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  <xsd:element id="cmre_FinanceLeaseLiabilityExcludingFinanceCostsCurrent" name="FinanceLeaseLiabilityExcludingFinanceCostsCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_FinanceLeaseLiabilityExcludingFinanceCostsNoncurrent" name="FinanceLeaseLiabilityExcludingFinanceCostsNoncurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_FinanceLeaseObligationsCurrentAndNoncurrentTableTextBlock" name="FinanceLeaseObligationsCurrentAndNoncurrentTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_FinancialArrangementSharePurchaseAgreementMember" name="FinancialArrangementSharePurchaseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_FinancingArrangementsMember" name="FinancingArrangementsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_FirstFourNewbuildVesselsPurchasedMember" name="FirstFourNewbuildVesselsPurchasedMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_FirstQuarterOf2021Member" name="FirstQuarterOf2021Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_FirstQuarterOf2022Member" name="FirstQuarterOf2022Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_FivePreAndPostDeliveryFinancialAgreementsMember" name="FivePreAndPostDeliveryFinancialAgreementsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ForeignExchangeGainsLossesInOperatingIncomeLoss" name="ForeignExchangeGainsLossesInOperatingIncomeLoss" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_FourthQuarterOf2020Member" name="FourthQuarterOf2020Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_FourthQuarterOf2021Member" name="FourthQuarterOf2021Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_FutureMinimumContractualCharterRevenuesAssumptionsMember" name="FutureMinimumContractualCharterRevenuesAssumptionsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_GainLossOnAssetsHeldForSale" name="GainLossOnAssetsHeldForSale" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_GainLossOnInterestRateSwapsNotDesignatedAsHedgingInstruments" name="GainLossOnInterestRateSwapsNotDesignatedAsHedgingInstruments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_GainLossOnSaleVessels" name="GainLossOnSaleVessels" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_GeneralAdministrativeExpensesRelatedParties" name="GeneralAdministrativeExpensesRelatedParties" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_GeyerMaritimeCoMember" name="GeyerMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_GoodwayMaritimeCoMember" name="GoodwayMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_HalifaxExpressMember" name="HalifaxExpressMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_HeldtomaturitySecuritiesEquityInterestAcquired" name="HeldtomaturitySecuritiesEquityInterestAcquired" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_HuntingLicenseFacilityAgreementForDryBulkVesselsMember" name="HuntingLicenseFacilityAgreementForDryBulkVesselsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_HuntingLicenseFacilityAgreementForPythiasEgyptianMikePhoenixBelstarTbrOracleUniversalBremenTbrLibraMember" name="HuntingLicenseFacilityAgreementForPythiasEgyptianMikePhoenixBelstarTbrOracleUniversalBremenTbrLibraMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_HuntingLicenseFacilityAgreementToAcquireBernisVerityDawnDiscoveryClaraSerenaParityTaiboThunderEquityCuracaoAndRoseMember" name="HuntingLicenseFacilityAgreementToAcquireBernisVerityDawnDiscoveryClaraSerenaParityTaiboThunderEquityCuracaoAndRoseMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_HuntingLicenseFacilityToPurchaseProgressMeridaMinerUruguayResourceKonstantinosCetusExCharmTitanIBermondiOrionMerchiaAndDamonMember" name="HuntingLicenseFacilityToPurchaseProgressMeridaMinerUruguayResourceKonstantinosCetusExCharmTitanIBermondiOrionMerchiaAndDamonMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_HuntingLicenseLoanAgreementWith15CompaniesMember" name="HuntingLicenseLoanAgreementWith15CompaniesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_HydeMaritimeCoAndSkerrettMaritimeCoLoanAgreementMember" name="HydeMaritimeCoAndSkerrettMaritimeCoLoanAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_HydeMaritimeCoAndSkerrettMaritimeCoLoanAgreementTrancheAMember" name="HydeMaritimeCoAndSkerrettMaritimeCoLoanAgreementTrancheAMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_HydeMaritimeCoAndSkerrettMaritimeCoLoanAgreementTrancheBMember" name="HydeMaritimeCoAndSkerrettMaritimeCoLoanAgreementTrancheBMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_IncreaseDecreaseInAccruedCharterRevenue" name="IncreaseDecreaseInAccruedCharterRevenue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_InterestAndFinanceCostsMember" name="InterestAndFinanceCostsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_InterestCostsCapitalizedToVesselsAndAdvancesNet" name="InterestCostsCapitalizedToVesselsAndAdvancesNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_InterestFinanceCostsTableTextBlock" name="InterestFinanceCostsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_InterestFinanceCostsTextBlock" name="InterestFinanceCostsTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_InterestRateCapThreeMonthLIBORExceeds150PercentMember" name="InterestRateCapThreeMonthLIBORExceeds150PercentMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_InterestRateCapThreeMonthLIBORExceeds3percentMember" name="InterestRateCapThreeMonthLIBORExceeds3percentMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_InvestmentInterestRateStatedPercentageDeferredAccrual" name="InvestmentInterestRateStatedPercentageDeferredAccrual" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_InvestmentStatedInterestRate" name="InvestmentStatedInterestRate" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_InvestmentStatedInterestRatePayableQuarterly" name="InvestmentStatedInterestRatePayableQuarterly" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_January152021ToApril142021DividendsMember" name="January152021ToApril142021DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_January152022ToApril142022DividendsMember" name="January152022ToApril142022DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_KelsenShippingCoLoanAgreementMember" name="KelsenShippingCoLoanAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_KempMaritimeCoLoanAgreementMember" name="KempMaritimeCoLoanAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_KonstantakopoulosFamilyMember" name="KonstantakopoulosFamilyMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LCLawStylianouAssociatesLlcMember" name="LCLawStylianouAssociatesLlcMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LegalServiceMember" name="LegalServiceMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LeonidioAndKyparissiaMember" name="LeonidioAndKyparissiaMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisMember" name="LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisTrancheAMember" name="LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisTrancheAMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisTrancheBMember" name="LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisTrancheBMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoanAgreementToPartiallyRefinanceTermLoanMember" name="LoanAgreementToPartiallyRefinanceTermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoanAgreementToPurchaseVolansVulpeculaVelaAndJpoVirgoMember" name="LoanAgreementToPurchaseVolansVulpeculaVelaAndJpoVirgoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoanAgreementToRefinanceCostamareInc3Member" name="LoanAgreementToRefinanceCostamareInc3Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoanAgreementWith11CompaniesMember" name="LoanAgreementWith11CompaniesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoanAgreementWith11CompaniesRefinancingTrancheMember" name="LoanAgreementWith11CompaniesRefinancingTrancheMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoanAgreementWith11CompaniesTrancheAMember" name="LoanAgreementWith11CompaniesTrancheAMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoanAgreementWith11CompaniesTrancheBMember" name="LoanAgreementWith11CompaniesTrancheBMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoanAgreementWith11CompaniesTrancheCMember" name="LoanAgreementWith11CompaniesTrancheCMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_LongTermDebtGrossIncludingTermLoansAndOtherFinancingArrangements" name="LongTermDebtGrossIncludingTermLoansAndOtherFinancingArrangements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFiveAndThereafter" name="LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFiveAndThereafter" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_LongshawMaritimeInvestmentsSAMember" name="LongshawMaritimeInvestmentsSAMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_LongtermDebtGrossCurrentMaturities" name="LongtermDebtGrossCurrentMaturities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_LoraStylianouMember" name="LoraStylianouMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MajorCustomerAMember" name="MajorCustomerAMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MajorCustomerBMember" name="MajorCustomerBMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MajorCustomerCMember" name="MajorCustomerCMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MajorCustomerDMember" name="MajorCustomerDMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MajorCustomerEMember" name="MajorCustomerEMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MajorCustomersABCDAndEMember" name="MajorCustomersABCDAndEMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ManagementFeePerDayPerVessel" name="ManagementFeePerDayPerVessel" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_ManagementFeePerDayPerVesselUnderBareboatCharter" name="ManagementFeePerDayPerVesselUnderBareboatCharter" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_ManagementFeesRelatedParties" name="ManagementFeesRelatedParties" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MscAthensAndMscAthosMember" name="MscAthensAndMscAthosMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NeridaShippingCompanyTermLoanMember" name="NeridaShippingCompanyTermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NetBookValueMember" name="NetBookValueMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_NetSettlementsOnInterestRateSwapsQualifyingForCashFlowHedge" name="NetSettlementsOnInterestRateSwapsQualifyingForCashFlowHedge" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NoteToFinancialStatementDetailsTextual" name="NoteToFinancialStatementDetailsTextual" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NotesToFinancialStatements" name="NotesToFinancialStatements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NotesToFinancialStatementsAbstract" name="NotesToFinancialStatementsAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementMember" name="NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheAAndBMember" name="NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheAAndBMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheAMember" name="NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheAMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheCMember" name="NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheCMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheDMember" name="NovaraShippingCoFinneyShippingCoAlfordShippingCoAndNisbetShippingCoLoanAgreementTrancheDMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_NumberOfAssetAcquired" name="NumberOfAssetAcquired" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_NumberOfCompaniesAcquired" name="NumberOfCompaniesAcquired" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_NumberOfContainerVessels" name="NumberOfContainerVessels" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfDryBulkVessels" name="NumberOfDryBulkVessels" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfDrybulkVesselsDelivered" name="NumberOfDrybulkVesselsDelivered" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfDrybulkVesselsNotSecuredEmployment" name="NumberOfDrybulkVesselsNotSecuredEmployment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfDrybulkVesselsWithIndexlinkedTimeCharterRate" name="NumberOfDrybulkVesselsWithIndexlinkedTimeCharterRate" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfJointlyOwnedCompanies" name="NumberOfJointlyOwnedCompanies" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfShipsSubcontracted" name="NumberOfShipsSubcontracted" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfSubsidiaries" name="NumberOfSubsidiaries" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfUnencumberedVessels" name="NumberOfUnencumberedVessels" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfVesselsAcquiredUnderSPA" name="NumberOfVesselsAcquiredUnderSPA" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfVesselsAgreedToAcquire" name="NumberOfVesselsAgreedToAcquire" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_NumberOfVesselsCompletedDdDuringPeriod" name="NumberOfVesselsCompletedDdDuringPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_NumberOfVesselsHeldForSale" name="NumberOfVesselsHeldForSale" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_NumberOfVesselsProvidedAsCollateralsToSecureLoans" name="NumberOfVesselsProvidedAsCollateralsToSecureLoans" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfVesselsSurveyInProcess" name="NumberOfVesselsSurveyInProcess" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_NumberVesselsManaged" name="NumberVesselsManaged" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_October152020ToJanuary142021DividendsMember" name="October152020ToJanuary142021DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_October152021ToJanuary142022DividendsMember" name="October152021ToJanuary142022DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_OfficersCompensationChargedPeriodEnd" name="OfficersCompensationChargedPeriodEnd" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_OracleLibraAndNormaMember" name="OracleLibraAndNormaMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_OtherMember" name="OtherMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_OtherThirdpartyManagersMember" name="OtherThirdpartyManagersMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ParticipationOfCompanysWhollyOwnedSubsidiary" name="ParticipationOfCompanysWhollyOwnedSubsidiary" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_PaymentsToAcquireVessels" name="PaymentsToAcquireVessels" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_PercentageOwnership" name="PercentageOwnership" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_PlattMaritimeCoMember" name="PlattMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ProceedsFromSaleVessels" name="ProceedsFromSaleVessels" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_PropertyPlantAndEquipmentNetPeriodIncreaseDecrease" name="PropertyPlantAndEquipmentNetPeriodIncreaseDecrease" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_QuarterlyFeeToRelatedParties" name="QuarterlyFeeToRelatedParties" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_QuarterlyFeeToRelatedPartiesShares" name="QuarterlyFeeToRelatedPartiesShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_RealizedGainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments" name="RealizedGainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_ReclassificationFromDeferredGainNetToRightOfUseAssetsMember" name="ReclassificationFromDeferredGainNetToRightOfUseAssetsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_ReclassificationFromPrepaidLeaseRentalsToRightOfUseAssetsMember" name="ReclassificationFromPrepaidLeaseRentalsToRightOfUseAssetsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ReclassifiedToVesselsAndAdvancesNet" name="ReclassifiedToVesselsAndAdvancesNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_ReddickShippingCoAndVerandiShippingCoSecondTermLoanEachTrancheMember" name="ReddickShippingCoAndVerandiShippingCoSecondTermLoanEachTrancheMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_ReddickShippingCoAndVerandiShippingCoSecondTermLoanMember" name="ReddickShippingCoAndVerandiShippingCoSecondTermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_ReddickShippingCoAndVerandiShippingTermLoanMember" name="ReddickShippingCoAndVerandiShippingTermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_RefinanceTermLoanForBernisVerityDawnDiscoveryAndParityMember" name="RefinanceTermLoanForBernisVerityDawnDiscoveryAndParityMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_RefinanceTermLoanForMeridaBermondiTitanIAndUruguayMember" name="RefinanceTermLoanForMeridaBermondiTitanIAndUruguayMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_RefinanceTermLoanToVulpeculaVolansVirgoAndVelaAndTrancheCOf11CompaniesTermLoanMember" name="RefinanceTermLoanToVulpeculaVolansVirgoAndVelaAndTrancheCOf11CompaniesTermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_RefinanceTermLoansForEquityThunderRoseAndClaraMember" name="RefinanceTermLoansForEquityThunderRoseAndClaraMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_RefinanceTermLoansOf17CompaniesMember" name="RefinanceTermLoansOf17CompaniesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_RevenueDaysPerAnnum" name="RevenueDaysPerAnnum" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_SaleAndLeasebackTransactionAdditionalAmount" name="SaleAndLeasebackTransactionAdditionalAmount" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_SaleLeasebackTransactionTerm" name="SaleLeasebackTransactionTerm" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SaleLeasebackTransactionsRegardingTheVesselsLeonidioAndKyparissiaMember" name="SaleLeasebackTransactionsRegardingTheVesselsLeonidioAndKyparissiaMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SaleLeasebackTransactionsRegardingTheVesselsMscAzovMscAjaccioAndMscAmalfiMember" name="SaleLeasebackTransactionsRegardingTheVesselsMscAzovMscAjaccioAndMscAmalfiMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SaleLeasebackTransactionsRegardingVesselsMSCAthensAndMSCAthosMember" name="SaleLeasebackTransactionsRegardingVesselsMSCAthensAndMSCAthosMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfDeferredChargesTableTextBlock" name="ScheduleOfDeferredChargesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfDerivativeAssetsAndLiabilitiesAtFairValueTableTextBlock" name="ScheduleOfDerivativeAssetsAndLiabilitiesAtFairValueTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfDerivativesInASC815CashFlowHedgingRelationshipsTableTextBlock" name="ScheduleOfDerivativesInASC815CashFlowHedgingRelationshipsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfDerivativesNotDesignatedAsHedgingInstrumentsUnderASC815TableTextBlock" name="ScheduleOfDerivativesNotDesignatedAsHedgingInstrumentsUnderASC815TableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfFinancingCostsTableTextBlock" name="ScheduleOfFinancingCostsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfNonCancelableLongtermTimeCharterContractsTableTextBlock" name="ScheduleOfNonCancelableLongtermTimeCharterContractsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfUnbilledReceivablesNotBillableAtBalanceSheetDateTableTextBlock" name="ScheduleOfUnbilledReceivablesNotBillableAtBalanceSheetDateTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleVesselsAndAdvancesNetTableTextBlock" name="ScheduleVesselsAndAdvancesNetTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SealandIllinoisMember" name="SealandIllinoisMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SealandIllinoisSealandMichiganYorkAndMessiniMember" name="SealandIllinoisSealandMichiganYorkAndMessiniMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SealandWashingtonAndMaerskKalamataMember" name="SealandWashingtonAndMaerskKalamataMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SecondFourNewbuildVesselsPurchasedMember" name="SecondFourNewbuildVesselsPurchasedMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SecondLoanAgreementToRefinanceCostamareInc3Member" name="SecondLoanAgreementToRefinanceCostamareInc3Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_ShanghaiCostamareShipManagementCoLtdMember" name="ShanghaiCostamareShipManagementCoLtdMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SmalesMaritimeCoMember" name="SmalesMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SteadmanMaritimeCoGeyerMaritimeCoAndGoodwayMaritimeCoMember" name="SteadmanMaritimeCoGeyerMaritimeCoAndGoodwayMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SteadmanMaritimeCoMember" name="SteadmanMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_StockRepurchasedAndRetiredDuringPeriodAveragePricePerShare" name="StockRepurchasedAndRetiredDuringPeriodAveragePricePerShare" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_StockholdersEquityGainLossFromCommonControlTransaction" name="StockholdersEquityGainLossFromCommonControlTransaction" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_SwapInterestExpenseNet" name="SwapInterestExpenseNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SykesMaritimeCoMember" name="SykesMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_TermLoanAndOtherFinancingArrangementsMember" name="TermLoanAndOtherFinancingArrangementsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_TermLoanValueMaintenanceClauses" name="TermLoanValueMaintenanceClauses" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_The16CompaniesWhichOwnedOrCommittedToAcquireBulkVesselsMember" name="The16CompaniesWhichOwnedOrCommittedToAcquireBulkVesselsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_The2008BuiltVesselMember" name="The2008BuiltVesselMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_The2009BuiltVesselMember" name="The2009BuiltVesselMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_The3PercentSeries1NotesDue2023Member" name="The3PercentSeries1NotesDue2023Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_The5PercentSeries2NotesDue2023Member" name="The5PercentSeries2NotesDue2023Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_TheBondMember" name="TheBondMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_TheFifthOrSixthCouponPaymentDateMember" name="TheFifthOrSixthCouponPaymentDateMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_TheNinthCouponPaymentDateMember" name="TheNinthCouponPaymentDateMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_TheSeventhOrEighthCouponPaymentDateMember" name="TheSeventhOrEighthCouponPaymentDateMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_ThreeTranchesPerTrancheInfoMember" name="ThreeTranchesPerTrancheInfoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_ThunderAndMessiniMember" name="ThunderAndMessiniMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_TimeCharterArrangementsRemainingTermsPeriod" name="TimeCharterArrangementsRemainingTermsPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_TotalChargesByManagerToCompanysAffiliates" name="TotalChargesByManagerToCompanysAffiliates" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_TotalMember" name="TotalMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_TrancheAMember" name="TrancheAMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_TrancheBMember" name="TrancheBMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_TritonMember" name="TritonMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_TwentyfootEquivalentUnitsMeasuredOnEachVesselAcquired" name="TwentyfootEquivalentUnitsMeasuredOnEachVesselAcquired" nillable="true" substitutionGroup="xbrli:item" type="xbrli:decimalItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_TwentyfootEquivalentUnitsMeasuredOnEachVesselAgreedToAcquire" name="TwentyfootEquivalentUnitsMeasuredOnEachVesselAgreedToAcquire" nillable="true" substitutionGroup="xbrli:item" type="xbrli:decimalItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_TwentyfootEquivalentUnitsMeasuredOnVessel" name="TwentyfootEquivalentUnitsMeasuredOnVessel" nillable="true" substitutionGroup="xbrli:item" type="xbrli:decimalItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_TwentyfootEquivaletUnitsMeasuredOnEachVesselsAgreedToPurchase" name="TwentyfootEquivaletUnitsMeasuredOnEachVesselsAgreedToPurchase" nillable="true" substitutionGroup="xbrli:item" type="xbrli:decimalItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_TwoTranchesPerTrancheInfoMember" name="TwoTranchesPerTrancheInfoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_USRelatedGrossTransportationIncomeThatTaxApplies" name="USRelatedGrossTransportationIncomeThatTaxApplies" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearFour" name="UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearFour" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearOne" name="UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearOne" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearThree" name="UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearThree" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearTwo" name="UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearTwo" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_UnbilledReceivablesNotBillableValueAmountExpectedToBeCollectedInRemainderOfFiscalYear" name="UnbilledReceivablesNotBillableValueAmountExpectedToBeCollectedInRemainderOfFiscalYear" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_UnearnedRevenuesRegardingCharterRevenuesResultingFromVaryingCharterRatesMember" name="UnearnedRevenuesRegardingCharterRevenuesResultingFromVaryingCharterRatesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_UnearnedRevenuesRegardingHiresCollectedInAdvanceMember" name="UnearnedRevenuesRegardingHiresCollectedInAdvanceMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_UrizaShippingCoTermLoan2Member" name="UrizaShippingCoTermLoan2Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_VShipsGreeceLtdMember" name="VShipsGreeceLtdMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_VenetikoMember" name="VenetikoMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_VernesShippingCoLoanAgreementMember" name="VernesShippingCoLoanAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_VesselCostMember" name="VesselCostMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VesselHeldForSale" name="VesselHeldForSale" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_VesselNameOrHullName" name="VesselNameOrHullName" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_VesselOwningCompaniesOfFiveVesselsPurchasedFromYorkMember" name="VesselOwningCompaniesOfFiveVesselsPurchasedFromYorkMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VesselsAndAdvancesNet" name="VesselsAndAdvancesNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_VesselsAndAdvancesNetTextBlock" name="VesselsAndAdvancesNetTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VesselsAtCost" name="VesselsAtCost" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_VesselsNet" name="VesselsNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_VesselsSaleAndLeasebackPrice" name="VesselsSaleAndLeasebackPrice" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_VesselsUnderTimeCharter" name="VesselsUnderTimeCharter" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VoyageExpenses" name="VoyageExpenses" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VoyageExpensesRelatedParties" name="VoyageExpensesRelatedParties" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_VshipsShanghaiLimitedMember" name="VshipsShanghaiLimitedMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_WorkingCapitalSecurity" name="WorkingCapitalSecurity" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_WorkingCapitalSecurityPerVessel" name="WorkingCapitalSecurityPerVessel" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_WriteoffAndOtherMovements" name="WriteoffAndOtherMovements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_WriteoffDerivingFromFairValueMeasurement" name="WriteoffDerivingFromFairValueMeasurement" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_YearOfEstablishmentOrAcquisition" name="YearOfEstablishmentOrAcquisition" nillable="true" substitutionGroup="xbrli:item" type="xbrli:dateItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_YmTargetAndYmTiptopMember" name="YmTargetAndYmTiptopMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_YorkMember" name="YorkMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_ZIMNewYorkMember" name="ZIMNewYorkMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_ZIMShanghaiMember" name="ZIMShanghaiMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_Zim3PercentSeries1NotesAnd5PercentSeries2NotesDue2023Member" name="Zim3PercentSeries1NotesAnd5PercentSeries2NotesDue2023Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_Zim3PercentSeries1NotesDue2023Member" name="Zim3PercentSeries1NotesDue2023Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_Zim5PercentSeries2NotesDue2023Member" name="Zim5PercentSeries2NotesDue2023Member" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_ZimIntegratedServicesMember" name="ZimIntegratedServicesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-1-basis-of-presentation-and-general-information-customer-concentration-risk-details" name="statement-statement-note-1-basis-of-presentation-and-general-information-customer-concentration-risk-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-1-basis-of-presentation-and-general-information-reconciliation-of-cash-cash-equivalents-and-restricted-cash-details" name="statement-statement-note-1-basis-of-presentation-and-general-information-reconciliation-of-cash-cash-equivalents-and-restricted-cash-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-1-basis-of-presentation-and-general-information-tables" name="statement-statement-note-1-basis-of-presentation-and-general-information-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-10-equity-method-investments-companies-accounted-for-as-equity-method-investments-details" name="statement-statement-note-10-equity-method-investments-companies-accounted-for-as-equity-method-investments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-10-equity-method-investments-summarized-financial-information-on-equity-method-investments-details" name="statement-statement-note-10-equity-method-investments-summarized-financial-information-on-equity-method-investments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-10-equity-method-investments-tables" name="statement-statement-note-10-equity-method-investments-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-11-longterm-debt-annual-repayments-under-credit-facilities-and-term-loans-details" name="statement-statement-note-11-longterm-debt-annual-repayments-under-credit-facilities-and-term-loans-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-11-longterm-debt-financing-costs-included-in-loan-balances-details" name="statement-statement-note-11-longterm-debt-financing-costs-included-in-loan-balances-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-11-longterm-debt-schedule-of-longterm-debt-details" name="statement-statement-note-11-longterm-debt-schedule-of-longterm-debt-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-11-longterm-debt-tables" name="statement-statement-note-11-longterm-debt-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-12-rightofuse-assets-and-finance-lease-liabilities-finance-lease-obligations-details" name="statement-statement-note-12-rightofuse-assets-and-finance-lease-liabilities-finance-lease-obligations-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-12-rightofuse-assets-and-finance-lease-liabilities-tables" name="statement-statement-note-12-rightofuse-assets-and-finance-lease-liabilities-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-13-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-schedule-of-accrued-revenue-details" name="statement-statement-note-13-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-schedule-of-accrued-revenue-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-13-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-schedule-of-unearned-revenue-details" name="statement-statement-note-13-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-schedule-of-unearned-revenue-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-13-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-tables" name="statement-statement-note-13-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-14-commitments-and-contingencies-schedule-of-time-charter-arrangements-details" name="statement-statement-note-14-commitments-and-contingencies-schedule-of-time-charter-arrangements-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-14-commitments-and-contingencies-tables" name="statement-statement-note-14-commitments-and-contingencies-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-16-earnings-per-share-schedule-of-earnings-per-share-details" name="statement-statement-note-16-earnings-per-share-schedule-of-earnings-per-share-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-16-earnings-per-share-tables" name="statement-statement-note-16-earnings-per-share-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-17-interest-and-finance-costs-schedule-of-income-statement-related-costs-details" name="statement-statement-note-17-interest-and-finance-costs-schedule-of-income-statement-related-costs-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-17-interest-and-finance-costs-tables" name="statement-statement-note-17-interest-and-finance-costs-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-19-derivatives-cross-currency-swaps-details" name="statement-statement-note-19-derivatives-cross-currency-swaps-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-19-derivatives-derivatives-not-designated-as-hedging-instruments-and-ineffectiveness-of-hedging-instruments-details" name="statement-statement-note-19-derivatives-derivatives-not-designated-as-hedging-instruments-and-ineffectiveness-of-hedging-instruments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-19-derivatives-effect-of-derivative-instruments-details" name="statement-statement-note-19-derivatives-effect-of-derivative-instruments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-19-derivatives-tables" name="statement-statement-note-19-derivatives-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-20-financial-instruments-fair-value-of-assets-and-liabilities-details" name="statement-statement-note-20-financial-instruments-fair-value-of-assets-and-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-20-financial-instruments-tables" name="statement-statement-note-20-financial-instruments-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-4-segmental-financial-information-tables" name="statement-statement-note-4-segmental-financial-information-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-4-segmented-financial-information-summary-of-reportable-segments-details" name="statement-statement-note-4-segmented-financial-information-summary-of-reportable-segments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-7-vessels-and-advances-net-summary-of-vessels-details" name="statement-statement-note-7-vessels-and-advances-net-summary-of-vessels-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-7-vessels-and-advances-net-tables" name="statement-statement-note-7-vessels-and-advances-net-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-8-deferred-charges-net-schedule-of-deferred-charges-net-details" name="statement-statement-note-8-deferred-charges-net-schedule-of-deferred-charges-net-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-8-deferred-charges-net-tables" name="statement-statement-note-8-deferred-charges-net-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-significant-accounting-policies-policies" name="statement-statement-significant-accounting-policies-policies" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
</xsd:schema>
