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        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
      </link:roleType>
    </xsd:appinfo>
  </xsd:annotation>
  <xsd:element id="cmre_AccruedCharterRevenueCurrentAndNoncurrentAndUnearnedRevenueCurrentAndNoncurrentTextBlock" name="AccruedCharterRevenueCurrentAndNoncurrentAndUnearnedRevenueCurrentAndNoncurrentTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_AccruedRevenueNet" name="AccruedRevenueNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_AdeleShippingCoLoanAgreementMember" name="AdeleShippingCoLoanAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_AggregatePayableInRelationToTheConstructionAndInstallationOfScrubbers" name="AggregatePayableInRelationToTheConstructionAndInstallationOfScrubbers" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_AggregatePayableUponVesselsDelivery" name="AggregatePayableUponVesselsDelivery" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_AinsleyMaritimeCoAmbroseMaritimeCoKempMaritimeCoAndHydeMaritimeCoandSkerrettMaritimeCoMember" name="AinsleyMaritimeCoAmbroseMaritimeCoKempMaritimeCoAndHydeMaritimeCoandSkerrettMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_AinsleyMaritimeCoAndAmbroseMaritimeCoMember" name="AinsleyMaritimeCoAndAmbroseMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_AinsleyMaritimeCoMember" name="AinsleyMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_AmbroseMaritimeCoMember" name="AmbroseMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_AmortizationDeferredDrydockingSpecialSurvey" name="AmortizationDeferredDrydockingSpecialSurvey" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_AmortizationOfDeferredGain" name="AmortizationOfDeferredGain" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_AmortizationOfPrepaidLeaseRentals" name="AmortizationOfPrepaidLeaseRentals" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_AmortizationOfPrepaidLeaseRentalsNet" name="AmortizationOfPrepaidLeaseRentalsNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_AmountsReclassifiedFromNetSettlementsOnInterestRateSwapsQualifyingForHedgeAccountingToDepreciation" name="AmountsReclassifiedFromNetSettlementsOnInterestRateSwapsQualifyingForHedgeAccountingToDepreciation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_AnnualFeeToRelatedParties" name="AnnualFeeToRelatedParties" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_AnnualFeeToRelatedPartiesCharteredInCurrentPeriod" name="AnnualFeeToRelatedPartiesCharteredInCurrentPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_AnnualFeeToRelatedPartiesShares" name="AnnualFeeToRelatedPartiesShares" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ApproximateTwentyfootEquivaletUnitsMeasuredOnEachVesselOrdered" name="ApproximateTwentyfootEquivaletUnitsMeasuredOnEachVesselOrdered" nillable="true" substitutionGroup="xbrli:item" type="xbrli:decimalItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_AssetAcquisitionPercentageOfAssets" name="AssetAcquisitionPercentageOfAssets" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_BankChargesAndOtherFinancingCosts" name="BankChargesAndOtherFinancingCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_BastianShippingCoAndCadenceShippingCoLoanAgreementMember" name="BastianShippingCoAndCadenceShippingCoLoanAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_BenedictBertrandBeardmoreSchofieldAndFairbankMaritimeCoMember" name="BenedictBertrandBeardmoreSchofieldAndFairbankMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_BlueNetCharteringGmbHCoKGMember" name="BlueNetCharteringGmbHCoKGMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_CapetanissaMaritimeCoTermLoanMember" name="CapetanissaMaritimeCoTermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_CapitalCommitmentsAtPeriodEnd" name="CapitalCommitmentsAtPeriodEnd" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_CarryingCapacityOfVesselsAtPeriodEndTEU" name="CarryingCapacityOfVesselsAtPeriodEndTEU" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_CarryingValueOfVesselsProvidedAsCollateralsToSecureLoans" name="CarryingValueOfVesselsProvidedAsCollateralsToSecureLoans" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsTableTextBlock" name="CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_CommissionChargedOnCharterHireAgreements" name="CommissionChargedOnCharterHireAgreements" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_CommonStockIssuedForDividendReinvestmentPlanMember" name="CommonStockIssuedForDividendReinvestmentPlanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_CommonStockIssuedForTheServicesAgreementMember" name="CommonStockIssuedForTheServicesAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_CommonStockIssuedToCostamareShippingServicesLTDMember" name="CommonStockIssuedToCostamareShippingServicesLTDMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_CompaniesOwningTritonTitanTalosTaurusAndTheseusMember" name="CompaniesOwningTritonTitanTalosTaurusAndTheseusMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ConstructionAndInstallationOfScrubbersAmountFinanced" name="ConstructionAndInstallationOfScrubbersAmountFinanced" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_ConstructionAndInstallationOfScrubbersNumberOfExistingVesselsForWhichAmountsArePayable" name="ConstructionAndInstallationOfScrubbersNumberOfExistingVesselsForWhichAmountsArePayable" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ConstructionAndInstallationOfScrubbersNumberOfVesselsFinanced" name="ConstructionAndInstallationOfScrubbersNumberOfVesselsFinanced" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ConstructionSupervisoryFee" name="ConstructionSupervisoryFee" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_CostamareInc1Member" name="CostamareInc1Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_CostamareInc2Member" name="CostamareInc2Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_CostamareInc3Member" name="CostamareInc3Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_CostamareInc4Member" name="CostamareInc4Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_CostamareInc5Member" name="CostamareInc5Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_CostamareShippingCompanySAAndCostamareShippingServicesLTDMember" name="CostamareShippingCompanySAAndCostamareShippingServicesLTDMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_CostamareVenturesIncTextBlock" name="CostamareVenturesIncTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_CostamareVenturesMember" name="CostamareVenturesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_CostisMaritimeCoAndChristosMaritimeCoTermLoansMember" name="CostisMaritimeCoAndChristosMaritimeCoTermLoansMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_CostisMaritimeCoChristosMaritimeCoAndCapetanissaMaritimeCoMember" name="CostisMaritimeCoChristosMaritimeCoAndCapetanissaMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_CostisMaritimeCoTermLoanMember" name="CostisMaritimeCoTermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_CreditFacilityMember" name="CreditFacilityMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_DebtAgreementMaximumBorrowingCapacity" name="DebtAgreementMaximumBorrowingCapacity" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_DebtGuaranteePercentage" name="DebtGuaranteePercentage" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_DebtInstrumentAmoutAvailableToBeDrawn" name="DebtInstrumentAmoutAvailableToBeDrawn" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_DebtInstrumentPrepaidPaymentOnPrincipal" name="DebtInstrumentPrepaidPaymentOnPrincipal" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_DeferredChargesAdditions" name="DeferredChargesAdditions" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_DeferredChargesTextBlock" name="DeferredChargesTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_DeferredFinanceCostsAdditions" name="DeferredFinanceCostsAdditions" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_DeferredFinanceCostsAmortizationAndWriteoff" name="DeferredFinanceCostsAmortizationAndWriteoff" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_DeferredFinanceCostsIncludingCapitalLeasesNetCurrent" name="DeferredFinanceCostsIncludingCapitalLeasesNetCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_DeferredFinanceCostsIncludingCaptialLeaseNetNoncurrent" name="DeferredFinanceCostsIncludingCaptialLeaseNetNoncurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_DeferredFinancingCostsIncludingCapitalLeaseNet" name="DeferredFinancingCostsIncludingCapitalLeaseNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_DerivativeInstrumentsGainLossReclassifiedFromAccumulatedOCIIntoIncomeIneffectivePortionAndAmountExcludedFromEffectivenessTestingNet" name="DerivativeInstrumentsGainLossReclassifiedFromAccumulatedOCIIntoIncomeIneffectivePortionAndAmountExcludedFromEffectivenessTestingNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_DocumentAndEntityInformation" name="DocumentAndEntityInformation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_DrydockingCosts" name="DrydockingCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_EquityMethodInvestmentsSummarizedFinancialInformationTableTextBlock" name="EquityMethodInvestmentsSummarizedFinancialInformationTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ExcessAmountOfAcquisition" name="ExcessAmountOfAcquisition" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_ExpectedCharterTimeOfVessels" name="ExpectedCharterTimeOfVessels" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_FairValueOfSharesIssuedToManager" name="FairValueOfSharesIssuedToManager" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_FeesPaidByVesselowningSubsidiaryPercentage" name="FeesPaidByVesselowningSubsidiaryPercentage" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_FinanceLeaseAssociatedWithTheMSCAzovMember" name="FinanceLeaseAssociatedWithTheMSCAzovMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_FinanceLeaseLiabilityCurrentExcludingLiabilitiesToBeSettledThroughTermLoanProceeds" name="FinanceLeaseLiabilityCurrentExcludingLiabilitiesToBeSettledThroughTermLoanProceeds" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_FinanceLeaseLiabilityCurrentToBeSettledThroughTermLoanProceeds" name="FinanceLeaseLiabilityCurrentToBeSettledThroughTermLoanProceeds" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_FinanceLeaseLiabilityDeferredFinanceCostsCurrent" name="FinanceLeaseLiabilityDeferredFinanceCostsCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_FinanceLeaseLiabilityDeferredFinanceCostsNoncurrent" name="FinanceLeaseLiabilityDeferredFinanceCostsNoncurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_FinanceLeaseLiabilityExcludingFinanceCostsCurrent" name="FinanceLeaseLiabilityExcludingFinanceCostsCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_FinanceLeaseLiabilityExcludingFinanceCostsNoncurrent" name="FinanceLeaseLiabilityExcludingFinanceCostsNoncurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_FinanceLeaseLiabilityExcludingFinancingCosts" name="FinanceLeaseLiabilityExcludingFinancingCosts" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_FinanceLeaseObligationsCurrentAndNoncurrentTableTextBlock" name="FinanceLeaseObligationsCurrentAndNoncurrentTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_FinanceLeasedAssetsNet" name="FinanceLeasedAssetsNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_FinancialArrangementSharePurchaseAgreementMember" name="FinancialArrangementSharePurchaseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_FinancialArrangementTotal" name="FinancialArrangementTotal" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_FirstQuarter2018DividendsMember" name="FirstQuarter2018DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_FirstQuarter2019DividendsMember" name="FirstQuarter2019DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_FiveNewbuildVesselsExpectedToBeDeliveredBetweenTheSecondQuarterOf2020AndTheSecondQuarterOf2021Member" name="FiveNewbuildVesselsExpectedToBeDeliveredBetweenTheSecondQuarterOf2020AndTheSecondQuarterOf2021Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_FivePreAndPostDeliveryFinancialAgreementsMember" name="FivePreAndPostDeliveryFinancialAgreementsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_FollowOnOfferingProceedsNetRelatedExpenses" name="FollowOnOfferingProceedsNetRelatedExpenses" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ForeignExchangeGainsLossesInOperatingIncomeLoss" name="ForeignExchangeGainsLossesInOperatingIncomeLoss" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_FourthQuarter2017DividendsMember" name="FourthQuarter2017DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_FourthQuarter2018DividendsMember" name="FourthQuarter2018DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_FutureMinimumContractualCharterRevenuesAssumptionsMember" name="FutureMinimumContractualCharterRevenuesAssumptionsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_GainLossOnInterestRateSwapsNotDesignatedAsHedgingInstruments" name="GainLossOnInterestRateSwapsNotDesignatedAsHedgingInstruments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_GainLossOnSaleVessels" name="GainLossOnSaleVessels" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_GeneralAdministrativeExpensesRelatedParties" name="GeneralAdministrativeExpensesRelatedParties" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_GeyerMaritimeCoMember" name="GeyerMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_GoodwayMaritimeCoMember" name="GoodwayMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_HeldtomaturitySecuritiesEquityInterestAcquired" name="HeldtomaturitySecuritiesEquityInterestAcquired" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_HortonMaritimeCoMember" name="HortonMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_HydeMaritimeCoMember" name="HydeMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ImpairmentLossTransferredFromDeferredCharges" name="ImpairmentLossTransferredFromDeferredCharges" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_IncreaseDecreaseInAccruedCharterRevenue" name="IncreaseDecreaseInAccruedCharterRevenue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_InterestCostsCapitalizedToVesselsAndAdvancesNet" name="InterestCostsCapitalizedToVesselsAndAdvancesNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_InterestFinanceCostsTableTextBlock" name="InterestFinanceCostsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_InterestFinanceCostsTextBlock" name="InterestFinanceCostsTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_InvestmentInterestRateStatedPercentageDeferredAccrual" name="InvestmentInterestRateStatedPercentageDeferredAccrual" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_InvestmentStatedInterestRate" name="InvestmentStatedInterestRate" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_InvestmentStatedInterestRatePayableQuarterly" name="InvestmentStatedInterestRatePayableQuarterly" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_January152018ToApril142018DividendsMember" name="January152018ToApril142018DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_January152019ToApril142019DividendsMember" name="January152019ToApril142019DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_January302018ToApril142018DividendsMember" name="January302018ToApril142018DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_KempMaritimeCoAndHydeMaritimeCoMember" name="KempMaritimeCoAndHydeMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_KempMaritimeCoMember" name="KempMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_KonstantakopoulosFamilyMember" name="KonstantakopoulosFamilyMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisMember" name="LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisTrancheAMember" name="LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisTrancheAMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisTrancheBMember" name="LoanAgreementToPartiallyFinanceTheAcquisitionOfMegalopolisAndMarathopolisTrancheBMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoanAgreementToPartiallyRefinanceTermLoanMember" name="LoanAgreementToPartiallyRefinanceTermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoanAgreementToRefinanceTermLoanMember" name="LoanAgreementToRefinanceTermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoanAgreementToRefinanceTermLoanTrancheAMember" name="LoanAgreementToRefinanceTermLoanTrancheAMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_LoanAgreementToRefinanceTermLoanTrancheBMember" name="LoanAgreementToRefinanceTermLoanTrancheBMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_LongTermDebtGrossIncludingTermLoansAndOtherFinancingArrangements" name="LongTermDebtGrossIncludingTermLoansAndOtherFinancingArrangements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_LongtermDebtGrossCurrentMaturities" name="LongtermDebtGrossCurrentMaturities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_MSCPylosAndPiraeusMember" name="MSCPylosAndPiraeusMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MSCPylosMember" name="MSCPylosMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MajorCustomerAMember" name="MajorCustomerAMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MajorCustomerBMember" name="MajorCustomerBMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MajorCustomerCMember" name="MajorCustomerCMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MajorCustomerDMember" name="MajorCustomerDMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ManagementFeePerDayPerVessel" name="ManagementFeePerDayPerVessel" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_ManagementFeePerDayPerVesselUnderBareboatCharter" name="ManagementFeePerDayPerVesselUnderBareboatCharter" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_ManagementFeesExpressedAsGrossRevenue" name="ManagementFeesExpressedAsGrossRevenue" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ManagementFeesRelatedParties" name="ManagementFeesRelatedParties" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MarchantMaritimeCoMember" name="MarchantMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MasShippingCoTermLoanMember" name="MasShippingCoTermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MichiganTraderMegalopolisMarathopolisMaerskKlevenAndMaerskKotkaMember" name="MichiganTraderMegalopolisMarathopolisMaerskKlevenAndMaerskKotkaMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MontesShippingCoAndKelsenShippingCoTermLoansMember" name="MontesShippingCoAndKelsenShippingCoTermLoansMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_MontesShippingCoTermLoanMember" name="MontesShippingCoTermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NeridaShippingCompanyTermLoanMember" name="NeridaShippingCompanyTermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_NetSettlementsOnInterestRateSwapsQualifyingForCashFlowHedge" name="NetSettlementsOnInterestRateSwapsQualifyingForCashFlowHedge" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NoteToFinancialStatementDetailsTextual" name="NoteToFinancialStatementDetailsTextual" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NotesToFinancialStatements" name="NotesToFinancialStatements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_NotesToFinancialStatementsAbstract" name="NotesToFinancialStatementsAbstract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_NumberOfJointlyOwnedCompanies" name="NumberOfJointlyOwnedCompanies" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfSubsidiaries" name="NumberOfSubsidiaries" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfUnencumberedVessels" name="NumberOfUnencumberedVessels" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfVessels" name="NumberOfVessels" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfVesselsAcquired" name="NumberOfVesselsAcquired" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_NumberOfVesselsCompletedDdDuringPeriod" name="NumberOfVesselsCompletedDdDuringPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_NumberOfVesselsOrdered" name="NumberOfVesselsOrdered" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_NumberOfVesselsProvidedAsCollateralsToSecureLoans" name="NumberOfVesselsProvidedAsCollateralsToSecureLoans" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfVesselsUnderSaleAndLeasebackTransactions" name="NumberOfVesselsUnderSaleAndLeasebackTransactions" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfVesselsUnderSharePurchaseAgreement" name="NumberOfVesselsUnderSharePurchaseAgreement" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfVesselsUnderShipManagementCell" name="NumberOfVesselsUnderShipManagementCell" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberOfVesselsWriteDown" name="NumberOfVesselsWriteDown" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_NumberVesselsManaged" name="NumberVesselsManaged" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_NumberVesselsUnderwentDdDuringPeriod" name="NumberVesselsUnderwentDdDuringPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_October152017ToJanuary142018DividendsMember" name="October152017ToJanuary142018DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_October152018ToJanuary142019DividendsMember" name="October152018ToJanuary142019DividendsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_OfficersCompensationChargedPeriodEnd" name="OfficersCompensationChargedPeriodEnd" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_OtherNoncurrentAssetsTextBlock" name="OtherNoncurrentAssetsTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ParticipationAfterRestatement" name="ParticipationAfterRestatement" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ParticipationOfCompanysWhollyOwnedSubsidiary" name="ParticipationOfCompanysWhollyOwnedSubsidiary" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_PaymentsToAcquireVessels" name="PaymentsToAcquireVessels" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_PercentageOwnership" name="PercentageOwnership" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_PlattMaritimeCoAndSykesMaritimeCoMember" name="PlattMaritimeCoAndSykesMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_PlattMaritimeCoMember" name="PlattMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_PreferredStockSeriesExpenses" name="PreferredStockSeriesExpenses" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_PreferredStockSeriesIssuedDuringPeriodSharesNewIssues" name="PreferredStockSeriesIssuedDuringPeriodSharesNewIssues" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_PreferredStockSeriesIssuedDuringPeriodValueNewIssues" name="PreferredStockSeriesIssuedDuringPeriodValueNewIssues" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_PrepaidLeaseRentalsCurrent" name="PrepaidLeaseRentalsCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_PrepaidLeaseRentalsNet" name="PrepaidLeaseRentalsNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_PrepaidLeaseRentalsNonCurrent" name="PrepaidLeaseRentalsNonCurrent" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_PrepaidLeaseRentalsTableTextBlock" name="PrepaidLeaseRentalsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ProceedsFromSaleVessels" name="ProceedsFromSaleVessels" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_PropertyPlantAndEquipmentNetPeriodIncreaseDecrease" name="PropertyPlantAndEquipmentNetPeriodIncreaseDecrease" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_PurchaseFromYorkMember" name="PurchaseFromYorkMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_RaymondShippingCoAndTeranceShippingCoTermLoansMember" name="RaymondShippingCoAndTeranceShippingCoTermLoansMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_RaymondShippingCoAndTeranceShippingCoTermLoansTracheBMember" name="RaymondShippingCoAndTeranceShippingCoTermLoansTracheBMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_RaymondShippingCoAndTeranceShippingCoTermLoansTrancheAMember" name="RaymondShippingCoAndTeranceShippingCoTermLoansTrancheAMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_RealizedGainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments" name="RealizedGainLossOnForeignCurrencyDerivativeInstrumentsNotDesignatedAsHedgingInstruments" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_ReddickShippingCoAndVerandiShippingCoTermLoanTrancheAMember" name="ReddickShippingCoAndVerandiShippingCoTermLoanTrancheAMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_ReddickShippingCoAndVerandiShippingTermLoanMember" name="ReddickShippingCoAndVerandiShippingTermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_RenaMaritimeCoFinchShippingCoAndJoynerCarriersSaMember" name="RenaMaritimeCoFinchShippingCoAndJoynerCarriersSaMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_RenaMaritimeCoTermLoanMember" name="RenaMaritimeCoTermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_RevenueDaysPerAnnum" name="RevenueDaysPerAnnum" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_SaleAndLeasebackTransactionAdditionalAmount" name="SaleAndLeasebackTransactionAdditionalAmount" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_SaleLeasebackTransactionTerm" name="SaleLeasebackTransactionTerm" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SaleLeasebackTransactionsRegardingTheVesselsLeonidioAndKyparissiaMember" name="SaleLeasebackTransactionsRegardingTheVesselsLeonidioAndKyparissiaMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SaleLeasebackTransactionsRegardingTheVesselsMscAzovMscAjaccioAndMscAmalfiMember" name="SaleLeasebackTransactionsRegardingTheVesselsMscAzovMscAjaccioAndMscAmalfiMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SaleLeasebackTransactionsRegardingVesselsMSCAthensAndMSCAthosMember" name="SaleLeasebackTransactionsRegardingVesselsMSCAthensAndMSCAthosMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfDeferredChargesTableTextBlock" name="ScheduleOfDeferredChargesTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfDerivativeAssetsAndLiabilitiesAtFairValueTableTextBlock" name="ScheduleOfDerivativeAssetsAndLiabilitiesAtFairValueTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfDerivativesInASC815CashFlowHedgingRelationshipsTableTextBlock" name="ScheduleOfDerivativesInASC815CashFlowHedgingRelationshipsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfDerivativesNotDesignatedAsHedgingInstrumentsUnderASC815TableTextBlock" name="ScheduleOfDerivativesNotDesignatedAsHedgingInstrumentsUnderASC815TableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfFinancingCostsTableTextBlock" name="ScheduleOfFinancingCostsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfNonCancelableLongtermTimeCharterContractsTableTextBlock" name="ScheduleOfNonCancelableLongtermTimeCharterContractsTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleOfUnbilledReceivablesNotBillableAtBalanceSheetDateTableTextBlock" name="ScheduleOfUnbilledReceivablesNotBillableAtBalanceSheetDateTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_ScheduleVesselsAndAdvancesNetTableTextBlock" name="ScheduleVesselsAndAdvancesNetTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_ScscChairmanAndCeoMember" name="ScscChairmanAndCeoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_ScscGmMember" name="ScscGmMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_SettlementsOnInterestRateSwapsQualifyingForCashFlowHedge" name="SettlementsOnInterestRateSwapsQualifyingForCashFlowHedge" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_ShanghaiCostamareShipManagementCoLtdMember" name="ShanghaiCostamareShipManagementCoLtdMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SingletonShippingCoAndTatumShippingCoTermLoanMember" name="SingletonShippingCoAndTatumShippingCoTermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SkerrettMaritimeCoMember" name="SkerrettMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SmalesMaritimeCoMember" name="SmalesMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SteadmanMaritimeCoHortonMaritimeCoAndMarchantMaritimeCoMember" name="SteadmanMaritimeCoHortonMaritimeCoAndMarchantMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SteadmanMaritimeCoMember" name="SteadmanMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_SwapInterestExpenseNet" name="SwapInterestExpenseNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_SwapsBreakageCost" name="SwapsBreakageCost" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_SykesMaritimeCoMember" name="SykesMaritimeCoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_TermLoanAndOtherFinancingArrangementsMember" name="TermLoanAndOtherFinancingArrangementsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_TermLoanValueMaintenanceClauses" name="TermLoanValueMaintenanceClauses" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_The3PercentSeries1NotesDue2023Member" name="The3PercentSeries1NotesDue2023Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_The5PercentSeries2NotesDue2023Member" name="The5PercentSeries2NotesDue2023Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_TimeCharterArrangementsRemainingTermsPeriod" name="TimeCharterArrangementsRemainingTermsPeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_TotalChargesByManagerToCompanysAffiliates" name="TotalChargesByManagerToCompanysAffiliates" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_TrancheATermLoanMember" name="TrancheATermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_TrancheBAndCTermLoanMember" name="TrancheBAndCTermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_TrancheBTermLoanMember" name="TrancheBTermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_TrancheCTermLoanMember" name="TrancheCTermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_TrancheDTermLoanMember" name="TrancheDTermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_TrancheETermLoanMember" name="TrancheETermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_TritonTitanTalosTaurusAndTheseusMember" name="TritonTitanTalosTaurusAndTheseusMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_TwentyfootEquivalentUnitsMeasuredOnEachVesselAcquired" name="TwentyfootEquivalentUnitsMeasuredOnEachVesselAcquired" nillable="true" substitutionGroup="xbrli:item" type="xbrli:decimalItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_USRelatedGrossTransportationIncomeThatTaxApplies" name="USRelatedGrossTransportationIncomeThatTaxApplies" nillable="true" substitutionGroup="xbrli:item" type="num:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearFive" name="UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearFive" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearFour" name="UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearFour" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearSix" name="UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearSix" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearThree" name="UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearThree" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearTwo" name="UnbilledReceivablesNotBillableAmountExpectedToBeCollectedInYearTwo" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="cmre_UndineQuentinAndSanderShippingCoTrancheAAndBMember" name="UndineQuentinAndSanderShippingCoTrancheAAndBMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_UndineQuentinAndSanderShippingCoTrancheCMember" name="UndineQuentinAndSanderShippingCoTrancheCMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_UndineShippingCoQuentinShippingCoAndSanderShippingCoMember" name="UndineShippingCoQuentinShippingCoAndSanderShippingCoMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_UnearnedRevenuesRegardingCharterRevenuesResultingFromVaryingCharterRatesMember" name="UnearnedRevenuesRegardingCharterRevenuesResultingFromVaryingCharterRatesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_UnearnedRevenuesRegardingHiresCollectedInAdvanceMember" name="UnearnedRevenuesRegardingHiresCollectedInAdvanceMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_UnearnedRevenuesRegardingNetDeferredGainsMember" name="UnearnedRevenuesRegardingNetDeferredGainsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_UrizaShippingCoTermLoanMember" name="UrizaShippingCoTermLoanMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VesselHeldForSale" name="VesselHeldForSale" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_VesselNameOrHullName" name="VesselNameOrHullName" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VesselsAndAdvancesNet" name="VesselsAndAdvancesNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_VesselsAndAdvancesNetTextBlock" name="VesselsAndAdvancesNetTextBlock" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VesselsAtCost" name="VesselsAtCost" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_VesselsImpairmentLoss" name="VesselsImpairmentLoss" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VesselsNet" name="VesselsNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_VesselsSaleAndLeasebackPrice" name="VesselsSaleAndLeasebackPrice" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_VoyageExpenses" name="VoyageExpenses" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_VoyageExpensesRelatedParties" name="VoyageExpensesRelatedParties" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_WorkingCapitalSecurity" name="WorkingCapitalSecurity" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element id="cmre_WorkingCapitalSecurityPerVessel" name="WorkingCapitalSecurityPerVessel" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:periodType="instant"/>
  <xsd:element id="cmre_WriteoffAndOtherMovements" name="WriteoffAndOtherMovements" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_WriteoffDerivingFromFairValueMeasurement" name="WriteoffDerivingFromFairValueMeasurement" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="cmre_YearOfEstablishmentOrAcquisition" name="YearOfEstablishmentOrAcquisition" nillable="true" substitutionGroup="xbrli:item" type="xbrli:dateItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_YorkMember" name="YorkMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_Zim3PercentSeries1NotesDue2023Member" name="Zim3PercentSeries1NotesDue2023Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_Zim5PercentSeries2NotesDue2023Member" name="Zim5PercentSeries2NotesDue2023Member" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_ZimIntegratedServicesMember" name="ZimIntegratedServicesMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_ZimInvestmentsMember" name="ZimInvestmentsMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-1-basis-of-presentation-and-general-information-reconciliation-of-cash-cash-equivalents-and-restricted-cash-details" name="statement-statement-note-1-basis-of-presentation-and-general-information-reconciliation-of-cash-cash-equivalents-and-restricted-cash-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-1-basis-of-presentation-and-general-information-revenues-from-significant-charterers-details" name="statement-statement-note-1-basis-of-presentation-and-general-information-revenues-from-significant-charterers-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-1-basis-of-presentation-and-general-information-tables" name="statement-statement-note-1-basis-of-presentation-and-general-information-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-10-longterm-debt-annual-repayments-under-credit-facilities-and-term-loans-details" name="statement-statement-note-10-longterm-debt-annual-repayments-under-credit-facilities-and-term-loans-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-10-longterm-debt-financing-costs-included-in-loan-balances-details" name="statement-statement-note-10-longterm-debt-financing-costs-included-in-loan-balances-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-10-longterm-debt-schedule-of-longterm-debt-details" name="statement-statement-note-10-longterm-debt-schedule-of-longterm-debt-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-10-longterm-debt-tables" name="statement-statement-note-10-longterm-debt-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-11-rightofuse-assets-and-finance-lease-liabilities-annual-lease-payments-details" name="statement-statement-note-11-rightofuse-assets-and-finance-lease-liabilities-annual-lease-payments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-11-rightofuse-assets-and-finance-lease-liabilities-finance-lease-obligations-details" name="statement-statement-note-11-rightofuse-assets-and-finance-lease-liabilities-finance-lease-obligations-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-11-rightofuse-assets-and-finance-lease-liabilities-schedule-of-prepaid-lease-rentals-details" name="statement-statement-note-11-rightofuse-assets-and-finance-lease-liabilities-schedule-of-prepaid-lease-rentals-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-11-rightofuse-assets-and-finance-lease-liabilities-tables" name="statement-statement-note-11-rightofuse-assets-and-finance-lease-liabilities-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-12-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-schedule-of-accrued-revenue-details" name="statement-statement-note-12-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-schedule-of-accrued-revenue-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-12-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-schedule-of-unearned-revenue-details" name="statement-statement-note-12-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-schedule-of-unearned-revenue-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-12-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-tables" name="statement-statement-note-12-accrued-charter-revenue-current-and-noncurrent-unearned-revenue-current-and-noncurrent-and-time-charter-assumed-current-and-noncurrent-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-13-commitments-and-contingencies-schedule-of-time-charter-arrangements-details" name="statement-statement-note-13-commitments-and-contingencies-schedule-of-time-charter-arrangements-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-13-commitments-and-contingencies-tables" name="statement-statement-note-13-commitments-and-contingencies-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-15-earnings-per-share-schedule-of-earnings-per-share-details" name="statement-statement-note-15-earnings-per-share-schedule-of-earnings-per-share-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-15-earnings-per-share-tables" name="statement-statement-note-15-earnings-per-share-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-16-interest-and-finance-costs-schedule-of-income-statement-related-costs-details" name="statement-statement-note-16-interest-and-finance-costs-schedule-of-income-statement-related-costs-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-16-interest-and-finance-costs-tables" name="statement-statement-note-16-interest-and-finance-costs-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-18-derivatives-derivatives-not-designated-as-hedging-instruments-and-ineffectiveness-of-hedging-instruments-details" name="statement-statement-note-18-derivatives-derivatives-not-designated-as-hedging-instruments-and-ineffectiveness-of-hedging-instruments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-18-derivatives-effect-of-derivative-instruments-details" name="statement-statement-note-18-derivatives-effect-of-derivative-instruments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-18-derivatives-tables" name="statement-statement-note-18-derivatives-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-19-financial-instruments-fair-value-of-assets-and-liabilities-details" name="statement-statement-note-19-financial-instruments-fair-value-of-assets-and-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-19-financial-instruments-tables" name="statement-statement-note-19-financial-instruments-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-6-vessels-and-advances-net-summary-of-vessels-details" name="statement-statement-note-6-vessels-and-advances-net-summary-of-vessels-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-6-vessels-and-advances-net-tables" name="statement-statement-note-6-vessels-and-advances-net-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-7-deferred-charges-net-schedule-of-deferred-charges-net-details" name="statement-statement-note-7-deferred-charges-net-schedule-of-deferred-charges-net-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-7-deferred-charges-net-tables" name="statement-statement-note-7-deferred-charges-net-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-9-equity-method-investments-companies-accounted-for-as-equity-method-investments-details" name="statement-statement-note-9-equity-method-investments-companies-accounted-for-as-equity-method-investments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-9-equity-method-investments-summarized-financial-information-on-equity-method-investments-details" name="statement-statement-note-9-equity-method-investments-summarized-financial-information-on-equity-method-investments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-note-9-equity-method-investments-tables" name="statement-statement-note-9-equity-method-investments-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="cmre_statement-statement-significant-accounting-policies-policies" name="statement-statement-significant-accounting-policies-policies" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
</xsd:schema>
