterestExpenseNet-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Interest expense for interest rate swaps qualifying for cash flow hedge during the reporting period.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_SwapInterestExpenseNet" xlink:to="cmre_SwapInterestExpenseNet-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredRevenue" xlink:label="us-gaap_DeferredRevenue" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DeferredRevenue-label" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Unearned Revenue</link:label>
    <link:label xlink:label="us-gaap_DeferredRevenue-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DeferredRevenue</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DeferredRevenue" xlink:to="us-gaap_DeferredRevenue-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredFinanceCostsCurrentNet" xlink:label="us-gaap_DeferredFinanceCostsCurrentNet" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DeferredFinanceCostsCurrentNet-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DeferredFinanceCostsCurrentNet</link:label>
    <link:label xlink:label="us-gaap_DeferredFinanceCostsCurrentNet-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Add: Deferred financing costs, current portion</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DeferredFinanceCostsCurrentNet" xlink:to="us-gaap_DeferredFinanceCostsCurrentNet-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_VenetikoMember" xlink:label="cmre_VenetikoMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_VenetikoMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Venetiko [Member]</link:label>
    <link:label xlink:label="cmre_VenetikoMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to Venetiko.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_VenetikoMember" xlink:to="cmre_VenetikoMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RepaymentsOfLongTermDebt" xlink:label="us-gaap_RepaymentsOfLongTermDebt" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_RepaymentsOfLongTermDebt-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_RepaymentsOfLongTermDebt</link:label>
    <link:label xlink:label="us-gaap_RepaymentsOfLongTermDebt-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Repayments of Long-term Debt, Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RepaymentsOfLongTermDebt" xlink:to="us-gaap_RepaymentsOfLongTermDebt-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RepaymentsOfLongTermDebtAndCapitalSecurities" xlink:label="us-gaap_RepaymentsOfLongTermDebtAndCapitalSecurities" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_RepaymentsOfLongTermDebtAndCapitalSecurities-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_RepaymentsOfLongTermDebtAndCapitalSecurities</link:label>
    <link:label xlink:label="us-gaap_RepaymentsOfLongTermDebtAndCapitalSecurities-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">Repayment of long-term debt and finance leases</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RepaymentsOfLongTermDebtAndCapitalSecurities" xlink:to="us-gaap_RepaymentsOfLongTermDebtAndCapitalSecurities-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_AcquisitionOfPegasusEraclePeaceSauvanPrideAcuityComityAndAthenaMember" xlink:label="cmre_AcquisitionOfPegasusEraclePeaceSauvanPrideAcuityComityAndAthenaMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_AcquisitionOfPegasusEraclePeaceSauvanPrideAcuityComityAndAthenaMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Acquisition of Pegasus, Eracle, Peace, Sauvan, Pride, Acuity, Comity and Athena [Member]</link:label>
    <link:label xlink:label="cmre_AcquisitionOfPegasusEraclePeaceSauvanPrideAcuityComityAndAthenaMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to Pegasus, Eracle, Peace, Sauvan, Pride, Acuity, Comity and Athena acquisition debt.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_AcquisitionOfPegasusEraclePeaceSauvanPrideAcuityComityAndAthenaMember" xlink:to="cmre_AcquisitionOfPegasusEraclePeaceSauvanPrideAcuityComityAndAthenaMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationAxis" xlink:label="us-gaap_BalanceSheetLocationAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_BalanceSheetLocationAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Balance Sheet Location [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_BalanceSheetLocationAxis" xlink:to="us-gaap_BalanceSheetLocationAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ZIMShanghaiMember" xlink:label="cmre_ZIMShanghaiMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_ZIMShanghaiMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">ZIM Shanghai [Member]</link:label>
    <link:label xlink:label="cmre_ZIMShanghaiMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to ZIM Shanghai.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ZIMShanghaiMember" xlink:to="cmre_ZIMShanghaiMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="us-gaap_BalanceSheetLocationDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_BalanceSheetLocationDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Balance Sheet Location [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_BalanceSheetLocationDomain" xlink:to="us-gaap_BalanceSheetLocationDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ZIMNewYorkMember" xlink:label="cmre_ZIMNewYorkMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_ZIMNewYorkMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">ZIM New York [Member]</link:label>
    <link:label xlink:label="cmre_ZIMNewYorkMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to ZIM New York.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ZIMNewYorkMember" xlink:to="cmre_ZIMNewYorkMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GeneralAndAdministrativeExpenseMember" xlink:label="us-gaap_GeneralAndAdministrativeExpenseMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_GeneralAndAdministrativeExpenseMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">General and Administrative Expense [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_GeneralAndAdministrativeExpenseMember" xlink:to="us-gaap_GeneralAndAdministrativeExpenseMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentCarryingAmount" xlink:label="us-gaap_DebtInstrumentCarryingAmount" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DebtInstrumentCarryingAmount-label" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Long-term debt</link:label>
    <link:label xlink:label="us-gaap_DebtInstrumentCarryingAmount-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DebtInstrumentCarryingAmount</link:label>
    <link:label xlink:label="us-gaap_DebtInstrumentCarryingAmount-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Long-Term Debt, Gross</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DebtInstrumentCarryingAmount" xlink:to="us-gaap_DebtInstrumentCarryingAmount-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="us-gaap_AccountingPoliciesAbstract" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_AccountingPoliciesAbstract-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accounting Policies [Abstract]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AccountingPoliciesAbstract" xlink:to="us-gaap_AccountingPoliciesAbstract-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SignificantAccountingPoliciesTextBlock" xlink:label="us-gaap_SignificantAccountingPoliciesTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_SignificantAccountingPoliciesTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Significant Accounting Policies [Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_SignificantAccountingPoliciesTextBlock" xlink:to="us-gaap_SignificantAccountingPoliciesTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_AcquisitionOfBuilderAdventureManzanilloAllianceSeabirdAeolianFarmerAndGrenetaMember" xlink:label="cmre_AcquisitionOfBuilderAdventureManzanilloAllianceSeabirdAeolianFarmerAndGrenetaMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_AcquisitionOfBuilderAdventureManzanilloAllianceSeabirdAeolianFarmerAndGrenetaMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Acquisition of Builder, Adventure, Manzanillo, Alliance, Seabird, Aeolian, Farmer and Greneta [Member]</link:label>
    <link:label xlink:label="cmre_AcquisitionOfBuilderAdventureManzanilloAllianceSeabirdAeolianFarmerAndGrenetaMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to Builder, Adventure, Manzanillo, Alliance, Seabird, Aeolian, Farmer and Greneta acquisition debt.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_AcquisitionOfBuilderAdventureManzanilloAllianceSeabirdAeolianFarmerAndGrenetaMember" xlink:to="cmre_AcquisitionOfBuilderAdventureManzanilloAllianceSeabirdAeolianFarmerAndGrenetaMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_RefinanceTermLoansForEquityThunderRoseAndClaraMember" xlink:label="cmre_RefinanceTermLoansForEquityThunderRoseAndClaraMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_RefinanceTermLoansForEquityThunderRoseAndClaraMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Refinance Term Loans for Equity, Thunder, Rose and Clara [Member]</link:label>
    <link:label xlink:label="cmre_RefinanceTermLoansForEquityThunderRoseAndClaraMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to refinance term loans for Equity, Thunder, Rose and Clara.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_RefinanceTermLoansForEquityThunderRoseAndClaraMember" xlink:to="cmre_RefinanceTermLoansForEquityThunderRoseAndClaraMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_RefinanceTermLoanForBernisVerityDawnDiscoveryAndParityMember" xlink:label="cmre_RefinanceTermLoanForBernisVerityDawnDiscoveryAndParityMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_RefinanceTermLoanForBernisVerityDawnDiscoveryAndParityMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Refinance Term Loan for Bernis, Verity, Dawn, Discovery and Parity [Member]</link:label>
    <link:label xlink:label="cmre_RefinanceTermLoanForBernisVerityDawnDiscoveryAndParityMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to refinance term loan for Bernis, Verity, Dawn, Discovery and Parity.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_RefinanceTermLoanForBernisVerityDawnDiscoveryAndParityMember" xlink:to="cmre_RefinanceTermLoanForBernisVerityDawnDiscoveryAndParityMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockDividendsPerShareCashPaid" xlink:label="us-gaap_CommonStockDividendsPerShareCashPaid" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_CommonStockDividendsPerShareCashPaid-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_CommonStockDividendsPerShareCashPaid</link:label>
    <link:label xlink:label="us-gaap_CommonStockDividendsPerShareCashPaid-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Common Stock, Dividends, Per Share, Cash Paid (in dollars per share)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CommonStockDividendsPerShareCashPaid" xlink:to="us-gaap_CommonStockDividendsPerShareCashPaid-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_HuntingLicenseFacilityAgreementForPythiasEgyptianMikePhoenixBelstarTbrOracleUniversalBremenTbrLibraMember" xlink:label="cmre_HuntingLicenseFacilityAgreementForPythiasEgyptianMikePhoenixBelstarTbrOracleUniversalBremenTbrLibraMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_HuntingLicenseFacilityAgreementForPythiasEgyptianMikePhoenixBelstarTbrOracleUniversalBremenTbrLibraMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Hunting License Facility Agreement for Pythias, Egyptian Mike, Phoenix, Belstar (tbr Oracle), Universal Bremen (tbr Libra) [Member]</link:label>
    <link:label xlink:label="cmre_HuntingLicenseFacilityAgreementForPythiasEgyptianMikePhoenixBelstarTbrOracleUniversalBremenTbrLibraMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to Hunting License Facility Agreement for Pythias, Egyptian Mike, Phoenix, Belstar (tbr Oracle), Universal Bremen (tbr Libra).</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_HuntingLicenseFacilityAgreementForPythiasEgyptianMikePhoenixBelstarTbrOracleUniversalBremenTbrLibraMember" xlink:to="cmre_HuntingLicenseFacilityAgreementForPythiasEgyptianMikePhoenixBelstarTbrOracleUniversalBremenTbrLibraMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNonoperatingIncomeExpenseMember" xlink:label="us-gaap_OtherNonoperatingIncomeExpenseMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_OtherNonoperatingIncomeExpenseMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Other Nonoperating Income (Expense) [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherNonoperatingIncomeExpenseMember" xlink:to="us-gaap_OtherNonoperatingIncomeExpenseMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesMember" xlink:label="us-gaap_DebtSecuritiesMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DebtSecuritiesMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Debt Securities [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DebtSecuritiesMember" xlink:to="us-gaap_DebtSecuritiesMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_HuntingLicenseFacilityToPurchaseProgressMeridaMinerUruguayResourceKonstantinosCetusExCharmTitanIBermondiOrionMerchiaAndDamonMember" xlink:label="cmre_HuntingLicenseFacilityToPurchaseProgressMeridaMinerUruguayResourceKonstantinosCetusExCharmTitanIBermondiOrionMerchiaAndDamonMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_HuntingLicenseFacilityToPurchaseProgressMeridaMinerUruguayResourceKonstantinosCetusExCharmTitanIBermondiOrionMerchiaAndDamonMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Hunting License Facility to Purchase Progress, Merida, Miner, Uruguay, Resource, Konstantinos, Cetus (ex. Charm), Titan I, Bermondi, Orion, Merchia and Damon [Member]</link:label>
    <link:label xlink:label="cmre_HuntingLicenseFacilityToPurchaseProgressMeridaMinerUruguayResourceKonstantinosCetusExCharmTitanIBermondiOrionMerchiaAndDamonMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to Hunting License Facility to acquire Progress, Merida, Miner, Uruguay, Resource, Konstantinos, Cetus (ex. Charm), Titan I, Bermondi, Orion, Merchia and Damon.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_HuntingLicenseFacilityToPurchaseProgressMeridaMinerUruguayResourceKonstantinosCetusExCharmTitanIBermondiOrionMerchiaAndDamonMember" xlink:to="cmre_HuntingLicenseFacilityToPurchaseProgressMeridaMinerUruguayResourceKonstantinosCetusExCharmTitanIBermondiOrionMerchiaAndDamonMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebtAndCapitalSecuritiesNet" xlink:label="us-gaap_ProceedsFromIssuanceOfLongTermDebtAndCapitalSecuritiesNet" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ProceedsFromIssuanceOfLongTermDebtAndCapitalSecuritiesNet-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Proceeds from long-term debt and finance leases</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ProceedsFromIssuanceOfLongTermDebtAndCapitalSecuritiesNet" xlink:to="us-gaap_ProceedsFromIssuanceOfLongTermDebtAndCapitalSecuritiesNet-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_HuntingLicenseFacilityAgreementToAcquireBernisVerityDawnDiscoveryClaraSerenaParityTaiboThunderEquityCuracaoAndRoseMember" xlink:label="cmre_HuntingLicenseFacilityAgreementToAcquireBernisVerityDawnDiscoveryClaraSerenaParityTaiboThunderEquityCuracaoAndRoseMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_HuntingLicenseFacilityAgreementToAcquireBernisVerityDawnDiscoveryClaraSerenaParityTaiboThunderEquityCuracaoAndRoseMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Hunting License Facility Agreement to Acquire Bernis, Verity, Dawn, Discovery, Clara, Serena, Parity, Taibo, Thunder, Equity, Curacao and Rose [Member]</link:label>
    <link:label xlink:label="cmre_HuntingLicenseFacilityAgreementToAcquireBernisVerityDawnDiscoveryClaraSerenaParityTaiboThunderEquityCuracaoAndRoseMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to Hunting License Facility to acquire Bernis, Verity, Dawn, Discovery, Clara, Serena, Parity, Taibo, Thunder, Equity, Curacao and Rose.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_HuntingLicenseFacilityAgreementToAcquireBernisVerityDawnDiscoveryClaraSerenaParityTaiboThunderEquityCuracaoAndRoseMember" xlink:to="cmre_HuntingLicenseFacilityAgreementToAcquireBernisVerityDawnDiscoveryClaraSerenaParityTaiboThunderEquityCuracaoAndRoseMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_HuntingLicenseFacilityAgreementForDryBulkVesselsMember" xlink:label="cmre_HuntingLicenseFacilityAgreementForDryBulkVesselsMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_HuntingLicenseFacilityAgreementForDryBulkVesselsMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Hunting License Facility Agreement for Dry Bulk Vessels [Member]</link:label>
    <link:label xlink:label="cmre_HuntingLicenseFacilityAgreementForDryBulkVesselsMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to Hunting License Facility Agreement for Dry Bulk Vessels.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_HuntingLicenseFacilityAgreementForDryBulkVesselsMember" xlink:to="cmre_HuntingLicenseFacilityAgreementForDryBulkVesselsMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeAxis" xlink:label="us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Equity Method Investment, Nonconsolidated Investee [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeAxis" xlink:to="us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt" xlink:label="us-gaap_ProceedsFromIssuanceOfLongTermDebt" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ProceedsFromIssuanceOfLongTermDebt-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_ProceedsFromIssuanceOfLongTermDebt</link:label>
    <link:label xlink:label="us-gaap_ProceedsFromIssuanceOfLongTermDebt-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Proceeds from Issuance of Long-term Debt, Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ProceedsFromIssuanceOfLongTermDebt" xlink:to="us-gaap_ProceedsFromIssuanceOfLongTermDebt-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ReddickShippingCoAndVerandiShippingCoSecondTermLoanEachTrancheMember" xlink:label="cmre_ReddickShippingCoAndVerandiShippingCoSecondTermLoanEachTrancheMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_ReddickShippingCoAndVerandiShippingCoSecondTermLoanEachTrancheMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Reddick Shipping Co. and Verandi Shipping Co Second Term Loan, Each Tranche [Member]</link:label>
    <link:label xlink:label="cmre_ReddickShippingCoAndVerandiShippingCoSecondTermLoanEachTrancheMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to debt.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ReddickShippingCoAndVerandiShippingCoSecondTermLoanEachTrancheMember" xlink:to="cmre_ReddickShippingCoAndVerandiShippingCoSecondTermLoanEachTrancheMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_AinsleyMaritimeCoAndAmbroseMaritimeCoLoanAgreementEachTrancheMember" xlink:label="cmre_AinsleyMaritimeCoAndAmbroseMaritimeCoLoanAgreementEachTrancheMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_AinsleyMaritimeCoAndAmbroseMaritimeCoLoanAgreementEachTrancheMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Ainsley Maritime Co. and Ambrose Maritime Co. Loan Agreement Each Tranche [Member]</link:label>
    <link:label xlink:label="cmre_AinsleyMaritimeCoAndAmbroseMaritimeCoLoanAgreementEachTrancheMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to debt.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_AinsleyMaritimeCoAndAmbroseMaritimeCoLoanAgreementEachTrancheMember" xlink:to="cmre_AinsleyMaritimeCoAndAmbroseMaritimeCoLoanAgreementEachTrancheMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeOrGroupOfInvesteesMember" xlink:label="us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeOrGroupOfInvesteesMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeOrGroupOfInvesteesMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Equity Method Investment, Nonconsolidated Investee or Group of Investees [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeOrGroupOfInvesteesMember" xlink:to="us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeOrGroupOfInvesteesMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeDomain" xlink:label="us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Equity Method Investment, Nonconsolidated Investee [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeDomain" xlink:to="us-gaap_EquityMethodInvestmentNonconsolidatedInvesteeDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationAxis" xlink:label="us-gaap_IncomeStatementLocationAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_IncomeStatementLocationAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Income Statement Location [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_IncomeStatementLocationAxis" xlink:to="us-gaap_IncomeStatementLocationAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain" xlink:label="us-gaap_IncomeStatementLocationDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_IncomeStatementLocationDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Income Statement Location [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_IncomeStatementLocationDomain" xlink:to="us-gaap_IncomeStatementLocationDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractReceivableDueThreeToFourYears" xlink:label="us-gaap_ContractReceivableDueThreeToFourYears" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ContractReceivableDueThreeToFourYears-label" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">2026</link:label>
    <link:label xlink:label="us-gaap_ContractReceivableDueThreeToFourYears-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_ContractReceivableDueThreeToFourYears</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ContractReceivableDueThreeToFourYears" xlink:to="us-gaap_ContractReceivableDueThreeToFourYears-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeFairValueOfDerivativeAssetAmountNotOffsetAgainstCollateral" xlink:label="us-gaap_DerivativeFairValueOfDerivativeAssetAmountNotOffsetAgainstCollateral" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DerivativeFairValueOfDerivativeAssetAmountNotOffsetAgainstCollateral-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DerivativeFairValueOfDerivativeAssetAmountNotOffsetAgainstCollateral</link:label>
    <link:label xlink:label="us-gaap_DerivativeFairValueOfDerivativeAssetAmountNotOffsetAgainstCollateral-label" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DerivativeFairValueOfDerivativeAssetAmountNotOffsetAgainstCollateral" xlink:to="us-gaap_DerivativeFairValueOfDerivativeAssetAmountNotOffsetAgainstCollateral-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractReceivableDueOneYearOrLess" xlink:label="us-gaap_ContractReceivableDueOneYearOrLess" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ContractReceivableDueOneYearOrLess-label" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">2023</link:label>
    <link:label xlink:label="us-gaap_ContractReceivableDueOneYearOrLess-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_ContractReceivableDueOneYearOrLess</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ContractReceivableDueOneYearOrLess" xlink:to="us-gaap_ContractReceivableDueOneYearOrLess-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementBusinessSegmentsAxis" xlink:label="us-gaap_StatementBusinessSegmentsAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_StatementBusinessSegmentsAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Segments [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StatementBusinessSegmentsAxis" xlink:to="us-gaap_StatementBusinessSegmentsAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentDomain" xlink:label="us-gaap_SegmentDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_SegmentDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Segments [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_SegmentDomain" xlink:to="us-gaap_SegmentDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractReceivableDueOneToTwoYears" xlink:label="us-gaap_ContractReceivableDueOneToTwoYears" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ContractReceivableDueOneToTwoYears-label" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">2024</link:label>
    <link:label xlink:label="us-gaap_ContractReceivableDueOneToTwoYears-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_ContractReceivableDueOneToTwoYears</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ContractReceivableDueOneToTwoYears" xlink:to="us-gaap_ContractReceivableDueOneToTwoYears-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractReceivableDueTwoToThreeYears" xlink:label="us-gaap_ContractReceivableDueTwoToThreeYears" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ContractReceivableDueTwoToThreeYears-label" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">2025</link:label>
    <link:label xlink:label="us-gaap_ContractReceivableDueTwoToThreeYears-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_ContractReceivableDueTwoToThreeYears</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ContractReceivableDueTwoToThreeYears" xlink:to="us-gaap_ContractReceivableDueTwoToThreeYears-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_AmortizationOfAssumedTimeCharter" xlink:label="cmre_AmortizationOfAssumedTimeCharter" xlink:type="locator"/>
    <link:label xlink:label="cmre_AmortizationOfAssumedTimeCharter-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Amortization of assumed time charter</link:label>
    <link:label xlink:label="cmre_AmortizationOfAssumedTimeCharter-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the amortization expense of Time charter assumed amounted and is included in Voyage revenue in the 2018 accompanying consolidated statement of income.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_AmortizationOfAssumedTimeCharter" xlink:to="cmre_AmortizationOfAssumedTimeCharter-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RepaymentsOfLinesOfCredit" xlink:label="us-gaap_RepaymentsOfLinesOfCredit" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_RepaymentsOfLinesOfCredit-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_RepaymentsOfLinesOfCredit</link:label>
    <link:label xlink:label="us-gaap_RepaymentsOfLinesOfCredit-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Repayments of Lines of Credit</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RepaymentsOfLinesOfCredit" xlink:to="us-gaap_RepaymentsOfLinesOfCredit-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromLinesOfCredit" xlink:label="us-gaap_ProceedsFromLinesOfCredit" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ProceedsFromLinesOfCredit-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_ProceedsFromLinesOfCredit</link:label>
    <link:label xlink:label="us-gaap_ProceedsFromLinesOfCredit-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Proceeds from Lines of Credit, Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ProceedsFromLinesOfCredit" xlink:to="us-gaap_ProceedsFromLinesOfCredit-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ReclassificationFromPrepaidLeaseRentalsToRightOfUseAssetsMember" xlink:label="cmre_ReclassificationFromPrepaidLeaseRentalsToRightOfUseAssetsMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_ReclassificationFromPrepaidLeaseRentalsToRightOfUseAssetsMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Reclassification from Prepaid Lease Rentals to Right-of-use Assets [Member]</link:label>
    <link:label xlink:label="cmre_ReclassificationFromPrepaidLeaseRentalsToRightOfUseAssetsMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents the amount reclassified from prepaid lease rentals to right-of-use assets.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ReclassificationFromPrepaidLeaseRentalsToRightOfUseAssetsMember" xlink:to="cmre_ReclassificationFromPrepaidLeaseRentalsToRightOfUseAssetsMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ReclassificationFromDeferredGainNetToRightOfUseAssetsMember" xlink:label="cmre_ReclassificationFromDeferredGainNetToRightOfUseAssetsMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_ReclassificationFromDeferredGainNetToRightOfUseAssetsMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Reclassification from Deferred Gain, Net to Right-of-use Assets [Member]</link:label>
    <link:label xlink:label="cmre_ReclassificationFromDeferredGainNetToRightOfUseAssetsMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents amounts reclassified from deferred gain, net to right-of-use assets.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ReclassificationFromDeferredGainNetToRightOfUseAssetsMember" xlink:to="cmre_ReclassificationFromDeferredGainNetToRightOfUseAssetsMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractReceivableDueInRemainderOfFiscalYear" xlink:label="us-gaap_ContractReceivableDueInRemainderOfFiscalYear" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ContractReceivableDueInRemainderOfFiscalYear-label" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">2022</link:label>
    <link:label xlink:label="us-gaap_ContractReceivableDueInRemainderOfFiscalYear-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_ContractReceivableDueInRemainderOfFiscalYear</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ContractReceivableDueInRemainderOfFiscalYear" xlink:to="us-gaap_ContractReceivableDueInRemainderOfFiscalYear-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable" xlink:label="us-gaap_StatementTable" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_StatementTable-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Statement [Table]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StatementTable" xlink:to="us-gaap_StatementTable-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MinorityInterestOwnershipPercentageByParent" xlink:label="us-gaap_MinorityInterestOwnershipPercentageByParent" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_MinorityInterestOwnershipPercentageByParent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_MinorityInterestOwnershipPercentageByParent</link:label>
    <link:label xlink:label="us-gaap_MinorityInterestOwnershipPercentageByParent-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Noncontrolling Interest, Ownership Percentage by Parent</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_MinorityInterestOwnershipPercentageByParent" xlink:to="us-gaap_MinorityInterestOwnershipPercentageByParent-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfFinancialPositionAbstract" xlink:label="us-gaap_StatementOfFinancialPositionAbstract" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_StatementOfFinancialPositionAbstract-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Statement of Financial Position [Abstract]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StatementOfFinancialPositionAbstract" xlink:to="us-gaap_StatementOfFinancialPositionAbstract-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:label="us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_WeightedAverageNumberOfSharesOutstandingBasic-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Weighted average number of shares, basic and diluted (Note 16) (in shares)</link:label>
    <link:label xlink:label="us-gaap_WeightedAverageNumberOfSharesOutstandingBasic-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Weighted average number of common shares, basic and diluted (in shares)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:to="us-gaap_WeightedAverageNumberOfSharesOutstandingBasic-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAxis" xlink:label="us-gaap_BusinessAcquisitionAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_BusinessAcquisitionAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Business Acquisition [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_BusinessAcquisitionAxis" xlink:to="us-gaap_BusinessAcquisitionAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareBasic" xlink:label="us-gaap_EarningsPerShareBasic" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_EarningsPerShareBasic-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Earnings per common share, basic and diluted (Note 16) (in dollars per share)</link:label>
    <link:label xlink:label="us-gaap_EarningsPerShareBasic-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Earnings per common share, basic and diluted (in dollars per share)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_EarningsPerShareBasic" xlink:to="us-gaap_EarningsPerShareBasic-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain" xlink:label="us-gaap_BusinessAcquisitionAcquireeDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_BusinessAcquisitionAcquireeDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Business Acquisition, Acquiree [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_BusinessAcquisitionAcquireeDomain" xlink:to="us-gaap_BusinessAcquisitionAcquireeDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfCashFlowsAbstract" xlink:label="us-gaap_StatementOfCashFlowsAbstract" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_StatementOfCashFlowsAbstract-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Statement of Cash Flows [Abstract]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StatementOfCashFlowsAbstract" xlink:to="us-gaap_StatementOfCashFlowsAbstract-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_DeadWeightTonnageOfDrybulkVessels" xlink:label="cmre_DeadWeightTonnageOfDrybulkVessels" xlink:type="locator"/>
    <link:label xlink:label="cmre_DeadWeightTonnageOfDrybulkVessels-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_DeadWeightTonnageOfDrybulkVessels</link:label>
    <link:label xlink:label="cmre_DeadWeightTonnageOfDrybulkVessels-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Dead Weight Tonnage of Dry-bulk Vessels</link:label>
    <link:label xlink:label="cmre_DeadWeightTonnageOfDrybulkVessels-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents dead weight tonnage of dry-bulk vessels.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_DeadWeightTonnageOfDrybulkVessels" xlink:to="cmre_DeadWeightTonnageOfDrybulkVessels-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeAssetsLiabilitiesAtFairValueNet" xlink:label="us-gaap_DerivativeAssetsLiabilitiesAtFairValueNet" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DerivativeAssetsLiabilitiesAtFairValueNet-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DerivativeAssetsLiabilitiesAtFairValueNet</link:label>
    <link:label xlink:label="us-gaap_DerivativeAssetsLiabilitiesAtFairValueNet-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative Assets (Liabilities), at Fair Value, Net, Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DerivativeAssetsLiabilitiesAtFairValueNet" xlink:to="us-gaap_DerivativeAssetsLiabilitiesAtFairValueNet-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear" xlink:label="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear</link:label>
    <link:label xlink:label="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">2022</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear" xlink:to="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfStockholdersEquityAbstract" xlink:label="us-gaap_StatementOfStockholdersEquityAbstract" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_StatementOfStockholdersEquityAbstract-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Statement of Stockholders' Equity [Abstract]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StatementOfStockholdersEquityAbstract" xlink:to="us-gaap_StatementOfStockholdersEquityAbstract-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockDividendsPerShareCashPaid" xlink:label="us-gaap_PreferredStockDividendsPerShareCashPaid" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_PreferredStockDividendsPerShareCashPaid-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_PreferredStockDividendsPerShareCashPaid</link:label>
    <link:label xlink:label="us-gaap_PreferredStockDividendsPerShareCashPaid-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Preferred Stock, Dividends, Per Share, Cash Paid (in dollars per share)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PreferredStockDividendsPerShareCashPaid" xlink:to="us-gaap_PreferredStockDividendsPerShareCashPaid-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementAbstract" xlink:label="us-gaap_IncomeStatementAbstract" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_IncomeStatementAbstract-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Income Statement [Abstract]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_IncomeStatementAbstract" xlink:to="us-gaap_IncomeStatementAbstract-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent" xlink:label="us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent</link:label>
    <link:label xlink:label="us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent-label" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Other comprehensive income/ (loss) for the period</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent" xlink:to="us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree" xlink:label="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree</link:label>
    <link:label xlink:label="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">2025</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree" xlink:to="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour" xlink:label="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour</link:label>
    <link:label xlink:label="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">2026</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour" xlink:to="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfDebt" xlink:label="us-gaap_ProceedsFromIssuanceOfDebt" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ProceedsFromIssuanceOfDebt-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_ProceedsFromIssuanceOfDebt</link:label>
    <link:label xlink:label="us-gaap_ProceedsFromIssuanceOfDebt-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Proceeds from Issuance of Debt</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ProceedsFromIssuanceOfDebt" xlink:to="us-gaap_ProceedsFromIssuanceOfDebt-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RepaymentsOfDebt" xlink:label="us-gaap_RepaymentsOfDebt" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_RepaymentsOfDebt-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_RepaymentsOfDebt</link:label>
    <link:label xlink:label="us-gaap_RepaymentsOfDebt-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Repayments of Debt</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_RepaymentsOfDebt" xlink:to="us-gaap_RepaymentsOfDebt-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths" xlink:label="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths</link:label>
    <link:label xlink:label="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">2023</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths" xlink:to="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo" xlink:label="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo</link:label>
    <link:label xlink:label="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">2024</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo" xlink:to="us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_VesselCostMember" xlink:label="cmre_VesselCostMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_VesselCostMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Vessel Cost [Member]</link:label>
    <link:label xlink:label="cmre_VesselCostMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents vessel cost.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_VesselCostMember" xlink:to="cmre_VesselCostMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_AccumulatedDepreciationMember" xlink:label="cmre_AccumulatedDepreciationMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_AccumulatedDepreciationMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accumulated Depreciation [Member]</link:label>
    <link:label xlink:label="cmre_AccumulatedDepreciationMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents accumulated depreciation.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_AccumulatedDepreciationMember" xlink:to="cmre_AccumulatedDepreciationMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NetBookValueMember" xlink:label="cmre_NetBookValueMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_NetBookValueMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Net Book Value [Member]</link:label>
    <link:label xlink:label="cmre_NetBookValueMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents net book value.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NetBookValueMember" xlink:to="cmre_NetBookValueMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseInterestExpense" xlink:label="us-gaap_FinanceLeaseInterestExpense" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_FinanceLeaseInterestExpense-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_FinanceLeaseInterestExpense</link:label>
    <link:label xlink:label="us-gaap_FinanceLeaseInterestExpense-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Finance Lease, Interest Expense</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FinanceLeaseInterestExpense" xlink:to="us-gaap_FinanceLeaseInterestExpense-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NumberOfVesselsAcquiredUnderSPA" xlink:label="cmre_NumberOfVesselsAcquiredUnderSPA" xlink:type="locator"/>
    <link:label xlink:label="cmre_NumberOfVesselsAcquiredUnderSPA-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_NumberOfVesselsAcquiredUnderSPA</link:label>
    <link:label xlink:label="cmre_NumberOfVesselsAcquiredUnderSPA-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Number of vessels acquired under SPA</link:label>
    <link:label xlink:label="cmre_NumberOfVesselsAcquiredUnderSPA-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents number of vessels acquired under SPA.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NumberOfVesselsAcquiredUnderSPA" xlink:to="cmre_NumberOfVesselsAcquiredUnderSPA-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_NumberOfDrybulkVesselsDelivered" xlink:label="cmre_NumberOfDrybulkVesselsDelivered" xlink:type="locator"/>
    <link:label xlink:label="cmre_NumberOfDrybulkVesselsDelivered-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_NumberOfDrybulkVesselsDelivered</link:label>
    <link:label xlink:label="cmre_NumberOfDrybulkVesselsDelivered-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Number of dry-bulk vessels delivered</link:label>
    <link:label xlink:label="cmre_NumberOfDrybulkVesselsDelivered-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">represents number of dry-bulk vessels delivered.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_NumberOfDrybulkVesselsDelivered" xlink:to="cmre_NumberOfDrybulkVesselsDelivered-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseRightOfUseAssetAmortization" xlink:label="us-gaap_FinanceLeaseRightOfUseAssetAmortization" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_FinanceLeaseRightOfUseAssetAmortization-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_FinanceLeaseRightOfUseAssetAmortization</link:label>
    <link:label xlink:label="us-gaap_FinanceLeaseRightOfUseAssetAmortization-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Finance Lease, Right-of-Use Asset, Amortization</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_FinanceLeaseRightOfUseAssetAmortization" xlink:to="us-gaap_FinanceLeaseRightOfUseAssetAmortization-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeAverageForwardExchangeRate1" xlink:label="us-gaap_DerivativeAverageForwardExchangeRate1" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DerivativeAverageForwardExchangeRate1-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DerivativeAverageForwardExchangeRate1</link:label>
    <link:label xlink:label="us-gaap_DerivativeAverageForwardExchangeRate1-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative, Average Forward Exchange Rate</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DerivativeAverageForwardExchangeRate1" xlink:to="us-gaap_DerivativeAverageForwardExchangeRate1-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLoss" xlink:label="us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLoss" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLoss-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLoss</link:label>
    <link:label xlink:label="us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLoss-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Debt Securities, Held-to-maturity, Allowance for Credit Loss, Ending Balance</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLoss" xlink:to="us-gaap_DebtSecuritiesHeldToMaturityAllowanceForCreditLoss-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeCostOfHedge" xlink:label="us-gaap_DerivativeCostOfHedge" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DerivativeCostOfHedge-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DerivativeCostOfHedge</link:label>
    <link:label xlink:label="us-gaap_DerivativeCostOfHedge-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Derivative, Cost of Hedge</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DerivativeCostOfHedge" xlink:to="us-gaap_DerivativeCostOfHedge-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetAcquisitionAxis" xlink:label="us-gaap_AssetAcquisitionAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_AssetAcquisitionAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Asset Acquisition [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AssetAcquisitionAxis" xlink:to="us-gaap_AssetAcquisitionAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesHeldToMaturityCreditLossExpenseReversal" xlink:label="us-gaap_DebtSecuritiesHeldToMaturityCreditLossExpenseReversal" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DebtSecuritiesHeldToMaturityCreditLossExpenseReversal-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DebtSecuritiesHeldToMaturityCreditLossExpenseReversal</link:label>
    <link:label xlink:label="us-gaap_DebtSecuritiesHeldToMaturityCreditLossExpenseReversal-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Debt Securities, Held-to-maturity, Credit Loss Expense (Reversal)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DebtSecuritiesHeldToMaturityCreditLossExpenseReversal" xlink:to="us-gaap_DebtSecuritiesHeldToMaturityCreditLossExpenseReversal-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesNoncurrent" xlink:label="us-gaap_LiabilitiesNoncurrent" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_LiabilitiesNoncurrent-label" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Non-current liabilities</link:label>
    <link:label xlink:label="us-gaap_LiabilitiesNoncurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_LiabilitiesNoncurrent</link:label>
    <link:label xlink:label="us-gaap_LiabilitiesNoncurrent-label" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total non-current liabilities</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LiabilitiesNoncurrent" xlink:to="us-gaap_LiabilitiesNoncurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DividendPayableDateToBePaidDayMonthAndYear" xlink:label="us-gaap_DividendPayableDateToBePaidDayMonthAndYear" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DividendPayableDateToBePaidDayMonthAndYear-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DividendPayableDateToBePaidDayMonthAndYear</link:label>
    <link:label xlink:label="us-gaap_DividendPayableDateToBePaidDayMonthAndYear-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Dividends Payable, Date to be Paid</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DividendPayableDateToBePaidDayMonthAndYear" xlink:to="us-gaap_DividendPayableDateToBePaidDayMonthAndYear-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Cash Flows From Financing Activities:</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:to="us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate" xlink:label="us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate</link:label>
    <link:label xlink:label="us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate" xlink:to="us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DividendsPayableDateDeclaredDayMonthAndYear" xlink:label="us-gaap_DividendsPayableDateDeclaredDayMonthAndYear" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DividendsPayableDateDeclaredDayMonthAndYear-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DividendsPayableDateDeclaredDayMonthAndYear</link:label>
    <link:label xlink:label="us-gaap_DividendsPayableDateDeclaredDayMonthAndYear-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Dividends Payable, Date Declared</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DividendsPayableDateDeclaredDayMonthAndYear" xlink:to="us-gaap_DividendsPayableDateDeclaredDayMonthAndYear-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetAcquisitionDomain" xlink:label="us-gaap_AssetAcquisitionDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_AssetAcquisitionDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Asset Acquisition [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AssetAcquisitionDomain" xlink:to="us-gaap_AssetAcquisitionDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DividendsPayableDateOfRecordDayMonthAndYear" xlink:label="us-gaap_DividendsPayableDateOfRecordDayMonthAndYear" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DividendsPayableDateOfRecordDayMonthAndYear-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DividendsPayableDateOfRecordDayMonthAndYear</link:label>
    <link:label xlink:label="us-gaap_DividendsPayableDateOfRecordDayMonthAndYear-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Dividends Payable, Date of Record</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DividendsPayableDateOfRecordDayMonthAndYear" xlink:to="us-gaap_DividendsPayableDateOfRecordDayMonthAndYear-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DividendsPayableAmountPerShare" xlink:label="us-gaap_DividendsPayableAmountPerShare" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DividendsPayableAmountPerShare-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DividendsPayableAmountPerShare</link:label>
    <link:label xlink:label="us-gaap_DividendsPayableAmountPerShare-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Dividends Payable, Amount Per Share (in dollars per share)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DividendsPayableAmountPerShare" xlink:to="us-gaap_DividendsPayableAmountPerShare-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromEquityMethodInvestmentDividendsOrDistributionsReturnOfCapital" xlink:label="us-gaap_ProceedsFromEquityMethodInvestmentDividendsOrDistributionsReturnOfCapital" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ProceedsFromEquityMethodInvestmentDividendsOrDistributionsReturnOfCapital-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Return of capital from equity method investments</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ProceedsFromEquityMethodInvestmentDividendsOrDistributionsReturnOfCapital" xlink:to="us-gaap_ProceedsFromEquityMethodInvestmentDividendsOrDistributionsReturnOfCapital-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeFairValueOfDerivativeNet" xlink:label="us-gaap_DerivativeFairValueOfDerivativeNet" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DerivativeFairValueOfDerivativeNet-label" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Fair value</link:label>
    <link:label xlink:label="us-gaap_DerivativeFairValueOfDerivativeNet-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DerivativeFairValueOfDerivativeNet</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DerivativeFairValueOfDerivativeNet" xlink:to="us-gaap_DerivativeFairValueOfDerivativeNet-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeLiabilitiesNoncurrent" xlink:label="us-gaap_DerivativeLiabilitiesNoncurrent" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DerivativeLiabilitiesNoncurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Fair value of derivatives, non-current portion (Notes 19 and 20)</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DerivativeLiabilitiesNoncurrent" xlink:to="us-gaap_DerivativeLiabilitiesNoncurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DividendsAxis" xlink:label="us-gaap_DividendsAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DividendsAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Dividends [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DividendsAxis" xlink:to="us-gaap_DividendsAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DividendsDomain" xlink:label="us-gaap_DividendsDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DividendsDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Dividends [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DividendsDomain" xlink:to="us-gaap_DividendsDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeriesCPreferredStockMember" xlink:label="us-gaap_SeriesCPreferredStockMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_SeriesCPreferredStockMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Series C Preferred Stock [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_SeriesCPreferredStockMember" xlink:to="us-gaap_SeriesCPreferredStockMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsReceivableBilledForLongTermContractsOrPrograms" xlink:label="us-gaap_AccountsReceivableBilledForLongTermContractsOrPrograms" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_AccountsReceivableBilledForLongTermContractsOrPrograms-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_AccountsReceivableBilledForLongTermContractsOrPrograms</link:label>
    <link:label xlink:label="us-gaap_AccountsReceivableBilledForLongTermContractsOrPrograms-label" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_AccountsReceivableBilledForLongTermContractsOrPrograms" xlink:to="us-gaap_AccountsReceivableBilledForLongTermContractsOrPrograms-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_FinancialArrangementSharePurchaseAgreementMember" xlink:label="cmre_FinancialArrangementSharePurchaseAgreementMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_FinancialArrangementSharePurchaseAgreementMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Financial Arrangement, Share Purchase Agreement [Member]</link:label>
    <link:label xlink:label="cmre_FinancialArrangementSharePurchaseAgreementMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents financing arrangement related to share purchase agreement.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_FinancialArrangementSharePurchaseAgreementMember" xlink:to="cmre_FinancialArrangementSharePurchaseAgreementMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeriesDPreferredStockMember" xlink:label="us-gaap_SeriesDPreferredStockMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_SeriesDPreferredStockMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Series D Preferred Stock [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_SeriesDPreferredStockMember" xlink:to="us-gaap_SeriesDPreferredStockMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeriesEPreferredStockMember" xlink:label="us-gaap_SeriesEPreferredStockMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_SeriesEPreferredStockMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Series E Preferred Stock [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_SeriesEPreferredStockMember" xlink:to="us-gaap_SeriesEPreferredStockMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_ReddickShippingCoAndVerandiShippingTermLoanMember" xlink:label="cmre_ReddickShippingCoAndVerandiShippingTermLoanMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_ReddickShippingCoAndVerandiShippingTermLoanMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Reddick Shipping Co. and Verandi Shipping Co.Term Loan [Member]</link:label>
    <link:label xlink:label="cmre_ReddickShippingCoAndVerandiShippingTermLoanMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents term loan issued by Riddick shipping Co. and Verandi Shipping Co.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_ReddickShippingCoAndVerandiShippingTermLoanMember" xlink:to="cmre_ReddickShippingCoAndVerandiShippingTermLoanMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_FivePreAndPostDeliveryFinancialAgreementsMember" xlink:label="cmre_FivePreAndPostDeliveryFinancialAgreementsMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_FivePreAndPostDeliveryFinancialAgreementsMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Five Pre- and Post-delivery Financial Agreements [Member]</link:label>
    <link:label xlink:label="cmre_FivePreAndPostDeliveryFinancialAgreementsMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Represents information pertaining to five pre- and post-delivery financial agreements.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_FivePreAndPostDeliveryFinancialAgreementsMember" xlink:to="cmre_FivePreAndPostDeliveryFinancialAgreementsMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeriesBPreferredStockMember" xlink:label="us-gaap_SeriesBPreferredStockMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_SeriesBPreferredStockMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Series B Preferred Stock [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_SeriesBPreferredStockMember" xlink:to="us-gaap_SeriesBPreferredStockMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearFour" xlink:label="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearFour" xlink:type="locator"/>
    <link:label xlink:label="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearFour-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearFour</link:label>
    <link:label xlink:label="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearFour-label" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xml:lang="en-US">2026 and thereafter</link:label>
    <link:label xlink:label="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearFour-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Amount of receivables under long-term contracts that have not been billed and were not billable that are expected to be collected in the forth fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearFour" xlink:to="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearFour-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity" xlink:label="us-gaap_StockholdersEquity" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_StockholdersEquity-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_StockholdersEquity</link:label>
    <link:label xlink:label="us-gaap_StockholdersEquity-label" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total stockholders&#8217; equity</link:label>
    <link:label xlink:label="us-gaap_StockholdersEquity-label" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xml:lang="en-US">Balance</link:label>
    <link:label xlink:label="us-gaap_StockholdersEquity-label" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xml:lang="en-US">Balance</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StockholdersEquity" xlink:to="us-gaap_StockholdersEquity-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ForeignExchangeForwardMember" xlink:label="us-gaap_ForeignExchangeForwardMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ForeignExchangeForwardMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Foreign Exchange Forward [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ForeignExchangeForwardMember" xlink:to="us-gaap_ForeignExchangeForwardMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt" xlink:label="us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt</link:label>
    <link:label xlink:label="us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Noncurrent Liabilities, Long-term Debt</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt" xlink:to="us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNoncurrentLiabilitiesLongTermDebt-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization" xlink:label="us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization</link:label>
    <link:label xlink:label="us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization-label" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xml:lang="en-US">Total fixed assets, net</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization" xlink:to="us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_AccountsReceivableNetNoncurrentMember" xlink:label="cmre_AccountsReceivableNetNoncurrentMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_AccountsReceivableNetNoncurrentMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accounts Receivable, Net, Noncurrent [Member]</link:label>
    <link:label xlink:label="cmre_AccountsReceivableNetNoncurrentMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to accounts receivable, net, noncurrent.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_AccountsReceivableNetNoncurrentMember" xlink:to="cmre_AccountsReceivableNetNoncurrentMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_AccountsReceivableNetMember" xlink:label="cmre_AccountsReceivableNetMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_AccountsReceivableNetMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Accounts Receivable, Net [Member]</link:label>
    <link:label xlink:label="cmre_AccountsReceivableNetMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to accounts receivable, net.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_AccountsReceivableNetMember" xlink:to="cmre_AccountsReceivableNetMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="us-gaap_StatementClassOfStockAxis" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_StatementClassOfStockAxis-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Class of Stock [Axis]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_StatementClassOfStockAxis" xlink:to="us-gaap_StatementClassOfStockAxis-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="us-gaap_ClassOfStockDomain" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ClassOfStockDomain-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Class of Stock [Domain]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ClassOfStockDomain" xlink:to="us-gaap_ClassOfStockDomain-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAcquiredFromAcquisition" xlink:label="us-gaap_CashAcquiredFromAcquisition" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_CashAcquiredFromAcquisition-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Cash acquired through asset acquisition</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_CashAcquiredFromAcquisition" xlink:to="us-gaap_CashAcquiredFromAcquisition-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtNoncurrent" xlink:label="us-gaap_LongTermDebtNoncurrent" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_LongTermDebtNoncurrent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Long-term debt, net of current portion and deferred financing costs (Note 11)</link:label>
    <link:label xlink:label="us-gaap_LongTermDebtNoncurrent-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Total long-term debt, non-current, net</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_LongTermDebtNoncurrent" xlink:to="us-gaap_LongTermDebtNoncurrent-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock" xlink:label="us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock" xlink:to="us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax" xlink:label="us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax-label" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Reclassification to Interest and finance costs</link:label>
    <link:label xlink:label="us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax</link:label>
    <link:label xlink:label="us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Other Comprehensive Income (Loss), Cash Flow Hedge, Gain (Loss), Reclassification, after Tax</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax" xlink:to="us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationAfterTax-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestRateSwapMember" xlink:label="us-gaap_InterestRateSwapMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_InterestRateSwapMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Interest Rate Swap [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InterestRateSwapMember" xlink:to="us-gaap_InterestRateSwapMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTaxParent" xlink:label="us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTaxParent" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTaxParent-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Unrealized gain on cash flow hedges, net (Notes 5, 19 and 21)</link:label>
    <link:label xlink:label="us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTaxParent-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Total</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTaxParent" xlink:to="us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTaxParent-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingSegmentsMember" xlink:label="us-gaap_OperatingSegmentsMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_OperatingSegmentsMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Operating Segments [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OperatingSegmentsMember" xlink:to="us-gaap_OperatingSegmentsMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeFixedInterestRate" xlink:label="us-gaap_DerivativeFixedInterestRate" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_DerivativeFixedInterestRate-label" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Fixed rate</link:label>
    <link:label xlink:label="us-gaap_DerivativeFixedInterestRate-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_DerivativeFixedInterestRate</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_DerivativeFixedInterestRate" xlink:to="us-gaap_DerivativeFixedInterestRate-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax" xlink:label="us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax-label" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xml:lang="en-US">Interest rate swaps, cross-currency swaps and interest rate caps</link:label>
    <link:label xlink:label="us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax</link:label>
    <link:label xlink:label="us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax-label" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xml:lang="en-US">Other Comprehensive Income (Loss), Cash Flow Hedge, Gain (Loss), before Reclassification, after Tax</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax" xlink:to="us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossBeforeReclassificationAfterTax-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_SteadmanMaritimeCoGeyerMaritimeCoAndGoodwayMaritimeCoMember" xlink:label="cmre_SteadmanMaritimeCoGeyerMaritimeCoAndGoodwayMaritimeCoMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_SteadmanMaritimeCoGeyerMaritimeCoAndGoodwayMaritimeCoMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Steadman Maritime Co., Geyer Maritime Co. and Goodway Maritime Co. [Member]</link:label>
    <link:label xlink:label="cmre_SteadmanMaritimeCoGeyerMaritimeCoAndGoodwayMaritimeCoMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to investments.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_SteadmanMaritimeCoGeyerMaritimeCoAndGoodwayMaritimeCoMember" xlink:to="cmre_SteadmanMaritimeCoGeyerMaritimeCoAndGoodwayMaritimeCoMember-label" xlink:type="arc"/>
    <link:loc xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestRateCapMember" xlink:label="us-gaap_InterestRateCapMember" xlink:type="locator"/>
    <link:label xlink:label="us-gaap_InterestRateCapMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Interest Rate Cap [Member]</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="us-gaap_InterestRateCapMember" xlink:to="us-gaap_InterestRateCapMember-label" xlink:type="arc"/>
    <link:loc xlink:href="cmre-20220630.xsd#cmre_LoanAgreementToPurchaseVolansVulpeculaVelaAndJpoVirgoMember" xlink:label="cmre_LoanAgreementToPurchaseVolansVulpeculaVelaAndJpoVirgoMember" xlink:type="locator"/>
    <link:label xlink:label="cmre_LoanAgreementToPurchaseVolansVulpeculaVelaAndJpoVirgoMember-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Loan Agreement to Purchase Volans, Vulpecula, Vela and JPO Virgo [Member]</link:label>
    <link:label xlink:label="cmre_LoanAgreementToPurchaseVolansVulpeculaVelaAndJpoVirgoMember-label" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xml:lang="en-US">Related to a loan agreement.</link:label>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="cmre_LoanAgreementToPurchaseVolansVulpeculaVelaAndJpoVirgoMember" xlink:to="cmre_LoanAgreementToPurchaseVolansVulpeculaVelaAndJpoVirgoMember-label" xlink:type="arc"/>
	<link:loc xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentType" xlink:label="dei_DocumentType" xlink:type="locator"/>
<link:label xlink:label="dei_DocumentType-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Document, Type</link:label>
<link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_DocumentType" xlink:to="dei_DocumentType-label" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentPeriodEndDate" xlink:label="dei_DocumentPeriodEndDate" xlink:type="locator"/>
<link:label xlink:label="dei_DocumentPeriodEndDate-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Document, Period End Date</link:label>
<link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_DocumentPeriodEndDate" xlink:to="dei_DocumentPeriodEndDate-label" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityFileNumber" xlink:label="dei_EntityFileNumber" xlink:type="locator"/>
<link:label xlink:label="dei_EntityFileNumber-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Entity, File Number</link:label>
<link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityFileNumber" xlink:to="dei_EntityFileNumber-label" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressAddressLine1" xlink:label="dei_EntityAddressAddressLine1" xlink:type="locator"/>
<link:label xlink:label="dei_EntityAddressAddressLine1-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Entity, Address, Address Line One</link:label>
<link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityAddressAddressLine1" xlink:to="dei_EntityAddressAddressLine1-label" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressCityOrTown" xlink:label="dei_EntityAddressCityOrTown" xlink:type="locator"/>
<link:label xlink:label="dei_EntityAddressCityOrTown-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Entity, Address, City or Town</link:label>
<link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityAddressCityOrTown" xlink:to="dei_EntityAddressCityOrTown-label" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressPostalZipCode" xlink:label="dei_EntityAddressPostalZipCode" xlink:type="locator"/>
<link:label xlink:label="dei_EntityAddressPostalZipCode-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Entity, Address, Postal Zip Code</link:label>
<link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityAddressPostalZipCode" xlink:to="dei_EntityAddressPostalZipCode-label" xlink:type="arc"/>

<link:loc xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressCountry" xlink:label="dei_EntityAddressCountry" xlink:type="locator"/>
<link:label xlink:label="dei_EntityAddressCountry-label" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xml:lang="en-US">Entity, Address, Country</link:label>
<link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityAddressCountry" xlink:to="dei_EntityAddressCountry-label" xlink:type="arc"/>

  </link:labelLink>
</link:linkbase>
